JP6262218B2 - 微小残存病変を検出するための方法、試薬およびキット。 - Google Patents

微小残存病変を検出するための方法、試薬およびキット。 Download PDF

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JP6262218B2
JP6262218B2 JP2015517213A JP2015517213A JP6262218B2 JP 6262218 B2 JP6262218 B2 JP 6262218B2 JP 2015517213 A JP2015517213 A JP 2015517213A JP 2015517213 A JP2015517213 A JP 2015517213A JP 6262218 B2 JP6262218 B2 JP 6262218B2
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cells
combination
conjugated
cd66c
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JP2015521733A5 (https=
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ドンゲン，ヤコブス ヨハネス マリア ファン
ドンゲン，ヤコブス ヨハネス マリア ファン
デ マトス コレイア エ ヴァレ，ホセ アルベルト オルファオ
デ マトス コレイア エ ヴァレ，ホセ アルベルト オルファオ
モンテロ，ファン アレハンドロ フロレス
モンテロ，ファン アレハンドロ フロレス
パラ，フリア マリア アルメイダ
パラ，フリア マリア アルメイダ
デル ヴェルデン，ヴィンセント ヘンリクス ヨハネス ファン
デル ヴェルデン，ヴィンセント ヘンリクス ヨハネス ファン
ベッチャー，セバスチャン
ウィレム ランゲラック，アントニー
ウィレム ランゲラック，アントニー
メジストリコヴァ，エスター
スチェパンスキー，トマシュ
リトゲン，マティアス
ダ シルヴァ ルシオ，パウロ ジョルジ モンテイロ
ダ シルヴァ ルシオ，パウロ ジョルジ モンテイロ
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Erasmus University Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1716—Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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JP2015517213A 2012-06-14 2013-06-14 微小残存病変を検出するための方法、試薬およびキット。 Active JP6262218B2 (ja)

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US61/659,524 2012-06-14
PCT/NL2013/050420 WO2013187765A2 (en) 2012-06-14 2013-06-14 Methods, reagents and kits for detecting minimal residual disease

