JP2015510759A5 - - Google Patents
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- Publication number
- JP2015510759A5 JP2015510759A5 JP2014561051A JP2014561051A JP2015510759A5 JP 2015510759 A5 JP2015510759 A5 JP 2015510759A5 JP 2014561051 A JP2014561051 A JP 2014561051A JP 2014561051 A JP2014561051 A JP 2014561051A JP 2015510759 A5 JP2015510759 A5 JP 2015510759A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide molecule
- molecule
- seq
- isolated
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 76
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 76
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 76
- 235000001014 amino acid Nutrition 0.000 claims description 75
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 38
- 150000001413 amino acids Chemical class 0.000 claims description 37
- 102000039446 nucleic acids Human genes 0.000 claims description 30
- 108020004707 nucleic acids Proteins 0.000 claims description 30
- 150000007523 nucleic acids Chemical class 0.000 claims description 30
- 210000004027 cell Anatomy 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 22
- 235000018417 cysteine Nutrition 0.000 claims description 18
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 18
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 12
- 235000004279 alanine Nutrition 0.000 claims description 12
- 230000004438 eyesight Effects 0.000 claims description 7
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 6
- 210000003994 retinal ganglion cell Anatomy 0.000 claims description 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004473 Threonine Substances 0.000 claims description 4
- 210000000411 amacrine cell Anatomy 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 208000003098 Ganglion Cysts Diseases 0.000 claims description 2
- 206010034972 Photosensitivity reaction Diseases 0.000 claims description 2
- 208000005400 Synovial Cyst Diseases 0.000 claims description 2
- 206010047571 Visual impairment Diseases 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 230000000763 evoking effect Effects 0.000 claims description 2
- 210000002287 horizontal cell Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000011065 in-situ storage Methods 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 108091008695 photoreceptors Proteins 0.000 claims description 2
- 230000036211 photosensitivity Effects 0.000 claims description 2
- 210000003569 retinal bipolar cell Anatomy 0.000 claims description 2
- 210000002508 rod bipolar cell Anatomy 0.000 claims description 2
- 208000029257 vision disease Diseases 0.000 claims description 2
- 210000000857 visual cortex Anatomy 0.000 claims description 2
- 230000000007 visual effect Effects 0.000 claims description 2
- 230000004393 visual impairment Effects 0.000 claims description 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 230000016776 visual perception Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 9
- 201000007737 Retinal degeneration Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261606663P | 2012-03-05 | 2012-03-05 | |
| US61/606,663 | 2012-03-05 | ||
| PCT/US2013/029171 WO2013134295A1 (en) | 2012-03-05 | 2013-03-05 | Identification of channelrhodopsin-2 (chop2) mutations and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018082403A Division JP2018134098A (ja) | 2012-03-05 | 2018-04-23 | チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510759A JP2015510759A (ja) | 2015-04-13 |
| JP2015510759A5 true JP2015510759A5 (https=) | 2016-04-28 |
| JP6395611B2 JP6395611B2 (ja) | 2018-09-26 |
Family
ID=47892055
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561051A Active JP6395611B2 (ja) | 2012-03-05 | 2013-03-05 | チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法 |
| JP2018082403A Withdrawn JP2018134098A (ja) | 2012-03-05 | 2018-04-23 | チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法 |
| JP2019123061A Pending JP2019193656A (ja) | 2012-03-05 | 2019-07-01 | チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018082403A Withdrawn JP2018134098A (ja) | 2012-03-05 | 2018-04-23 | チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法 |
| JP2019123061A Pending JP2019193656A (ja) | 2012-03-05 | 2019-07-01 | チャネルロドプシン−２（Ｃｈｏｐ２）の変異の同定および使用法 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10947281B2 (https=) |
| EP (1) | EP2822964B1 (https=) |
| JP (3) | JP6395611B2 (https=) |
| KR (1) | KR102137717B1 (https=) |
| CN (2) | CN111378020A (https=) |
| AU (4) | AU2013230112A1 (https=) |
| CA (1) | CA2866405A1 (https=) |
| DK (1) | DK2822964T3 (https=) |
| EA (1) | EA201491643A1 (https=) |
| ES (1) | ES2703324T3 (https=) |
| HU (1) | HUE040487T2 (https=) |
| MX (1) | MX360085B (https=) |
| NZ (1) | NZ629843A (https=) |
| PL (1) | PL2822964T3 (https=) |
| PT (1) | PT2822964T (https=) |
| WO (1) | WO2013134295A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101484005A (zh) | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
| WO2011140279A1 (en) | 2010-05-04 | 2011-11-10 | Wayne State University | Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
| CA2866405A1 (en) * | 2012-03-05 | 2013-09-12 | Wayne State University | Identification of channelopsin-2 (chop2) mutations and methods of use |
| EP2968476B1 (en) | 2013-03-14 | 2021-05-05 | Wayne State University | A plasmin for use in enhancing delivery of therapeutic compounds to the eyes or for improving vision |
