JP2015522246A5 - - Google Patents
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- JP2015522246A5 JP2015522246A5 JP2015503288A JP2015503288A JP2015522246A5 JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5 JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- antibody
- cdr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616394P | 2012-03-27 | 2012-03-27 | |
| US61/616,394 | 2012-03-27 | ||
| US201261707411P | 2012-09-28 | 2012-09-28 | |
| US61/707,411 | 2012-09-28 | ||
| PCT/US2013/031178 WO2013148232A1 (en) | 2012-03-27 | 2013-03-14 | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522246A JP2015522246A (ja) | 2015-08-06 |
| JP2015522246A5 true JP2015522246A5 (OSRAM) | 2016-05-12 |
| JP6404208B2 JP6404208B2 (ja) | 2018-10-10 |
Family
ID=49261043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503288A Active JP6404208B2 (ja) | 2012-03-27 | 2013-03-14 | 特発性肺線維症の予後予測、診断および処置の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20160230226A1 (OSRAM) |
| EP (2) | EP3725892A1 (OSRAM) |
| JP (1) | JP6404208B2 (OSRAM) |
| KR (1) | KR102197524B1 (OSRAM) |
| CN (2) | CN104334744A (OSRAM) |
| AR (1) | AR090339A1 (OSRAM) |
| AU (2) | AU2013240344A1 (OSRAM) |
| BR (1) | BR112014023348A2 (OSRAM) |
| CA (1) | CA2864884A1 (OSRAM) |
| HK (1) | HK1206796A1 (OSRAM) |
| IL (1) | IL256396A (OSRAM) |
| MX (2) | MX370486B (OSRAM) |
| NZ (1) | NZ628458A (OSRAM) |
| RU (1) | RU2014139546A (OSRAM) |
| SG (2) | SG11201405830VA (OSRAM) |
| WO (1) | WO2013148232A1 (OSRAM) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| JP6078339B2 (ja) | 2009-05-07 | 2017-02-08 | ベラサイト インコーポレイテッド | 甲状腺状態の診断のための方法および組成物 |
| WO2013035799A1 (ja) | 2011-09-06 | 2013-03-14 | 株式会社シノテスト | ペリオスチンの特定領域に結合する抗体及びこれを用いたペリオスチンの測定方法 |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| WO2018048960A1 (en) * | 2016-09-07 | 2018-03-15 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク. | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| CA2924873A1 (en) * | 2013-10-23 | 2015-04-30 | Genentech, Inc. | Methods of diagnosing and treating eosinophilic disorders |
| JP6312054B2 (ja) * | 2013-11-06 | 2018-04-18 | 学校法人日本大学 | 間質性肺炎のバイオマーカー |
| JP2016537427A (ja) * | 2013-11-14 | 2016-12-01 | プロテリス, インコーポレイテッド | 一酸化炭素を用いた肺疾患の治療または予防 |
| US11119093B2 (en) | 2013-12-20 | 2021-09-14 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
| US9970935B2 (en) | 2014-02-06 | 2018-05-15 | The Brigham And Women's Hospital, Inc. | Uses of GLI1 in detecting tissue fibrosis |
| TW201618795A (zh) | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
| US9994905B2 (en) | 2014-04-25 | 2018-06-12 | Brown University | Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome |
| US9913819B2 (en) | 2014-06-12 | 2018-03-13 | Yale University | Methods of treating or preventing fibrotic lung diseases |
| EP2957634A1 (en) | 2014-06-20 | 2015-12-23 | Consejo Superior De Investigaciones Científicas | Compounds for prevention and/or treatment of fibrotic diseases |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US20170335396A1 (en) | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| CN104792998B (zh) * | 2015-03-09 | 2016-06-08 | 中国人民解放军第四军医大学 | Loxl2抗原用于制备甲状腺癌预示、侵袭、转移试剂盒的应用 |
| CN106290892A (zh) * | 2015-06-26 | 2017-01-04 | 上海市肿瘤研究所 | Cthrc1在肝硬化诊断和治疗中的应用 |
| US20180244792A1 (en) * | 2015-09-10 | 2018-08-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Anti-fibrotic effect of cd70 |
| CN108368043B (zh) * | 2015-10-27 | 2022-11-29 | 台北医学大学 | 用于治疗及/或预防纤维化疾病的吲哚啉衍生物 |
