JP2015509710A5 - - Google Patents

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JP2015509710A5
JP2015509710A5 JP2014557122A JP2014557122A JP2015509710A5 JP 2015509710 A5 JP2015509710 A5 JP 2015509710A5 JP 2014557122 A JP2014557122 A JP 2014557122A JP 2014557122 A JP2014557122 A JP 2014557122A JP 2015509710 A5 JP2015509710 A5 JP 2015509710A5
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feature vector
polymer
derived
measurement
measurements
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JP6226888B2 (ja
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JP2014557122A 2012-02-16 2013-02-18 ポリマーの測定の解析 Active JP6226888B2 (ja)

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US201261599573P 2012-02-16 2012-02-16
US61/599,573 2012-02-16
PCT/GB2013/050381 WO2013121224A1 (en) 2012-02-16 2013-02-18 Analysis of measurements of a polymer

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JP2015509710A JP2015509710A (ja) 2015-04-02
JP2015509710A5 true JP2015509710A5 (enExample) 2017-08-31
JP6226888B2 JP6226888B2 (ja) 2017-11-08

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US (3) US20150057948A1 (enExample)
EP (2) EP3736339B1 (enExample)
JP (1) JP6226888B2 (enExample)
KR (1) KR102106499B1 (enExample)
CN (1) CN104321441B (enExample)
AU (1) AU2013220179B2 (enExample)
BR (1) BR112014020211A2 (enExample)
CA (1) CA2866587C (enExample)
IN (1) IN2014DN06795A (enExample)
WO (1) WO2013121224A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
US8285719B1 (en) 2008-08-08 2012-10-09 The Research Foundation Of State University Of New York System and method for probabilistic relational clustering
EP3663412B1 (en) 2011-09-23 2022-03-09 Oxford Nanopore Technologies PLC Analysis of a polymer comprising polymer units by means of translocation through a nanopore
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
EP3736339B1 (en) 2012-02-16 2022-07-27 Oxford Nanopore Technologies plc Analysis of measurements of a polymer
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
GB201222928D0 (en) 2012-12-19 2013-01-30 Oxford Nanopore Tech Ltd Analysis of a polynucleotide
EP3971300B1 (en) 2014-10-16 2024-06-05 Oxford Nanopore Technologies plc Sorting of polymers
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
US10794895B2 (en) 2015-02-05 2020-10-06 President And Fellows Of Harvard College Nanopore sensor including fluidic passage
GB201508669D0 (en) 2015-05-20 2015-07-01 Oxford Nanopore Tech Ltd Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown
EP3332033B1 (en) 2015-08-06 2021-04-21 Pacific Biosciences of California, Inc. Single-molecule nanofet sequencing systems and methods
WO2017082875A1 (en) 2015-11-10 2017-05-18 Hewlett Packard Enterprise Development Lp Data allocation based on secure information retrieval
KR102222191B1 (ko) 2016-03-02 2021-03-02 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 기공
US11514289B1 (en) * 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
EP3482196B1 (en) 2016-07-05 2022-02-23 Quantapore, Inc. Optically based nanopore sequencing
ES2967443T3 (es) * 2016-07-06 2024-04-30 Guardant Health Inc Procedimientos de perfilado de fragmentoma de ácidos nucleicos sin células
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
WO2018034745A1 (en) * 2016-08-18 2018-02-22 The Regents Of The University Of California Nanopore sequencing base calling
US11080301B2 (en) 2016-09-28 2021-08-03 Hewlett Packard Enterprise Development Lp Storage allocation based on secure data comparisons via multiple intermediaries
GB201619930D0 (en) 2016-11-24 2017-01-11 Oxford Nanopore Tech Apparatus and methods for controlling insertion of a membrane channel into a membrane
CN110178012B (zh) * 2016-12-16 2022-04-05 艾珀尔有限公司 分类分析方法、分类分析装置及分类分析用记录介质
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
GB201707138D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Machine learning analysis of nanopore measurements
