JP2015515974A5 - - Google Patents
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- Publication number
- JP2015515974A5 JP2015515974A5 JP2015509496A JP2015509496A JP2015515974A5 JP 2015515974 A5 JP2015515974 A5 JP 2015515974A5 JP 2015509496 A JP2015509496 A JP 2015509496A JP 2015509496 A JP2015509496 A JP 2015509496A JP 2015515974 A5 JP2015515974 A5 JP 2015515974A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- administration
- alfentanil
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims 6
- 229960001391 alfentanil Drugs 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000036470 plasma concentration Effects 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 239000000463 material Substances 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000007580 dry-mixing Methods 0.000 claims 1
- 239000008240 homogeneous mixture Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 230000000474 nursing effect Effects 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims 1
- 235000019801 trisodium phosphate Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1207701.2 | 2012-05-02 | ||
| GBGB1207701.2A GB201207701D0 (en) | 2012-05-02 | 2012-05-02 | New pharmaceutical composition |
| GB1221130.6 | 2012-11-23 | ||
| GBGB1221130.6A GB201221130D0 (en) | 2012-11-23 | 2012-11-23 | New pharmaceutical composition |
| PCT/GB2013/051131 WO2013164620A1 (en) | 2012-05-02 | 2013-05-01 | New alfentanil composition for the treatment of acute pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015515974A JP2015515974A (ja) | 2015-06-04 |
| JP2015515974A5 true JP2015515974A5 (https=) | 2016-06-30 |
| JP6275696B2 JP6275696B2 (ja) | 2018-02-14 |
Family
ID=48577134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509496A Expired - Fee Related JP6275696B2 (ja) | 2012-05-02 | 2013-05-01 | 急性疼痛の処置のための新規なアルフェンタニール組成物 |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US8815911B2 (https=) |
| EP (2) | EP3150199B1 (https=) |
| JP (1) | JP6275696B2 (https=) |
| KR (1) | KR20150005695A (https=) |
| CN (1) | CN104427978B (https=) |
| AU (1) | AU2013255640B2 (https=) |
| BR (1) | BR112014027213A8 (https=) |
| CA (1) | CA2871805A1 (https=) |
| CL (1) | CL2014002979A1 (https=) |
| CO (1) | CO7170181A2 (https=) |
| CY (2) | CY1118570T1 (https=) |
| DK (2) | DK3150199T3 (https=) |
| EA (1) | EA028110B1 (https=) |
| ES (2) | ES2614757T3 (https=) |
| HR (2) | HRP20161634T1 (https=) |
| HU (1) | HUE031792T2 (https=) |
| IL (1) | IL235272B (https=) |
| IN (1) | IN2014MN02156A (https=) |
| LT (2) | LT3150199T (https=) |
| ME (1) | ME02644B (https=) |
| MX (1) | MX360665B (https=) |
| NZ (1) | NZ701428A (https=) |
| PE (1) | PE20142444A1 (https=) |
| PH (1) | PH12014502407A1 (https=) |
| PL (2) | PL2849730T3 (https=) |
| PT (2) | PT3150199T (https=) |
| RS (2) | RS55489B1 (https=) |
| SG (1) | SG11201407081PA (https=) |
| SI (2) | SI2849730T1 (https=) |
| SM (3) | SMT201700086T1 (https=) |
| TR (1) | TR201815935T4 (https=) |
| WO (1) | WO2013164620A1 (https=) |
| ZA (1) | ZA201407559B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6210988B2 (ja) | 2011-09-19 | 2017-10-11 | オレクソ・アクチエボラゲット | オピオイド依存を治療するための新規乱用耐性医薬組成物 |
| EP3150199B1 (en) * | 2012-05-02 | 2018-08-08 | Orexo AB | New alfentanil composition for the treatment of acute pain |
| WO2017180659A1 (en) * | 2016-04-11 | 2017-10-19 | Arizona Board Of Regents On Behalf Of University Of Arizona | Opioid receptor modulators |
| JP7023054B2 (ja) * | 2017-04-05 | 2022-02-21 | 東和薬品株式会社 | レベチラセタム含有医薬組成物及びその製造方法 |
| CN115047109B (zh) * | 2022-06-17 | 2024-05-31 | 三明海关综合技术服务中心 | 一种检测食品中芬太尼类新精神活性物质的方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288497A (en) | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
| US5785989A (en) * | 1985-05-01 | 1998-07-28 | University Utah Research Foundation | Compositions and methods of manufacturing of oral dissolvable medicaments |
