JP2015517983A5 - - Google Patents

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Publication number
JP2015517983A5
JP2015517983A5 JP2015500634A JP2015500634A JP2015517983A5 JP 2015517983 A5 JP2015517983 A5 JP 2015517983A5 JP 2015500634 A JP2015500634 A JP 2015500634A JP 2015500634 A JP2015500634 A JP 2015500634A JP 2015517983 A5 JP2015517983 A5 JP 2015517983A5
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Japan
Prior art keywords
nitric oxide
delivery system
oxide delivery
pulses
patient
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JP2015500634A
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English (en)
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JP6245613B2 (ja
JP2015517983A (ja
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Priority claimed from US13/420,852 external-priority patent/US20130239962A1/en
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Priority claimed from PCT/US2013/031665 external-priority patent/WO2013138654A1/en
Publication of JP2015517983A publication Critical patent/JP2015517983A/ja
Publication of JP2015517983A5 publication Critical patent/JP2015517983A5/ja
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Claims (12)

  1. 一酸化窒素送達システムであって、患者に一酸化窒素（ＮＯ）を含む治療用ガスの複数のパルスを送達し、少なくとも一つのパルスは、
    ｉ． ２，２００ ｐｐｍＮＯか又は２，２００ ｐｐｍＮＯより高いＮＯ送達濃度を含み、
    ｉｉ． ８３μｇＮＯ／秒か又は８３μｇＮＯ／秒より低い用量速度で投与され、
    ｉｉｉ．０．８Ｌ／分か又は０．８Ｌ／分より低い治療用ガスの流速で投与され、
    ｉｖ． １ｍＬか又は１ｍＬより小さいパルス容積を有し、
    ｖ． ４２０ｎｍｏｌより少ないＮＯを含む
    一酸化窒素送達システム。
  2. 送達濃度が２，２００ ｐｐｍＮＯから５，０００ ｐｐｍＮＯの範囲にある、請求項１に記載の一酸化窒素送達システム。
  3. 治療用ガスが呼吸毎に患者に投与される、請求項１又は２に記載の一酸化窒素送達システム。
  4. 治療用ガスが間欠的に患者に投与される、請求項１又は２に記載の一酸化窒素送達システム。
  5. 複数のパルスが０．００１から４．５ｍｇＮＯ／ｋｇ／時間の範囲の用量で患者に送達される、請求項１から４のいずれか一項に記載の一酸化窒素送達システム。
  6. 複数のパルスが０．００１から０．５ｍｇＮＯ／ｋｇ／時間の範囲の用量で患者に送達される、請求項１から４のいずれか一項に記載の一酸化窒素送達システム。
  7. 複数のパルスが少なくとも４８時間の処置期間に送達される、請求項１から６のいずれか一項に記載の一酸化窒素送達システム。
  8. 複数のパルスが少なくとも７２時間の処置期間に送達される、請求項１から６のいずれか一項に記載の一酸化窒素送達システム。
  9. 治療用ガスが未希釈の形態であり、それにより送達濃度が貯蔵濃度と同一である、請求項１から８のいずれか一項に記載の一酸化窒素送達システム。
  10. 肺高血圧症の治療における使用のための、請求項１から９のいずれか一項に記載の一酸化窒素送達システム。
  11. 肺高血圧症が肺動脈高血圧症（ＰＡＨ）である、請求項１０に記載の一酸化窒素送達システム。
  12. 肺高血圧症が慢性閉塞性肺疾患（ＣＯＰＤ）に関連している、請求項１０に記載の一酸化窒素送達システム。
JP2015500634A 2012-03-15 2013-03-14 高濃度の一酸化窒素の投与法 Active JP6245613B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/420,852 US20130239962A1 (en) 2012-03-15 2012-03-15 Methods Of Administering High Concentrations Of Nitric Oxide
US13/420,852 2012-03-15
US13/827,240 2013-03-14
PCT/US2013/031665 WO2013138654A1 (en) 2012-03-15 2013-03-14 Methods of administering high concentrations of nitric oxide
US13/827,240 US10556086B2 (en) 2012-03-15 2013-03-14 Methods of administering high concentrations of nitric oxide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017215161A Division JP6466543B2 (ja) 2012-03-15 2017-11-08 高濃度の一酸化窒素の投与法

Publications (3)

Publication Number Publication Date
JP2015517983A JP2015517983A (ja) 2015-06-25
JP2015517983A5 true JP2015517983A5 (ja) 2016-05-12
JP6245613B2 JP6245613B2 (ja) 2017-12-13

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Family Applications (3)

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JP2015500634A Active JP6245613B2 (ja) 2012-03-15 2013-03-14 高濃度の一酸化窒素の投与法
JP2017215161A Active JP6466543B2 (ja) 2012-03-15 2017-11-08 高濃度の一酸化窒素の投与法
JP2019001785A Active JP6807409B2 (ja) 2012-03-15 2019-01-09 高濃度の一酸化窒素の投与法

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JP2017215161A Active JP6466543B2 (ja) 2012-03-15 2017-11-08 高濃度の一酸化窒素の投与法
JP2019001785A Active JP6807409B2 (ja) 2012-03-15 2019-01-09 高濃度の一酸化窒素の投与法

Country Status (8)

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US (3) US10556086B2 (ja)
JP (3) JP6245613B2 (ja)
CN (1) CN104411317A (ja)
AU (4) AU2013231976B9 (ja)
BR (1) BR112014022627A8 (ja)
CA (1) CA2867022C (ja)
MX (3) MX368858B (ja)
WO (1) WO2013138654A1 (ja)

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