JP2015512426A5 - - Google Patents
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- Publication number
- JP2015512426A5 JP2015512426A5 JP2015503778A JP2015503778A JP2015512426A5 JP 2015512426 A5 JP2015512426 A5 JP 2015512426A5 JP 2015503778 A JP2015503778 A JP 2015503778A JP 2015503778 A JP2015503778 A JP 2015503778A JP 2015512426 A5 JP2015512426 A5 JP 2015512426A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitors
- compound
- leukemia
- receptor modulator
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012006884.0 | 2012-04-04 | ||
| DE102012006884A DE102012006884A1 (de) | 2012-04-04 | 2012-04-04 | Cyclische Amide als MetAP-2 Inhibitoren |
| PCT/EP2013/000867 WO2013149704A1 (de) | 2012-04-04 | 2013-03-21 | Cyclische amide als metap-2 inhibitoren |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017050869A Division JP6438514B2 (ja) | 2012-04-04 | 2017-03-16 | Ｍｅｔａｐ−２インヒビターとしての環状アミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512426A JP2015512426A (ja) | 2015-04-27 |
| JP2015512426A5 true JP2015512426A5 (https=) | 2016-05-19 |
| JP6273258B2 JP6273258B2 (ja) | 2018-01-31 |
Family
ID=47915149
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503778A Active JP6273258B2 (ja) | 2012-04-04 | 2013-03-21 | Ｍｅｔａｐ−２インヒビターとしての環状アミド |
| JP2017050869A Active JP6438514B2 (ja) | 2012-04-04 | 2017-03-16 | Ｍｅｔａｐ−２インヒビターとしての環状アミド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017050869A Active JP6438514B2 (ja) | 2012-04-04 | 2017-03-16 | Ｍｅｔａｐ−２インヒビターとしての環状アミド |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US10093623B2 (https=) |
| EP (1) | EP2834221B1 (https=) |
| JP (2) | JP6273258B2 (https=) |
| KR (1) | KR102079923B1 (https=) |
| CN (1) | CN104245675B (https=) |
| AR (1) | AR090602A1 (https=) |
| AU (1) | AU2013243020B2 (https=) |
| BR (1) | BR112014024753B1 (https=) |
| CA (1) | CA2869337C (https=) |
| CL (1) | CL2014002640A1 (https=) |
| DE (1) | DE102012006884A1 (https=) |
| DK (1) | DK2834221T3 (https=) |
| EA (1) | EA026851B1 (https=) |
| ES (1) | ES2587953T3 (https=) |
| HR (1) | HRP20161032T1 (https=) |
| HU (1) | HUE030400T2 (https=) |
| IL (1) | IL234953A (https=) |
| MX (1) | MX354569B (https=) |
| MY (1) | MY176680A (https=) |
| NZ (1) | NZ630196A (https=) |
| PE (1) | PE20142452A1 (https=) |
| PH (1) | PH12014501964B1 (https=) |
| PL (1) | PL2834221T3 (https=) |
| PT (1) | PT2834221T (https=) |
| RS (1) | RS55063B1 (https=) |
| SG (1) | SG11201406059PA (https=) |
| SI (1) | SI2834221T1 (https=) |
| UA (1) | UA112684C2 (https=) |
| WO (1) | WO2013149704A1 (https=) |
| ZA (1) | ZA201408021B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3045448A4 (en) * | 2013-09-12 | 2017-01-25 | Sumitomo Chemical Company Limited | Nitrogen-containing saturated heterocyclic compound |
| WO2015130958A1 (en) * | 2014-02-26 | 2015-09-03 | Howard University | 5-oxopyrrolidine derivatives as hiv integrase inhibitors |
| EP3110794A1 (en) * | 2014-02-27 | 2017-01-04 | Merck Patent GmbH | Heterocyclic compounds as nav channel inhibitors and uses thereof |
| JP6619420B2 (ja) * | 2014-08-04 | 2019-12-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｍｅｔａｐ−２阻害剤としてのピロリジノン誘導体 |
| US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
| WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
