JP2015521733A5 - - Google Patents
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- JP2015521733A5 JP2015521733A5 JP2015517213A JP2015517213A JP2015521733A5 JP 2015521733 A5 JP2015521733 A5 JP 2015521733A5 JP 2015517213 A JP2015517213 A JP 2015517213A JP 2015517213 A JP2015517213 A JP 2015517213A JP 2015521733 A5 JP2015521733 A5 JP 2015521733A5
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- 239000003153 chemical reaction reagent Substances 0.000 claims 21
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 14
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 14
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 13
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 13
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 13
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 13
- 102100027221 CD81 antigen Human genes 0.000 claims 11
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 11
- 102100027207 CD27 antigen Human genes 0.000 claims 8
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 8
- 239000007850 fluorescent dye Substances 0.000 claims 8
- 102100022464 5'-nucleotidase Human genes 0.000 claims 7
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 claims 7
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 7
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 claims 7
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 7
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 7
- 101000577540 Homo sapiens Neuropilin-1 Proteins 0.000 claims 7
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 7
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 7
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 7
- 102100028762 Neuropilin-1 Human genes 0.000 claims 7
- 102100035721 Syndecan-1 Human genes 0.000 claims 7
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 6
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 6
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 6
- 102000003729 Neprilysin Human genes 0.000 claims 6
- 108090000028 Neprilysin Proteins 0.000 claims 6
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 6
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 claims 5
- 101001018021 Homo sapiens T-lymphocyte surface antigen Ly-9 Proteins 0.000 claims 5
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 5
- 102100033447 T-lymphocyte surface antigen Ly-9 Human genes 0.000 claims 5
- 208000007660 Residual Neoplasm Diseases 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- -1 and the panel Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 208000021161 Plasma cell disease Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000000513 principal component analysis Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 1
- 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 1
- 102100039564 Leukosialin Human genes 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims 1
- 108010006700 Receptor Tyrosine Kinase-like Orphan Receptors Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 238000000491 multivariate analysis Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659524P | 2012-06-14 | 2012-06-14 | |
| US61/659,524 | 2012-06-14 | ||
