JP2015512938A5 - - Google Patents
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- Publication number
- JP2015512938A5 JP2015512938A5 JP2015505769A JP2015505769A JP2015512938A5 JP 2015512938 A5 JP2015512938 A5 JP 2015512938A5 JP 2015505769 A JP2015505769 A JP 2015505769A JP 2015505769 A JP2015505769 A JP 2015505769A JP 2015512938 A5 JP2015512938 A5 JP 2015512938A5
- Authority
- JP
- Japan
- Prior art keywords
- triblock copolymer
- protected
- micelle
- independently
- formula vii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000428 triblock copolymer Polymers 0.000 claims 35
- 239000000693 micelle Substances 0.000 claims 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 15
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 14
- 150000001412 amines Chemical class 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 14
- 229940079593 drug Drugs 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- 239000001301 oxygen Substances 0.000 claims 14
- 239000011593 sulfur Substances 0.000 claims 14
- 229910052717 sulfur Inorganic materials 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 13
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 13
- 229920006395 saturated elastomer Polymers 0.000 claims 13
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 150000001735 carboxylic acids Chemical class 0.000 claims 7
- 150000003983 crown ethers Chemical class 0.000 claims 7
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 7
- 230000002209 hydrophobic effect Effects 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 229910021645 metal ion Inorganic materials 0.000 claims 7
- 150000003573 thiols Chemical class 0.000 claims 7
- 125000002619 bicyclic group Chemical group 0.000 claims 6
- TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 claims 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims 1
- XOZIUKBZLSUILX-SDMHVBBESA-N Epothilone D Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C(/C)=C/C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C XOZIUKBZLSUILX-SDMHVBBESA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229960003896 aminopterin Drugs 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims 1
- 229940093265 berberine Drugs 0.000 claims 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims 1
- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 1
- 229960001573 cabazitaxel Drugs 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- XOZIUKBZLSUILX-UHFFFAOYSA-N desoxyepothilone B Natural products O1C(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCCC(C)=CCC1C(C)=CC1=CSC(C)=N1 XOZIUKBZLSUILX-UHFFFAOYSA-N 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- XOZIUKBZLSUILX-GIQCAXHBSA-N epothilone D Chemical compound O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C(C)=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-GIQCAXHBSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622755P | 2012-04-11 | 2012-04-11 | |
| US61/622,755 | 2012-04-11 | ||
| US201261659841P | 2012-06-14 | 2012-06-14 | |
| US61/659,841 | 2012-06-14 | ||
| PCT/US2013/032409 WO2013154774A1 (en) | 2012-04-11 | 2013-03-15 | Block copolymers for stable micelles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015162006A Division JP6466283B2 (ja) | 2012-04-11 | 2015-08-19 | 安定なミセルのためのブロックコポリマー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512938A JP2015512938A (ja) | 2015-04-30 |
| JP2015512938A5 true JP2015512938A5 (cg-RX-API-DMAC7.html) | 2015-10-08 |
| JP5927338B2 JP5927338B2 (ja) | 2016-06-01 |
Family
ID=47901746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505769A Active JP5927338B2 (ja) | 2012-04-11 | 2013-03-15 | 安定なミセルのためのブロックコポリマー |
| JP2015162006A Active JP6466283B2 (ja) | 2012-04-11 | 2015-08-19 | 安定なミセルのためのブロックコポリマー |
| JP2019001801A Active JP6740391B2 (ja) | 2012-04-11 | 2019-01-09 | 安定なミセルのためのブロックコポリマー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015162006A Active JP6466283B2 (ja) | 2012-04-11 | 2015-08-19 | 安定なミセルのためのブロックコポリマー |