| DE19758564A1 (de) | 1997-11-11 | 1999-08-26 | Gruenenthal Gmbh | Formulierung einer Kombination aus Morphin und einem alpha¶2¶-adrenergem Agonisten und deren Verwendung |
| SE9803240D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
| SE9803239D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | Composition for the treatment of acute pain |
| GB9904911D0 (en) | 1999-03-03 | 1999-04-28 | Scherer Ltd R P | Pharmaceutical compositions |
| US6264981B1 (en) | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| US20020160043A1 (en) | 2001-02-27 | 2002-10-31 | Dennis Coleman | Compositions and method of manufacture for oral dissolvable dosage forms |
| JP4850346B2 (ja) * | 2001-03-15 | 2012-01-11 | 救急薬品工業株式会社 | 粘膜貼付剤 |
| US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| NZ541167A (en) | 2003-01-31 | 2008-07-31 | Orexo Ab | A rapid-acting pharmaceutical composition comprising e.g. fentanyl and particles insoluble in water |
| EP2343045A3 (en) | 2003-02-24 | 2011-09-21 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
| US20050042281A1 (en) | 2003-08-21 | 2005-02-24 | Singh Nikhilesh N. | Compositions for delivering therapeutic agents across the oral mucosa |
| CN102078310B (zh) | 2003-12-31 | 2013-01-23 | 奇马实验室公司 | 大体线性的泡腾口服芬太尼剂型和施用方法 |
| US20070036853A1 (en) | 2003-12-31 | 2007-02-15 | Cima Labs Inc. | Generally linear effervescent oral fentanyl dosage form and methods of administering |
| US7862833B2 (en) | 2003-12-31 | 2011-01-04 | Cima Labs, Inc. | Effervescent oral opiate dosage forms and methods of administering opiates |
| WO2005065317A2 (en) * | 2003-12-31 | 2005-07-21 | Cima Labs Inc. | Effervescent oral fentanyl dosage form |
| FR2883179B1 (fr) | 2005-03-18 | 2009-04-17 | Ethypharm Sa | Comprime enrobe |
| WO2006103418A1 (en) | 2005-03-28 | 2006-10-05 | Orexo Ab | New pharmaceutical compositions useful in the treatment of pain |
| US20060281775A1 (en) * | 2005-06-14 | 2006-12-14 | Applied Pharmacy Services, Inc. | Two-component pharmaceutical composition for the treatment of pain |
| US20070104763A1 (en) * | 2005-11-10 | 2007-05-10 | Navinta Llc | Composition of fentanyl citrate oral solid transmucosal dosage form, excipient and binding material therefore, and methods of making |
| US8202535B2 (en) * | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US8535714B2 (en) * | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8252328B2 (en) | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US20100233257A1 (en) | 2006-06-09 | 2010-09-16 | Ethypharm | Low dose sublingual tablets of opioid analgesics and preparation process |
| US20070286900A1 (en) | 2006-06-09 | 2007-12-13 | Catherine Herry | Low dose tablets of opioid analgesics and preparation process |
| DK2054031T3 (en) * | 2006-07-21 | 2016-05-17 | Biodelivery Sciences Int Inc | Transmucosal delivery devices with improved uptake |
| ES2439581T3 (es) * | 2006-12-04 | 2014-01-23 | Orexo Ab | Nueva composición farmacéutica no susceptible de abuso que comprende opioides |
| EP1964564A1 (en) | 2007-04-19 | 2008-09-03 | LAB International SRL | Breakthrough Pain Management |
| EP2604257B1 (en) | 2007-08-07 | 2017-06-28 | Acelrx Pharmaceuticals, Inc. | Oral transmucosal dosage forms comprising sufentanil and triazolam |
| US20090263476A1 (en) * | 2008-04-16 | 2009-10-22 | Jobdevairakkam Christopher N | Composition of Rapid Disintegrating Direct Compression Buccal Tablet |
| US8343978B2 (en) | 2008-08-04 | 2013-01-01 | Adds Pharmaceuticals Llc | Fast onset orodispersable tablets |
| US20100056574A1 (en) | 2008-09-04 | 2010-03-04 | Mallinckrodt Inc. | Crystalline Forms of Sufentanil |
| US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| US20100291160A1 (en) | 2009-05-13 | 2010-11-18 | Carver David R | Pharmaceutical system for trans-membrane delivery |
| WO2010141505A1 (en) | 2009-06-01 | 2010-12-09 | Protect Pharmaceutical Corporation | Abuse-resistant delivery systems |