| PCT/NL2013/050420 WO2013187765A2 (en) | 2012-06-14 | 2013-06-14 | Methods, reagents and kits for detecting minimal residual disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017238962A Division JP6524197B2 (ja) | 2012-06-14 | 2017-12-13 | 微小残存病変を検出するための方法、試薬およびキット。 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521733A JP2015521733A (ja) | 2015-07-30 |
| JP2015521733A5 true JP2015521733A5 (https=) | 2016-07-21 |
| JP6262218B2 JP6262218B2 (ja) | 2018-01-17 |
Family
ID=48741458
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517213A Active JP6262218B2 (ja) | 2012-06-14 | 2013-06-14 | 微小残存病変を検出するための方法、試薬およびキット。 |
| JP2017238962A Active JP6524197B2 (ja) | 2012-06-14 | 2017-12-13 | 微小残存病変を検出するための方法、試薬およびキット。 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017238962A Active JP6524197B2 (ja) | 2012-06-14 | 2017-12-13 | 微小残存病変を検出するための方法、試薬およびキット。 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20150160226A1 (https=) |
| EP (2) | EP3064942B1 (https=) |
| JP (2) | JP6262218B2 (https=) |
| CN (2) | CN107422122B (https=) |
| AU (2) | AU2013274965B2 (https=) |
| CA (2) | CA3022975C (https=) |
| DK (2) | DK2861987T3 (https=) |
| ES (1) | ES2660429T3 (https=) |
| WO (1) | WO2013187765A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150160226A1 (en) | 2012-06-14 | 2015-06-11 | Erasmus University Medical Center Rotterdam | Method, reagents, and kits for detecting minimal residual disease |
| WO2015160226A1 (ko) * | 2014-04-17 | 2015-10-22 | 주식회사 건강사랑 | 레드클로버 및 석류의 복합 추출물을 유효성분으로 포함하는 조성물의 여성 갱년기 개선 용도 |
| CA2993267A1 (en) * | 2015-08-07 | 2017-02-16 | Dana-Farber Cancer Institute, Inc. | Genetic abnormalities in plasma cell dyscrasias |
| CN105223360B (zh) * | 2015-08-28 | 2017-03-22 | 北京大学人民医院 | 鉴别检测正常浆细胞和克隆性浆细胞的试剂盒及其应用 |
| CN106290812A (zh) * | 2016-09-08 | 2017-01-04 | 北京海思特临床检验所有限公司 | B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法 |
| JP7084695B2 (ja) * | 2017-03-28 | 2022-06-15 | シスメックス株式会社 | 試薬選択支援装置、方法、プログラムおよび記録媒体並びに試料測定装置 |
| CN108458964A (zh) * | 2017-10-31 | 2018-08-28 | 天津协和华美医学诊断技术有限公司 | 一种抗体组合物及其在淋巴浆细胞性淋巴瘤微小残留检测中的应用 |
| CN121555430A (zh) | 2018-05-11 | 2026-02-24 | 比姆医疗股份有限公司 | 使用可编程碱基编辑器系统取代病原性氨基酸的方法 |
| CN109655616B (zh) * | 2018-12-19 | 2022-05-06 | 广州金域医学检验中心有限公司 | 检测急性髓系白血病细胞的组合试剂及系统 |
| CN109752548B (zh) * | 2019-02-01 | 2022-05-06 | 广州金域医学检验中心有限公司 | 评估慢性淋巴细胞白血病预后的组合试剂及系统 |
| CN109884313A (zh) * | 2019-02-22 | 2019-06-14 | 武汉康圣达医学检验所有限公司 | 急性b淋巴细胞白血病微小残留的检测试剂盒 |
| US11933783B2 (en) | 2020-02-25 | 2024-03-19 | Seema Singhal | Liquid biopsy yield enhancement |
| CN114487422A (zh) * | 2020-10-26 | 2022-05-13 | 苏州云泰生物医药科技有限公司 | 用于监测急性b淋巴细胞白血病微小残留病灶的流式细胞术试剂盒及监测方法 |
| CN112578117B (zh) * | 2021-02-22 | 2021-05-25 | 信纳克(北京)生化标志物检测医学研究有限责任公司 | 抗体组合物及其筛查移植后淋巴细胞增殖性疾病的应用 |
| CN112552407B (zh) * | 2021-02-24 | 2021-05-25 | 信纳克(北京)生化标志物检测医学研究有限责任公司 | 抗体组合物及其在检测急性b淋巴细胞白血病中的应用 |
| CN112698037B (zh) * | 2021-03-25 | 2021-06-25 | 北京积水潭医院 | 一种检测多发性骨髓瘤治疗效果的抗体组合物及其试剂盒和应用 |
| CN113419066B (zh) * | 2021-08-23 | 2021-11-02 | 信纳克(北京)生化标志物检测医学研究有限责任公司 | 一步法筛查和/或诊断克隆性疾病的试剂组合物及其应用 |
| CN113777327B (zh) * | 2021-09-13 | 2022-09-02 | 北京大学人民医院 | 用于白血病/淋巴瘤免疫分型初筛的抗体组合物及其应用 |
| CN113933511B (zh) * | 2021-09-18 | 2024-03-22 | 广州金域医学检验中心有限公司 | 检测急性b淋巴细胞白血病微小残留的抗体组合物及方法 |
| CN115197322B (zh) * | 2022-07-21 | 2024-01-30 | 江苏省人民医院（南京医科大学第一附属医院） | 用于慢性淋巴细胞白血病微小残留病灶检测的抗体组合物及其应用 |
| CN115491423A (zh) * | 2022-09-23 | 2022-12-20 | 珠海横琴铂华医学检验有限公司 | 一种用于b细胞淋巴瘤mrd监测的基因组合、试剂盒与应用 |
| CN116087518B (zh) * | 2022-11-02 | 2025-01-07 | 北京海思特医学检验实验室有限公司 | 一种mrd检测产品 |
