CN104487435A - 用于抑制白三烯生成的苯并二氧杂环己烷与其他活性剂的组合 - Google Patents
用于抑制白三烯生成的苯并二氧杂环己烷与其他活性剂的组合 Download PDFInfo
- Publication number
- CN104487435A CN104487435A CN201380022189.8A CN201380022189A CN104487435A CN 104487435 A CN104487435 A CN 104487435A CN 201380022189 A CN201380022189 A CN 201380022189A CN 104487435 A CN104487435 A CN 104487435A
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- Prior art keywords
- dihydro
- benzyl
- benzodioxin
- pyridin
- dioxino
- Prior art date
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- ZSUDRFSFONYWNQ-HXUWFJFHSA-N NC1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1 Chemical compound NC1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1 ZSUDRFSFONYWNQ-HXUWFJFHSA-N 0.000 description 2
- MRSNPTMJHJKUAY-UHFFFAOYSA-N C(c1ccc(C2OC3NC=CC=C3OC2)cc1)N1CCOCC1 Chemical compound C(c1ccc(C2OC3NC=CC=C3OC2)cc1)N1CCOCC1 MRSNPTMJHJKUAY-UHFFFAOYSA-N 0.000 description 1
- ZWUUPDYTGUTSJH-KRWDZBQOSA-N C(c1ccc([C@H]2Oc3ncccc3OC2)cc1)N1CCOCC1 Chemical compound C(c1ccc([C@H]2Oc3ncccc3OC2)cc1)N1CCOCC1 ZWUUPDYTGUTSJH-KRWDZBQOSA-N 0.000 description 1
- MTJXVNHBIYNAHL-IQHZPMLTSA-N CC(C)(C)OC(N(C1)c2ccccc2C11CCN(CC2=CCC([C@@H]3Oc4ncccc4OC3)C=C2)CC1)=O Chemical compound CC(C)(C)OC(N(C1)c2ccccc2C11CCN(CC2=CCC([C@@H]3Oc4ncccc4OC3)C=C2)CC1)=O MTJXVNHBIYNAHL-IQHZPMLTSA-N 0.000 description 1
- HJMSTIKEZKTZED-JOCHJYFZSA-N CC(C)(C1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1)C(O)=O Chemical compound CC(C)(C1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1)C(O)=O HJMSTIKEZKTZED-JOCHJYFZSA-N 0.000 description 1
- SDIFFRCHBAENSZ-XMMPIXPASA-N CCOC(C(C)(C)C1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1)=O Chemical compound CCOC(C(C)(C)C1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1)=O SDIFFRCHBAENSZ-XMMPIXPASA-N 0.000 description 1
- TWGOBCCPOSEQIA-HXUWFJFHSA-N CCOC(C1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1)=O Chemical compound CCOC(C1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1)=O TWGOBCCPOSEQIA-HXUWFJFHSA-N 0.000 description 1
- LKHCONQEXOYJIZ-HHHXNRCGSA-N COC(c1ccc(CN2CCN(Cc3ccc([C@@H]4Oc(cccc5)c5OC4)cc3)CC2)cc1)=O Chemical compound COC(c1ccc(CN2CCN(Cc3ccc([C@@H]4Oc(cccc5)c5OC4)cc3)CC2)cc1)=O LKHCONQEXOYJIZ-HHHXNRCGSA-N 0.000 description 1
- MSDDPTBJKVNZGD-IIBYNOLFSA-N C[C@H](C(NC1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1)=O)NC Chemical compound C[C@H](C(NC1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1)=O)NC MSDDPTBJKVNZGD-IIBYNOLFSA-N 0.000 description 1
- VLHQXRIIQSTJCQ-ZCFIWIBFSA-O C[C@H](C([OH2+])=O)N(C)C(OC(C)(C)C)=O Chemical compound C[C@H](C([OH2+])=O)N(C)C(OC(C)(C)C)=O VLHQXRIIQSTJCQ-ZCFIWIBFSA-O 0.000 description 1
- AMHUMMCEAZPFIC-RUZDIDTESA-N Cc1ccc2OC[C@H](c3ccc(CN(CC4)CCC44c(cccc5)c5NC4)cc3)Oc2n1 Chemical compound Cc1ccc2OC[C@H](c3ccc(CN(CC4)CCC44c(cccc5)c5NC4)cc3)Oc2n1 AMHUMMCEAZPFIC-RUZDIDTESA-N 0.000 description 1
- YFLIVPLAEITJMX-GOSISDBHSA-N NC1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1 Chemical compound NC1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1 YFLIVPLAEITJMX-GOSISDBHSA-N 0.000 description 1
- LHJIYRIMYXKDLW-FKAXQMLKSA-N O=C(C1CCN(Cc2ccc([C@@H]3Oc4nc(COC(C5CCN(Cc6ccc([C@@H]7Oc8ncccc8OC7)cc6)CC5)=O)ccc4OC3)cc2)CC1)NC[C@H]1OCCC1 Chemical compound O=C(C1CCN(Cc2ccc([C@@H]3Oc4nc(COC(C5CCN(Cc6ccc([C@@H]7Oc8ncccc8OC7)cc6)CC5)=O)ccc4OC3)cc2)CC1)NC[C@H]1OCCC1 LHJIYRIMYXKDLW-FKAXQMLKSA-N 0.000 description 1
- GEHUCVSRHYNIBO-UHFFFAOYSA-N O=C1OCCN1Cc1ccc(C2Oc3ncccc3OC2)cc1 Chemical compound O=C1OCCN1Cc1ccc(C2Oc3ncccc3OC2)cc1 GEHUCVSRHYNIBO-UHFFFAOYSA-N 0.000 description 1
- ZLTGUVXUZAHLER-OAHLLOKOSA-N O=Cc1ccc([C@@H]2Oc3ccccc3OC2)cc1 Chemical compound O=Cc1ccc([C@@H]2Oc3ccccc3OC2)cc1 ZLTGUVXUZAHLER-OAHLLOKOSA-N 0.000 description 1
