JP2016534078A5 - - Google Patents
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- Publication number
- JP2016534078A5 JP2016534078A5 JP2016525966A JP2016525966A JP2016534078A5 JP 2016534078 A5 JP2016534078 A5 JP 2016534078A5 JP 2016525966 A JP2016525966 A JP 2016525966A JP 2016525966 A JP2016525966 A JP 2016525966A JP 2016534078 A5 JP2016534078 A5 JP 2016534078A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- glycosaminoglycan
- sulfated polysaccharide
- drug according
- polysaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 16
- 150000004676 glycans Chemical class 0.000 claims 16
- 229920001282 polysaccharide Polymers 0.000 claims 16
- 239000005017 polysaccharide Substances 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 9
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 7
- 229920000669 heparin Polymers 0.000 claims 5
- 229960000633 dextran sulfate Drugs 0.000 claims 4
- 229960002897 heparin Drugs 0.000 claims 4
- 229940043138 pentosan polysulfate Drugs 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000010399 physical interaction Effects 0.000 claims 2
- 230000010152 pollination Effects 0.000 claims 2
- 230000019635 sulfation Effects 0.000 claims 2
- 238000005670 sulfation reaction Methods 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 229920000855 Fucoidan Polymers 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960004969 dalteparin Drugs 0.000 claims 1
- 229960000610 enoxaparin Drugs 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000003055 low molecular weight heparin Substances 0.000 claims 1
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960005062 tinzaparin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102013111630 | 2013-10-22 | ||
| DE102013111630.2 | 2013-10-22 | ||
| PCT/EP2014/072620 WO2015059177A1 (en) | 2013-10-22 | 2014-10-22 | Sulfated polysaccharides for use in the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016534078A JP2016534078A (ja) | 2016-11-04 |
| JP2016534078A5 true JP2016534078A5 (https=) | 2017-01-19 |
| JP6444399B2 JP6444399B2 (ja) | 2018-12-26 |
Family
ID=51795625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525966A Active JP6444399B2 (ja) | 2013-10-22 | 2014-10-22 | 癌の処置に用いるための硫酸化多糖 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10098906B2 (https=) |
| EP (1) | EP3060223B1 (https=) |
| JP (1) | JP6444399B2 (https=) |
| AU (1) | AU2014339000B2 (https=) |
| CA (1) | CA2926888C (https=) |
| WO (1) | WO2015059177A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10434085B2 (en) | 2015-06-04 | 2019-10-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
| EP3402812B1 (en) * | 2016-01-11 | 2024-03-27 | Dignity Health | Modulators of zinc activated cation channel |
| AU2018319344B2 (en) * | 2017-08-23 | 2024-04-04 | Cell Receptor AG | Combination of a MAPK/ERK pathway inhibitor and a glycosaminoglycan for the treatment of cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5262403A (en) * | 1986-03-10 | 1993-11-16 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II |
| US7781416B2 (en) * | 2000-01-25 | 2010-08-24 | Sigma-Tau Research Switzerland S.A. | Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect |
| US20060154894A1 (en) | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| EP2398482B1 (en) * | 2009-02-17 | 2017-04-19 | NovelMed Therapeutics, Inc. | Methods and compositions for inhibiting cellular proliferation and surgical adhesion |
| EP2550004A4 (en) * | 2010-03-12 | 2014-07-02 | Univ Australian | HEPARANSULFATERSATZTHERAPIE |
| IT1401253B1 (it) * | 2010-04-23 | 2013-07-18 | Uni Degli Studi Carlo Bo Urbino | Uso del sulodexide per la riduzione delle metalloproteinasi di matrice. |
| TWI520740B (zh) * | 2011-02-02 | 2016-02-11 | 模範健康科技私人企業有限公司 | 利用多硫酸化多醣之骨髓水腫（水腫）的治療 |
| EP2861273B1 (en) * | 2012-06-13 | 2017-08-23 | ExThera Medical Corporation | Use of heparin and carbohydrates to treat cancer |
| US20150328254A1 (en) * | 2014-04-17 | 2015-11-19 | Memorial Sloan Kettering Cancer Center | Fucoidan nanogels and methods of their use and manufacture |
-
2014
- 2014-10-22 CA CA2926888A patent/CA2926888C/en active Active
- 2014-10-22 EP EP14789548.6A patent/EP3060223B1/en active Active
- 2014-10-22 AU AU2014339000A patent/AU2014339000B2/en active Active
- 2014-10-22 US US15/031,020 patent/US10098906B2/en active Active
- 2014-10-22 JP JP2016525966A patent/JP6444399B2/ja active Active
- 2014-10-22 WO PCT/EP2014/072620 patent/WO2015059177A1/en not_active Ceased
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