JP2006518750A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006518750A5 JP2006518750A5 JP2006503763A JP2006503763A JP2006518750A5 JP 2006518750 A5 JP2006518750 A5 JP 2006518750A5 JP 2006503763 A JP2006503763 A JP 2006503763A JP 2006503763 A JP2006503763 A JP 2006503763A JP 2006518750 A5 JP2006518750 A5 JP 2006518750A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- functionally equivalent
- inhibitor
- fragment
- fragments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012634 fragment Substances 0.000 claims 14
- 239000004074 complement inhibitor Substances 0.000 claims 7
- 229940124073 Complement inhibitor Drugs 0.000 claims 6
- RDTRHBCZFDCUPW-KWICJJCGSA-N 2-[(4r,7s,10s,13s,19s,22s,25s,28s,31s,34r)-4-[[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-34-[[(2s,3s)-2-amino-3-methylpentanoyl]amino]-25-(3-amino-3-oxopropyl)-7-[3-(diaminomethylideneamino)propyl]-10,13-bis(1h-imidazol-5-ylmethyl)-19-(1h-indol Chemical compound C([C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CSSC[C@@H](C(N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)NCC(=O)N[C@@H](CC=2NC=NC=2)C(=O)N1)C(C)C)C(C)C)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C1=CN=CN1 RDTRHBCZFDCUPW-KWICJJCGSA-N 0.000 claims 2
- 108010009575 CD55 Antigens Proteins 0.000 claims 2
- 108010027437 compstatin Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 229940123362 C1Q inhibitor Drugs 0.000 claims 1
- -1 C1q inhibitor Proteins 0.000 claims 1
- 101710159767 C4b-binding protein alpha chain Proteins 0.000 claims 1
- 102100037084 C4b-binding protein alpha chain Human genes 0.000 claims 1
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 1
- 102000003780 Clusterin Human genes 0.000 claims 1
- 108090000197 Clusterin Proteins 0.000 claims 1
- 108700040183 Complement C1 Inhibitor Proteins 0.000 claims 1
- 102000055157 Complement C1 Inhibitor Human genes 0.000 claims 1
- 102000016550 Complement Factor H Human genes 0.000 claims 1
- 108010053085 Complement Factor H Proteins 0.000 claims 1
- 102100031673 Corneodesmosin Human genes 0.000 claims 1
- 101710139375 Corneodesmosin Proteins 0.000 claims 1
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 1
- 108010085169 Lysine carboxypeptidase Proteins 0.000 claims 1
- 201000005085 Meconium Aspiration Syndrome Diseases 0.000 claims 1
- 102000050019 Membrane Cofactor Human genes 0.000 claims 1
- 101710146216 Membrane cofactor protein Proteins 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44904503P | 2003-02-21 | 2003-02-21 | |
| PCT/US2004/005143 WO2004075838A2 (en) | 2003-02-21 | 2004-02-20 | Method and compositions for the treatment of meconium aspiration syndrome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006518750A JP2006518750A (ja) | 2006-08-17 |
| JP2006518750A5 true JP2006518750A5 (https=) | 2007-04-12 |
Family
ID=32927491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503763A Pending JP2006518750A (ja) | 2003-02-21 | 2004-02-20 | 胎便吸引症候群の治療のための方法および組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070065433A1 (https=) |
| EP (1) | EP1594541A4 (https=) |
| JP (1) | JP2006518750A (https=) |
| WO (1) | WO2004075838A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050019326A1 (en) * | 2003-06-16 | 2005-01-27 | The Brigham And Women's Hospital, Inc. | C1q complement inhibitors and methods of use thereof |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| WO2006128006A1 (en) * | 2005-05-26 | 2006-11-30 | The Regents Of The University Of Colorado | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| US8168584B2 (en) * | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| HUE026001T2 (en) * | 2007-02-05 | 2016-04-28 | Apellis Pharmaceuticals Inc | Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system |
| CN101668773B (zh) | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
| EP2155205B1 (en) | 2007-06-21 | 2011-12-21 | Pantarhei Bioscience B.V. | Treatment of meconium aspiration syndrome with estrogens |
| WO2009050693A1 (en) * | 2007-10-16 | 2009-04-23 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Device and method for identification of meconium in amniotic fluid |
| US8937046B2 (en) * | 2008-09-22 | 2015-01-20 | The Regents Of The University Of Colorado, A Body Corporate | Modulating the alternative complement pathway |