| JP2009280611A (ja) * | 2009-08-26 | 2009-12-03 | Kyukyu Yakuhin Kogyo Kk | 口腔内粘膜フィルム剤 |
| US20110091544A1 (en) | 2009-10-16 | 2011-04-21 | Acelrx Pharmaceuticals, Inc. | Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting |
| WO2011057199A1 (en) | 2009-11-06 | 2011-05-12 | Adenios, Inc. | Compositions for treating cns disorders |
| US20110150989A1 (en) | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
| EP3150199B1 (en) * | 2012-05-02 | 2018-08-08 | Orexo AB | New alfentanil composition for the treatment of acute pain |
-
2013
- 2013-05-01 EP EP16197166.8A patent/EP3150199B1/en active Active
- 2013-05-01 DK DK16197166.8T patent/DK3150199T3/en active
- 2013-05-01 US US13/874,762 patent/US8815911B2/en not_active Expired - Fee Related
- 2013-05-01 ES ES13727314.0T patent/ES2614757T3/es active Active
- 2013-05-01 TR TR2018/15935T patent/TR201815935T4/tr unknown
- 2013-05-01 PL PL13727314T patent/PL2849730T3/pl unknown
- 2013-05-01 JP JP2015509496A patent/JP6275696B2/ja not_active Expired - Fee Related
- 2013-05-01 ES ES16197166.8T patent/ES2694644T3/es active Active
- 2013-05-01 KR KR1020147033700A patent/KR20150005695A/ko not_active Ceased
- 2013-05-01 HR HRP20161634TT patent/HRP20161634T1/hr unknown
- 2013-05-01 IN IN2156MUN2014 patent/IN2014MN02156A/en unknown
- 2013-05-01 WO PCT/GB2013/051131 patent/WO2013164620A1/en not_active Ceased
- 2013-05-01 ME MEP-2017-9A patent/ME02644B/me unknown
- 2013-05-01 NZ NZ701428A patent/NZ701428A/en not_active IP Right Cessation
- 2013-05-01 SM SM20170086T patent/SMT201700086T1/it unknown
- 2013-05-01 EP EP13727314.0A patent/EP2849730B1/en active Active
- 2013-05-01 MX MX2014013176A patent/MX360665B/es active IP Right Grant
- 2013-05-01 CN CN201380022630.2A patent/CN104427978B/zh not_active Expired - Fee Related
- 2013-05-01 RS RS20161161A patent/RS55489B1/sr unknown
- 2013-05-01 AU AU2013255640A patent/AU2013255640B2/en not_active Ceased
- 2013-05-01 SM SM20180585T patent/SMT201800585T1/it unknown
- 2013-05-01 SG SG11201407081PA patent/SG11201407081PA/en unknown
- 2013-05-01 PE PE2014001937A patent/PE20142444A1/es not_active Application Discontinuation
- 2013-05-01 SI SI201330490A patent/SI2849730T1/sl unknown
- 2013-05-01 CA CA2871805A patent/CA2871805A1/en not_active Abandoned
- 2013-05-01 EA EA201401200A patent/EA028110B1/ru not_active IP Right Cessation
- 2013-05-01 BR BR112014027213A patent/BR112014027213A8/pt not_active Application Discontinuation
- 2013-05-01 RS RS20181295A patent/RS57951B1/sr unknown
- 2013-05-01 PT PT16197166T patent/PT3150199T/pt unknown
- 2013-05-01 HU HUE13727314A patent/HUE031792T2/en unknown
- 2013-05-01 PT PT137273140T patent/PT2849730T/pt unknown
- 2013-05-01 PL PL16197166T patent/PL3150199T3/pl unknown
- 2013-05-01 DK DK13727314.0T patent/DK2849730T3/en active
- 2013-05-01 LT LTEP16197166.8T patent/LT3150199T/lt unknown
- 2013-05-01 LT LTEP13727314.0T patent/LT2849730T/lt unknown
- 2013-05-01 SI SI201331238T patent/SI3150199T1/sl unknown
-
2014
- 2014-07-15 US US14/331,507 patent/US9345698B2/en not_active Expired - Fee Related
- 2014-10-17 ZA ZA2014/07559A patent/ZA201407559B/en unknown
- 2014-10-22 IL IL235272A patent/IL235272B/en not_active IP Right Cessation
- 2014-10-27 PH PH12014502407A patent/PH12014502407A1/en unknown
- 2014-10-29 CO CO14239767A patent/CO7170181A2/es not_active Application Discontinuation
- 2014-11-03 CL CL2014002979A patent/CL2014002979A1/es unknown
-
2016
- 2016-04-26 US US15/138,570 patent/US9782396B2/en not_active Expired - Fee Related
-
2017
- 2017-01-31 CY CY20171100139T patent/CY1118570T1/el unknown
- 2017-02-08 SM SM201700086T patent/SMT201700086B/it unknown
- 2017-09-11 US US15/701,300 patent/US20180214437A1/en not_active Abandoned
-
2018
- 2018-10-25 HR HRP20181761TT patent/HRP20181761T1/hr unknown
- 2018-11-05 CY CY181101154T patent/CY1120820T1/el unknown
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