JP2015521192A5 - - Google Patents
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- Publication number
- JP2015521192A5 JP2015521192A5 JP2015514375A JP2015514375A JP2015521192A5 JP 2015521192 A5 JP2015521192 A5 JP 2015521192A5 JP 2015514375 A JP2015514375 A JP 2015514375A JP 2015514375 A JP2015514375 A JP 2015514375A JP 2015521192 A5 JP2015521192 A5 JP 2015521192A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- independently
- ring
- phenyl
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170227.8 | 2012-05-31 | ||
| EP20120170227 EP2669286A1 (en) | 2012-05-31 | 2012-05-31 | Spiro tetrahydro-benzothiophen derivatives useful for the treatment of neurodegenerative diseases |
| US201261655078P | 2012-06-04 | 2012-06-04 | |
| US61/655,078 | 2012-06-04 | ||
| PCT/EP2013/001389 WO2013178322A1 (en) | 2012-05-31 | 2013-05-10 | Spiro tetrahydro - benzothiophen derivatives useful for the treatment neurodegenerative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521192A JP2015521192A (ja) | 2015-07-27 |
| JP2015521192A5 true JP2015521192A5 (https=) | 2017-09-14 |
| JP6209210B2 JP6209210B2 (ja) | 2017-10-04 |
Family
ID=46210136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514375A Expired - Fee Related JP6209210B2 (ja) | 2012-05-31 | 2013-05-10 | 神経変性疾患の処置のために有用なスピロテトラヒドロ−ベンゾチオフェン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9233982B2 (https=) |
| EP (2) | EP2669286A1 (https=) |
| JP (1) | JP6209210B2 (https=) |
| CN (1) | CN104364258B (https=) |
| AU (1) | AU2013269996B2 (https=) |
| CA (1) | CA2875132C (https=) |
| ES (1) | ES2581540T3 (https=) |
| IL (1) | IL235955B (https=) |
| WO (1) | WO2013178322A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015518048A (ja) | 2012-05-30 | 2015-06-25 | コメンティス， インコーポレイテッド | クロマン化合物 |
| US9580396B2 (en) | 2012-12-21 | 2017-02-28 | Merck Sharp & Dohme Corp. | C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and their use |
| WO2015038446A1 (en) | 2013-09-13 | 2015-03-19 | Merck Sharp & Dohme Corp. | C5-spiro iminothiazine dioxides as bace inhibitors, compositions, and their use |
| EP3201204B1 (en) | 2014-10-03 | 2021-02-24 | Merck Sharp & Dohme Corp. | C5-c6-fused tricyclic iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| KR102114536B1 (ko) | 2015-05-07 | 2020-05-22 | 브리스톨-마이어스 스큅 컴퍼니 | RORγ 조정제로서의 트리시클릭 술폰 |
| EP3523279A1 (en) | 2016-10-10 | 2019-08-14 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror gamma modulators |
| JP6785965B2 (ja) * | 2017-06-14 | 2020-11-18 | 日本曹達株式会社 | オキサジアゾリン化合物および有害生物防除剤 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TWI391385B (zh) * | 2006-07-18 | 2013-04-01 | Astellas Pharma Inc | An amine-based indane derivative or a salt thereof |
| EP2151435A4 (en) * | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| EP2318416B1 (en) | 2008-07-28 | 2013-09-04 | Eisai R&D Management Co., Ltd. | Spiroaminodihydrothiazine derivatives |
| JP5444240B2 (ja) * | 2008-07-28 | 2014-03-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スピロアミノジヒドロチアジン誘導体 |
| CA2753730C (en) * | 2009-03-13 | 2020-12-22 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
| CN102812005B (zh) * | 2010-02-24 | 2014-12-10 | 生命医药公司 | β-分泌酶抑制剂 |
| US20120065195A1 (en) * | 2010-03-31 | 2012-03-15 | Clark Christopher T | Compounds for treating neurodegenerative diseases |
-
2012
- 2012-05-31 EP EP20120170227 patent/EP2669286A1/en not_active Withdrawn
-
2013
- 2013-05-10 EP EP13722992.8A patent/EP2855486B1/en not_active Not-in-force
- 2013-05-10 ES ES13722992.8T patent/ES2581540T3/es active Active
- 2013-05-10 JP JP2015514375A patent/JP6209210B2/ja not_active Expired - Fee Related
- 2013-05-10 WO PCT/EP2013/001389 patent/WO2013178322A1/en not_active Ceased
- 2013-05-10 AU AU2013269996A patent/AU2013269996B2/en not_active Ceased
- 2013-05-10 CA CA2875132A patent/CA2875132C/en active Active
- 2013-05-10 CN CN201380028207.3A patent/CN104364258B/zh not_active Expired - Fee Related
- 2013-05-10 US US14/401,959 patent/US9233982B2/en not_active Expired - Fee Related
-
2014
- 2014-11-27 IL IL235955A patent/IL235955B/en active IP Right Grant
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