JP2015520762A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015520762A5 JP2015520762A5 JP2015513209A JP2015513209A JP2015520762A5 JP 2015520762 A5 JP2015520762 A5 JP 2015520762A5 JP 2015513209 A JP2015513209 A JP 2015513209A JP 2015513209 A JP2015513209 A JP 2015513209A JP 2015520762 A5 JP2015520762 A5 JP 2015520762A5
- Authority
- JP
- Japan
- Prior art keywords
- pasireotide
- weight
- formulation
- component
- receptor agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 35
- 238000009472 formulation Methods 0.000 claims 22
- VMZMNAABQBOLAK-DBILLSOUSA-N pasireotide Chemical compound C([C@H]1C(=O)N2C[C@@H](C[C@H]2C(=O)N[C@H](C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@H](C(N[C@@H](CC=2C=CC(OCC=3C=CC=CC=3)=CC=2)C(=O)N1)=O)CCCCN)C=1C=CC=CC=1)OC(=O)NCCN)C1=CC=CC=C1 VMZMNAABQBOLAK-DBILLSOUSA-N 0.000 claims 20
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 20
- 229960005415 pasireotide Drugs 0.000 claims 13
- 108700017947 pasireotide Proteins 0.000 claims 13
- 229940123051 Somatostatin receptor agonist Drugs 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- 239000003963 antioxidant agent Substances 0.000 claims 7
- 230000003078 antioxidant effect Effects 0.000 claims 7
- 235000006708 antioxidants Nutrition 0.000 claims 7
- 150000001982 diacylglycerols Chemical class 0.000 claims 5
- 239000002798 polar solvent Substances 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 5
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- HSXBEUMRBMAVDP-QKXVGOHISA-N [(3s,6s,9s,12r,15s,18s,20r)-9-(4-aminobutyl)-3-benzyl-12-(1h-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] n-(2-aminoethyl)carbamate;4-[(3-carboxy-2-hydroxynaphtha Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1.C([C@H]1C(=O)N2C[C@@H](C[C@H]2C(=O)N[C@H](C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@H](C(N[C@@H](CC=2C=CC(OCC=3C=CC=CC=3)=CC=2)C(=O)N1)=O)CCCCN)C=1C=CC=CC=1)OC(=O)NCCN)C1=CC=CC=C1 HSXBEUMRBMAVDP-QKXVGOHISA-N 0.000 claims 4
- 229960002570 pasireotide pamoate Drugs 0.000 claims 4
- 206010000599 Acromegaly Diseases 0.000 claims 3
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 3
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 3
- 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 claims 3
- 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- AFSHUZFNMVJNKX-UHFFFAOYSA-N 1,2-di-(9Z-octadecenoyl)glycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCC=CCCCCCCCC AFSHUZFNMVJNKX-UHFFFAOYSA-N 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims 2
- AFSHUZFNMVJNKX-LLWMBOQKSA-N 1,2-dioleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC\C=C/CCCCCCCC AFSHUZFNMVJNKX-LLWMBOQKSA-N 0.000 claims 2
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims 2
- RFVFQQWKPSOBED-PSXMRANNSA-N 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCC RFVFQQWKPSOBED-PSXMRANNSA-N 0.000 claims 2
- TYAQXZHDAGZOEO-KXQOOQHDSA-N 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCC TYAQXZHDAGZOEO-KXQOOQHDSA-N 0.000 claims 2
- MZWGYEJOZNRLQE-KXQOOQHDSA-N 1-stearoyl-2-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC MZWGYEJOZNRLQE-KXQOOQHDSA-N 0.000 claims 2
