JP2014504613A5 - - Google Patents
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- Publication number
- JP2014504613A5 JP2014504613A5 JP2013552065A JP2013552065A JP2014504613A5 JP 2014504613 A5 JP2014504613 A5 JP 2014504613A5 JP 2013552065 A JP2013552065 A JP 2013552065A JP 2013552065 A JP2013552065 A JP 2013552065A JP 2014504613 A5 JP2014504613 A5 JP 2014504613A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polysulfate
- molecular weight
- pentosan polysulfate
- weight heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 10
- 229940043138 pentosan polysulfate Drugs 0.000 claims 8
- 150000004676 glycans Chemical class 0.000 claims 5
- 229920001282 polysaccharide Polymers 0.000 claims 5
- 239000005017 polysaccharide Substances 0.000 claims 5
- 229920002971 Heparan sulfate Polymers 0.000 claims 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 239000003055 low molecular weight heparin Substances 0.000 claims 3
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 3
- 206010051763 Bone marrow oedema Diseases 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 229920002567 Chondroitin Polymers 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 238000011269 treatment regimen Methods 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 159000000007 calcium salts Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 159000000003 magnesium salts Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011900325A AU2011900325A0 (en) | 2011-02-02 | Treatment of bone marrow edema (oedema) with polysulfated polysaccharides | |
| AU2011900325 | 2011-02-02 | ||
| PCT/AU2012/000091 WO2012103588A1 (en) | 2011-02-02 | 2012-02-02 | Treatment of bone marrow edema (oedema) with polysulfated polysaccharides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504613A JP2014504613A (ja) | 2014-02-24 |
| JP2014504613A5 true JP2014504613A5 (https=) | 2015-03-19 |
| JP5883458B2 JP5883458B2 (ja) | 2016-03-15 |
Family
ID=46602012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552065A Active JP5883458B2 (ja) | 2011-02-02 | 2012-02-02 | ポリ硫酸化多糖類を用いる骨髄浮腫（ｅｄｅｍａ（ｏｅｄｅｍａ））の治療 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9101650B2 (https=) |
| EP (1) | EP2670412B1 (https=) |
| JP (1) | JP5883458B2 (https=) |
| KR (1) | KR101840079B1 (https=) |
| CN (1) | CN103415293B (https=) |
| AU (1) | AU2012212398B2 (https=) |
| CA (1) | CA2826166C (https=) |
| DK (1) | DK2670412T3 (https=) |
| ES (1) | ES2664611T3 (https=) |
| MY (1) | MY164728A (https=) |
| NO (1) | NO2670412T3 (https=) |
| PT (1) | PT2670412T (https=) |
| SG (1) | SG192238A1 (https=) |
| TW (1) | TWI520740B (https=) |
| WO (1) | WO2012103588A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10098906B2 (en) * | 2013-10-22 | 2018-10-16 | Cell Receptor AG | Modulation of the physical interaction between platelets and the cell surface effecting cell proliferation |
| CN111417399A (zh) * | 2017-08-04 | 2020-07-14 | 帕拉迪生物制药有限公司 | 多硫酸化多糖治疗骨髓病变 |
| WO2019157560A1 (en) | 2018-02-16 | 2019-08-22 | Proteobioactives Pty Limited | Methods and compositions for the treatment of pain and/or inflammation |
| JP7391858B2 (ja) * | 2018-02-28 | 2023-12-05 | パラダイム バイオファーマシューティカルズ リミテッド | ポリ硫酸化多糖類を用いた術後関節痛の処置 |
| FI3863647T3 (fi) * | 2018-10-10 | 2024-03-01 | Paradigm Biopharmaceuticals Ltd | Pahanlaatuisen luustokivun hoitaminen pentosaanipolysulfaatilla |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668116A (en) | 1987-03-19 | 1997-09-16 | Anthropharm Pty. Limited | Anti-inflammatory compounds and compositions |
| US6593310B1 (en) | 2000-11-21 | 2003-07-15 | Arthropharm Pty. Ltd. | Treatment of osteoporosis |
| US6564083B2 (en) * | 2000-12-18 | 2003-05-13 | Hoffmann-La Roche Inc. | Bone marrow edema as predictive of susceptibility to developing progressive osteoarthritis |
| DE10225551A1 (de) * | 2002-06-06 | 2003-12-24 | Schering Ag | Verwendung von oral verfügbaren Prostacyclinderivaten für die Herstellung eines Arzneimittels zur Behandlung von Krankheiten, die mit Knochenmarködemen assoziiert sind |
| KR101718375B1 (ko) | 2007-12-04 | 2017-03-22 | 프로테오바이오엑티브스 피티와이 엘티디 | 전구 세포의 보호 및 그의 분화 조절 |
-
2012
- 2012-02-01 TW TW101103252A patent/TWI520740B/zh active
- 2012-02-02 CA CA2826166A patent/CA2826166C/en active Active
- 2012-02-02 CN CN201280007433.9A patent/CN103415293B/zh active Active
- 2012-02-02 EP EP12741560.2A patent/EP2670412B1/en active Active
- 2012-02-02 KR KR1020137022985A patent/KR101840079B1/ko active Active
- 2012-02-02 NO NO12741560A patent/NO2670412T3/no unknown
- 2012-02-02 PT PT127415602T patent/PT2670412T/pt unknown
- 2012-02-02 DK DK12741560.2T patent/DK2670412T3/en active
- 2012-02-02 WO PCT/AU2012/000091 patent/WO2012103588A1/en not_active Ceased
- 2012-02-02 MY MYPI2013701355A patent/MY164728A/en unknown
- 2012-02-02 AU AU2012212398A patent/AU2012212398B2/en active Active
- 2012-02-02 ES ES12741560.2T patent/ES2664611T3/es active Active
- 2012-02-02 SG SG2013058268A patent/SG192238A1/en unknown
- 2012-02-02 US US13/983,406 patent/US9101650B2/en active Active
- 2012-02-02 JP JP2013552065A patent/JP5883458B2/ja active Active
-
2015
- 2015-07-02 US US14/790,476 patent/US9861657B2/en active Active
-
2017
- 2017-09-29 US US15/720,884 patent/US10610542B2/en active Active
-
2020
- 2020-02-25 US US16/800,245 patent/US11406660B2/en active Active
-
2022
- 2022-07-05 US US17/857,420 patent/US20220362284A1/en not_active Abandoned
-
2023
- 2023-11-21 US US18/515,823 patent/US20240156858A1/en active Pending
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