JP2015517982A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015517982A5 JP2015517982A5 JP2014560096A JP2014560096A JP2015517982A5 JP 2015517982 A5 JP2015517982 A5 JP 2015517982A5 JP 2014560096 A JP2014560096 A JP 2014560096A JP 2014560096 A JP2014560096 A JP 2014560096A JP 2015517982 A5 JP2015517982 A5 JP 2015517982A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- binding fragment
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261606220P | 2012-03-02 | 2012-03-02 | |
| US61/606,220 | 2012-03-02 | ||
| PCT/US2013/028667 WO2013131001A1 (en) | 2012-03-02 | 2013-03-01 | ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517982A JP2015517982A (ja) | 2015-06-25 |
| JP2015517982A5 true JP2015517982A5 (enExample) | 2016-06-23 |
| JP6163502B2 JP6163502B2 (ja) | 2017-07-12 |
Family
ID=49083343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560096A Active JP6163502B2 (ja) | 2012-03-02 | 2013-03-01 | 抗上皮細胞接着分子（ＥｐＣＡＭ）抗体及びその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9187558B2 (enExample) |
| EP (1) | EP2819695B1 (enExample) |
| JP (1) | JP6163502B2 (enExample) |
| CN (1) | CN104168916B (enExample) |
| TW (1) | TWI485161B (enExample) |
| WO (1) | WO2013131001A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107315086B (zh) | 2011-06-29 | 2019-09-10 | 中央研究院 | 使用表面涂层对生物物质的捕获、纯化和释放 |
| TW201623605A (zh) | 2014-04-01 | 2016-07-01 | 中央研究院 | 用於癌症診斷及預後之方法及系統 |
| EP3328897A1 (en) | 2015-07-31 | 2018-06-06 | Sutro Biopharma, Inc. | ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EPCAM ANTIBODIES |
| HUE054131T2 (hu) | 2015-11-19 | 2021-08-30 | Revitope Ltd | Funkcionális ellenanyag-fragmens-komplementáció nemkívánatos sejtek elpusztítására szolgáló kétkomponensû rendszerben |
| US10107726B2 (en) | 2016-03-16 | 2018-10-23 | Cellmax, Ltd. | Collection of suspended cells using a transferable membrane |
| CN110035768A (zh) | 2016-07-26 | 2019-07-19 | 泰莎治疗私人有限公司 | 嵌合抗原受体 |
| JP6433951B2 (ja) * | 2016-08-09 | 2018-12-05 | 東芝デジタルソリューションズ株式会社 | ネットワーク監視装置およびプログラム |
| US10787499B2 (en) | 2017-02-13 | 2020-09-29 | Regents Of The University Of Minnesota | EpCAM targeted polypeptides, conjugates thereof, and methods of use thereof |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
| US20210324335A1 (en) * | 2018-09-04 | 2021-10-21 | Academia Sinica | Medium composition and method for culturing mesenchymal stem cells |
| CN119954959A (zh) * | 2019-03-11 | 2025-05-09 | 詹森生物科技公司 | 抗Vβ17/抗CD123双特异性抗体 |
| CN114026127B (zh) | 2019-06-11 | 2024-10-29 | 生物蛋白有限公司 | 条件活性抗epcam抗体、抗体片段、其免疫缀合物以及其用途 |
| JP7696343B2 (ja) * | 2019-11-14 | 2025-06-20 | アカデミア シニカ | がん治療における抗ＥｐＣＡＭ抗体の使用 |
| CN110950959B (zh) * | 2020-02-25 | 2020-07-03 | 和铂医药(上海)有限责任公司 | 靶向EpCAM的抗体及其制备和应用 |
| CN112094350B (zh) * | 2020-06-01 | 2024-01-05 | 普众发现医药科技(上海)有限公司 | 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体 |
| WO2022037323A1 (zh) * | 2020-08-19 | 2022-02-24 | 上海易慕峰生物科技有限公司 | 人源化抗体、嵌合抗原受体、核酸、载体、细胞及应用 |
| CA3205465A1 (en) * | 2020-12-18 | 2022-06-23 | Bioardis, Llc | Epcam binding molecules and uses thereof |
| TWI754504B (zh) * | 2020-12-25 | 2022-02-01 | 龍華科技大學 | 棉花棒棒體之膠體檢測系統及其檢測方法 |
| KR20240026985A (ko) * | 2021-06-25 | 2024-02-29 | 아카데미아 시니카 | 상피 세포 부착 분자(epcam) 억제제 및 간세포 성장 인자 수용체(hgfr) 억제제와의 조합된 암 요법 |
| WO2022272050A1 (en) * | 2021-06-25 | 2022-12-29 | Academia Sinica | Combined cancer therapy with an epithelial cell adhesion molecule (epcam) inhibitor and a wnt inhibitor |
| JP7794605B2 (ja) * | 2021-11-05 | 2026-01-06 | シスメックス株式会社 | 抗体の製造方法及び抗体 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3876002B2 (ja) | 1997-04-14 | 2007-01-31 | ミクロメート・アクチエンゲゼルシャフト | 抗ヒト抗原受容体を産生するための斬新な方法およびそれらの使用 |