- ATHVAWFAEPLPPQ-VRDBWYNSSA-N 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC ATHVAWFAEPLPPQ-VRDBWYNSSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 208000014446 corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920002946 poly[2-(methacryloxy)ethyl phosphorylcholine] polymer Polymers 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000010254 subcutaneous injection Methods 0.000 claims 2
- 239000007929 subcutaneous injection Substances 0.000 claims 2
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 1
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 208000000668 Chronic Pancreatitis Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000008279 Dumping Syndrome Diseases 0.000 claims 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- 108010016076 Octreotide Proteins 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010033647 Pancreatitis acute Diseases 0.000 claims 1
- 206010033649 Pancreatitis chronic Diseases 0.000 claims 1
- 208000032395 Post gastric surgery syndrome Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000009311 VIPoma Diseases 0.000 claims 1
- WFKFNBBHVLMWQH-QKXVGOHISA-N acetic acid;[(3s,6s,9s,12r,15s,18s,20r)-9-(4-aminobutyl)-3-benzyl-12-(1h-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] n-(2-aminoethyl)carbamate Chemical compound CC(O)=O.C([C@H]1C(=O)N2C[C@@H](C[C@H]2C(=O)N[C@H](C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@H](C(N[C@@H](CC=2C=CC(OCC=3C=CC=CC=3)=CC=2)C(=O)N1)=O)CCCCN)C=1C=CC=CC=1)OC(=O)NCCN)C1=CC=CC=C1 WFKFNBBHVLMWQH-QKXVGOHISA-N 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000003229 acute pancreatitis Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 claims 1
- 239000003629 gastrointestinal hormone Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 239000004973 liquid crystal related substance Substances 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 229960002700 octreotide Drugs 0.000 claims 1
- 201000011116 pancreatic cholera Diseases 0.000 claims 1
- 208000030761 polycystic kidney disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2012/059917 | 2012-05-25 | ||
| PCT/EP2012/059917 WO2012160213A1 (en) | 2011-05-25 | 2012-05-25 | Controlled release peptide formulations |
| US201261730613P | 2012-11-28 | 2012-11-28 | |
| US61/730,613 | 2012-11-28 | ||
| PCT/EP2013/060739 WO2013174978A1 (en) | 2012-05-25 | 2013-05-24 | Somatostatin receptor agonist formulations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520762A JP2015520762A (ja) | 2015-07-23 |
| JP2015520762A5 true JP2015520762A5 (enExample) | 2016-07-28 |
| JP6374380B2 JP6374380B2 (ja) | 2018-08-15 |
Family
ID=49623188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513209A Active JP6374380B2 (ja) | 2012-05-25 | 2013-05-24 | ソマトスタチン受容体作動薬製剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11672843B2 (enExample) |
| JP (1) | JP6374380B2 (enExample) |
| KR (1) | KR102139080B1 (enExample) |
| CN (1) | CN104487050B (enExample) |
| AU (1) | AU2013265210B2 (enExample) |
| BR (1) | BR112014029425A2 (enExample) |
| CA (1) | CA2874367C (enExample) |
| CL (1) | CL2014003185A1 (enExample) |
| CO (1) | CO7160067A2 (enExample) |
| DK (1) | DK2861209T3 (enExample) |
| EA (1) | EA035495B1 (enExample) |
| ES (1) | ES2834318T3 (enExample) |
| HK (1) | HK1207985A1 (enExample) |
| IL (1) | IL235740A0 (enExample) |
| IN (1) | IN2014DN09831A (enExample) |
| MA (1) | MA37672A1 (enExample) |
| MX (1) | MX350964B (enExample) |
| NZ (1) | NZ702028A (enExample) |
| PE (1) | PE20150195A1 (enExample) |
