JP2015508760A5 - - Google Patents
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- JP2015508760A5 JP2015508760A5 JP2014556826A JP2014556826A JP2015508760A5 JP 2015508760 A5 JP2015508760 A5 JP 2015508760A5 JP 2014556826 A JP2014556826 A JP 2014556826A JP 2014556826 A JP2014556826 A JP 2014556826A JP 2015508760 A5 JP2015508760 A5 JP 2015508760A5
- Authority
- JP
- Japan
- Prior art keywords
- paracrine
- vector
- nucleic acid
- gene
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000003076 paracrine Effects 0.000 claims description 124
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 115
- 150000007523 nucleic acids Chemical class 0.000 claims description 109
- 102000005630 Urocortins Human genes 0.000 claims description 106
- 108010059705 Urocortins Proteins 0.000 claims description 106
- 239000000777 urocortin Substances 0.000 claims description 106
- 108020004707 nucleic acids Proteins 0.000 claims description 105
- 102000039446 nucleic acids Human genes 0.000 claims description 105
- 239000013598 vector Substances 0.000 claims description 92
- 210000004027 cell Anatomy 0.000 claims description 89
- 238000002347 injection Methods 0.000 claims description 74
- 239000007924 injection Substances 0.000 claims description 74
- ZEBBPGHOLWPSGI-KPLDDXDLSA-N urocortin ii Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CS)C(N)=O)CC1=CN=CN1 ZEBBPGHOLWPSGI-KPLDDXDLSA-N 0.000 claims description 71
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- HPNRHPKXQZSDFX-OAQDCNSJSA-N nesiritide Chemical compound C([C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 HPNRHPKXQZSDFX-OAQDCNSJSA-N 0.000 claims description 10
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- DTLOVISJEFBXLX-REAFJZEQSA-N relexan 2 Chemical compound C([C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(N1)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(O)=O)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DTLOVISJEFBXLX-REAFJZEQSA-N 0.000 claims description 8
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261598772P | 2012-02-14 | 2012-02-14 | |
| US61/598,772 | 2012-02-14 | ||
| PCT/US2013/025997 WO2013123094A2 (en) | 2012-02-14 | 2013-02-13 | Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017163244A Division JP2017203048A (ja) | 2012-02-14 | 2017-08-28 | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
| JP2019096752A Division JP2019135263A (ja) | 2012-02-14 | 2019-05-23 | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508760A JP2015508760A (ja) | 2015-03-23 |
| JP2015508760A5 true JP2015508760A5 (cg-RX-API-DMAC7.html) | 2016-03-31 |
| JP6562632B2 JP6562632B2 (ja) | 2019-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2014556826A Active JP6562632B2 (ja) | 2012-02-14 | 2013-02-13 | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
| JP2017163244A Pending JP2017203048A (ja) | 2012-02-14 | 2017-08-28 | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
| JP2019096752A Withdrawn JP2019135263A (ja) | 2012-02-14 | 2019-05-23 | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017163244A Pending JP2017203048A (ja) | 2012-02-14 | 2017-08-28 | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
| JP2019096752A Withdrawn JP2019135263A (ja) | 2012-02-14 | 2019-05-23 | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
Country Status (18)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| RU2642605C2 (ru) * | 2012-02-14 | 2018-01-25 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Системная доставка и регулируемая экспрессия паракринных генов для лечения сердечно-сосудистых и иных заболеваний |
| CN106456803A (zh) * | 2014-04-03 | 2017-02-22 | 加利福尼亚大学董事会 | 编码尿皮质素‑2和相关基因的病毒载体的全身递送以治疗糖尿病相关性心脏功能障碍和充血性心力衰竭 |
| US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
| EP3209311B1 (en) | 2014-10-21 | 2024-03-06 | University of Massachusetts | Recombinant aav variants and uses thereof |
| RU2020109343A (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
| WO2016077687A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| CN112375760A (zh) | 2014-11-14 | 2021-02-19 | 沃雅戈治疗公司 | 调节性多核苷酸 |
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