| CN115902216B (zh) * | 2022-12-22 | 2025-03-18 | 苏州元德维康生物科技有限公司 | 筛查和/或诊断浆细胞肿瘤的试剂组合物及其应用 |
| CN115856302B (zh) * | 2023-03-02 | 2023-06-02 | 北京大学人民医院 | 用于成熟b细胞肿瘤免疫分型的抗体组合物及其应用 |
| WO2025080137A1 (en) | 2023-10-12 | 2025-04-17 | Stichting Euroflow | Methods, reagents and kits for detecting minimal/measurable disease in chronic lymphocytic leukemia (cll) |
| BG113932A (bg) | 2024-07-19 | 2026-01-30 | Медицински университет – Пловдив | Панели и китове от реагенти за измерване на минимална резидуална болест при детска в-клетъчна прекурсорна остра лимфобластна левкемия чрез имунофенотипизация |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2051651B1 (es) | 1992-12-10 | 1995-01-01 | Univ Salamanca | Procedimiento para la cuantificacion simultanea, en una sola medicion, de los principales tipos de linfocitos humanos y sus subpoblaciones. |
| NZ528205A (en) * | 2001-03-12 | 2006-09-29 | Monogen Inc | Cell-based detection and differentiation of disease status in a cytological sample using a panel comprising a plurality of probes |
| CN1646910A (zh) * | 2002-04-09 | 2005-07-27 | 学校法人东海大学 | 白血病、前白血病或非白血病性恶性血液疾病的判定方法以及诊断药 |
| US7507548B2 (en) * | 2003-03-04 | 2009-03-24 | University Of Salamanca | Multidimensional detection of aberrant phenotypes in neoplastic cells to be used to monitor minimal disease levels using flow cytometry measurements |
| WO2007053189A2 (en) * | 2005-06-01 | 2007-05-10 | Northwestern University | Compositions and methods for altering immune function |
| US20080254047A1 (en) * | 2007-02-23 | 2008-10-16 | Baylor Research Institute | Activation of Human Antigen-Presenting Cells Through CLEC-6 |
| EP2259065A1 (en) * | 2009-06-03 | 2010-12-08 | Erasmus University Medical Center Rotterdam | Methods, reagents and kits for flow cytometric immunophenotyping |
| US9677125B2 (en) * | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| CN102353793B (zh) * | 2011-07-07 | 2014-01-29 | 山东轻工业学院 | 白血病细胞内融合蛋白的二元流式液相阵列检测方法 |
| US20150160226A1 (en) | 2012-06-14 | 2015-06-11 | Erasmus University Medical Center Rotterdam | Method, reagents, and kits for detecting minimal residual disease |
-
2013
- 2013-06-14 US US14/407,268 patent/US20150160226A1/en not_active Abandoned
- 2013-06-14 DK DK13733084.1T patent/DK2861987T3/en active
- 2013-06-14 CN CN201710436056.5A patent/CN107422122B/zh active Active
- 2013-06-14 CN CN201380037624.4A patent/CN104471393B/zh active Active
- 2013-06-14 CA CA3022975A patent/CA3022975C/en active Active
- 2013-06-14 DK DK16166647.4T patent/DK3064942T3/en active
- 2013-06-14 CA CA2876405A patent/CA2876405C/en active Active
- 2013-06-14 JP JP2015517213A patent/JP6262218B2/ja active Active
- 2013-06-14 ES ES16166647.4T patent/ES2660429T3/es active Active
- 2013-06-14 AU AU2013274965A patent/AU2013274965B2/en active Active
- 2013-06-14 EP EP16166647.4A patent/EP3064942B1/en active Active
- 2013-06-14 WO PCT/NL2013/050420 patent/WO2013187765A2/en not_active Ceased
- 2013-06-14 EP EP13733084.1A patent/EP2861987B1/en active Active
-
2017
- 2017-11-14 US US15/812,384 patent/US10874710B2/en active Active
- 2017-12-13 JP JP2017238962A patent/JP6524197B2/ja active Active
-
2018
- 2018-06-20 AU AU2018204429A patent/AU2018204429B2/en active Active
-
2020
- 2020-10-30 US US17/085,840 patent/US11571457B2/en active Active
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