JP2015513552A5 - - Google Patents
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- Publication number
- JP2015513552A5 JP2015513552A5 JP2014560334A JP2014560334A JP2015513552A5 JP 2015513552 A5 JP2015513552 A5 JP 2015513552A5 JP 2014560334 A JP2014560334 A JP 2014560334A JP 2014560334 A JP2014560334 A JP 2014560334A JP 2015513552 A5 JP2015513552 A5 JP 2015513552A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- benzyl
- benzodioxin
- dioxino
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607149P | 2012-03-06 | 2012-03-06 | |
| US61/607,149 | 2012-03-06 | ||
| PCT/EP2013/054381 WO2013131901A1 (en) | 2012-03-06 | 2013-03-05 | Benzodioxanes in combination with other actives for inhibiting leukotriene production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513552A JP2015513552A (ja) | 2015-05-14 |
| JP2015513552A5 true JP2015513552A5 (https=) | 2016-04-21 |
| JP6080226B2 JP6080226B2 (ja) | 2017-02-15 |
Family
ID=47833062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560334A Active JP6080226B2 (ja) | 2012-03-06 | 2013-03-05 | 他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9662339B2 (https=) |
| EP (1) | EP2822941B1 (https=) |
| JP (1) | JP6080226B2 (https=) |
| KR (1) | KR20140138851A (https=) |
| CN (1) | CN104487435A (https=) |
| AR (1) | AR090259A1 (https=) |
| AU (1) | AU2013229560A1 (https=) |
| CA (1) | CA2866471A1 (https=) |
| CL (1) | CL2014002326A1 (https=) |
| EA (1) | EA201400976A1 (https=) |
| MX (1) | MX2014010563A (https=) |
| NZ (1) | NZ628587A (https=) |
| PH (1) | PH12014501967A1 (https=) |
| TW (1) | TW201350475A (https=) |
| UY (1) | UY34661A (https=) |
| WO (1) | WO2013131901A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2835617C (en) | 2011-03-14 | 2020-07-21 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production |
| EP2734516B1 (en) | 2011-07-19 | 2015-06-17 | Boehringer Ingelheim International GmbH | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| TW201350474A (zh) * | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | 白三烯素生成之苯并二噁烷抑制劑 |
| NZ628587A (en) | 2012-03-06 | 2016-07-29 | Boehringer Ingelheim Int | Benzodioxanes in combination with other actives for inhibiting leukotriene production |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| EP2978859B1 (en) | 2013-03-27 | 2018-06-27 | F.Hoffmann-La Roche Ag | Genetic markers for predicting responsiveness to therapy |
| JP6353899B2 (ja) | 2013-07-15 | 2018-07-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| JP2016523982A (ja) | 2013-07-15 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| RU2703192C2 (ru) | 2014-07-30 | 2019-10-15 | Ф. Хоффманн-Ля Рош Аг | Генетические маркеры для прогнозирования ответа на терапию поднимающими уровень hdl или имитирующими hdl агентами |
| US10968193B2 (en) * | 2014-08-08 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| CN104181252B (zh) * | 2014-09-01 | 2015-12-02 | 广东东阳光药业有限公司 | 一种分离检测安塞曲匹及其异构体的方法 |
| CN105748469B (zh) * | 2016-02-24 | 2019-07-23 | 长沙佰顺生物科技有限公司 | 一种安塞曲匹辛伐他汀药物组合物 |
| WO2017170830A1 (ja) * | 2016-03-31 | 2017-10-05 | 武田薬品工業株式会社 | 複素環化合物 |
| MX2023001725A (es) | 2020-08-14 | 2023-02-22 | Novartis Ag | Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmaceuticos de los mismos. |
| CN112076189B (zh) * | 2020-09-23 | 2021-11-12 | 唐怡庭 | 一种酰胺化合物在制备治疗脓毒症药物中的应用 |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US498770A (en) * | 1893-06-06 | Electrolytic apparatus | ||
| US4918092A (en) * | 1983-12-21 | 1990-04-17 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
| US5120758A (en) * | 1991-02-08 | 1992-06-09 | Ciba-Geigy Corporation | Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors |
