JP2015511664A5 - - Google Patents
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- Publication number
- JP2015511664A5 JP2015511664A5 JP2015503158A JP2015503158A JP2015511664A5 JP 2015511664 A5 JP2015511664 A5 JP 2015511664A5 JP 2015503158 A JP2015503158 A JP 2015503158A JP 2015503158 A JP2015503158 A JP 2015503158A JP 2015511664 A5 JP2015511664 A5 JP 2015511664A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- heparan sulfate
- chemically modified
- modified heparin
- heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 20
- 229920002971 Heparan sulfate Polymers 0.000 claims 19
- 230000013948 uterine smooth muscle contraction Effects 0.000 claims 10
- 238000011282 treatment Methods 0.000 claims 9
- 150000004676 glycans Polymers 0.000 claims 8
- 230000035800 maturation Effects 0.000 claims 8
- 230000001737 promoting effect Effects 0.000 claims 7
- 150000004804 polysaccharides Polymers 0.000 claims 5
- 229960002986 dinoprostone Drugs 0.000 claims 4
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 4
- 150000002016 disaccharides Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 4
- 150000003180 prostaglandins Chemical class 0.000 claims 4
- 210000003679 cervix uteri Anatomy 0.000 claims 3
- 150000002301 glucosamine derivatives Chemical class 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 2
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical class OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 claims 2
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 2
- 101800000989 Oxytocin Proteins 0.000 claims 2
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 238000011374 additional therapy Methods 0.000 claims 2
- 230000002429 anti-coagulating effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000011284 combination treatment Methods 0.000 claims 2
- 230000001186 cumulative effect Effects 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N glucosamine group Chemical group OC1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 2
- 229940097043 glucuronic acid Drugs 0.000 claims 2
- 229920000669 heparin Polymers 0.000 claims 2
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims 2
- 229960005249 misoprostol Drugs 0.000 claims 2
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 2
- 229960001723 oxytocin Drugs 0.000 claims 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- 210000004291 uterus Anatomy 0.000 claims 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615398P | 2012-03-26 | 2012-03-26 | |
| US61/615,398 | 2012-03-26 | ||
| PCT/SE2013/050332 WO2013147689A1 (en) | 2012-03-26 | 2013-03-25 | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511664A JP2015511664A (ja) | 2015-04-20 |
| JP2015511664A5 true JP2015511664A5 (https=) | 2016-05-26 |
| JP6234989B2 JP6234989B2 (ja) | 2017-11-22 |
Family
ID=49260783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503158A Active JP6234989B2 (ja) | 2012-03-26 | 2013-03-25 | 分娩を誘発するための療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20150045322A1 (https=) |
| EP (1) | EP2830635A4 (https=) |
| JP (1) | JP6234989B2 (https=) |
| CN (1) | CN104203256B (https=) |
| AU (1) | AU2013240597A1 (https=) |
| CA (1) | CA2868444A1 (https=) |
| HK (1) | HK1203369A1 (https=) |
| IL (1) | IL234689A0 (https=) |
| MX (1) | MX2014011505A (https=) |
| MY (1) | MY175743A (https=) |
| RU (1) | RU2014143017A (https=) |
| SG (1) | SG11201406119WA (https=) |
| UA (1) | UA117908C2 (https=) |
| WO (1) | WO2013147689A1 (https=) |
| ZA (1) | ZA201406901B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104144950B (zh) | 2011-12-19 | 2017-09-05 | 迪乐方有限责任公司 | 含有重复的二糖单元的非抗凝的葡糖胺聚糖及其医药用途 |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| JP2015516415A (ja) * | 2012-05-08 | 2015-06-11 | ディラフォール・アクチボラゲットＤｉｌａｆｏｒ Ａｂ | 化学修飾ヘパリンまたはヘパラン硫酸および子宮収縮剤を用いた分娩後出血の処置 |
| JP7621366B2 (ja) * | 2020-02-17 | 2025-01-24 | ディラフォール アクチエボラグ | 子癇前症の処置のためのタフォキシパリン |
| EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
| AU2023266079A1 (en) | 2022-05-03 | 2024-10-31 | Dilafor Ab | New medical use of tafoxiparin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5993810A (en) * | 1996-03-15 | 1999-11-30 | Lebovitz; Shamir Israel | Method of softening or ripening the cervix of a female mammal using collagenase |
| SE521676C2 (sv) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| WO2009073184A1 (en) * | 2007-12-03 | 2009-06-11 | Florida State University Research Foundation, Inc. | Compositions for inducing labor and associated methods |
| WO2013081896A1 (en) * | 2011-11-28 | 2013-06-06 | Corning Incorporated | Robust optical touch-screen systems and methods using a planar transparent sheet |
| CN104144950B (zh) * | 2011-12-19 | 2017-09-05 | 迪乐方有限责任公司 | 含有重复的二糖单元的非抗凝的葡糖胺聚糖及其医药用途 |
-
2013
- 2013-03-25 HK HK15103908.8A patent/HK1203369A1/xx unknown
- 2013-03-25 JP JP2015503158A patent/JP6234989B2/ja active Active
- 2013-03-25 CN CN201380016550.6A patent/CN104203256B/zh active Active
- 2013-03-25 MY MYPI2014002745A patent/MY175743A/en unknown
- 2013-03-25 EP EP13770213.0A patent/EP2830635A4/en not_active Withdrawn
- 2013-03-25 WO PCT/SE2013/050332 patent/WO2013147689A1/en not_active Ceased
- 2013-03-25 SG SG11201406119WA patent/SG11201406119WA/en unknown
- 2013-03-25 AU AU2013240597A patent/AU2013240597A1/en not_active Abandoned
- 2013-03-25 US US14/387,936 patent/US20150045322A1/en not_active Abandoned
- 2013-03-25 UA UAA201411546A patent/UA117908C2/uk unknown
- 2013-03-25 CA CA2868444A patent/CA2868444A1/en not_active Abandoned
- 2013-03-25 MX MX2014011505A patent/MX2014011505A/es unknown
- 2013-03-25 RU RU2014143017A patent/RU2014143017A/ru not_active Application Discontinuation
-
2014
- 2014-09-16 ZA ZA2014/06901A patent/ZA201406901B/en unknown
- 2014-09-16 IL IL234689A patent/IL234689A0/en unknown
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