| DE60035434T2 (de) * | 1999-12-27 | 2008-05-15 | Crucell Holland B.V. | Auswahl von epitop-bindungsfähigen verbindungen aus bibliotheken |
| BR0209177A (pt) * | 2001-05-03 | 2004-10-05 | Merck Patent Gmbh | Anticorpo especìfico a tumor recombinante e uso do mesmo |
| US20100311954A1 (en) * | 2002-03-01 | 2010-12-09 | Xencor, Inc. | Optimized Proteins that Target Ep-CAM |
| US7696320B2 (en) * | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US20070243201A1 (en) | 2003-06-02 | 2007-10-18 | Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-Ag | Method for Selecting Epitopes for Immunotherapy |
| US20050180979A1 (en) * | 2004-02-13 | 2005-08-18 | Micromet Ag | Anti-EpCAM immunoglobulins |
| WO2007008943A2 (en) * | 2005-07-08 | 2007-01-18 | Xencor, Inc. | Optimized anti-ep-cam antibodies |
| US7521195B1 (en) * | 2005-07-21 | 2009-04-21 | Celera Corporation | Lung disease targets and uses thereof |
| CN101970497B (zh) * | 2007-04-04 | 2017-05-10 | 希格马托制药工业公司 | 抗‑EpCAM抗体及其用途 |
| JP2011193728A (ja) * | 2008-07-17 | 2011-10-06 | Murata Mfg Co Ltd | ＥｐＣＡＭに結合能を有するペプチド |
| GB0909904D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Product |
| US20120252022A1 (en) * | 2009-09-21 | 2012-10-04 | Paul Walfish | Methods and compositions for the diagnosis and treatment of thyroid cancer |
| TW201125583A (en) * | 2009-12-23 | 2011-08-01 | Bioalliance Cv | Anti-EpCAM antibodies that induce apoptosis of cancer cells and methods using same |
| SG185100A1 (en) * | 2010-05-04 | 2012-11-29 | Paul Walfish | Method for the diagnosis of epithelial cancers by the detection of epicd polypeptide |
-
2013
- 2013-03-01 EP EP13754991.1A patent/EP2819695B1/en active Active
- 2013-03-01 CN CN201380012187.0A patent/CN104168916B/zh active Active
- 2013-03-01 JP JP2014560096A patent/JP6163502B2/ja active Active
- 2013-03-01 TW TW102107344A patent/TWI485161B/zh active
- 2013-03-01 WO PCT/US2013/028667 patent/WO2013131001A1/en not_active Ceased
- 2013-03-01 US US14/381,362 patent/US9187558B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112154157B (zh) | 抗ror1抗体及其用途 | |
| CN108026169B (zh) | 抗人cd137的完全人抗体及其应用 | |
| JP6239503B2 (ja) | 新規な抗ｃｘｃｒ４抗体並びに癌の検出および診断のためのその使用 | |
| CN112010978B (zh) | TrkA的抗体及其应用 | |
| JP2019511904A5 (enExample) | ||
| US20230287128A1 (en) | Antigen-binding proteins targeting kklc-1 shared antigen | |
| TW201350507A (zh) | 抗上皮細胞黏著分子(EpCAM)抗體及其使用方法 | |
| US20190204324A1 (en) | Antigenic composition for detecting auto-antibody with specific response to exosomal protein eif3a, and method for diagnosing liver cancer using antigenic composition | |
| WO2023025315A1 (zh) | 抗b7-h3抗体、其制备方法及用途 | |
| Gellini et al. | Generation of human single-chain antibody to the CD99 cell surface determinant specifically recognizing Ewing’s sarcoma tumor cells | |
| TW202246321A (zh) | 抗pt217 tau抗體 | |
| JP6707660B2 (ja) | 抗ポドカリキシン様タンパク質前駆体サブタイプ２モノクローナル抗体とその生成方法及び使用 | |
| AU2022223337A1 (en) | Vegfa-binding molecules | |
| JP6977105B2 (ja) | Ｉｇｆ−１ｒ抗体および癌の診断のためのその使用 | |
| KR20210126057A (ko) | 암세포에 존재하는 케라틴 14(krt14)의 세포외 부분을 표적화함으로써 암을 치료하거나 예방하는 방법 | |
| JP7229503B2 (ja) | ＣＡＤＭ１ｖ９認識抗体 | |
| WO2019066617A2 (ko) | 항 c-met 항체 및 이의 용도 | |
| JP7086607B2 (ja) | Ｉｇｆ－１ｒ抗体および癌の診断のためのその使用 | |
| JP2014516922A (ja) | プレキシンｂ２活性の変調剤 | |
| CN112079928B (zh) | 一种抗pd-l1的单克隆抗体 | |
| KR102688094B1 (ko) | Cobll1 단백질 특이 항체 또는 이의 항원 결합 단편, 및 이의 용도 | |
| CN117157401A (zh) | 针对胰腺癌干细胞的抗体 | |
| EA051051B1 (ru) | Способ лечения или профилактики рака путем целенаправленного воздействия на внеклеточную часть кератина 14 (krt14), присутствующую на раковых клетках |