| PH (1) | PH12014502614A1 (enExample) |
| SG (1) | SG11201407678YA (enExample) |
| TN (1) | TN2014000483A1 (enExample) |
| WO (1) | WO2013174978A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG173326A1 (en) * | 2004-06-04 | 2011-08-29 | Camurus Ab | Liquid depot formulations |
| KR102066755B1 (ko) * | 2011-05-25 | 2020-01-15 | 카무러스 에이비 | 조절 방출형 펩티드 제형 |
| WO2018060212A1 (en) * | 2016-09-27 | 2018-04-05 | Camurus Ab | Mixtures and formulations comprising an alkyl ammonium edta salt |
| CN113018248B (zh) * | 2019-12-23 | 2022-07-22 | 南京清普生物科技有限公司 | 一种缓释递药系统 |
| CN114240934B (zh) * | 2022-02-21 | 2022-05-10 | 深圳大学 | 一种基于肢端肥大症的图像数据分析方法及系统 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2209937B (en) | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5340802A (en) | 1989-06-30 | 1994-08-23 | Abbott Laboratories | Peptide analog type-B CCK receptor ligands |
| CA2535463A1 (en) | 1989-07-07 | 1991-01-08 | Novartis Ag | Octreotide-pamoate and its use in sustained release formulations of water soluble peptides |
| PH30995A (en) | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| MY107937A (en) | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
| AU2699892A (en) | 1991-10-04 | 1993-05-03 | Gs Biochem Ab | Particles, method of preparing said particles and uses thereof |
| WO1993006921A1 (en) | 1991-10-04 | 1993-04-15 | Gs Biochem Ab | Particles, method of preparing said particles and uses thereof |
| US6228383B1 (en) | 1994-03-03 | 2001-05-08 | Gs Development Ab | Use of fatty acid esters as bioadhesive substances |
| WO1995026715A2 (en) | 1994-03-30 | 1995-10-12 | Dumex-Alpharma A/S | Use of fatty acid esters as bioadhesive substances |
| SE518578C2 (sv) | 1994-06-15 | 2002-10-29 | Gs Dev Ab | Lipidbaserad komposition |
| FR2725369B1 (fr) | 1994-10-07 | 1997-01-03 | Oreal | Composition cosmetique ou dermatologique constituee d'une emulsion huile dans eau a base de globules huileux pourvus d'un enrobage cristal liquide lamellaire |
| CA2231273A1 (en) | 1995-10-12 | 1997-04-17 | Lise Sylvest Nielsen | A pharmaceutical composition for administration of an active substance to or through a skin or mucosal surface |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| EP0839525B1 (en) | 1996-10-31 | 2004-08-04 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| EP0975331A1 (en) | 1997-04-17 | 2000-02-02 | Dumex-Alpharma A/S | A novel bioadhesive drug delivery system based on liquid crystals |
| US6638621B2 (en) | 2000-08-16 | 2003-10-28 | Lyotropic Therapeutics, Inc. | Coated particles, methods of making and using |
| US20040018241A1 (en) | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| BE1011899A6 (fr) | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
| SI1140148T1 (sl) | 1998-12-22 | 2006-04-30 | Lilly Co Eli | Stabilna formulacija raztopine glukagonu podobnega peptida-1 |
| US6011067A (en) | 1999-06-11 | 2000-01-04 | Thione International, Inc. | Antioxidant composition for the treatment of psoriasis and related diseases |
| GB0018891D0 (en) * | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| US20020153508A1 (en) | 2000-06-29 | 2002-10-24 | Lynch Matthew Lawrence | Cubic liquid crystalline compositions and methods for their preparation |
| US7008646B2 (en) | 2001-02-20 | 2006-03-07 | Patrick Thomas Spicer | Cubic liquid crystalline compositions and methods for their preparation |