- ITBOMVWBEIYVLY-GOSISDBHSA-N OC(C1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1)=O Chemical compound OC(C1CCN(Cc2ccc([C@@H]3Oc4ncccc4OC3)cc2)CC1)=O ITBOMVWBEIYVLY-GOSISDBHSA-N 0.000 description 1
- VPZVETXXMUYAKD-AREMUKBSSA-N OC(c1ccc(CN2CCN(Cc3ccc([C@@H]4Oc(cccc5)c5OC4)cc3)CC2)cc1)=O Chemical compound OC(c1ccc(CN2CCN(Cc3ccc([C@@H]4Oc(cccc5)c5OC4)cc3)CC2)cc1)=O VPZVETXXMUYAKD-AREMUKBSSA-N 0.000 description 1
- GFTQSTZTKFGGLL-OAQYLSRUSA-N OCC(NC1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1)=O Chemical compound OCC(NC1CCN(Cc2ccc([C@@H]3Oc4ccccc4OC3)cc2)CC1)=O GFTQSTZTKFGGLL-OAQYLSRUSA-N 0.000 description 1
Classifications
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- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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| CA2835617C (en) | 2011-03-14 | 2020-07-21 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production |
| EP2734516B1 (en) | 2011-07-19 | 2015-06-17 | Boehringer Ingelheim International GmbH | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| TW201350474A (zh) * | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | 白三烯素生成之苯并二噁烷抑制劑 |
| NZ628587A (en) | 2012-03-06 | 2016-07-29 | Boehringer Ingelheim Int | Benzodioxanes in combination with other actives for inhibiting leukotriene production |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| EP2978859B1 (en) | 2013-03-27 | 2018-06-27 | F.Hoffmann-La Roche Ag | Genetic markers for predicting responsiveness to therapy |
| JP6353899B2 (ja) | 2013-07-15 | 2018-07-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| JP2016523982A (ja) | 2013-07-15 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| RU2703192C2 (ru) | 2014-07-30 | 2019-10-15 | Ф. Хоффманн-Ля Рош Аг | Генетические маркеры для прогнозирования ответа на терапию поднимающими уровень hdl или имитирующими hdl агентами |
| US10968193B2 (en) * | 2014-08-08 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| CN104181252B (zh) * | 2014-09-01 | 2015-12-02 | 广东东阳光药业有限公司 | 一种分离检测安塞曲匹及其异构体的方法 |
| CN105748469B (zh) * | 2016-02-24 | 2019-07-23 | 长沙佰顺生物科技有限公司 | 一种安塞曲匹辛伐他汀药物组合物 |
| WO2017170830A1 (ja) * | 2016-03-31 | 2017-10-05 | 武田薬品工業株式会社 | 複素環化合物 |
| MX2023001725A (es) | 2020-08-14 | 2023-02-22 | Novartis Ag | Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmaceuticos de los mismos. |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
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| NZ628587A (en) | 2012-03-06 | 2016-07-29 | Boehringer Ingelheim Int | Benzodioxanes in combination with other actives for inhibiting leukotriene production |
| TW201350474A (zh) | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | 白三烯素生成之苯并二噁烷抑制劑 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112076189A (zh) * | 2020-09-23 | 2020-12-15 | 唐怡庭 | 一种酰胺化合物在制备治疗脓毒症药物中的应用 |
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| EP2822941B1 (en) | 2017-05-10 |
| CL2014002326A1 (es) | 2014-11-14 |
| EA201400976A1 (ru) | 2015-02-27 |
| PH12014501967B1 (en) | 2014-11-17 |
| NZ628587A (en) | 2016-07-29 |
| CA2866471A1 (en) | 2013-09-12 |
| US9662339B2 (en) | 2017-05-30 |
| WO2013131901A1 (en) | 2013-09-12 |
| UY34661A (es) | 2013-09-30 |
| TW201350475A (zh) | 2013-12-16 |
| US20130236468A1 (en) | 2013-09-12 |
| AU2013229560A1 (en) | 2014-08-28 |
| PH12014501967A1 (en) | 2014-11-17 |
| JP6080226B2 (ja) | 2017-02-15 |
| EP2822941A1 (en) | 2015-01-14 |
| KR20140138851A (ko) | 2014-12-04 |
| AR090259A1 (es) | 2014-10-29 |
| MX2014010563A (es) | 2014-12-05 |
| JP2015513552A (ja) | 2015-05-14 |
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