JP2016511256A5 - - Google Patents
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- JP2016511256A5 JP2016511256A5 JP2015560296A JP2015560296A JP2016511256A5 JP 2016511256 A5 JP2016511256 A5 JP 2016511256A5 JP 2015560296 A JP2015560296 A JP 2015560296A JP 2015560296 A JP2015560296 A JP 2015560296A JP 2016511256 A5 JP2016511256 A5 JP 2016511256A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cancer
- epas1
- nucleotides
- antisense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 201000010099 disease Diseases 0.000 claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 108091030071 RNAI Proteins 0.000 claims description 33
- 230000009368 gene silencing by RNA Effects 0.000 claims description 33
- 102100036448 Endothelial PAS domain-containing protein 1 Human genes 0.000 claims description 32
- 108010018033 endothelial PAS domain-containing protein 1 Proteins 0.000 claims description 32
- 239000003795 chemical substances by application Substances 0.000 claims description 29
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770713P | 2013-02-28 | 2013-02-28 | |
| US61/770,713 | 2013-02-28 | ||
| PCT/US2014/018873 WO2014134255A2 (en) | 2013-02-28 | 2014-02-27 | Organic compositions to treat epas1-related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028972A Division JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016511256A JP2016511256A (ja) | 2016-04-14 |
| JP2016511256A5 true JP2016511256A5 (https=) | 2017-03-30 |
Family
ID=50483469
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560296A Withdrawn JP2016511256A (ja) | 2013-02-28 | 2014-02-27 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2019028972A Pending JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2021031732A Pending JP2021091710A (ja) | 2013-02-28 | 2021-03-01 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2023046940A Pending JP2023068147A (ja) | 2013-02-28 | 2023-03-23 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028972A Pending JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2021031732A Pending JP2021091710A (ja) | 2013-02-28 | 2021-03-01 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2023046940A Pending JP2023068147A (ja) | 2013-02-28 | 2023-03-23 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9868949B2 (https=) |
| EP (1) | EP2961843A2 (https=) |
| JP (4) | JP2016511256A (https=) |
| CN (1) | CN105247051A (https=) |
| AU (3) | AU2014223432A1 (https=) |
| CA (1) | CA2902393C (https=) |
| HK (1) | HK1214301A1 (https=) |
| SG (2) | SG10201706960TA (https=) |
| WO (1) | WO2014134255A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201706960TA (en) * | 2013-02-28 | 2017-10-30 | Arrowhead Res Corp | Organic compositions to treat epas1-related diseases |
| HK1252852A1 (zh) * | 2015-05-29 | 2019-06-06 | Arrowhead Pharmaceuticals, Inc. | 阻止HIF2α基因表达的组合物及方法 |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| US20210093725A1 (en) * | 2018-04-27 | 2021-04-01 | Arrowhead Pharmaceuticals, Inc. | Integrin targeting ligands and uses thereof |
| WO2019210308A1 (en) | 2018-04-27 | 2019-10-31 | Arrowhead Pharmaceuticals, Inc. | Integrin targeting ligands and uses thereof |
| SG11202105577TA (en) | 2019-01-09 | 2021-06-29 | Arrowhead Pharmaceuticals Inc | Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use |
| CA3235013A1 (en) * | 2021-10-18 | 2023-04-27 | Jing Lu | Hypoxia inducible factor-2(alpha) inhibitors for the treatment of bladder cancer |
| WO2024102894A2 (en) * | 2022-11-11 | 2024-05-16 | The Regents Of The University Of California | Methods for treating monge's disease |
| CN119523991B (zh) * | 2024-12-06 | 2025-09-05 | 湖南师范大学 | 表木栓醇在制备抗肺癌物质中的用途和抗肺癌组合物 |
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| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| WO2011076807A2 (en) | 2009-12-23 | 2011-06-30 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| DK2539451T3 (da) | 2010-02-24 | 2016-04-04 | Arrowhead Res Corp | Sammensætninger til målrettet tilførsel af siRNA |
| KR101223660B1 (ko) | 2010-05-20 | 2013-01-17 | 광주과학기술원 | ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| EP2652134B1 (en) | 2010-12-17 | 2017-03-01 | Arrowhead Pharmaceuticals, Inc. | Galactose cluster-pharmacokinetic modulator targeting moiety for sirna |
| ES2605990T3 (es) | 2010-12-29 | 2017-03-17 | F. Hoffmann-La Roche Ag | Conjugados de molécula pequeña para la administración intracelular de ácidos nucleicos |
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| WO2013032829A1 (en) | 2011-08-26 | 2013-03-07 | Arrowhead Research Corporation | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
| JP2015515530A (ja) | 2012-04-18 | 2015-05-28 | アローヘッド リサーチ コーポレイション | インビボ核酸送達のためのポリ（アクリラート）ポリマー |
| SG10201706960TA (en) * | 2013-02-28 | 2017-10-30 | Arrowhead Res Corp | Organic compositions to treat epas1-related diseases |
| US9504747B2 (en) | 2013-03-08 | 2016-11-29 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
-
2014
- 2014-02-27 SG SG10201706960TA patent/SG10201706960TA/en unknown
- 2014-02-27 HK HK16102257.6A patent/HK1214301A1/zh unknown
- 2014-02-27 SG SG11201506805QA patent/SG11201506805QA/en unknown
- 2014-02-27 JP JP2015560296A patent/JP2016511256A/ja not_active Withdrawn
- 2014-02-27 US US14/770,765 patent/US9868949B2/en active Active
- 2014-02-27 CA CA2902393A patent/CA2902393C/en active Active
- 2014-02-27 CN CN201480011225.5A patent/CN105247051A/zh active Pending
- 2014-02-27 EP EP14717233.2A patent/EP2961843A2/en active Pending
- 2014-02-27 AU AU2014223432A patent/AU2014223432A1/en not_active Abandoned
- 2014-02-27 WO PCT/US2014/018873 patent/WO2014134255A2/en not_active Ceased
-
2017
- 2017-12-07 US US15/834,323 patent/US10538765B2/en active Active
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2019
- 2019-02-21 JP JP2019028972A patent/JP2019089836A/ja active Pending
-
2020
- 2020-01-21 US US16/747,729 patent/US11261444B2/en active Active
- 2020-03-04 AU AU2020201617A patent/AU2020201617A1/en not_active Abandoned
-
2021
- 2021-03-01 JP JP2021031732A patent/JP2021091710A/ja active Pending
-
2022
- 2022-05-23 AU AU2022203490A patent/AU2022203490A1/en not_active Abandoned
-
2023
- 2023-03-23 JP JP2023046940A patent/JP2023068147A/ja active Pending
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