JP2015519923A5 - - Google Patents
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- JP2015519923A5 JP2015519923A5 JP2015518551A JP2015518551A JP2015519923A5 JP 2015519923 A5 JP2015519923 A5 JP 2015519923A5 JP 2015518551 A JP2015518551 A JP 2015518551A JP 2015518551 A JP2015518551 A JP 2015518551A JP 2015519923 A5 JP2015519923 A5 JP 2015519923A5
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- JP
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- Prior art keywords
- allele
- cells
- talen
- embryo
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 21
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- 238000012217 deletion Methods 0.000 claims description 16
- 230000037430 deletion Effects 0.000 claims description 16
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- 238000012546 transfer Methods 0.000 claims description 8
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- 238000000338 in vitro Methods 0.000 claims description 4
- 244000144972 livestock Species 0.000 claims description 4
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- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003809 male germ line stem cell Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 230000005937 nuclear translocation Effects 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000003822 preparative gas chromatography Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000024540 transposon integration Effects 0.000 description 1
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662767P | 2012-06-21 | 2012-06-21 | |
| US61/662,767 | 2012-06-21 | ||
| US13/594,694 | 2012-08-24 | ||
| US13/594,694 US20130117870A1 (en) | 2011-02-25 | 2012-08-24 | Genetically modified animals and methods for making the same |
| PCT/US2013/046590 WO2013192316A1 (en) | 2012-06-21 | 2013-06-19 | Genetically modified animals and methods for making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015519923A JP2015519923A (ja) | 2015-07-16 |
| JP2015519923A5 true JP2015519923A5 (enExample) | 2016-07-28 |
Family
ID=49769336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518551A Pending JP2015519923A (ja) | 2012-06-21 | 2013-06-19 | 遺伝子改変動物およびそれを作製するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2863736B1 (enExample) |
| JP (1) | JP2015519923A (enExample) |
| KR (1) | KR20150029715A (enExample) |
| CN (2) | CN105101787B (enExample) |
| AR (1) | AR091482A1 (enExample) |
| AU (1) | AU2013277214C1 (enExample) |
| CA (1) | CA2877297A1 (enExample) |
| MX (1) | MX2015000074A (enExample) |
| RU (1) | RU2015101740A (enExample) |
| WO (1) | WO2013192316A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9528124B2 (en) * | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| EP3060682B1 (en) | 2013-10-25 | 2023-08-30 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| JP6606088B2 (ja) * | 2014-02-24 | 2019-11-13 | サンガモ セラピューティクス， インコーポレイテッド | ヌクレアーゼ媒介性標的化組み込みのための方法および組成物 |
| CN103952424B (zh) | 2014-04-23 | 2017-01-11 | 尹熙俊 | 生产mstn双侧基因敲除的双肌性状体细胞克隆猪的方法 |
| MX2016014066A (es) * | 2014-04-28 | 2017-05-03 | Recombinetics Inc | Edicion de genes multiples en cerdos. |
| CN103952405B (zh) * | 2014-05-13 | 2016-02-10 | 扬州大学 | 一种山羊mstn基因定点修饰系统及其应用 |