| DE4127849A1 (de) | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6506876B1 (en) | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| DE19705450A1 (de) | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclische aromatische Aminosäuren |
| DE19821003A1 (de) | 1998-05-11 | 1999-11-18 | Dresden Arzneimittel | Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| HUP0302337A3 (en) | 2000-10-26 | 2004-01-28 | Pfizer Prod Inc | Pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| EP2133340B1 (en) | 2002-12-20 | 2013-01-16 | Glaxo Group Limited | Novel benzazepine derivatives |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| UA86283C2 (uk) | 2005-01-07 | 2009-04-10 | Пфайзер Продактс Инк. | Гетероароматичні сполуки хіноліну і їх застосування як інгібіторів pde10 |
| US20060223792A1 (en) | 2005-03-31 | 2006-10-05 | Butler Christopher R | Phenyl and pyridyl LTA4H modulators |
| US20070078263A1 (en) | 2005-09-21 | 2007-04-05 | Decode Chemistry, Inc. | Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation |
| CA2634699A1 (en) | 2005-12-21 | 2007-06-28 | Decode Genetics Ehf | N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation |
| US7750012B2 (en) | 2005-12-21 | 2010-07-06 | Decode Genetics Ehf | Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation |
| TW200823187A (en) | 2006-10-24 | 2008-06-01 | Wyeth Corp | Benzodioxane derivatives and uses thereof |
| SI2336125T1 (sl) | 2008-04-11 | 2013-04-30 | Janssen Pharmaceutica N.V. | Tiazolopiridin-2-iloksi-fenil in tiazolopirazin-2-iloksi-fenil amini kot modulatorji levkotrien a4 hidrolaze |
| KR101694563B1 (ko) | 2009-04-08 | 2017-01-09 | 액테리온 파마슈티칼 리미티드 | Ａｄｐ 수용체 길항제로서 6-(3-아자-비시클로〔3.1.0〕헥스-3-일)-2-페닐-피리미딘 |
| WO2011032050A2 (en) | 2009-09-11 | 2011-03-17 | Trius Therapeutics, Inc. | Gyrase inhibitors |
| GB2494787B (en) | 2010-03-18 | 2018-10-17 | Univ Hong Kong Sci & Tech | Neuro-protective effects of adelostemma gracillimum and its isolated compounds |
| CA2835617C (en) * | 2011-03-14 | 2020-07-21 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production |
| EP2734516B1 (en) | 2011-07-19 | 2015-06-17 | Boehringer Ingelheim International GmbH | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| NZ628587A (en) | 2012-03-06 | 2016-07-29 | Boehringer Ingelheim Int | Benzodioxanes in combination with other actives for inhibiting leukotriene production |
| TW201350474A (zh) | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | 白三烯素生成之苯并二噁烷抑制劑 |
| US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
-
2013
- 2013-03-05 NZ NZ628587A patent/NZ628587A/en not_active IP Right Cessation
- 2013-03-05 JP JP2014560334A patent/JP6080226B2/ja active Active
- 2013-03-05 AR ARP130100729A patent/AR090259A1/es unknown
- 2013-03-05 MX MX2014010563A patent/MX2014010563A/es unknown
- 2013-03-05 WO PCT/EP2013/054381 patent/WO2013131901A1/en not_active Ceased
- 2013-03-05 CA CA2866471A patent/CA2866471A1/en not_active Abandoned
- 2013-03-05 AU AU2013229560A patent/AU2013229560A1/en not_active Abandoned
- 2013-03-05 EA EA201400976A patent/EA201400976A1/ru unknown
- 2013-03-05 KR KR1020147027959A patent/KR20140138851A/ko not_active Withdrawn
- 2013-03-05 US US13/785,097 patent/US9662339B2/en active Active
- 2013-03-05 EP EP13707858.0A patent/EP2822941B1/en active Active
- 2013-03-05 CN CN201380022189.8A patent/CN104487435A/zh active Pending
- 2013-03-05 TW TW102107706A patent/TW201350475A/zh unknown
- 2013-03-06 UY UY0001034661A patent/UY34661A/es unknown
-
2014
- 2014-09-01 CL CL2014002326A patent/CL2014002326A1/es unknown
- 2014-09-03 PH PH12014501967A patent/PH12014501967A1/en unknown
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