JP2015514072A5 - - Google Patents
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- Publication number
- JP2015514072A5 JP2015514072A5 JP2015501784A JP2015501784A JP2015514072A5 JP 2015514072 A5 JP2015514072 A5 JP 2015514072A5 JP 2015501784 A JP2015501784 A JP 2015501784A JP 2015501784 A JP2015501784 A JP 2015501784A JP 2015514072 A5 JP2015514072 A5 JP 2015514072A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- phenyl
- indazol
- acrylic acid
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613442P | 2012-03-20 | 2012-03-20 | |
| US61/613,442 | 2012-03-20 | ||
| PCT/US2013/031507 WO2013142266A1 (en) | 2012-03-20 | 2013-03-14 | Estrogen receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514072A JP2015514072A (ja) | 2015-05-18 |
| JP2015514072A5 true JP2015514072A5 (OSRAM) | 2017-02-09 |
| JP6154887B2 JP6154887B2 (ja) | 2017-06-28 |
Family
ID=49223229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501784A Active JP6154887B2 (ja) | 2012-03-20 | 2013-03-14 | エストロゲン受容体モジュレーターおよびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9499538B2 (OSRAM) |
| EP (1) | EP2828243B1 (OSRAM) |
| JP (1) | JP6154887B2 (OSRAM) |
| KR (1) | KR20140138296A (OSRAM) |
| CN (1) | CN104220426B (OSRAM) |
| AU (1) | AU2013235499A1 (OSRAM) |
| CA (1) | CA2866891A1 (OSRAM) |
| CO (1) | CO7170179A2 (OSRAM) |
| CR (1) | CR20140479A (OSRAM) |
| EA (1) | EA201491530A1 (OSRAM) |
| IL (1) | IL234487A0 (OSRAM) |
| MX (1) | MX2014011217A (OSRAM) |
| NZ (1) | NZ630124A (OSRAM) |
| PE (1) | PE20142461A1 (OSRAM) |
| PH (1) | PH12014502095A1 (OSRAM) |
| SG (1) | SG11201405918XA (OSRAM) |
| WO (1) | WO2013142266A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ630124A (en) | 2012-03-20 | 2016-01-29 | Seragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| CA2899969A1 (en) | 2013-03-14 | 2014-09-25 | Seragon Pharmaceuticals, Inc. | Polycyclic estrogen receptor modulators and uses thereof |
| SG11201507459YA (en) | 2013-03-15 | 2015-10-29 | Epigen Biosciences Inc | Heterocyclic compounds useful in the treatment of disease |
| JP6576916B2 (ja) | 2013-06-19 | 2019-09-18 | セラゴン ファーマシューティカルズ， インク． | エストロゲン受容体モジュレーター及びその使用 |
| CN105451735B (zh) | 2013-06-19 | 2019-01-11 | 西拉根制药公司 | 氮杂环丁烷雌激素受体调节剂和其用途 |
| CN105916501A (zh) | 2013-12-06 | 2016-08-31 | 豪夫迈·罗氏有限公司 | 用于治疗局部晚期或转移性雌激素受体阳性乳腺癌的雌激素受体调节剂 |
| CA2941161A1 (en) * | 2014-03-13 | 2015-09-17 | F.Hoffmann-La Roche Ag | Methods and compositions for modulating estrogen receptor mutants |
| SG11201607334YA (en) | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Therapeutic combinations with estrogen receptor modulators |
| WO2016023847A1 (en) | 2014-08-11 | 2016-02-18 | F. Hoffmann-La Roche Ag | Crystalline forms of an estrogen receptor modulator |
| EP3303326B1 (en) | 2015-05-26 | 2020-12-16 | H. Hoffnabb-La Roche Ag | Heterocyclic estrogen receptor modulators and uses thereof |
| UA120882C2 (uk) * | 2015-05-29 | 2020-02-25 | ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. | Тетразаміщені алкенові сполуки і їх застосування |
| CN105061316B (zh) * | 2015-07-17 | 2017-12-22 | 苏州大学 | 稠环类化合物、制备方法和用途 |
| CN106518768B (zh) * | 2015-09-15 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的应用 |
| US9975856B2 (en) | 2015-10-07 | 2018-05-22 | Genentech, Inc. | Process for the preparation of (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid |
| WO2017100715A1 (en) | 2015-12-09 | 2017-06-15 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective estrogen receptor downregulator compounds |
