JP2015517982A5 - - Google Patents

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Publication number
JP2015517982A5
JP2015517982A5 JP2014560096A JP2014560096A JP2015517982A5 JP 2015517982 A5 JP2015517982 A5 JP 2015517982A5 JP 2014560096 A JP2014560096 A JP 2014560096A JP 2014560096 A JP2014560096 A JP 2014560096A JP 2015517982 A5 JP2015517982 A5 JP 2015517982A5
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JP
Japan
Prior art keywords
antibody
seq
binding fragment
chain variable
variable region
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JP2014560096A
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English (en)
Japanese (ja)
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JP6163502B2 (ja
JP2015517982A (ja
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Priority claimed from PCT/US2013/028667 external-priority patent/WO2013131001A1/en
Publication of JP2015517982A publication Critical patent/JP2015517982A/ja
Publication of JP2015517982A5 publication Critical patent/JP2015517982A5/ja
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Publication of JP6163502B2 publication Critical patent/JP6163502B2/ja
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JP2014560096A 2012-03-02 2013-03-01 抗上皮細胞接着分子（ＥｐＣＡＭ）抗体及びその使用方法 Active JP6163502B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261606220P 2012-03-02 2012-03-02
US61/606,220 2012-03-02
PCT/US2013/028667 WO2013131001A1 (en) 2012-03-02 2013-03-01 ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF

Publications (3)

Publication Number Publication Date
JP2015517982A JP2015517982A (ja) 2015-06-25
JP2015517982A5 true JP2015517982A5 (enExample) 2016-06-23
JP6163502B2 JP6163502B2 (ja) 2017-07-12

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ID=49083343

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014560096A Active JP6163502B2 (ja) 2012-03-02 2013-03-01 抗上皮細胞接着分子（ＥｐＣＡＭ）抗体及びその使用方法

Country Status (6)

Country Link
US (1) US9187558B2 (enExample)
EP (1) EP2819695B1 (enExample)
JP (1) JP6163502B2 (enExample)
CN (1) CN104168916B (enExample)
TW (1) TWI485161B (enExample)
WO (1) WO2013131001A1 (enExample)

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Publication number Priority date Publication date Assignee Title
US9541480B2 (en) 2011-06-29 2017-01-10 Academia Sinica Capture, purification, and release of biological substances using a surface coating
TW201623605A (zh) 2014-04-01 2016-07-01 中央研究院 用於癌症診斷及預後之方法及系統
WO2017023704A1 (en) * 2015-07-31 2017-02-09 Sutro Biopharma, Inc. ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EpCAM ANTIBODIES
PT3377103T (pt) * 2015-11-19 2021-05-26 Revitope Ltd Complementação de fragmento de anticorpo funcional para um sistema de dois componentes para exterminação redirecionada de células indesejadas
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
EP3490589A1 (en) 2016-07-26 2019-06-05 Tessa Therapeutics Pte. Ltd. Chimeric antigen receptor
JP6433951B2 (ja) * 2016-08-09 2018-12-05 東芝デジタルソリューションズ株式会社 ネットワーク監視装置およびプログラム
US10787499B2 (en) 2017-02-13 2020-09-29 Regents Of The University Of Minnesota EpCAM targeted polypeptides, conjugates thereof, and methods of use thereof
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
US20210324335A1 (en) * 2018-09-04 2021-10-21 Academia Sinica Medium composition and method for culturing mesenchymal stem cells
WO2020183245A2 (en) * 2019-03-11 2020-09-17 Janssen Pharmaceutica Nv ANTI-Vβ17/ANTI-CD123 BISPECIFIC ANTIBODIES
MX2021015356A (es) * 2019-06-11 2022-04-06 Bioatla Inc Anticuerpos y fragmentos de anticuerpos anti-epcam condicionalmente activos, sus inmunoconjugados y usos de estos.
CA3161565A1 (en) * 2019-11-14 2021-05-20 Academia Sinica Use of anti-epcam antibodies in cancer therapy
CN110950959B (zh) * 2020-02-25 2020-07-03 和铂医药(上海)有限责任公司 靶向EpCAM的抗体及其制备和应用
CN112094350B (zh) * 2020-06-01 2024-01-05 普众发现医药科技(上海)有限公司 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体
EP4190808A4 (en) * 2020-08-19 2024-07-31 Suzhou Immunofoco Biotechnology Co., Ltd. Humanized antibody, chimeric antigen receptor, nucleic acid, vector, cell and use
EP4263601A4 (en) * 2020-12-18 2025-04-02 Bioardis LLC Epcam binding molecules and uses thereof
TWI754504B (zh) * 2020-12-25 2022-02-01 龍華科技大學 棉花棒棒體之膠體檢測系統及其檢測方法
TW202317628A (zh) * 2021-06-25 2023-05-01 中央研究院 上皮細胞黏附分子（ｅｐｃａｍ）抑制劑及ｗｎｔ抑制劑的結合癌症治療
TW202317189A (zh) * 2021-06-25 2023-05-01 中央研究院 上皮細胞粘附分子(epcam)抑制劑及肝臟生長因子受體(hgfr)抑制劑的結合癌症治療
JP7794605B2 (ja) * 2021-11-05 2026-01-06 シスメックス株式会社 抗体の製造方法及び抗体

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
SI0970126T1 (en) * 1997-04-14 2001-08-31 Micromet Ag Novel method for the production of antihuman antigen receptors and uses thereof
CA2396029A1 (en) * 1999-12-27 2001-07-05 Crucell Holland B.V. Use of a native epitope for selecting evolved binding members from a library of mutants of a protein capable of binding to said epitope
CA2446087C (en) * 2001-05-03 2013-06-18 Stephen D. Gillies Recombinant tumor specific antibody and use thereof
US20100311954A1 (en) * 2002-03-01 2010-12-09 Xencor, Inc. Optimized Proteins that Target Ep-CAM
US7696320B2 (en) * 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
US20070243201A1 (en) 2003-06-02 2007-10-18 Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-Ag Method for Selecting Epitopes for Immunotherapy
US20050180979A1 (en) * 2004-02-13 2005-08-18 Micromet Ag Anti-EpCAM immunoglobulins
US7557190B2 (en) * 2005-07-08 2009-07-07 Xencor, Inc. Optimized proteins that target Ep-CAM
US7521195B1 (en) * 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
CA2682296C (en) * 2007-04-04 2017-02-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Anti-epcam antibody and uses thereof
JP2011193728A (ja) * 2008-07-17 2011-10-06 Murata Mfg Co Ltd ＥｐＣＡＭに結合能を有するペプチド
GB0909904D0 (en) * 2009-06-09 2009-07-22 Affitech As Product
CN102844443B (zh) * 2009-09-21 2014-08-06 保罗·沃尔菲什 用于甲状腺癌诊断和治疗的方法和组合物
WO2011079283A1 (en) * 2009-12-23 2011-06-30 Bioalliance C.V. Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same
WO2011137513A1 (en) * 2010-05-04 2011-11-10 Paul Walfish Method for the diagnosis of epithelial cancers by the detection of epicd polypeptide

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