EP3682020B1 (en) * 2017-09-15 2025-09-03 Illumina, Inc. Sequence-detection system
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
GB2569630B (en) 2017-12-21 2022-10-12 Sharp Life Science Eu Ltd Droplet Interfaces in Electro-wetting Devices
EP3731959B1 (en) 2017-12-29 2025-10-08 Clear Labs, Inc. Automated priming and library loading device
WO2019149626A1 (de) 2018-02-02 2019-08-08 Bayer Aktiengesellschaft Bekämpfung resistenter schadorganismen
WO2019204720A1 (en) * 2018-04-20 2019-10-24 The Regents Of The University Of California Nucleic acid sequencing methods and computer-readable media for practicing same
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
EP3801901A1 (en) 2018-05-24 2021-04-14 Oxford Nanopore Technologies Limited Droplet interfaces in electro-wetting devices
GB201814369D0 (en) * 2018-09-04 2018-10-17 Oxford Nanopore Tech Ltd Method for determining a polymersequence
GB201819378D0 (en) * 2018-11-28 2019-01-09 Oxford Nanopore Tech Ltd Analysis of nanopore signal using a machine-learning technique
WO2020109800A1 (en) 2018-11-28 2020-06-04 Oxford Nanopore Technologies Ltd. Sensing system and method of operation
WO2020183172A1 (en) 2019-03-12 2020-09-17 Oxford Nanopore Technologies Inc. Nanopore sensing device and methods of operation and of forming it
EP3973077A4 (en) * 2019-05-22 2023-06-21 Icahn School of Medicine at Mount Sinai Method for de novo detection, identification and fine mapping of multiple forms of nucleic acid modifications
CN110628597B (zh) * 2019-10-19 2023-04-25 上海新微技术研发中心有限公司 拉曼光谱法生物分子测序方法
US11651281B2 (en) * 2020-05-18 2023-05-16 International Business Machines Corporation Feature catalog enhancement through automated feature correlation
CN115989410A (zh) 2020-07-17 2023-04-18 牛津纳米孔科技公开有限公司 纳米孔感测装置
CN113030548A (zh) * 2021-03-09 2021-06-25 南京邮电大学 基于局域阈值的纳米孔检测电流信号特征信息提取方法及装置
GB202103605D0 (en) * 2021-03-16 2021-04-28 Oxford Nanopore Tech Ltd Alignment of target and reference sequences of polymer units
US20240240248A1 (en) 2021-05-19 2024-07-18 Oxford Nanopore Technologies Plc Methods for complement strand sequencing
WO2023029044A1 (zh) * 2021-09-06 2023-03-09 百图生科(北京)智能技术有限公司 用于单细胞测序的方法、装置、设备、介质和程序产品
CN113837036B (zh) * 2021-09-09 2024-08-02 成都齐碳科技有限公司 生物聚合物的表征方法、装置、设备及计算机存储介质
CN114908358B8 (zh) * 2022-04-14 2024-06-21 孔确(成都)科技有限公司 一种两亲性分子层的制备方法及装置
GB202215442D0 (en) 2022-10-19 2022-11-30 Oxford Nanopore Tech Plc Analysis of a polymer
CN120457488A (zh) 2022-11-10 2025-08-08 拜耳公司 基于遗传谱的靶向性作物保护产品施用
GB202216905D0 (en) 2022-11-11 2022-12-28 Oxford Nanopore Tech Plc Novel pore monomers and pores
JP7630538B2 (ja) * 2023-03-15 2025-02-17 Dic株式会社 樹脂物性値予測装置及び樹脂物性値の予測方法
GB202305524D0 (en) 2023-04-14 2023-05-31 Oxford Nanopore Tech Plc Novel pore monomers and pores
GB202307141D0 (en) 2023-05-12 2023-06-28 Oxford Nanopore Tech Plc Modified helicases

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6128587A (en) * 1997-01-14 2000-10-03 The Regents Of The University Of California Method and apparatus using Bayesian subfamily identification for sequence analysis
JPH11178575A (ja) * 1997-12-22 1999-07-06 Hitachi Ltd Dna塩基配列解析装置、方法及び記録媒体
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
WO2000039333A1 (en) 1998-12-23 2000-07-06 Jones Elizabeth Louise Sequencing method using magnifying tags
EP1192103A1 (en) 1999-06-22 2002-04-03 President And Fellows of Harvard College Control of solid state dimensional features
AU2002239284A1 (en) 2000-11-27 2002-06-03 The Regents Of The University Of California Methods and devices for characterizing duplex nucleic acid molecules
US20020197618A1 (en) 2001-01-20 2002-12-26 Sampson Jeffrey R. Synthesis and amplification of unstructured nucleic acids for rapid sequencing
JP2002325581A (ja) * 2001-04-27 2002-11-12 Adgene Co Ltd 核酸溶解曲線及び核酸解離曲線を用いた未知あるいは既知核酸変異検出法及び表示法
JP2003256435A (ja) 2002-03-06 2003-09-12 Fujitsu Ltd 配列データ統合処理方法、配列データ統合処理装置及び配列データ統合処理プログラム