| JP2019001801A Active JP6740391B2 (ja) | 2012-04-11 | 2019-01-09 | 安定なミセルのためのブロックコポリマー |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US20130296531A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2660255B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5927338B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101607422B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104487481B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013201541B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2868274C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2560235T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL235003A (cg-RX-API-DMAC7.html) |
| MX (1) | MX340992B (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ700397A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013154774A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| MX2013003681A (es) | 2010-10-01 | 2013-11-20 | Moderna Therapeutics Inc | Ácidos nucleicos manipulados y métodos de uso de los mismos. |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US9428535B2 (en) | 2011-10-03 | 2016-08-30 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| SMT202200355T1 (it) | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| US20140114051A1 (en) * | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| MX340992B (es) | 2012-04-11 | 2016-08-03 | Intezyne Tech Inc | Copolimeros de bloque para micelas estables. |
| US9944752B2 (en) | 2012-04-11 | 2018-04-17 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140127271A1 (en) * | 2012-04-11 | 2014-05-08 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140113879A1 (en) * | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| CN104856973A (zh) * | 2014-02-25 | 2015-08-26 | 苏州雷纳药物研发有限公司 | 一种卡巴他赛胶束载药系统及其制备方法 |
| CN105640882A (zh) * | 2015-10-16 | 2016-06-08 | 姚俊华 | 一种卡巴他赛胶束载药系统及其制备方法和应用 |
| CN109476841B (zh) | 2016-07-30 | 2021-08-24 | 日本化药株式会社 | 新型高分子衍生物和使用其的新型高分子衍生物成像探针 |
| WO2018025699A1 (ja) * | 2016-08-02 | 2018-02-08 | 日本化薬株式会社 | アクティブターゲティング型高分子誘導体、その高分子誘導体を含む組成物、及びそれらの用途 |
| JPWO2018088541A1 (ja) * | 2016-11-11 | 2019-10-10 | 国立大学法人北陸先端科学技術大学院大学 | 薬物放出制御用ハイドロゲル及びその製造方法 |
| US10143689B2 (en) | 2017-02-08 | 2018-12-04 | Interzyne Technologies, Inc. | SN-38 loaded iron crosslinked micelle and methods thereof |
| IL302880A (en) | 2017-04-04 | 2023-07-01 | Avidea Tech Inc | Peptide-based ingredients, production methods, and their uses for inducing an immune response |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| WO2019013814A1 (en) | 2017-07-14 | 2019-01-17 | Hewlett-Packard Development Company, L.P. | 3D PRINTING |
| CA3073211A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| KR20200090193A (ko) * | 2017-11-22 | 2020-07-28 | 힐스트림 바이오파마 인크. | 보르테조밉을 포함하는 중합체 나노입자 |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US12435048B2 (en) | 2018-09-28 | 2025-10-07 | Lonza Ltd | Method for preparation of n-carboxyanhydrides |
| WO2020072681A1 (en) * | 2018-10-03 | 2020-04-09 | Avidea Technologies, Inc. | Aromatic ring substituted amphiphilic polymers as drug delivery systems |
| CN109762150B (zh) * | 2018-12-14 | 2020-09-22 | 华南理工大学 | 一种具有内在荧光特性可降解生物医用材料及其制备方法 |
| EP3943182A4 (en) | 2019-03-20 | 2022-05-25 | Mitsubishi Chemical Corporation | POLYMER, RELEASING AGENT, METHOD OF MAKING A POLYMER, METHOD OF SEPARATING A JOINT AND METHOD OF MAKING A JOINT |
| CN110105562B (zh) * | 2019-04-23 | 2021-10-12 | 华东师范大学 | 含多巴胺配体的两嵌段聚合物及其合成方法和应用 |
| US11541007B2 (en) * | 2019-05-16 | 2023-01-03 | Megapro Biomedical Co., Ltd. | Pharmaceutical compositions containing mixed polymeric micelles |
| EP4087535A1 (en) | 2020-01-10 | 2022-11-16 | Tyndall Formulation Services, LLC | Formulations of sn-38 with poly(amino acid) block polymers |
| US11286344B2 (en) | 2020-01-10 | 2022-03-29 | Tyndall Formulation Services, LLC | Polymer excipients for drug delivery applications |
| EP4087545A1 (en) * | 2020-01-10 | 2022-11-16 | R-Pharm US Operating LLC | Compositions of ixabepilone |
| US10918619B1 (en) | 2020-01-10 | 2021-02-16 | Tyndall Formulation Services, LLC | Formulations of paclitaxel with poly(amino acid) block polymers |
| IL294481B1 (en) * | 2020-01-10 | 2025-10-01 | Tyndall Formulation Services Llc | Polymeric excipients for drug delivery applications |
| US10836869B1 (en) | 2020-01-10 | 2020-11-17 | Tyndall Formulation Services, LLC | Polymer excipients for drug delivery applications |
