JP2015514705A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015514705A5 JP2015514705A5 JP2015503159A JP2015503159A JP2015514705A5 JP 2015514705 A5 JP2015514705 A5 JP 2015514705A5 JP 2015503159 A JP2015503159 A JP 2015503159A JP 2015503159 A JP2015503159 A JP 2015503159A JP 2015514705 A5 JP2015514705 A5 JP 2015514705A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- heparan sulfate
- chemically modified
- modified heparin
- heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002971 Heparan sulfate Polymers 0.000 claims 30
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 29
- 150000004676 glycans Polymers 0.000 claims 8
- 208000037805 labour Diseases 0.000 claims 8
- 150000004804 polysaccharides Polymers 0.000 claims 6
- 230000013948 uterine smooth muscle contraction Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 230000032696 parturition Effects 0.000 claims 5
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 4
- 101800000989 Oxytocin Proteins 0.000 claims 4
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 4
- 150000002016 disaccharides Chemical class 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 4
- 229960001723 oxytocin Drugs 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 4
- 229960002897 heparin Drugs 0.000 claims 3
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 2
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical class OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 230000002429 anti-coagulating effect Effects 0.000 claims 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000001186 cumulative effect Effects 0.000 claims 2
- 238000009826 distribution Methods 0.000 claims 2
- 229960002442 glucosamine Drugs 0.000 claims 2
- 229940097043 glucuronic acid Drugs 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 206010021718 Induced labour Diseases 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 150000002301 glucosamine derivatives Chemical class 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615400P | 2012-03-26 | 2012-03-26 | |
| US61/615,400 | 2012-03-26 | ||
| PCT/SE2013/050333 WO2013147690A1 (en) | 2012-03-26 | 2013-03-25 | Method for treatment of labor arrest |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514705A JP2015514705A (ja) | 2015-05-21 |
| JP2015514705A5 true JP2015514705A5 (https=) | 2016-05-26 |
Family
ID=49260784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503159A Pending JP2015514705A (ja) | 2012-03-26 | 2013-03-25 | 分娩停止の処置のための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20150057226A1 (https=) |
| EP (1) | EP2830634A4 (https=) |
| JP (1) | JP2015514705A (https=) |
| CN (1) | CN104244957B (https=) |
| AU (1) | AU2013240598A1 (https=) |
| CA (1) | CA2868479A1 (https=) |
| HK (1) | HK1203370A1 (https=) |
| MX (1) | MX2014011451A (https=) |
| MY (1) | MY185108A (https=) |
| NZ (1) | NZ631279A (https=) |
| RU (1) | RU2014143008A (https=) |
| SG (1) | SG11201406118QA (https=) |
| UA (1) | UA117907C2 (https=) |
| WO (1) | WO2013147690A1 (https=) |
| ZA (1) | ZA201406567B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2617764C2 (ru) | 2011-12-19 | 2017-04-26 | Дилафор Аб | Неантикоагулянтные гликозаминогликаны, содержащие повторяющиеся дисахаридные звенья, и их медицинское применение |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| KR101536885B1 (ko) | 2012-03-26 | 2015-07-14 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 함유 점안액 |
| RU2014149230A (ru) * | 2012-05-08 | 2016-06-27 | Дилафор Аб | Лечение послеродового кровотечения (прк) |
| WO2021165240A1 (en) | 2020-02-17 | 2021-08-26 | Dilafor Ab | Tafoxiparin for the treatment of preeclampsia |
| EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
| EP4518872A1 (en) | 2022-05-03 | 2025-03-12 | Dilafor AB | New medical use of tafoxiparin |
| JP2026504393A (ja) * | 2023-02-01 | 2026-02-05 | マテルナ・メディカル・インコーポレイテッド | 出産時の膣裂傷を防止するための方法及びデバイス |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000065837A (ja) * | 1998-08-24 | 2000-03-03 | Seikagaku Kogyo Co Ltd | グリコサミノグリカン又はグリコサミノグリカン結合性分子の測定方法及びその測定用キット |
| JP2000309544A (ja) * | 1999-02-25 | 2000-11-07 | Seikagaku Kogyo Co Ltd | 早産または流産防止剤および子宮頚管熟化抑制剤ならびにヒアルロニダーゼの阻害剤 |
| SE521676C2 (sv) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| WO2009073184A1 (en) * | 2007-12-03 | 2009-06-11 | Florida State University Research Foundation, Inc. | Compositions for inducing labor and associated methods |
| RU2617764C2 (ru) * | 2011-12-19 | 2017-04-26 | Дилафор Аб | Неантикоагулянтные гликозаминогликаны, содержащие повторяющиеся дисахаридные звенья, и их медицинское применение |
-
2013
- 2013-03-25 MX MX2014011451A patent/MX2014011451A/es unknown
- 2013-03-25 WO PCT/SE2013/050333 patent/WO2013147690A1/en not_active Ceased
- 2013-03-25 SG SG11201406118QA patent/SG11201406118QA/en unknown
- 2013-03-25 MY MYPI2014002744A patent/MY185108A/en unknown
- 2013-03-25 JP JP2015503159A patent/JP2015514705A/ja active Pending
- 2013-03-25 RU RU2014143008A patent/RU2014143008A/ru not_active Application Discontinuation
- 2013-03-25 NZ NZ631279A patent/NZ631279A/en unknown
- 2013-03-25 CN CN201380016529.6A patent/CN104244957B/zh active Active
- 2013-03-25 UA UAA201411545A patent/UA117907C2/uk unknown
- 2013-03-25 CA CA2868479A patent/CA2868479A1/en not_active Abandoned
- 2013-03-25 EP EP13768034.4A patent/EP2830634A4/en not_active Withdrawn
- 2013-03-25 US US14/387,929 patent/US20150057226A1/en not_active Abandoned
- 2013-03-25 HK HK15103909.7A patent/HK1203370A1/xx unknown
- 2013-03-25 AU AU2013240598A patent/AU2013240598A1/en not_active Abandoned
-
2014
- 2014-09-08 ZA ZA2014/06567A patent/ZA201406567B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015514705A5 (https=) | ||
| RU2014143008A (ru) | Способ лечения остановки родов | |
| JP2015500388A5 (https=) | ||
| Yang et al. | Strategies for sustained release of heparin: A review | |
| JP2015511664A5 (https=) | ||
| PH12014501387B1 (en) | Low anticoagulant heparins | |
| RU2014129816A (ru) | Неантикоагулянтные гликозаминогликаны, содержащие повторяющиеся дисахаридные звенья, и их медицинское применение | |
| JP2011522879A5 (https=) | ||
| RU2014143017A (ru) | Препараты для индукции родов | |
| JP2013525306A5 (https=) | ||
| JP2011037849A (ja) | 消化性潰瘍及び十二指腸潰瘍の治療及び予防に使用されるヒアルロン酸混合物 | |
| RU2016116786A (ru) | Иммуностимулятор | |
| HRP20230820T1 (hr) | Heparan-sulfat, s visokom stopom 3-o-sulfatiranja u glukozaminskim ostacima | |
| JP2015516415A5 (https=) | ||
| CN100341518C (zh) | 硫酸化葡糖胺聚糖在制备预防和治疗足月分娩进展缓慢的药物制剂中的用途 | |
| RU2014149230A (ru) | Лечение послеродового кровотечения (прк) | |
| JP2014504613A5 (https=) | ||
| FI3730521T3 (fi) | Pentosaanipolysulfaatti ja pentosaanipolysulfaattia sisältävä lääke | |
| JP2016534078A5 (https=) | ||
| Cacique et al. | Heparin-hidden pillar in the management of burns | |
| Choi et al. | Low molecular weight heparin associated intramuscular hematoma with compartment syndrome | |
| CN103705500A (zh) | Myrtucommuacetalone在治疗肾功能不全药物中的应用 | |
| TH152504A (th) | การบำบัดรักษาของภาวะตกเลือดหลังคลอดด้วยเฮปาริน หรือ เฮปารินซัลเฟตที่ถูกดัดแปลงทางเคมี และยากระตุ้นการหดตัวของมดลูก | |
| Ukovich et al. | Parnaparin: A Review of its Safety and Efficacy | |
| Sobieszczanska | Enoxaparin sodium |