| CN105400870B (zh) * | 2015-11-11 | 2018-09-25 | 南方医科大学 | CD1c在菌阴肺结核诊断中的应用 |
| BR112018010337A2 (pt) * | 2015-11-23 | 2018-12-04 | Merck Patent Gmbh | anticorpo anti-alfa-v integrina para o tratamento de fibrose e/ou transtornos fibróticos |
| US20190144547A1 (en) | 2015-11-23 | 2019-05-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| EP3464240A1 (en) * | 2016-05-27 | 2019-04-10 | Boehringer Ingelheim International GmbH | Use of ecm biomarkers for the determining the treatment onset with nintedanib and pirfenidone |
| CN106319058B (zh) * | 2016-08-31 | 2019-09-10 | 汪道文 | 一种检测特发性肺纤维化致病基因的dna文库及其应用 |
| US11397178B2 (en) | 2016-10-28 | 2022-07-26 | Cedars-Sinai Medical Center | Method of predicting progression of idiopathic pulmonary fibrosis and monitoring of therapeutic efficacy |
| WO2018160925A1 (en) * | 2017-03-02 | 2018-09-07 | President And Fellows Of Harvard College | Methods and systems for predicting treatment responses in subjects |
| IT201700026858A1 (it) * | 2017-03-10 | 2018-09-10 | Univ Degli Studi Padova | Uso di inibitori delle serin proteasi, in particolare di serpinb3 |
| US20190127456A1 (en) * | 2017-10-31 | 2019-05-02 | Fibrogen, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| CN108931645A (zh) * | 2018-07-26 | 2018-12-04 | 北京大学第医院 | 一种hcv清除后肝纤维化评估系统及评估方法 |
| WO2020055812A1 (en) | 2018-09-10 | 2020-03-19 | Lung Therapeutics, Inc. | Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis |
| WO2020090683A1 (ja) * | 2018-10-29 | 2020-05-07 | 国立大学法人東京医科歯科大学 | 間質性肺炎患者の呼吸機能の低下リスクに関する情報を取得する方法及びその利用 |
| WO2020146887A1 (en) | 2019-01-11 | 2020-07-16 | University Of Virginia Patent Foundation | Compositions and methods for predicting lung function decline in idiopathic pulmonary fibrosis |
| CN116157688A (zh) * | 2020-07-31 | 2023-05-23 | 基因泰克公司 | 用于治疗炎症性呼吸系统疾病的恶化的方法 |
| EP4297768A4 (en) | 2021-02-25 | 2025-01-15 | Lung Therapeutics, LLC | Biomarkers for the treatment of interstitial lung disease |
| ES2957479B2 (es) * | 2022-06-07 | 2025-07-28 | Baigene S L | Metodo de obtencion de datos utiles para la prediccion del riesgo de un sujeto de sufrir fibrosis |
| CR20250009A (es) | 2022-06-17 | 2025-05-07 | Apogee Biologics Inc | Anticuerpos que se unen a interleuquina 13 y métodos de uso |
| CN115925920B (zh) * | 2022-08-04 | 2023-07-25 | 瑞因细胞工程科技(广州)有限公司 | 一种基因增强型免疫细胞治疗肝硬化的方法 |
| EP4619762A1 (en) * | 2022-11-14 | 2025-09-24 | Alentis Therapeutics AG | Biomarkers for fibrosis treatment using anti-claudin-1 antibodies |
| CN117747093B (zh) * | 2024-02-20 | 2024-06-07 | 神州医疗科技股份有限公司 | 一种特发性肺纤维化诊断模型的构建方法及诊断系统 |
| CN119162300A (zh) * | 2024-09-12 | 2024-12-20 | 中国人民解放军陆军军医大学第一附属医院 | 用于预测肺纤维化程度及预后情况的标志物、模型及应用 |
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| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| KR970000862B1 (ko) | 1992-06-09 | 1997-01-20 | 호프 아크티엔게젤샤프트 | 래치 및 잠금장치 |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| AR045614A1 (es) * | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
| ES2775204T3 (es) * | 2003-12-23 | 2020-07-24 | Genentech Inc | Nuevos anticuerpos anti IL13 y usos de los mismos |
| US20080044420A1 (en) | 2005-05-11 | 2008-02-21 | Heavner George A | Anti-IL-13 antibodies, compositions, methods and uses |
| WO2007036745A2 (en) | 2005-09-30 | 2007-04-05 | Medimmune Limited | Interleukin-13 antibody composition |
| JP5006330B2 (ja) | 2005-10-21 | 2012-08-22 | ノバルティス アーゲー | Il13に対するヒト抗体および治療的使用 |