| CA2766565A1 (en) | 2009-06-23 | 2010-12-29 | Alexion Pharmaceuticals, Inc. | Bispecific antibodies that bind to complement proteins |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| ES2728278T3 (es) * | 2011-12-21 | 2019-10-23 | Novartis Ag | Composiciones que comprenden anticuerpos dirigidos al factor P y C5 |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| MX366404B (es) | 2012-11-15 | 2019-07-08 | Apellis Pharmaceuticals Inc | Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados. |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| US11903994B2 (en) | 2015-10-07 | 2024-02-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| WO2017127761A1 (en) | 2016-01-20 | 2017-07-27 | Vitrisa Therapeutics, Inc. | Compositions and methods for inhibiting factor d |
| WO2018136827A1 (en) | 2017-01-20 | 2018-07-26 | Vitrisa Therapeutics, Inc. | Stem-loop compositions and methods for inhibiting factor d |
| IL269844B2 (en) | 2017-04-07 | 2025-01-01 | Apellis Pharmaceuticals Inc | Dosage regimens and related compositions and methods |
| WO2019118938A1 (en) | 2017-12-15 | 2019-06-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| GB2583560A (en) | 2018-12-11 | 2020-11-04 | Admirx Inc | Fusion protein constructs for complement associated disease |
| CN115666651A (zh) * | 2020-05-21 | 2023-01-31 | 视点制药公司 | 用tie-2激活剂治疗急性呼吸窘迫综合征的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6013619A (en) * | 1988-01-06 | 2000-01-11 | The Scripps Research Institute | Pulmonary surfactants and therapeutic uses, including pulmonary lavage |
| US5514598A (en) * | 1993-11-30 | 1996-05-07 | Doody; Michael | Prenatal detection of meconium |
| US5562077B1 (en) * | 1995-04-04 | 2000-09-05 | Joseph Schultz | Method and apparatus for ventilation and aspiration |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US6044284A (en) * | 1998-10-08 | 2000-03-28 | Leonard I. Eisenfeld | Apparatus and method for measuring the concentration of meconium in amniotic fluid |
| US6492403B1 (en) * | 1999-02-09 | 2002-12-10 | 3-Dimensional Pharmaceuticals, Inc. | Methods of treating C1s-mediated diseases and conditions and compositions thereof |
| JP2001089391A (ja) * | 1999-09-16 | 2001-04-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Ｉｒｄｓおよびａｌｉの治療用の製薬的組成物、その使用、およびそれを有する製品 |
| KR20030074693A (ko) * | 2000-12-28 | 2003-09-19 | 알투스 바이올로직스 인코포레이티드 | 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법 |
-
2004
- 2004-02-20 WO PCT/US2004/005143 patent/WO2004075838A2/en not_active Ceased
- 2004-02-20 JP JP2006503763A patent/JP2006518750A/ja active Pending
- 2004-02-20 US US10/546,253 patent/US20070065433A1/en not_active Abandoned
- 2004-02-20 EP EP04713391A patent/EP1594541A4/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006518750A5 (https=) | ||
| US10945962B2 (en) | Controlled-release peptide compositions and uses thereof | |
| Furci et al. | Inhibition of HIV-1 infection by human α-defensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae | |
| JP2018052983A5 (https=) | ||
| JP2009528369A (ja) | 補体活性を抑制することによる同種移植片の生存の延長 | |
| JP2011518179A5 (https=) | ||
| Lalani et al. | Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease | |
| JP5190518B2 (ja) | 免疫関連疾患を予防および治療するための組成物 | |
| JP2005535588A5 (https=) | ||
| JP2005515214A5 (https=) | ||
| JP2008518090A5 (https=) | ||
| JP2023510864A (ja) | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体の持続型結合体の肺疾患の治療的使用 | |
| JP2011522864A5 (https=) | ||
| Ishimitsu et al. | Interferon gamma attenuates hypertensive renal injury in salt-sensitive Dahl rats. | |
| CA3174566A1 (en) | Anti-cd6 antibody compositions and methods for treating and reducing negative effects of a coronavirus including covid-19 | |
| Harfouch et al. | Therapeutic approaches for COVID 19: Challenges and successes | |
| Ayala et al. | Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis | |
| WO2015104596A1 (en) | Vasoactive intestinal peptide | |
| Huang et al. | Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41 | |
| JP2007500693A (ja) | 移植片拒絶反応を予防するための合成ペプチドコポリマーを含む併用療法 | |
| CN100341573C (zh) | 用于预防和治疗获得性免疫缺陷综合症的协同组合物 | |
| EP3356389A1 (en) | Use of human derived immunosuppressive proteins and peptides as medicaments | |
| US7494975B2 (en) | Anti-HIV composition, production method thereof and medicament | |
| JP2010511706A5 (https=) | ||
| CN106539813B (zh) | 干扰素刺激基因(sting)激活剂在抗炎症中的应用 |