US7220405B2 (en) 2003-09-08 2007-05-22 E. I. Du Pont De Nemours And Company Peptide-based conditioners and colorants for hair, skin, and nails
US20050136408A1 (en) 2003-12-19 2005-06-23 May Tom-Moy Methods and systems for characterizing a polymer
JP2005176730A (ja) 2003-12-19 2005-07-07 Hitachi Ltd cDNA配列をゲノム配列にマッピングする方法
US7279337B2 (en) 2004-03-10 2007-10-09 Agilent Technologies, Inc. Method and apparatus for sequencing polymers through tunneling conductance variation detection
WO2006028508A2 (en) * 2004-03-23 2006-03-16 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
KR100614827B1 (ko) 2004-05-06 2006-08-25 재단법인서울대학교산학협력재단 양방향 은닉 마코프 모델을 이용한 완숙한마이크로알엔에이 위치예측방법 및 이를 구현하기 위한컴퓨터 프로그램을 기록한 저장매체
WO2005124888A1 (en) 2004-06-08 2005-12-29 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
US20060019259A1 (en) 2004-07-22 2006-01-26 Joyce Timothy H Characterization of biopolymers by resonance tunneling and fluorescence quenching
US20130071837A1 (en) 2004-10-06 2013-03-21 Stephen N. Winters-Hilt Method and System for Characterizing or Identifying Molecules and Molecular Mixtures
US20060086626A1 (en) 2004-10-22 2006-04-27 Joyce Timothy H Nanostructure resonant tunneling with a gate voltage source
GB0505971D0 (en) 2005-03-23 2005-04-27 Isis Innovation Delivery of molecules to a lipid bilayer
WO2007065025A2 (en) 2005-11-29 2007-06-07 Wisconsin Alumni Research Foundation Method of dna analysis using micro/nanochannel
US20100291548A1 (en) 2006-03-12 2010-11-18 Applera Corporation Methods of Detecting Target Nucleic Acids
US8116988B2 (en) 2006-05-19 2012-02-14 The University Of Chicago Method for indexing nucleic acid sequences for computer based searching
US7731826B2 (en) 2006-08-17 2010-06-08 Electronic Bio Sciences, Llc Controlled translocation of a polymer in an electrolytic sensing system
US8003319B2 (en) 2007-02-02 2011-08-23 International Business Machines Corporation Systems and methods for controlling position of charged polymer inside nanopore
EP2122344B8 (en) 2007-02-20 2019-08-21 Oxford Nanopore Technologies Limited Lipid bilayer sensor system
WO2008124107A1 (en) 2007-04-04 2008-10-16 The Regents Of The University Of California Compositions, devices, systems, and methods for using a nanopore
EP3540436B1 (en) 2007-09-12 2023-11-01 President And Fellows Of Harvard College High-resolution molecular sensor
GB2453377A (en) * 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
US8628940B2 (en) 2008-09-24 2014-01-14 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US20110229877A1 (en) 2008-07-07 2011-09-22 Oxford Nanopore Technologies Limited Enzyme-pore constructs
CA2730068A1 (en) * 2008-07-07 2010-01-14 Oxford Nanopore Technologies Limited Base-detecting pore
DE202009019021U1 (de) 2008-09-22 2015-09-24 University Of Washington Msp-nanoporen
WO2010053820A1 (en) 2008-10-29 2010-05-14 Trustees Of Boston University Sequence preserved dna conversion
US8452546B1 (en) 2008-11-07 2013-05-28 Electronic Biosciences, Inc. Method for deducing a polymer sequence from a nominal base-by-base measurement
GB0820927D0 (en) * 2008-11-14 2008-12-24 Isis Innovation Method
CN102482330A (zh) 2009-01-30 2012-05-30 牛津纳米孔技术有限公司 酶突变体
EP2391732B1 (en) 2009-01-30 2015-05-27 Oxford Nanopore Technologies Limited Methods using adaptors for nucleic acid constructs in transmembrane sequencing
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
WO2010117470A2 (en) 2009-04-10 2010-10-14 Pacific Biosciences Of California, Inc. Nanopore sequencing devices and methods
CA2758617C (en) 2009-04-20 2017-10-03 Oxford Nanopore Technologies Limited Lipid bilayer sensor array
AU2010307229B2 (en) 2009-09-18 2016-02-25 President And Fellows Of Harvard College Bare single-layer graphene membrane having a nanopore enabling high-sensitivity molecular detection and analysis
EP2507387B1 (en) 2009-12-01 2017-01-25 Oxford Nanopore Technologies Limited Biochemical analysis instrument and method