| JP6469669B2 (ja) | 2013-07-08 | 2019-02-13 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | オキシムエステル光開始剤 |
| EP4678754A3 (en) | 2014-03-11 | 2026-04-08 | Wayne State University | A modified mglur6 promoter and methods of use |
| US20170319669A1 (en) | 2016-05-03 | 2017-11-09 | Wayne State University | Method of enhancing viral-mediated gene delivery |
| CN109476720A (zh) * | 2016-06-03 | 2019-03-15 | 马克斯-普朗克科学促进协会 | 通道视紫红质的突变型光诱导离子通道 |
| EP3504227A1 (en) * | 2016-08-29 | 2019-07-03 | Wayne State University | Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof |
| JP6779546B2 (ja) * | 2016-11-06 | 2020-11-04 | ナノスコープ テクノロジーズ エルエルシーＮａｎｏｓｃｏｐｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ | 視力回復のための多特性オプシンによる光遺伝学的調節及びその別の用途 |
| US20200115419A1 (en) * | 2017-04-12 | 2020-04-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | New optogenetic tool |
| DK3720428T3 (da) * | 2017-12-04 | 2023-03-20 | Salvat Lab Sa | Oftalmisk topisk sammensætning omfattende dobesilsyre til behandling af sygdomme i det bageste øjensegment |
| JP6567153B1 (ja) * | 2018-09-28 | 2019-08-28 | 学校法人東北工業大学 | 対象化合物の特性の予測を行うための方法、コンピュータシステム、プログラム |
| EP4704877A2 (en) * | 2023-04-24 | 2026-03-11 | Nanoscope Therapeutics Inc. | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4498919A (en) | 1983-10-31 | 1985-02-12 | Corning Glass Works | Method for making colored photochromic prescription ophthalmic lenses |
| US6610287B1 (en) | 1990-04-16 | 2003-08-26 | The General Hospital Corporation | Transfer and expression of gene sequences into nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
| US5827702A (en) | 1994-10-31 | 1998-10-27 | Genentech, Inc. | Ocular gene therapy |
| EP0977880A2 (en) | 1997-04-21 | 2000-02-09 | University Of Florida | Materials and methods for treatment of retinal diseases |
| CA2346262A1 (en) | 1998-09-17 | 2000-03-23 | University Of Florida | Methods for treatment of degenerative retinal diseases |
| US7056502B2 (en) | 2000-04-28 | 2006-06-06 | The Trustees Of The University Of Pennsylvania | Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids |
| WO2002082904A2 (en) | 2001-04-13 | 2002-10-24 | The Trustees Of The University Of Pennsylvania | Method of treating or retarding the development of blindness |
| AU2002323210A1 (en) | 2001-08-16 | 2003-03-03 | Sloan Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
| DE10216005A1 (de) | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| WO2004009022A2 (en) | 2002-07-18 | 2004-01-29 | The General Hospital Corp. | Method for augmenting vision in persons suffering from photoreceptor cell degeneration |
| US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
| US7427138B2 (en) | 2003-11-05 | 2008-09-23 | Neurovision, Inc. | Method and apparatus for improving visual perception |
| EP1919497B1 (en) | 2005-07-22 | 2020-02-12 | The Board of Trustees of the Leland Stanford Junior University | Light-activated cation channel and uses thereof |
| CN101484005A (zh) | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
| WO2011140279A1 (en) * | 2010-05-04 | 2011-11-10 | Wayne State University | Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
| KR101945962B1 (ko) * | 2010-09-08 | 2019-02-08 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | 돌연변이 채널로돕신 2 |
| CA2866405A1 (en) * | 2012-03-05 | 2013-09-12 | Wayne State University | Identification of channelopsin-2 (chop2) mutations and methods of use |
| KR101639859B1 (ko) | 2014-03-06 | 2016-07-14 | 포항공과대학교 산학협력단 | 광 자극에 의한 미토콘드리아 활성의 시공간적 가역 조절 방법 |
-
2013
- 2013-03-05 CA CA2866405A patent/CA2866405A1/en active Pending
- 2013-03-05 NZ NZ629843A patent/NZ629843A/en unknown
- 2013-03-05 US US14/383,211 patent/US10947281B2/en active Active
- 2013-03-05 EP EP13710253.9A patent/EP2822964B1/en active Active
- 2013-03-05 MX MX2014010664A patent/MX360085B/es active IP Right Grant
- 2013-03-05 CN CN202010025519.0A patent/CN111378020A/zh active Pending
- 2013-03-05 EA EA201491643A patent/EA201491643A1/ru unknown
- 2013-03-05 KR KR1020147027985A patent/KR102137717B1/ko active Active
- 2013-03-05 PT PT13710253T patent/PT2822964T/pt unknown
- 2013-03-05 AU AU2013230112A patent/AU2013230112A1/en not_active Abandoned
- 2013-03-05 JP JP2014561051A patent/JP6395611B2/ja active Active
- 2013-03-05 DK DK13710253.9T patent/DK2822964T3/en active
- 2013-03-05 WO PCT/US2013/029171 patent/WO2013134295A1/en not_active Ceased
- 2013-03-05 PL PL13710253T patent/PL2822964T3/pl unknown
- 2013-03-05 ES ES13710253T patent/ES2703324T3/es active Active
- 2013-03-05 CN CN201380022635.5A patent/CN104334575A/zh active Pending
- 2013-03-05 HU HUE13710253A patent/HUE040487T2/hu unknown
-
2017
- 2017-10-06 AU AU2017239601A patent/AU2017239601B2/en active Active
-
2018
- 2018-04-23 JP JP2018082403A patent/JP2018134098A/ja not_active Withdrawn
-
2019
- 2019-07-01 JP JP2019123061A patent/JP2019193656A/ja active Pending
- 2019-08-14 AU AU2019216638A patent/AU2019216638B2/en active Active
-
2021
- 2021-03-15 US US17/202,064 patent/US20220033449A1/en not_active Abandoned
- 2021-10-07 AU AU2021245195A patent/AU2021245195B2/en active Active
-
2024
- 2024-04-18 US US18/639,381 patent/US20250066431A1/en active Pending
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