| EP2672266B1 (en) * | 2006-01-13 | 2018-08-01 | Indiana University Research & Technology Corporation | Method for screening a lung transplant candidate for an elevated risk of rejection |
| TWI395754B (zh) * | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之c-kit抗體 |
| MX2009003762A (es) * | 2006-10-05 | 2009-07-10 | Centocor Ortho Biotech Inc | Antagonistas del receptor cc-quimiocina 2 para el tratamiento de fibrosis. |
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| AR066240A1 (es) * | 2007-04-23 | 2009-08-05 | Wyeth Corp | Metodos y composiciones para tratar y monitorear el tratamiento de trastornos asociados con il-13 |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| CA2705486C (en) * | 2007-11-19 | 2019-04-02 | Celera Corporation | Lung cancer markers and uses thereof |
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| WO2010028274A1 (en) * | 2008-09-05 | 2010-03-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation |
| BRPI0823231A2 (pt) * | 2008-11-26 | 2015-06-16 | Glaxo Group Ltd | Domínio variável único da imunoglobulina anti-interleucina-13 (il-13), antagonista da interleucina-13 (il-13), uso da antagonista, método para tratar e/ou prevenir uma condição mediada pela il-13 em um paciente, dispositivo de dispensação pulmonar contendo o antagonista, ligando específico duplo, ácido nucléico isolado ou recombinante, vetor, célula hospedeira, método para produzir polipeptídeo, e, proteína de fusão. |
| US8911960B2 (en) * | 2009-06-01 | 2014-12-16 | Case Western Reserve University | Method for identifying idiopathic pneumonia progression by measuring the level of mannose-binding protein C |
| WO2012083132A2 (en) * | 2010-12-16 | 2012-06-21 | Genentech, Inc. | Diagnosis and treatments relating to th2 inhibition |
-
2013
- 2013-03-14 SG SG11201405830VA patent/SG11201405830VA/en unknown
- 2013-03-14 AR ARP130100827A patent/AR090339A1/es unknown
- 2013-03-14 HK HK15107420.8A patent/HK1206796A1/xx unknown
- 2013-03-14 CN CN201380027564.8A patent/CN104334744A/zh active Pending
- 2013-03-14 NZ NZ628458A patent/NZ628458A/en not_active IP Right Cessation
- 2013-03-14 JP JP2015503288A patent/JP6404208B2/ja active Active
- 2013-03-14 AU AU2013240344A patent/AU2013240344A1/en not_active Abandoned
- 2013-03-14 WO PCT/US2013/031178 patent/WO2013148232A1/en not_active Ceased
- 2013-03-14 MX MX2014011503A patent/MX370486B/es active IP Right Grant
- 2013-03-14 RU RU2014139546A patent/RU2014139546A/ru not_active Application Discontinuation
- 2013-03-14 CA CA2864884A patent/CA2864884A1/en not_active Abandoned
- 2013-03-14 BR BR112014023348-9A patent/BR112014023348A2/pt not_active IP Right Cessation
- 2013-03-14 KR KR1020147029554A patent/KR102197524B1/ko not_active Expired - Fee Related
- 2013-03-14 CN CN201611178102.8A patent/CN107099581B/zh active Active
- 2013-03-14 SG SG10201702842SA patent/SG10201702842SA/en unknown
- 2013-03-14 EP EP20153153.0A patent/EP3725892A1/en not_active Withdrawn
- 2013-03-14 EP EP13768451.0A patent/EP2831280B1/en active Active
-
2014
- 2014-09-23 US US14/493,649 patent/US20160230226A1/en not_active Abandoned
- 2014-09-25 MX MX2019015159A patent/MX2019015159A/es unknown
-
2017
- 2017-12-18 IL IL256396A patent/IL256396A/en unknown
-
2018
- 2018-03-16 US US15/924,114 patent/US20190062836A1/en not_active Abandoned
- 2018-10-16 AU AU2018250393A patent/AU2018250393A1/en not_active Abandoned
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