US8748091B2 (en) 2009-12-18 2014-06-10 The Board Of Trustees Of The University Of Illinois Characterizing stretched polynucleotides in a synthetic nanopassage
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
ES2978883T3 (es) 2010-02-23 2024-09-23 Univ Washington Secuenciación de analitos con nanoporos
US8828211B2 (en) 2010-06-08 2014-09-09 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
EP2614156B1 (en) 2010-09-07 2018-08-01 The Regents of The University of California Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme
WO2012109483A2 (en) 2011-02-09 2012-08-16 Life Technologies Corporation A method of analysis of genetic markers
BR112013020411B1 (pt) 2011-02-11 2021-09-08 Oxford Nanopore Technologies Limited Monômero de msp mutante, construto, polinucleotídeo, poro, kit e aparelho para caracterizar uma sequência de ácido nucleico alvo, e, método para caracterizar uma sequência de ácido nucleico alvo
WO2012135658A2 (en) 2011-03-30 2012-10-04 Noblegen Biosciences, Inc. Sequence preserved dna conversion for optical nanopore sequencing
WO2012138357A1 (en) 2011-04-04 2012-10-11 President And Fellows Of Harvard College Nanopore sensing by local electrical potential measurement
SG10201604316WA (en) 2011-05-27 2016-07-28 Oxford Nanopore Tech Ltd Coupling method
US9145623B2 (en) 2011-07-20 2015-09-29 Thermo Fisher Scientific Oy Transposon nucleic acids comprising a calibration sequence for DNA sequencing
KR20140050067A (ko) 2011-07-25 2014-04-28 옥스포드 나노포어 테크놀로지즈 리미티드 막횡단 포어를 사용한 이중 가닥 폴리뉴클레오티드 서열분석을 위한 헤어핀 루프 방법
EP3663412B1 (en) 2011-09-23 2022-03-09 Oxford Nanopore Technologies PLC Analysis of a polymer comprising polymer units by means of translocation through a nanopore
CN104039979B (zh) 2011-10-21 2016-08-24 牛津纳米孔技术公司 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法
EP2798083B1 (en) 2011-12-29 2017-08-09 Oxford Nanopore Technologies Limited Method for characterising a polynucelotide by using a xpd helicase
CA2861808C (en) 2011-12-29 2021-02-23 Oxford Nanopore Technologies Limited Enzyme method
CA2861457A1 (en) 2012-01-20 2013-07-25 Genia Technologies, Inc. Nanopore based molecular detection and sequencing
EP3736339B1 (en) 2012-02-16 2022-07-27 Oxford Nanopore Technologies plc Analysis of measurements of a polymer
JP6312607B2 (ja) 2012-02-16 2018-04-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 酵素仲介タンパク質トランスロケーションのためのナノポアセンサー
WO2013153359A1 (en) 2012-04-10 2013-10-17 Oxford Nanopore Technologies Limited Mutant lysenin pores
WO2013159042A1 (en) 2012-04-19 2013-10-24 University Of Washington Through Its Center For Commercialization Methods and compositions for generating reference maps for nanopore-based polymer analysis
GB2559073A (en) 2012-06-08 2018-07-25 Pacific Biosciences California Inc Modified base detection with nanopore sequencing
CA2879355C (en) 2012-07-19 2021-09-21 Oxford Nanopore Technologies Limited Helicase construct and its use in characterising polynucleotides
US11155860B2 (en) 2012-07-19 2021-10-26 Oxford Nanopore Technologies Ltd. SSB method
AU2013291763B2 (en) 2012-07-19 2019-06-20 Oxford Nanopore Technologies Limited Modified helicases
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
JP6375301B2 (ja) 2012-10-26 2018-08-15 オックスフォード ナノポール テクノロジーズ リミテッド 液滴界面
GB201222928D0 (en) 2012-12-19 2013-01-30 Oxford Nanopore Tech Ltd Analysis of a polynucleotide
ES2735015T3 (es) 2013-11-26 2019-12-13 Illumina Inc Composiciones y métodos para secuenciar polinucleótidos
CN106255767A (zh) 2014-03-21 2016-12-21 牛津楠路珀尔科技有限公司 由多维测量分析聚合物
GB201408652D0 (en) 2014-05-15 2014-07-02 Oxford Nanopore Tech Ltd Model adjustment during analysis of a polymer from nanopore measurements
US9925679B2 (en) 2014-05-19 2018-03-27 I+D+M Creative, Llc Devices and methods for assisting with slicing items
EP3971300B1 (en) 2014-10-16 2024-06-05 Oxford Nanopore Technologies plc Sorting of polymers

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