| US10519143B2 (en) | 2016-03-25 | 2019-12-31 | Luoxin Pharmaceutical (Shanghai) Co., Ltd. | Substituted-indole-compounds as estrogen receptor down-regulators |
| RU2738646C2 (ru) | 2016-04-01 | 2020-12-15 | РЕКЬЮРИУМ АйПи ХОЛДИНГС, ЛЛС | Модуляторы эстрогеновых рецепторов |
| AU2017317988B2 (en) | 2016-08-31 | 2020-12-24 | Jiangsu Hengrui Medicine Co., Ltd. | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| EP3544974A1 (en) * | 2016-11-24 | 2019-10-02 | Eisai R&D Management Co., Ltd. | Tetrasubstituted alkene compounds and their use for the treatment of breast cancer |
| MX385930B (es) | 2016-11-28 | 2025-03-18 | Eisai R&D Man Co Ltd | Sales de derivado de indazol y cristales de las mismas. |
| CA3048057A1 (en) | 2017-01-06 | 2018-07-12 | G1 Therapeutics, Inc. | Combination therapy for the treatment of cancer |
| CA3052810A1 (en) | 2017-02-10 | 2018-08-16 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| CN108976187B (zh) * | 2017-06-02 | 2021-11-26 | 上海青东生物科技有限公司 | 一种取代苯并呋喃衍生物及其制备与在制备抗肿瘤药物中的应用 |
| WO2019225552A1 (en) * | 2018-05-22 | 2019-11-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
| CA3109090A1 (en) | 2018-08-17 | 2020-02-20 | F. Hoffmann-La Roche Ag | Diagnostic and therapeutic methods for the treatment of breast cancer |
| SG11202106401UA (en) | 2018-12-17 | 2021-07-29 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Estrogen receptor antagonist |
| JP2022537330A (ja) * | 2019-06-19 | 2022-08-25 | 江蘇恒瑞医薬股▲ふん▼有限公司 | インダゾール誘導体、その製造方法及び医薬上のその使用 |
| AU2020326691A1 (en) | 2019-08-06 | 2022-03-03 | Recurium Ip Holdings, Llc | Estrogen receptor modulators for treating mutants |
| EP4267578A4 (en) | 2020-12-23 | 2024-11-20 | Recurium IP Holdings, LLC | ESTROGEN RECEPTOR MODULATORS |
| CN115745895A (zh) * | 2021-11-13 | 2023-03-07 | 温州奥洋科技有限公司 | 一种紫外线吸收剂二苯嘧啶乙烯的结构与合成路线 |
| CN116239562B (zh) * | 2021-12-07 | 2024-12-31 | 江苏师范大学 | 一种以苯并呋喃酮为原料合成盐酸多塞平的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2860900D1 (en) | 1977-08-22 | 1981-11-05 | Ici Plc | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them |
| US4229447A (en) | 1979-06-04 | 1980-10-21 | American Home Products Corporation | Intraoral methods of using benzodiazepines |
| US4596795A (en) | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| EP0230654B1 (en) | 1985-12-28 | 1992-03-18 | Sumitomo Pharmaceuticals Company, Limited | Sustained pulsewise release pharmaceutical preparation |
| US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5739136A (en) | 1989-10-17 | 1998-04-14 | Ellinwood, Jr.; Everett H. | Intraoral dosing method of administering medicaments |
| US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| US5229135A (en) | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| JP3409366B2 (ja) | 1993-06-18 | 2003-05-26 | 東洋インキ製造株式会社 | 有機エレクトロルミネッセンス素子 |
| US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| DE19807760A1 (de) | 1997-02-27 | 1998-09-03 | Fuji Electric Co Ltd | Elektrofotografischer Fotoleiter |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| PL338555A1 (en) | 1997-08-15 | 2000-11-06 | Univ Duke | Method of preventing or treating oestrogen-dependent diseases and disorders |
| DE19801597C2 (de) | 1998-01-17 | 2001-05-03 | Aventis Res & Tech Gmbh & Co | Basenkatalysierte Synthese von 1-Aryl-4-(arylethyl)piperazinen aus aromatischen Olefinen und 1-Arylpiperazinen |
| DE19801598C2 (de) | 1998-01-17 | 2000-05-11 | Aventis Res & Tech Gmbh & Co | Katalytische Synthese von N-alkylierten Anilinen aus Olefinen und Anilinen |
| TW593256B (en) | 1999-11-16 | 2004-06-21 | Hormos Medical Oy Ltd | Triphenylalkene derivatives and their use as selective estrogen receptor modulators |