| US6936187B2 (en) | 2001-02-21 | 2005-08-30 | Matthew Lawrence Lynch | Functionalized cubic liquid crystalline phase materials and methods for their preparation and use |
| US6656385B2 (en) | 2001-02-21 | 2003-12-02 | The Procter & Gamble Company | Functionalized cubic liquid crystalline phase materials and methods for their preparation and use |
| CA2451432A1 (en) | 2001-06-23 | 2003-01-03 | Lyotropic Therapeutics, Inc. | Particles with improved solubilization capacity |
| DK1412384T3 (da) | 2001-06-28 | 2008-04-28 | Novo Nordisk As | Stabil formulering af modificeret GLP-1 |
| CA2472882A1 (en) | 2002-01-10 | 2003-07-17 | Imperial College Innovations Ltd | Use of pyy and glp-1, or an agonist thereof, for the modification of feeding behaviour |
| US7622118B2 (en) | 2002-07-15 | 2009-11-24 | Board Of Regents, The University Of Texas System | Cancer treatment methods using selected antibodies to aminophospholipids |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| GB0305941D0 (en) | 2003-03-14 | 2003-04-23 | Camurus Ab | Composition |
| GB0307777D0 (en) | 2003-04-04 | 2003-05-07 | Medical Res Council | Conjugate compounds |
| JP5180474B2 (ja) | 2003-08-04 | 2013-04-10 | カムルス エービー | 両親媒性粒子の特性を改良する方法 |
| JP5518282B2 (ja) | 2003-09-01 | 2014-06-11 | ノヴォ ノルディスク アー／エス | 安定なペプチドの製剤 |
| GB0322033D0 (en) | 2003-09-19 | 2003-10-22 | Camurus Ab | Composition |
| ES2623881T3 (es) | 2003-11-07 | 2017-07-12 | Camurus Ab | Composiciones de lípidos y péptidos catiónicos |
| WO2005063213A1 (en) | 2003-12-19 | 2005-07-14 | Biodelivery Sciences International, Inc. | Rigid liposomal cochleate and methods of use and manufacture |
| GB0401513D0 (en) | 2004-01-23 | 2004-02-25 | Camurus Ab | Compositions |
| JP4966018B2 (ja) | 2004-01-23 | 2012-07-04 | カムルス エービー | 三元非ラメラ脂質組成物 |
| SG173326A1 (en) * | 2004-06-04 | 2011-08-29 | Camurus Ab | Liquid depot formulations |
| PL1778187T3 (pl) | 2004-08-04 | 2012-09-28 | Camurus Ab | Kompozycje tworzące nielamelarne dyspersje |
| KR100983746B1 (ko) * | 2005-01-14 | 2010-09-24 | 카무러스 에이비 | 소마토스타틴 유사 제형 |
| DE602005026998D1 (de) | 2005-01-14 | 2011-04-28 | Camurus Ab | Somatostatin-analog-formulierungen |
| ES2343641T3 (es) | 2005-01-14 | 2010-08-05 | Camurus Ab | Formulaciones bioadhesivas topicas. |
| EP1848403B8 (en) | 2005-01-14 | 2010-05-19 | Camurus Ab | Topical bioadhesive formulations |
| US9060935B2 (en) * | 2005-01-21 | 2015-06-23 | Camurus Ab | Pharmaceutical lipid compositions |
| ES2399645T3 (es) | 2005-06-06 | 2013-04-02 | Camurus Ab | Formulaciones de análogos de GLP-1 |
| WO2007061896A1 (en) | 2005-11-17 | 2007-05-31 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
| GB0602639D0 (en) * | 2006-02-09 | 2006-03-22 | Novartis Ag | Organic compounds |
| PE20090387A1 (es) * | 2007-05-24 | 2009-04-28 | Novartis Ag | Formulacion de pasireotida |
| GB0711656D0 (en) | 2007-06-15 | 2007-07-25 | Camurus Ab | Formulations |
| GB0716385D0 (en) | 2007-08-22 | 2007-10-03 | Camurus Ab | Formulations |
| JP5721624B2 (ja) | 2008-07-08 | 2015-05-20 | ノバルティス アーゲー | 内因性高インスリン血症性低血糖症の治療のためのパシレオチドの使用 |
| GB0815435D0 (en) | 2008-08-22 | 2008-10-01 | Camurus Ab | Formulations |
| KR102066755B1 (ko) * | 2011-05-25 | 2020-01-15 | 카무러스 에이비 | 조절 방출형 펩티드 제형 |
