CL2022000729A1 - Derivado de heteroarilamidopiridinol y composición farmacéutica que comprende el mismo como ingrediente activo para prevención o tratamiento de enfermedad autoinmune - Google Patents

Derivado de heteroarilamidopiridinol y composición farmacéutica que comprende el mismo como ingrediente activo para prevención o tratamiento de enfermedad autoinmune

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Publication number
CL2022000729A1
CL2022000729A1 CL2022000729A CL2022000729A CL2022000729A1 CL 2022000729 A1 CL2022000729 A1 CL 2022000729A1 CL 2022000729 A CL2022000729 A CL 2022000729A CL 2022000729 A CL2022000729 A CL 2022000729A CL 2022000729 A1 CL2022000729 A1 CL 2022000729A1
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CL
Chile
Prior art keywords
heteroarylamidopyridinol
derivative
treatment
autoimmune disease
prevention
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CL2022000729A
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English (en)
Inventor
Byeong-Seon Jeong
Jung-Ae Kim
Tae-Gyu Nam
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Innovo Therapeutics Inc
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Publication date
Application filed by Innovo Therapeutics Inc filed Critical Innovo Therapeutics Inc
Publication of CL2022000729A1 publication Critical patent/CL2022000729A1/es

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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Abstract

La presente invención se refiere a se refiere a un derivado de heteroarilamidopiridinol y una composición farmacéutica que comprende el mismo como un ingrediente activo para la prevención o tratamiento de una enfermedad autoinmune, específicamente, enfermedad intestinal inflamatoria, artritis reumatoide, etc. El derivado de heteroarilamidopiridinol presenta un excelente efecto para inhibir la adhesión del monocito inducida por el TNF-a o IL-6 a células epiteliales intestinales y se ha probado que tienen un efecto terapéutico en la enfermedad intestinal inflamatoria y artritis reumatoide in vivo. De este modo, el derivado de heteroarilamidopiridinol puede ser usado ventajosamente para el tratamiento de una enfermedad autoinmune, específicamente, enfermedad intestinal inflamatoria o artritis reumatoide.
CL2022000729A 2019-09-24 2022-03-23 Derivado de heteroarilamidopiridinol y composición farmacéutica que comprende el mismo como ingrediente activo para prevención o tratamiento de enfermedad autoinmune CL2022000729A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020190117253A KR102426921B1 (ko) 2019-09-24 2019-09-24 헤테로아릴아미도피리딘올 유도체 및 이를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약학적 조성물

Publications (1)

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CL2022000729A1 true CL2022000729A1 (es) 2023-01-20

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US (1) US20220324834A1 (es)
EP (1) EP4008718A4 (es)
JP (1) JP7353683B2 (es)
KR (1) KR102426921B1 (es)
CN (1) CN114450275A (es)
AU (2) AU2020354138B2 (es)
BR (1) BR112022004925A2 (es)
CA (1) CA3154502C (es)
CL (1) CL2022000729A1 (es)
CO (1) CO2022002998A2 (es)
IL (1) IL291168A (es)
MX (1) MX2022003422A (es)
NZ (1) NZ785829A (es)
UA (1) UA128298C2 (es)
WO (1) WO2021060890A1 (es)

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EP4370207A1 (en) * 2021-07-12 2024-05-22 Nido Biosciences, Inc. Bicyclic compounds as androgen receptor modulators
WO2024026290A1 (en) * 2022-07-25 2024-02-01 Cayman Chemical Company Incorporated NOVEL HETEROCYCLES AS sPLA2-X INHIBITORS
KR20240055482A (ko) 2022-10-20 2024-04-29 주식회사 이노보테라퓨틱스 글리코겐 가인산분해효소 (pygl) 저해제를 유효성분으로 포함하는 염증성 장 질환 치료용 약학적 조성물
KR20240111515A (ko) 2023-01-10 2024-07-17 광주과학기술원 신규한 화합물 및 이를 포함하는 약학 조성물
KR20240031874A (ko) 2023-06-28 2024-03-08 주식회사 이노보테라퓨틱스 글리코겐 포스포릴라제(pygl) 저해제를 포함하는 자가면역 질환의 예방 또는 치료용 약학 조성물

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JP7499698B2 (ja) * 2017-11-03 2024-06-14 ウニヴェルシテ ド モントリオール 化合物及び幹細胞及び/又は前駆細胞の増殖におけるその使用

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CA3154502C (en) 2024-04-23
UA128298C2 (uk) 2024-05-29
WO2021060890A1 (ko) 2021-04-01
JP7353683B2 (ja) 2023-10-02
JP2022551431A (ja) 2022-12-09
EP4008718A4 (en) 2022-08-17
IL291168A (en) 2022-05-01
CA3154502A1 (en) 2021-04-01
CO2022002998A2 (es) 2022-04-19
KR20210035454A (ko) 2021-04-01
NZ785829A (en) 2024-08-30
US20220324834A1 (en) 2022-10-13
CN114450275A (zh) 2022-05-06
AU2023226778A1 (en) 2023-09-28
BR112022004925A2 (pt) 2022-06-14
KR102426921B1 (ko) 2022-07-29
AU2020354138A1 (en) 2022-03-24
MX2022003422A (es) 2022-04-18
EP4008718A1 (en) 2022-06-08
AU2020354138B2 (en) 2023-07-13

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