| GB9929988D0 (en) | 1999-12-17 | 2000-02-09 | Celltech Therapeutics Ltd | Chemical compounds |
| US6528681B2 (en) | 2000-04-05 | 2003-03-04 | Bristol-Meyers Squibb Pharma Company | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators |
| WO2003016270A2 (en) * | 2001-08-11 | 2003-02-27 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
| AU2003248630A1 (en) | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| ES2307068T3 (es) | 2003-10-08 | 2008-11-16 | Smithkline Beecham Corporation | Compuestos de trifeniletileno como modularores selectivos de receptores de estrogenos. |
| DE102004028862A1 (de) * | 2004-06-15 | 2005-12-29 | Merck Patent Gmbh | 3-Aminoindazole |
| US20070292545A1 (en) | 2005-10-18 | 2007-12-20 | Aaron Monte | Anti-infective agents and methods of use |
| CN101146796A (zh) * | 2005-01-26 | 2008-03-19 | 先灵公司 | 作为蛋白激酶抑制剂用于治疗癌症的3-(吲唑-5-基)-(1,2,4)三嗪衍生物及相关化合物 |
| WO2007020636A1 (en) | 2005-08-15 | 2007-02-22 | Technion Research And Development Foundation Ltd. | Printable materials |
| WO2008057857A1 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
| JP2008156313A (ja) | 2006-12-26 | 2008-07-10 | Fyuuensu:Kk | アミロイド疾患の治療およびモニタリングのための薬剤 |
| GB0704407D0 (en) | 2007-03-07 | 2007-04-18 | Glaxo Group Ltd | Compounds |
| DE102007049451A1 (de) * | 2007-10-16 | 2009-04-23 | Merck Patent Gmbh | 5-Cyano-thienopyridine |
| JP5223362B2 (ja) | 2008-02-07 | 2013-06-26 | コニカミノルタビジネステクノロジーズ株式会社 | 光電変換素子及び太陽電池 |
| US7897631B2 (en) | 2008-04-21 | 2011-03-01 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives |
| WO2010059658A1 (en) | 2008-11-20 | 2010-05-27 | Glaxosmithkline Llc | Chemical compounds |
| WO2010077603A1 (en) | 2008-12-08 | 2010-07-08 | North Carolina State University | Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives |
| WO2010107474A1 (en) | 2009-03-16 | 2010-09-23 | The Research Foundation Of State University Of New York | Antiestrogens for breast cancer therapy |
| WO2010144959A1 (en) | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
| GB2483736B (en) * | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| NZ630124A (en) | 2012-03-20 | 2016-01-29 | Seragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| JP6126562B2 (ja) * | 2014-08-27 | 2017-05-10 | 三星ダイヤモンド工業株式会社 | 光ファイバ装置 |
-
2013
- 2013-03-14 NZ NZ630124A patent/NZ630124A/en not_active IP Right Cessation
- 2013-03-14 AU AU2013235499A patent/AU2013235499A1/en not_active Abandoned
- 2013-03-14 PE PE2014001451A patent/PE20142461A1/es not_active Application Discontinuation
- 2013-03-14 KR KR1020147028984A patent/KR20140138296A/ko not_active Withdrawn
- 2013-03-14 WO PCT/US2013/031507 patent/WO2013142266A1/en not_active Ceased
- 2013-03-14 JP JP2015501784A patent/JP6154887B2/ja active Active
- 2013-03-14 MX MX2014011217A patent/MX2014011217A/es unknown
- 2013-03-14 US US14/386,313 patent/US9499538B2/en active Active
- 2013-03-14 CN CN201380019700.9A patent/CN104220426B/zh active Active
- 2013-03-14 EA EA201491530A patent/EA201491530A1/ru unknown
- 2013-03-14 CA CA2866891A patent/CA2866891A1/en not_active Abandoned
- 2013-03-14 SG SG11201405918XA patent/SG11201405918XA/en unknown
- 2013-03-14 EP EP13763661.9A patent/EP2828243B1/en active Active
-
2014
- 2014-09-07 IL IL234487A patent/IL234487A0/en unknown
- 2014-09-22 PH PH12014502095A patent/PH12014502095A1/en unknown
- 2014-10-15 CR CR20140479A patent/CR20140479A/es not_active Application Discontinuation
- 2014-10-17 CO CO14230728A patent/CO7170179A2/es unknown
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