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EP (2) EP3064942B1 (https=)
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AU (2) AU2013274965B2 (https=)
CA (2) CA3022975C (https=)
DK (2) DK2861987T3 (https=)
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US20150160226A1 (en) 2012-06-14 2015-06-11 Erasmus University Medical Center Rotterdam Method, reagents, and kits for detecting minimal residual disease
WO2015160226A1 (ko) * 2014-04-17 2015-10-22 주식회사 건강사랑 레드클로버 및 석류의 복합 추출물을 유효성분으로 포함하는 조성물의 여성 갱년기 개선 용도
CA2993267A1 (en) * 2015-08-07 2017-02-16 Dana-Farber Cancer Institute, Inc. Genetic abnormalities in plasma cell dyscrasias
CN105223360B (zh) * 2015-08-28 2017-03-22 北京大学人民医院 鉴别检测正常浆细胞和克隆性浆细胞的试剂盒及其应用
CN106290812A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法
JP7084695B2 (ja) * 2017-03-28 2022-06-15 シスメックス株式会社 試薬選択支援装置、方法、プログラムおよび記録媒体並びに試料測定装置
CN108458964A (zh) * 2017-10-31 2018-08-28 天津协和华美医学诊断技术有限公司 一种抗体组合物及其在淋巴浆细胞性淋巴瘤微小残留检测中的应用
CN121555430A (zh) 2018-05-11 2026-02-24 比姆医疗股份有限公司 使用可编程碱基编辑器系统取代病原性氨基酸的方法
CN109655616B (zh) * 2018-12-19 2022-05-06 广州金域医学检验中心有限公司 检测急性髓系白血病细胞的组合试剂及系统
CN109752548B (zh) * 2019-02-01 2022-05-06 广州金域医学检验中心有限公司 评估慢性淋巴细胞白血病预后的组合试剂及系统
CN109884313A (zh) * 2019-02-22 2019-06-14 武汉康圣达医学检验所有限公司 急性b淋巴细胞白血病微小残留的检测试剂盒
US11933783B2 (en) 2020-02-25 2024-03-19 Seema Singhal Liquid biopsy yield enhancement
CN114487422A (zh) * 2020-10-26 2022-05-13 苏州云泰生物医药科技有限公司 用于监测急性b淋巴细胞白血病微小残留病灶的流式细胞术试剂盒及监测方法
CN112578117B (zh) * 2021-02-22 2021-05-25 信纳克(北京)生化标志物检测医学研究有限责任公司 抗体组合物及其筛查移植后淋巴细胞增殖性疾病的应用
CN112552407B (zh) * 2021-02-24 2021-05-25 信纳克(北京)生化标志物检测医学研究有限责任公司 抗体组合物及其在检测急性b淋巴细胞白血病中的应用
CN112698037B (zh) * 2021-03-25 2021-06-25 北京积水潭医院 一种检测多发性骨髓瘤治疗效果的抗体组合物及其试剂盒和应用
CN113419066B (zh) * 2021-08-23 2021-11-02 信纳克(北京)生化标志物检测医学研究有限责任公司 一步法筛查和/或诊断克隆性疾病的试剂组合物及其应用
CN113777327B (zh) * 2021-09-13 2022-09-02 北京大学人民医院 用于白血病/淋巴瘤免疫分型初筛的抗体组合物及其应用
CN113933511B (zh) * 2021-09-18 2024-03-22 广州金域医学检验中心有限公司 检测急性b淋巴细胞白血病微小残留的抗体组合物及方法
CN115197322B (zh) * 2022-07-21 2024-01-30 江苏省人民医院（南京医科大学第一附属医院） 用于慢性淋巴细胞白血病微小残留病灶检测的抗体组合物及其应用
CN115491423A (zh) * 2022-09-23 2022-12-20 珠海横琴铂华医学检验有限公司 一种用于b细胞淋巴瘤mrd监测的基因组合、试剂盒与应用
CN116087518B (zh) * 2022-11-02 2025-01-07 北京海思特医学检验实验室有限公司 一种mrd检测产品
CN115902216B (zh) * 2022-12-22 2025-03-18 苏州元德维康生物科技有限公司 筛查和/或诊断浆细胞肿瘤的试剂组合物及其应用
CN115856302B (zh) * 2023-03-02 2023-06-02 北京大学人民医院 用于成熟b细胞肿瘤免疫分型的抗体组合物及其应用
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US20150160226A1 (en) 2015-06-11
CN104471393B (zh) 2017-07-07
US20210177936A1 (en) 2021-06-17
EP3064942A3 (en) 2016-10-19
CA2876405C (en) 2020-01-07
EP3064942B1 (en) 2017-12-20
WO2013187765A3 (en) 2014-04-24
CN104471393A (zh) 2015-03-25
AU2013274965A1 (en) 2015-01-22
AU2018204429A1 (en) 2018-07-05
US11571457B2 (en) 2023-02-07
CA3022975A1 (en) 2013-12-19
CN107422122B (zh) 2020-06-26
AU2013274965B2 (en) 2018-07-19
WO2013187765A2 (en) 2013-12-19
DK3064942T3 (en) 2018-03-05
CA3022975C (en) 2019-10-01
EP3064942A2 (en) 2016-09-07
US20180140664A1 (en) 2018-05-24
JP2015521733A (ja) 2015-07-30
ES2660429T3 (es) 2018-03-22
EP2861987A2 (en) 2015-04-22
DK2861987T3 (en) 2016-07-04
US10874710B2 (en) 2020-12-29
JP6524197B2 (ja) 2019-06-05
JP2018066752A (ja) 2018-04-26
CN107422122A (zh) 2017-12-01
AU2018204429B2 (en) 2020-04-02
EP2861987B1 (en) 2016-04-27
CA2876405A1 (en) 2013-12-19

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