| US10729112B2 (en) | 2014-08-28 | 2020-08-04 | Aarhus Universitet | Pig model for diabetes |
| SG10201902811TA (en) * | 2014-09-29 | 2019-04-29 | Jackson Lab | High efficiency, high throughput generation of genetically modified mammals by electroporation |
| CN104293833B (zh) * | 2014-10-09 | 2017-10-10 | 西北农林科技大学 | 一种基于TALEN介导的Sp110巨噬细胞特异打靶载体及重组细胞 |
| WO2017079428A1 (en) * | 2015-11-04 | 2017-05-11 | President And Fellows Of Harvard College | Site specific germline modification |
| CN105567659A (zh) * | 2016-01-05 | 2016-05-11 | 上海中医药大学附属曙光医院 | 小鼠nrdp1基因定点修饰系统及其应用 |
| CN105543257A (zh) * | 2016-01-18 | 2016-05-04 | 安徽农业大学 | 一种pAPN基因定点修饰猪 |
| WO2017135317A1 (ja) * | 2016-02-04 | 2017-08-10 | 花王株式会社 | 変異糸状菌の製造方法 |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| CN108690840B (zh) * | 2017-04-07 | 2020-10-09 | 北京百奥赛图基因生物技术有限公司 | Apoe基因敲除的动物模型的构建方法及其短肽 |
| JP7210028B2 (ja) * | 2017-07-18 | 2023-01-23 | 国立大学法人京都大学 | 遺伝子変異導入方法 |
| CN110484549B (zh) * | 2018-04-20 | 2023-10-03 | 北京大学 | 基因组靶向修饰方法 |
| CN111154801B (zh) * | 2018-11-07 | 2021-09-10 | 武汉纤然生物科技有限公司 | 一种提高基因编辑效率的方法 |
| CN111466338B (zh) * | 2019-01-23 | 2022-03-22 | 中国科学院广州生物医药与健康研究院 | Ddx5基因缺失的生精障碍小鼠模型及其构建方法 |
| CN114829882B (zh) | 2019-11-05 | 2023-02-28 | 阿比尔技术公司 | 植物产品中感染的预测 |
| CN112352739A (zh) * | 2020-11-11 | 2021-02-12 | 大连医科大学 | 一种非酒精性脂肪肝小鼠模型及其构建方法 |
| GB202118058D0 (en) | 2021-12-14 | 2022-01-26 | Univ Warwick | Methods to increase yields in crops |
| CN114574493A (zh) * | 2022-04-02 | 2022-06-03 | 中国科学院遗传与发育生物学研究所 | 一种编辑绵羊SOCS2基因的sgRNA组合、扩增用引物和应用 |
| CN114794029B (zh) * | 2022-06-09 | 2023-02-28 | 上海大学 | 一种计数秀丽隐杆线虫子宫内发育胚胎数目的方法 |
| GB2621813A (en) | 2022-06-30 | 2024-02-28 | Univ Newcastle | Preventing disease recurrence in Mitochondrial replacement therapy |
| CN115341044A (zh) * | 2022-10-19 | 2022-11-15 | 佛山科学技术学院 | 一种利用微生物及其相关snp位点预测猪日增重的方法 |
| GB202314578D0 (en) | 2023-09-22 | 2023-11-08 | Univ Manchester | Methods of producing homoplasmic modified plants or parts thereof |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888274A (en) | 1985-09-18 | 1989-12-19 | Yale University | RecA nucleoprotein filament and methods |
| US5763240A (en) | 1992-04-24 | 1998-06-09 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
| US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
| DE69841139D1 (de) * | 1997-07-14 | 2009-10-22 | Univ Liege | Mutationen im myostatingen steigern muskelmasse in säugetieren |
| US6632672B2 (en) | 1998-08-19 | 2003-10-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
| US6686515B1 (en) | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
| ATE490338T1 (de) | 2000-02-18 | 2010-12-15 | Univ Leland Stanford Junior | Veränderte rekombinasen zur modifizierung des genoms |
| DK1311661T3 (da) | 2000-08-14 | 2012-11-26 | Us Gov Health & Human Serv | Forøget homolog rekombination medieret ved lambda-rekombinationsproteiner |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AU2002324941A1 (en) | 2001-09-07 | 2003-03-24 | The Regents Of The University Of California | Method of generating a transgenic livestock animal |
| AU2002951347A0 (en) * | 2002-09-09 | 2002-09-26 | Benitec Australia Ltd | Genetic silencing |