| AU2012348640B2 (en) * | 2011-12-05 | 2016-07-21 | Camurus Ab | Robust controlled-release peptide formulations |
-
2013
- 2013-05-24 IN IN9831DEN2014 patent/IN2014DN09831A/en unknown
- 2013-05-24 BR BR112014029425A patent/BR112014029425A2/pt not_active Application Discontinuation
- 2013-05-24 MX MX2014014379A patent/MX350964B/es active IP Right Grant
- 2013-05-24 PE PE2014002215A patent/PE20150195A1/es not_active Application Discontinuation
- 2013-05-24 MA MA37672A patent/MA37672A1/fr unknown
- 2013-05-24 HK HK15108712.3A patent/HK1207985A1/xx unknown
- 2013-05-24 NZ NZ702028A patent/NZ702028A/en not_active IP Right Cessation
- 2013-05-24 CA CA2874367A patent/CA2874367C/en active Active
- 2013-05-24 SG SG11201407678YA patent/SG11201407678YA/en unknown
- 2013-05-24 ES ES13724299T patent/ES2834318T3/es active Active
- 2013-05-24 WO PCT/EP2013/060739 patent/WO2013174978A1/en not_active Ceased
- 2013-05-24 CN CN201380034030.8A patent/CN104487050B/zh active Active
- 2013-05-24 US US14/401,559 patent/US11672843B2/en active Active
- 2013-05-24 KR KR1020147036398A patent/KR102139080B1/ko active Active
- 2013-05-24 AU AU2013265210A patent/AU2013265210B2/en active Active
- 2013-05-24 DK DK13724299.6T patent/DK2861209T3/da active
- 2013-05-24 JP JP2015513209A patent/JP6374380B2/ja active Active
- 2013-05-24 EA EA201491928A patent/EA035495B1/ru not_active IP Right Cessation
-
2014
- 2014-11-17 IL IL235740A patent/IL235740A0/en unknown
- 2014-11-21 TN TN2014000483A patent/TN2014000483A1/fr unknown
- 2014-11-24 CL CL2014003185A patent/CL2014003185A1/es unknown
- 2014-11-24 PH PH12014502614A patent/PH12014502614A1/en unknown
- 2014-12-18 CO CO14278535A patent/CO7160067A2/es unknown
-
2023
- 2023-04-26 US US18/307,124 patent/US20230372436A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015520762A5 (enExample) | ||
| HRP20240781T1 (hr) | Formulacije peptida s kontroliranim oslobađanjem | |
| AR088458A1 (es) | Tratamiento de esclerosis multiple con la combinacion de laquinimod y fingolimod | |
| CA2594711A1 (en) | Somatostatin analogue formulations | |
| HRP20200072T1 (hr) | Načini doziranja za spojeve klase ehinokandina | |
| JP2017519018A5 (enExample) | ||
| JP2017031213A5 (enExample) | ||
| JP2015512392A5 (enExample) | ||
| TW200936167A (en) | Non-polymeric compositions for controlled drug delivery | |
| HRP20161500T1 (hr) | Formulacije cikličkog somatostatina s polaganim otpuštanjem | |
| US12097179B2 (en) | Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof | |
| JP2008521840A5 (enExample) | ||
| CH677449A5 (enExample) | ||
| CN105919998A (zh) | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 | |
| HRP20250009T1 (hr) | Čvrsta formulacija | |
| RU2017132330A (ru) | Соли производного хиназолина и способ их получения | |
| JP2022097600A (ja) | 抗ＴＮＦα抗体の液状製剤 | |
| RU2008136073A (ru) | Комбинация аналогов соматостатина с различной селективностью в отношении подтипов рецепторов соматостатина человека | |
| JP2020522502A5 (enExample) | ||
| JP2020527574A5 (enExample) | ||
| AU2022298186A1 (en) | Sustained release formulation composition comprising semaglutide or pharmaceutically acceptable salt thereof | |
| Bush et al. | Management of acromegaly: is there a role for primary medical therapy? | |
| JP6374380B2 (ja) | ソマトスタチン受容体作動薬製剤 | |
| JP2016503026A5 (enExample) | ||
| JP2016535015A5 (enExample) |