JP2008518090A5 - - Google Patents
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- Publication number
- JP2008518090A5 JP2008518090A5 JP2007539188A JP2007539188A JP2008518090A5 JP 2008518090 A5 JP2008518090 A5 JP 2008518090A5 JP 2007539188 A JP2007539188 A JP 2007539188A JP 2007539188 A JP2007539188 A JP 2007539188A JP 2008518090 A5 JP2008518090 A5 JP 2008518090A5
- Authority
- JP
- Japan
- Prior art keywords
- heparin
- medicament
- desulfated
- thrombosis
- platelet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 13
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 10
- 206010062506 Heparin-induced thrombocytopenia Diseases 0.000 claims 7
- 230000010118 platelet activation Effects 0.000 claims 5
- 208000007536 Thrombosis Diseases 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 229960002897 heparin Drugs 0.000 claims 2
- 229920000669 heparin Polymers 0.000 claims 2
- 230000003113 alkalizing effect Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 239000004019 antithrombin Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
- 239000003805 procoagulant Substances 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 230000019635 sulfation Effects 0.000 claims 1
- 238000005670 sulfation reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/974,566 US7468358B2 (en) | 2004-06-16 | 2004-10-27 | Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome |
| PCT/US2005/039011 WO2006047755A2 (en) | 2004-10-27 | 2005-10-26 | Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (hit) syndrome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008518090A JP2008518090A (ja) | 2008-05-29 |
| JP2008518090A5 true JP2008518090A5 (https=) | 2008-12-11 |
Family
ID=36228513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539188A Pending JP2008518090A (ja) | 2004-10-27 | 2005-10-26 | ヘパリン起因性血小板減少症（ｈｉｔ）症候群の硫酸化多糖類治療のための方法および医薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7468358B2 (https=) |
| EP (1) | EP1807095B1 (https=) |
| JP (1) | JP2008518090A (https=) |
| AT (1) | ATE507836T1 (https=) |
| AU (1) | AU2005299568A1 (https=) |
| CA (1) | CA2585640C (https=) |
| DE (1) | DE602005027883D1 (https=) |
| ES (1) | ES2366342T3 (https=) |
| WO (1) | WO2006047755A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050261241A1 (en) * | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
| CA2678587A1 (en) * | 2007-02-28 | 2008-09-04 | Paringenix, Inc. | O-desulfated heparins treating acute exacerbations of chronic obstructive pulmonary disease |
| WO2009015183A1 (en) * | 2007-07-23 | 2009-01-29 | University Of Utah Research Foundation | Method for blocking ligation of the receptor for advanced glycation end-products (rage) |
| WO2009117677A2 (en) * | 2008-03-21 | 2009-09-24 | University Of Utah Research Foundation | Methods for controlling intracellular calcium levels associated with an ischemic event |
| CA2777099C (en) * | 2009-07-31 | 2018-03-27 | Reliable Biopharmaceutical Corporation | Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof |
| US8420790B2 (en) | 2009-10-30 | 2013-04-16 | Reliable Biopharmaceutical Corporation | Efficient and scalable process for the manufacture of Fondaparinux sodium |
| KR102082276B1 (ko) * | 2010-09-14 | 2020-02-27 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 고순도 헤파린 및 그 제조방법 |
| JP2014501730A (ja) * | 2010-12-01 | 2014-01-23 | ジ オーストラリアン ナショナル ユニバーシティ | ヒストン阻害 |
| WO2013016181A1 (en) * | 2011-07-22 | 2013-01-31 | Paringenix, Inc. | Compositions and methods for anti-coagulation |
| EP2809678B1 (en) | 2012-02-02 | 2017-03-22 | Reliable Biopharmaceutical Corporation | An efficient and scalable process for the manufacture of fondaparinux sodium |
| CN104411316B (zh) * | 2012-05-09 | 2018-05-01 | 坎泰克斯制药股份有限公司 | 骨髓抑制的治疗 |
| AU2016234916A1 (en) * | 2012-05-09 | 2016-11-17 | Cantex Pharmaceuticals, Inc. | Treatment of myelosuppression |
| US20170096549A1 (en) | 2014-03-17 | 2017-04-06 | Cantex Pharmaceuticals, Inc. | Multivalent cation formulations of partially desulfated heparins |
| US10052346B2 (en) | 2015-02-17 | 2018-08-21 | Cantex Pharmaceuticals, Inc. | Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids |
| CN107430137B (zh) * | 2015-03-03 | 2020-11-20 | 美国控股实验室公司 | 用于测量样品中的血清素的方法和系统 |
| EP3810125B1 (en) * | 2018-06-03 | 2025-07-23 | Glycomira Therapeutics, Inc. | Sulfated polysaccharide for use in preventing oral mucositis after exposure to ionizing radiation |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| GB202006960D0 (en) * | 2020-05-12 | 2020-06-24 | Aplagon Oy | Therapeutic |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1164145E (pt) * | 1992-07-24 | 2008-03-17 | Paringenix Inc | Heparinas dessulfatadas não anticoagulantes como medicamentos |
| US5668118A (en) * | 1992-07-24 | 1997-09-16 | Cavalier Pharmaceuticals | Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G |
| US5696100A (en) * | 1992-12-22 | 1997-12-09 | Glycomed Incorporated | Method for controlling O-desulfation of heparin and compositions produced thereby |
| US5990097A (en) * | 1996-07-29 | 1999-11-23 | Cavalier Pharmaceuticals | Methods of treating asthma with o-desulfated heparin |
| CN1326355A (zh) * | 1998-11-13 | 2001-12-12 | 伊莱利利公司 | 治疗肝素诱导的血小板减少症的方法 |
| EP1223948A2 (en) | 1999-09-13 | 2002-07-24 | CHARLOTTE-MECKLENBURG HOSPITAL doing business as Carolinas Medical Center | Method of inhibiting nf-kappa-b with heparin, for treating cardiovascular diseases and inflammations |
| US6489311B1 (en) * | 2000-05-02 | 2002-12-03 | Charlotte-Mecklenburg Hospital Authoirty | Method for the prevention of apoptosis |
| WO2004050673A2 (en) | 2002-11-27 | 2004-06-17 | Massachusetts Institute Of Technology | Methods for synthesizing polysaccharides |
| US20050261241A1 (en) * | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
| US20050282775A1 (en) | 2004-06-16 | 2005-12-22 | Paringenix, Inc. | Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome |
-
2004
- 2004-10-27 US US10/974,566 patent/US7468358B2/en not_active Expired - Lifetime
-
2005
- 2005-10-26 EP EP05824840A patent/EP1807095B1/en not_active Expired - Lifetime
- 2005-10-26 ES ES05824840T patent/ES2366342T3/es not_active Expired - Lifetime
- 2005-10-26 CA CA2585640A patent/CA2585640C/en not_active Expired - Lifetime
- 2005-10-26 AU AU2005299568A patent/AU2005299568A1/en not_active Abandoned
- 2005-10-26 JP JP2007539188A patent/JP2008518090A/ja active Pending
- 2005-10-26 WO PCT/US2005/039011 patent/WO2006047755A2/en not_active Ceased
- 2005-10-26 AT AT05824840T patent/ATE507836T1/de not_active IP Right Cessation
- 2005-10-26 DE DE602005027883T patent/DE602005027883D1/de not_active Expired - Lifetime
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