| MX2017010102A (es) * | 2015-02-15 | 2017-11-23 | Jiangsu Hengrui Medicine Co | Conjugado farmaco citotoxico-ligando, metodo de preparacion del mismo, y sus aplicaciones. |
| WO2017005069A1 (en) * | 2015-07-08 | 2017-01-12 | Eli Lilly And Company | Pyrrolidinone compounds |
| WO2017084096A1 (en) * | 2015-11-20 | 2017-05-26 | Eli Lilly And Company | Pyrrolidinone compounds |
| WO2018098781A1 (en) * | 2016-12-01 | 2018-06-07 | Eli Lilly And Company | Pyrrolidinone compounds |
| CN111278816B (zh) * | 2017-09-04 | 2024-03-15 | C4医药公司 | 二氢喹啉酮 |
| US20210261539A1 (en) * | 2018-02-06 | 2021-08-26 | Shanghai Haihe Pharmaceutical Co., Ltd. | Compound having bet inhibitory activity and preparation method and use therefor |
| US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
| JP2021534123A (ja) | 2018-08-09 | 2021-12-09 | ヴァロ アーリー ディスカバリー， インコーポレイテッド | ユビキチン特異的プロテアーゼ阻害剤としてのカルボキサミド |
| CN110963957B (zh) * | 2018-09-28 | 2021-10-22 | 深圳恩多凯医药科技有限公司 | N-芳香酰胺类化合物及其制备方法和用途 |
| ES2934986T3 (es) * | 2019-01-22 | 2023-02-28 | Merck Patent Gmbh | Derivados heterocíclicos |
| KR102281485B1 (ko) | 2019-06-19 | 2021-07-28 | 주식회사 오쎄인 | 시안화아크릴레이트의 점도 변화에 따른 물성변화를 통한 골대체용 복합재료의 제조방법 및 그것의 조성물 |
| SI3994134T1 (sl) | 2019-07-03 | 2024-06-28 | Merck Patent Gmbh | Postopek za izdelavo (s)-3-hidroksi-1-(1h-indol-5-il)-2-okso-pirolidin-3-karboksilne kisline 3,5-difluoro-benzilamida |
| US20220305048A1 (en) | 2019-08-26 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
| CN112480100B (zh) * | 2019-09-11 | 2022-10-14 | 康威(广州)生物科技有限公司 | 吡咯烷酮衍生物 |
| CN115989027A (zh) | 2020-07-09 | 2023-04-18 | 默克专利股份公司 | 甲硫氨酸氨肽酶2抑制剂和vegfr/vegf抑制剂的组合 |
| CN111728969B (zh) * | 2020-08-25 | 2021-03-19 | 广州市万千粉丝化妆品有限公司 | 抗衰老抗氧化的化合物在制备药物或者抗衰老化妆品中的用途 |
| CN116888097A (zh) * | 2021-02-16 | 2023-10-13 | Fmc公司 | 卤代烷基磺酰苯胺基n-取代的除草环酰胺 |
| KR20230170693A (ko) * | 2021-03-28 | 2023-12-19 | 캔웰 바이오테크 리미티드 | Metap-2 억제제, 약제학적 조성물 및 이의 치료 방법 |
| WO2023144053A1 (en) | 2022-01-26 | 2023-08-03 | Merck Patent Gmbh | Heterocyclic derivatives |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4508724A (en) | 1984-02-03 | 1985-04-02 | A. H. Robins Company, Inc. | Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarrhythmic or hypotensive activity |
| JPS63208590A (ja) | 1987-02-24 | 1988-08-30 | Yamanouchi Pharmaceut Co Ltd | ヘテロ環式スピロ化合物及びその製造法 |
| US5173484A (en) | 1988-02-05 | 1992-12-22 | Bayer Aktiengesellschaft | Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them |
| DE3814517A1 (de) * | 1988-02-05 | 1989-08-17 | Bayer Ag | Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| US6635661B2 (en) | 2000-05-25 | 2003-10-21 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| US6677332B1 (en) | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| US20080234247A1 (en) | 1999-05-25 | 2008-09-25 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| US6645980B1 (en) | 2000-05-25 | 2003-11-11 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| US7361666B2 (en) | 1999-05-25 | 2008-04-22 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| JP2003500392A (ja) | 1999-05-25 | 2003-01-07 | セプラコール， インク． | 複素環式鎮痛性化合物およびその使用方法 |
| AR028537A1 (es) | 2000-04-14 | 2003-05-14 | Abbott Lab | Hidrazidas y alcoxiamidas inhibidoras de la angiogénesis |
| US20070161570A1 (en) | 2000-11-01 | 2007-07-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