| JP7560274B2 (ja) * | 2020-06-08 | 2024-10-02 | 公益財団法人川崎市産業振興財団 | 共重合体、該共重合体の製造方法、およびカルボキシ基またはその塩を有する共重合体の製造方法 |
| CN112190565B (zh) * | 2020-10-27 | 2022-06-14 | 华南理工大学 | 一种能减轻吉非替尼毒性的肾靶向纳米粒子及其制备方法 |
| JP7604878B2 (ja) * | 2020-12-22 | 2024-12-24 | Dic株式会社 | 構造色発現用組成物 |
| CN115368560B (zh) * | 2022-08-26 | 2023-11-14 | 天津大学 | 聚乙二醇-嵌段-聚甲硫氨酸-接枝-海藻糖聚合物及制备方法和应用 |
| KR102640099B1 (ko) * | 2022-11-17 | 2024-02-23 | 주식회사 삼양홀딩스 | 조직 수복용 분말 제형 및 이를 포함하는 조직 수복용 주사제 조성물 |
| IT202300015291A1 (it) * | 2023-07-20 | 2025-01-20 | Fond Riccardo Terzi E Silvio Albini | Sistema di rilascio comprendente nanoparticelle lipidiche o polimeriche comprendenti ormoni tiroidei |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002224526A1 (en) * | 2000-07-24 | 2002-02-05 | Ono Pharmaceutical Co. Ltd. | Freeze-dried preparation of n-(o-(p-pivaloyloxybenzenesulfonylamino)benzoyl)glycine monosodium salt tetrahydrate and process for producing the same |
| EP2502941A1 (en) | 2004-10-25 | 2012-09-26 | Intezyne Technologies Inc. | Heterobifunctional poly (ethylene glycol) and uses thereof |
| EP1833958A4 (en) | 2005-01-04 | 2009-01-14 | Intezyne Technologies Inc | SYNTHESIS OF HYBRID BLOCK COPOLYMERS AND USES THEREOF |
| NZ562064A (en) | 2005-04-01 | 2011-03-31 | Intezyne Technologies Inc | Polymeric micelles for drug delivery |
| US8759465B2 (en) * | 2006-04-25 | 2014-06-24 | Purdue Research Foundation | Cross-linkable polymeric compositions |
| EP2155177A2 (en) | 2007-04-30 | 2010-02-24 | Intezyne Technologies Incorporated | Modification of biological targeting groups for the treatment of cancer |
| EP2359862B1 (en) | 2007-04-30 | 2013-07-24 | Intezyne Technologies Inc. | Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents |
| US8287910B2 (en) * | 2009-04-30 | 2012-10-16 | Intezyne Technologies, Inc. | Polymeric micelles for polynucleotide encapsulation |
| MX2011011730A (es) * | 2009-05-04 | 2011-12-08 | Intezyne Technologies Inc | Micelas polimericas que contienen sn-38 para el tratamiento de cancer. |
| US8609146B2 (en) * | 2011-09-19 | 2013-12-17 | Intezyne Technologies, Inc. | Multi-block copolymers for the preparation of stabilized micelles |
| US9944752B2 (en) | 2012-04-11 | 2018-04-17 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140113879A1 (en) | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140114051A1 (en) * | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| MX340992B (es) * | 2012-04-11 | 2016-08-03 | Intezyne Tech Inc | Copolimeros de bloque para micelas estables. |
| US20140127271A1 (en) * | 2012-04-11 | 2014-05-08 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
-
2013
- 2013-03-15 MX MX2014011980A patent/MX340992B/es active IP Right Grant
- 2013-03-15 KR KR1020147028330A patent/KR101607422B1/ko active Active
- 2013-03-15 ES ES13001333.7T patent/ES2560235T3/es active Active
- 2013-03-15 JP JP2015505769A patent/JP5927338B2/ja active Active
- 2013-03-15 CN CN201380023578.2A patent/CN104487481B/zh active Active
- 2013-03-15 US US13/839,715 patent/US20130296531A1/en not_active Abandoned
- 2013-03-15 US US13/839,994 patent/US20130288991A1/en not_active Abandoned
- 2013-03-15 EP EP13001333.7A patent/EP2660255B1/en active Active
- 2013-03-15 AU AU2013201541A patent/AU2013201541B2/en not_active Ceased
- 2013-03-15 US US13/840,133 patent/US9078930B2/en active Active
- 2013-03-15 NZ NZ700397A patent/NZ700397A/en not_active IP Right Cessation
- 2013-03-15 WO PCT/US2013/032409 patent/WO2013154774A1/en not_active Ceased
- 2013-03-15 NZ NZ709953A patent/NZ709953A/en not_active IP Right Cessation
- 2013-03-15 EP EP15191496.7A patent/EP3000833B1/en active Active
- 2013-03-15 CA CA2868274A patent/CA2868274C/en active Active
- 2013-03-15 CN CN201610908380.8A patent/CN106511270A/zh active Pending
-
2014
- 2014-10-06 IL IL235003A patent/IL235003A/en active IP Right Grant
-
2015
- 2015-04-23 US US14/694,760 patent/US9499665B2/en active Active
- 2015-08-19 JP JP2015162006A patent/JP6466283B2/ja active Active
-
2016
- 2016-09-28 US US15/279,042 patent/US10047197B2/en active Active
- 2016-09-28 US US15/279,017 patent/US9944754B2/en active Active
-
2019
- 2019-01-09 JP JP2019001801A patent/JP6740391B2/ja active Active
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