JP2015516945A5 - - Google Patents
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- Publication number
- JP2015516945A5 JP2015516945A5 JP2015500539A JP2015500539A JP2015516945A5 JP 2015516945 A5 JP2015516945 A5 JP 2015516945A5 JP 2015500539 A JP2015500539 A JP 2015500539A JP 2015500539 A JP2015500539 A JP 2015500539A JP 2015516945 A5 JP2015516945 A5 JP 2015516945A5
- Authority
- JP
- Japan
- Prior art keywords
- bis
- quaternary alkaloid
- methoxy
- vinyl
- salt according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 alkaloid salts Chemical class 0.000 claims 8
- 229930013930 alkaloid Natural products 0.000 claims 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610746P | 2012-03-14 | 2012-03-14 | |
| US61/610,746 | 2012-03-14 | ||
| PCT/US2013/030688 WO2013138413A1 (en) | 2012-03-14 | 2013-03-13 | Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516945A JP2015516945A (ja) | 2015-06-18 |
| JP2015516945A5 true JP2015516945A5 (enExample) | 2016-05-12 |
| JP6140266B2 JP6140266B2 (ja) | 2017-05-31 |
Family
ID=49161748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500539A Active JP6140266B2 (ja) | 2012-03-14 | 2013-03-13 | 不斉相間移動触媒としてのビス四級シンコナアルカロイド塩 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9376431B2 (enExample) |
| EP (4) | EP3680240A1 (enExample) |
| JP (1) | JP6140266B2 (enExample) |
| KR (2) | KR102061180B1 (enExample) |
| CN (1) | CN104144929B (enExample) |
| AU (6) | AU2013232191B2 (enExample) |
| BR (1) | BR112014021828B8 (enExample) |
| CA (1) | CA2865941A1 (enExample) |
| ES (1) | ES2806150T3 (enExample) |
| MX (1) | MX351657B (enExample) |
| RU (1) | RU2667909C2 (enExample) |
| WO (1) | WO2013138413A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI487706B (zh) * | 2010-11-12 | 2015-06-11 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| US9487523B2 (en) | 2012-03-14 | 2016-11-08 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| US9174989B2 (en) | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| CA2937315A1 (en) | 2014-02-05 | 2015-08-13 | Merck Sharp & Dohme Corp. | Tablet formulation for cgrp-active compounds |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| MX384019B (es) * | 2016-06-07 | 2025-03-14 | Pirelli | Neumatico para ruedas de vehiculos. |
| CA3065683A1 (en) | 2017-05-30 | 2018-12-06 | Millennium Pharmaceuticals, Inc. | Method for producing optically active compound |
| US12383545B1 (en) | 2018-06-08 | 2025-08-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| CN109180606B (zh) * | 2018-09-30 | 2021-04-06 | 浙江工业大学 | 一类具有光学活性的β-氨基酮的合成方法 |
| CA3181189A1 (en) * | 2020-05-06 | 2021-11-11 | Amgen Inc. | Synthesis of vinylic alcohol intermediates |
| AU2021319090A1 (en) | 2020-07-29 | 2023-03-02 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| AU2021409718A1 (en) | 2020-12-22 | 2023-07-13 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| JP2024533756A (ja) | 2021-09-27 | 2024-09-12 | アラガン ファーマスーティカルズ インターナショナル リミテッド | アトゲパントを含む片頭痛の併用療法 |
| CN115974867B (zh) * | 2023-01-31 | 2025-11-28 | 成都大学 | 一种手性相转移催化剂及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE170173T1 (de) * | 1990-01-22 | 1998-09-15 | Hoechst Marion Roussel Inc | Verfahren zur enantioselektiven synthese alkylierter oxindole zur verwendung als zwischenprodukte bei der herstellung von physostigminen |
| US6313247B1 (en) * | 1996-06-05 | 2001-11-06 | Wolfgang Lindner | Cinchonan based chiral selectors for separation of stereoisomers |
| US6596870B2 (en) * | 2000-07-13 | 2003-07-22 | Brandeis University | Asymmetric synthetic methods based on phase transfer catalysis |
| WO2005000109A2 (en) * | 2003-06-27 | 2005-01-06 | University Of Maryland Biotechnology Institute | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids |
| GB0601286D0 (en) * | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
| PL213306B1 (pl) * | 2008-02-04 | 2013-02-28 | Politechnika Lodzka | Sposób otrzymywania wzbogaconych enancjomerycznie produktów kondensacji z kwasów racemicznych lub kwasów o niskiej czystosci enancjomerycznej |
| WO2011005731A2 (en) * | 2009-07-08 | 2011-01-13 | Merck Sharp & Dohme Corp. | Process for making cgrp receptor antagonist |
| US9487523B2 (en) | 2012-03-14 | 2016-11-08 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| US9174989B2 (en) | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
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2013
- 2013-03-13 BR BR112014021828A patent/BR112014021828B8/pt active IP Right Grant
- 2013-03-13 RU RU2014141166A patent/RU2667909C2/ru active
- 2013-03-13 JP JP2015500539A patent/JP6140266B2/ja active Active
- 2013-03-13 KR KR1020147025142A patent/KR102061180B1/ko active Active
- 2013-03-13 US US14/384,355 patent/US9376431B2/en active Active
- 2013-03-13 EP EP20154142.2A patent/EP3680240A1/en not_active Withdrawn
- 2013-03-13 AU AU2013232191A patent/AU2013232191B2/en active Active
- 2013-03-13 CN CN201380013400.XA patent/CN104144929B/zh active Active
- 2013-03-13 WO PCT/US2013/030688 patent/WO2013138413A1/en not_active Ceased
- 2013-03-13 KR KR1020197038179A patent/KR102153850B1/ko active Active
- 2013-03-13 EP EP21202495.4A patent/EP4019516A1/en not_active Withdrawn
- 2013-03-13 EP EP13761100.0A patent/EP2825536B1/en active Active
- 2013-03-13 EP EP23217661.0A patent/EP4357020A3/en active Pending
- 2013-03-13 MX MX2014010999A patent/MX351657B/es active IP Right Grant
- 2013-03-13 CA CA2865941A patent/CA2865941A1/en active Pending
- 2013-03-13 ES ES13761100T patent/ES2806150T3/es active Active
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2017
- 2017-06-29 AU AU2017204464A patent/AU2017204464B2/en active Active
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2019
- 2019-07-17 AU AU2019206049A patent/AU2019206049B2/en active Active
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2021
- 2021-07-01 AU AU2021204629A patent/AU2021204629A1/en not_active Abandoned
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2023
- 2023-10-24 AU AU2023254886A patent/AU2023254886A1/en not_active Abandoned
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2025
- 2025-08-25 AU AU2025220879A patent/AU2025220879A1/en active Pending