| AU2002306907A1 (en) | 2001-04-03 | 2002-10-21 | Smithkline Beecham Corporation | Method for inhibiting metap2 |
| WO2002080928A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| AU2003274037A1 (en) | 2002-10-18 | 2004-05-13 | Basf Aktiengesellschaft | 1-phenylpyrrolidine-2-one-3-carboxamides |
| US7691850B2 (en) | 2004-06-15 | 2010-04-06 | Glaxo Group Limited | Antibacterial agents |
| US20070123508A1 (en) * | 2005-05-27 | 2007-05-31 | Roger Olsson | PAR2-modulating compounds and their use |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| DE102008027574A1 (de) | 2008-06-10 | 2009-12-17 | Merck Patent Gmbh | Neue Pyrrolidinderivate als MetAP-2 Inhibitoren |
| BR112012016793A2 (pt) | 2010-01-08 | 2018-07-31 | Zafgen Corp | compostos tipo fumagilol e métodos de fazer e usar os mesmos |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| WO2012033956A1 (en) * | 2010-09-08 | 2012-03-15 | Mithridion, Inc. | Cognition enhancing compounds and compositions, methods of making, and methods of treating |
| DE102010048374A1 (de) * | 2010-10-13 | 2012-04-19 | Merck Patent Gmbh | Pyrrolidinone als MetAP-2 Inhibitoren |
-
2012
- 2012-04-04 DE DE102012006884A patent/DE102012006884A1/de not_active Withdrawn
-
2013
- 2013-03-21 NZ NZ630196A patent/NZ630196A/en unknown
- 2013-03-21 UA UAA201411743A patent/UA112684C2/uk unknown
- 2013-03-21 SI SI201330274A patent/SI2834221T1/sl unknown
- 2013-03-21 KR KR1020147030512A patent/KR102079923B1/ko active Active
- 2013-03-21 AU AU2013243020A patent/AU2013243020B2/en active Active
- 2013-03-21 EP EP13711291.8A patent/EP2834221B1/de active Active
- 2013-03-21 ES ES13711291.8T patent/ES2587953T3/es active Active
- 2013-03-21 SG SG11201406059PA patent/SG11201406059PA/en unknown
- 2013-03-21 PE PE2014001514A patent/PE20142452A1/es active IP Right Grant
- 2013-03-21 DK DK13711291.8T patent/DK2834221T3/en active
- 2013-03-21 PT PT137112918T patent/PT2834221T/pt unknown
- 2013-03-21 HU HUE13711291A patent/HUE030400T2/en unknown
- 2013-03-21 RS RS20160697A patent/RS55063B1/sr unknown
- 2013-03-21 PL PL13711291.8T patent/PL2834221T3/pl unknown
- 2013-03-21 EA EA201401081A patent/EA026851B1/ru not_active IP Right Cessation
- 2013-03-21 CN CN201380018197.5A patent/CN104245675B/zh active Active
- 2013-03-21 US US14/390,926 patent/US10093623B2/en active Active
- 2013-03-21 HR HRP20161032TT patent/HRP20161032T1/hr unknown
- 2013-03-21 BR BR112014024753-6A patent/BR112014024753B1/pt active IP Right Grant
- 2013-03-21 MY MYPI2014702868A patent/MY176680A/en unknown
- 2013-03-21 CA CA2869337A patent/CA2869337C/en active Active
- 2013-03-21 MX MX2014011906A patent/MX354569B/es active IP Right Grant
- 2013-03-21 WO PCT/EP2013/000867 patent/WO2013149704A1/de not_active Ceased
- 2013-03-21 JP JP2015503778A patent/JP6273258B2/ja active Active
- 2013-04-04 AR ARP130101102A patent/AR090602A1/es active IP Right Grant
-
2014
- 2014-09-02 PH PH12014501964A patent/PH12014501964B1/en unknown
- 2014-09-30 CL CL2014002640A patent/CL2014002640A1/es unknown
- 2014-10-02 IL IL234953A patent/IL234953A/en active IP Right Grant
- 2014-11-03 ZA ZA2014/08021A patent/ZA201408021B/en unknown
-
2017
- 2017-03-16 JP JP2017050869A patent/JP6438514B2/ja active Active
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