| CA2563064A1 (en) * | 2004-04-22 | 2005-11-10 | Kirin Beer Kabushiki Kaisha | Transgenic animals and uses thereof |
| CN1970749B (zh) * | 2005-11-25 | 2011-09-28 | 上海杰隆生物工程股份有限公司 | 一种制备朊蛋白基因敲除家畜的方法 |
| CN101565706A (zh) * | 2008-04-25 | 2009-10-28 | 武汉市星站生物技术有限公司 | 构建基因重组运动发酵单胞菌应用于乙醇发酵 |
| WO2010008562A2 (en) | 2008-07-16 | 2010-01-21 | Recombinetics | Methods and materials for producing transgenic animals |
| US20100105140A1 (en) | 2008-07-16 | 2010-04-29 | Fahrenkrug Scott C | Plaice dna transposon system |
| US8212019B2 (en) * | 2008-07-30 | 2012-07-03 | University Of Massachusetts | Nucleic acid silencing sequences |
| US20110023158A1 (en) * | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Bovine genome editing with zinc finger nucleases |
| US20120030778A1 (en) * | 2008-12-04 | 2012-02-02 | Sigma-Aldrich Co., Llc. | Genomic editing of genes involved with parkinsons disease |
| WO2011002988A1 (en) * | 2009-07-01 | 2011-01-06 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for severe combined immunodeficiency (scid) |
| JP2013500018A (ja) * | 2009-07-24 | 2013-01-07 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | ゲノム編集のための方法 |
| NZ598457A (en) | 2009-08-03 | 2014-06-27 | Recombinetics Inc | Methods and compositions for targeted gene modification |
| KR20170125406A (ko) * | 2009-08-11 | 2017-11-14 | 상가모 테라퓨틱스, 인코포레이티드 | 표적화 변형에 대한 동형접합성 유기체 |
| CA2783351C (en) * | 2009-12-10 | 2021-09-07 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| EP2516652B1 (en) * | 2009-12-21 | 2014-11-05 | Keygene N.V. | Improved techniques for transfecting protoplasts |
| BR112012020257A8 (pt) | 2010-02-11 | 2018-02-14 | Recombinetics Inc | métodos e aparelhos para produzir artiodátilos transgênicos |
| JP5817955B2 (ja) * | 2010-04-27 | 2015-11-18 | プライムテック株式会社 | 血友病ａモデルブタの作出 |
| CA2798988C (en) * | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
| EP2392208B1 (en) * | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use |
| US20140127814A1 (en) * | 2010-08-10 | 2014-05-08 | Srinivasan Chandrasegaran | Generation and use of pluripotent stem cells |
| EP3450563A1 (en) * | 2011-02-25 | 2019-03-06 | Recombinetics, Inc. | Genetically modified animals and methods for making the same |
| CN102212545B (zh) * | 2011-04-07 | 2013-05-08 | 北京济福霖生物技术有限公司 | 利用锌指核酸酶敲除牛β-乳球蛋白基因的方法 |
-
2013
- 2013-06-18 AR ARP130102152 patent/AR091482A1/es unknown
- 2013-06-19 RU RU2015101740A patent/RU2015101740A/ru not_active Application Discontinuation
- 2013-06-19 MX MX2015000074A patent/MX2015000074A/es unknown
- 2013-06-19 JP JP2015518551A patent/JP2015519923A/ja active Pending
- 2013-06-19 CN CN201380042554.1A patent/CN105101787B/zh active Active
- 2013-06-19 WO PCT/US2013/046590 patent/WO2013192316A1/en not_active Ceased
- 2013-06-19 EP EP13806511.5A patent/EP2863736B1/en active Active
- 2013-06-19 CA CA2877297A patent/CA2877297A1/en not_active Abandoned
- 2013-06-19 CN CN201810934057.7A patent/CN109321603A/zh active Pending
- 2013-06-19 KR KR1020157001690A patent/KR20150029715A/ko not_active Ceased
- 2013-06-19 AU AU2013277214A patent/AU2013277214C1/en active Active
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