JP2015517466A5 - - Google Patents

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Publication number
JP2015517466A5
JP2015517466A5 JP2015510380A JP2015510380A JP2015517466A5 JP 2015517466 A5 JP2015517466 A5 JP 2015517466A5 JP 2015510380 A JP2015510380 A JP 2015510380A JP 2015510380 A JP2015510380 A JP 2015510380A JP 2015517466 A5 JP2015517466 A5 JP 2015517466A5
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JP
Japan
Prior art keywords
rnai agent
composition
kras
strand
nucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015510380A
Other languages
English (en)
Japanese (ja)
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JP2015517466A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/038847 external-priority patent/WO2013166004A2/en
Publication of JP2015517466A publication Critical patent/JP2015517466A/ja
Publication of JP2015517466A5 publication Critical patent/JP2015517466A5/ja
Pending legal-status Critical Current

Links

JP2015510380A 2012-05-02 2013-04-30 Ｋｒａｓ関連疾患を処置するための有機組成物 Pending JP2015517466A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261641588P 2012-05-02 2012-05-02
US61/641,588 2012-05-02
PCT/US2013/038847 WO2013166004A2 (en) 2012-05-02 2013-04-30 Organic compositions to treat kras-related diseases

Publications (2)

Publication Number Publication Date
JP2015517466A JP2015517466A (ja) 2015-06-22
JP2015517466A5 true JP2015517466A5 (https=) 2016-06-23

Family

ID=48366565

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015510380A Pending JP2015517466A (ja) 2012-05-02 2013-04-30 Ｋｒａｓ関連疾患を処置するための有機組成物

Country Status (12)

Country Link
US (3) US20150238515A1 (https=)
EP (3) EP3272868A1 (https=)
JP (1) JP2015517466A (https=)
KR (1) KR20150004414A (https=)
CN (2) CN109481455A (https=)
AU (5) AU2013256471A1 (https=)
BR (1) BR112014027337A2 (https=)
CA (2) CA3173610A1 (https=)
EA (1) EA201492004A1 (https=)
HK (1) HK1206387A1 (https=)
MX (1) MX2014013367A (https=)
WO (1) WO2013166004A2 (https=)

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TW201620525A (zh) * 2014-03-14 2016-06-16 波士頓生醫公司 使ｋ－ｒａｓ靜默之非對稱干擾ｒｎａ組成物及其使用方法
KR102589295B1 (ko) 2014-05-14 2023-10-13 타르그이뮨 테라퓨틱스 아게 개선된 폴리에틸렌이민 폴리에틸렌글리콜 벡터
US11180759B2 (en) * 2016-01-19 2021-11-23 The University Of North Carolina At Chapel Hill Methods and compositions using RNA interference and antisense oligonucleotides for inhibition of KRAS
JP2019513371A (ja) 2016-04-01 2019-05-30 アビディティー バイオサイエンシーズ エルエルシー 核酸ポリペプチド組成物とその使用
WO2017173304A1 (en) * 2016-04-01 2017-10-05 Avidity Biosciences Llc Kras nucleic acids and uses thereof
KR102543645B1 (ko) * 2016-07-20 2023-06-16 주식회사 지씨지놈 유전성 발달장애 진단용 조성물 및 이의 용도
JP7506601B2 (ja) 2017-12-06 2024-06-26 アビディティー バイオサイエンシーズ，インク． 筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法
AU2020287343A1 (en) * 2019-06-05 2021-12-09 Southern Research Institute Thiarabine- and thiarabine prodrug-based treatments
US12146139B2 (en) * 2019-11-14 2024-11-19 The Board Of Regents Of The University Of Oklahoma Oligonucleotide interference treatments of prostate cancer
US11555190B2 (en) 2020-03-19 2023-01-17 Avidity Biosciences, Inc. Compositions and methods of treating Facioscapulohumeral muscular dystrophy
JP7839554B2 (ja) * 2020-04-07 2026-04-02 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル Ｋｒａｓの阻害のためのｒｎａ干渉およびアンチセンスオリゴヌクレオチドを使用する方法および組成物
WO2023034537A1 (en) * 2021-09-02 2023-03-09 Molecular Axiom, Llc Compositions and methods for modulating kras expression
MX2024003266A (es) 2021-09-16 2024-04-03 Avidity Biosciences Inc Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.
CN120677241A (zh) * 2023-01-18 2025-09-19 美国微哲默理有限责任公司 用于调节kras表达的组合物及其用途
CN120769911A (zh) * 2023-02-22 2025-10-10 艾尔塔米拉治疗公司 用于治疗疾病的抑制kras的组合物和方法
WO2026026715A1 (zh) * 2024-07-31 2026-02-05 前沿生物药业(南京)股份有限公司 一种用于抑制KRAS基因表达的siRNA及其修饰物与应用

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