JP2015517982A5 - - Google Patents
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- Publication number
- JP2015517982A5 JP2015517982A5 JP2014560096A JP2014560096A JP2015517982A5 JP 2015517982 A5 JP2015517982 A5 JP 2015517982A5 JP 2014560096 A JP2014560096 A JP 2014560096A JP 2014560096 A JP2014560096 A JP 2014560096A JP 2015517982 A5 JP2015517982 A5 JP 2015517982A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- binding fragment
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261606220P | 2012-03-02 | 2012-03-02 | |
| US61/606,220 | 2012-03-02 | ||
| PCT/US2013/028667 WO2013131001A1 (en) | 2012-03-02 | 2013-03-01 | ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517982A JP2015517982A (ja) | 2015-06-25 |
| JP2015517982A5 true JP2015517982A5 (enExample) | 2016-06-23 |
| JP6163502B2 JP6163502B2 (ja) | 2017-07-12 |
Family
ID=49083343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560096A Active JP6163502B2 (ja) | 2012-03-02 | 2013-03-01 | 抗上皮細胞接着分子（ＥｐＣＡＭ）抗体及びその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9187558B2 (enExample) |
| EP (1) | EP2819695B1 (enExample) |
| JP (1) | JP6163502B2 (enExample) |
| CN (1) | CN104168916B (enExample) |
| TW (1) | TWI485161B (enExample) |
| WO (1) | WO2013131001A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110763842A (zh) | 2011-06-29 | 2020-02-07 | 中央研究院 | 使用表面涂层对生物物质的捕获、纯化和释放 |
| CN106662514A (zh) | 2014-04-01 | 2017-05-10 | 中央研究院 | 用于癌症诊断及预后的方法和系统 |
| EP3328897A1 (en) * | 2015-07-31 | 2018-06-06 | Sutro Biopharma, Inc. | ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EPCAM ANTIBODIES |
| EP3903818A1 (en) * | 2015-11-19 | 2021-11-03 | Revitope Limited | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
| US10107726B2 (en) | 2016-03-16 | 2018-10-23 | Cellmax, Ltd. | Collection of suspended cells using a transferable membrane |
| AU2017301826A1 (en) | 2016-07-26 | 2019-03-14 | Tessa Therapeutics Ltd. | Chimeric antigen receptor |
| JP6433951B2 (ja) * | 2016-08-09 | 2018-12-05 | 東芝デジタルソリューションズ株式会社 | ネットワーク監視装置およびプログラム |
| US10787499B2 (en) | 2017-02-13 | 2020-09-29 | Regents Of The University Of Minnesota | EpCAM targeted polypeptides, conjugates thereof, and methods of use thereof |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
| WO2020051141A1 (en) * | 2018-09-04 | 2020-03-12 | Academia Sinica | A medium composition and method for culturing mesenchymal stem cells |
| CN113874400B (zh) * | 2019-03-11 | 2025-02-07 | 詹森生物科技公司 | 抗Vβ17/抗CD123双特异性抗体 |
| EP3983446A4 (en) * | 2019-06-11 | 2023-04-19 | BioAtla, Inc. | CONDITIONALLY ACTIVE ANTI-EPCAM ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND THEIR USE |
| JP7696343B2 (ja) * | 2019-11-14 | 2025-06-20 | アカデミア シニカ | がん治療における抗ＥｐＣＡＭ抗体の使用 |
| CN110950959B (zh) * | 2020-02-25 | 2020-07-03 | 和铂医药(上海)有限责任公司 | 靶向EpCAM的抗体及其制备和应用 |
| CN112094350B (zh) * | 2020-06-01 | 2024-01-05 | 普众发现医药科技(上海)有限公司 | 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体 |
| JP7570653B2 (ja) * | 2020-08-19 | 2024-10-22 | ▲蘇▼州易慕峰生物科技有限公司 | ヒト化抗体、キメラ抗原受容体、核酸、ベクター、細胞及び応用 |
| CA3205465A1 (en) * | 2020-12-18 | 2022-06-23 | Bioardis, Llc | Epcam binding molecules and uses thereof |
| TWI754504B (zh) * | 2020-12-25 | 2022-02-01 | 龍華科技大學 | 棉花棒棒體之膠體檢測系統及其檢測方法 |
| CA3221800A1 (en) * | 2021-06-25 | 2022-12-29 | Han-Chung Wu | Combined cancer therapy with an epithelial cell adhesion molecule (epcam) inhibitor and a wnt inhibitor |
| TW202317189A (zh) * | 2021-06-25 | 2023-05-01 | 中央研究院 | 上皮細胞粘附分子(epcam)抑制劑及肝臟生長因子受體(hgfr)抑制劑的結合癌症治療 |
| JP7794605B2 (ja) * | 2021-11-05 | 2026-01-06 | シスメックス株式会社 | 抗体の製造方法及び抗体 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199902553T2 (xx) * | 1997-04-14 | 2000-03-21 | Micromet Gesellschaft F�R Biomedizinische Forschung Mbh | �nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�. |
| CA2396029A1 (en) * | 1999-12-27 | 2001-07-05 | Crucell Holland B.V. | Use of a native epitope for selecting evolved binding members from a library of mutants of a protein capable of binding to said epitope |
| KR100900166B1 (ko) * | 2001-05-03 | 2009-06-02 | 메르크 파텐트 게엠베하 | 재조합 종양 특이적 항체 및 이들의 용도 |
| US20100311954A1 (en) * | 2002-03-01 | 2010-12-09 | Xencor, Inc. | Optimized Proteins that Target Ep-CAM |
| US7696320B2 (en) * | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| WO2004106917A2 (de) * | 2003-06-02 | 2004-12-09 | Igeneon Krebs-Immuntherapie Forschungs- Und Entwicklungs-Ag | Verfahren zur selektion von epitopen zur immuntherapie |
| US20050180979A1 (en) * | 2004-02-13 | 2005-08-18 | Micromet Ag | Anti-EpCAM immunoglobulins |
| EP2004695A2 (en) * | 2005-07-08 | 2008-12-24 | Xencor, Inc. | Optimized anti-ep-cam antibodies |
| US7521195B1 (en) * | 2005-07-21 | 2009-04-21 | Celera Corporation | Lung disease targets and uses thereof |
| ES2367675T3 (es) * | 2007-04-04 | 2011-11-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Anticuerpo anti-epcam y usos del mismo. |
| JP2011193728A (ja) * | 2008-07-17 | 2011-10-06 | Murata Mfg Co Ltd | ＥｐＣＡＭに結合能を有するペプチド |
| GB0909904D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Product |
| JP6048660B2 (ja) * | 2009-09-21 | 2016-12-21 | ランジュ ラルハン | 甲状腺癌を診断および処置するための方法および組成物 |
| US20110165161A1 (en) | 2009-12-23 | 2011-07-07 | Shih-Yao Lin | Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same |
| EP2567235B1 (en) * | 2010-05-04 | 2017-08-30 | Paul Walfish | Method for the diagnosis of epithelial cancers by the detection of epicd polypeptide |
-
2013
- 2013-03-01 CN CN201380012187.0A patent/CN104168916B/zh active Active
- 2013-03-01 JP JP2014560096A patent/JP6163502B2/ja active Active
- 2013-03-01 WO PCT/US2013/028667 patent/WO2013131001A1/en not_active Ceased
- 2013-03-01 TW TW102107344A patent/TWI485161B/zh active
- 2013-03-01 US US14/381,362 patent/US9187558B2/en active Active
- 2013-03-01 EP EP13754991.1A patent/EP2819695B1/en active Active
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