JP2015508310A5 - - Google Patents
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- JP2015508310A5 JP2015508310A5 JP2014550513A JP2014550513A JP2015508310A5 JP 2015508310 A5 JP2015508310 A5 JP 2015508310A5 JP 2014550513 A JP2014550513 A JP 2014550513A JP 2014550513 A JP2014550513 A JP 2014550513A JP 2015508310 A5 JP2015508310 A5 JP 2015508310A5
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- 239000000853 adhesive Substances 0.000 description 17
- 230000001070 adhesive Effects 0.000 description 17
- 229920000642 polymer Polymers 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000010030 laminating Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229920002413 Polyhexanide Polymers 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 2
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 2
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 2
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 2
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 2
- ZVXNYZWXUADSRV-UHFFFAOYSA-N N-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine Chemical group C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 ZVXNYZWXUADSRV-UHFFFAOYSA-N 0.000 description 2
- 229960001774 OCTENIDINE Drugs 0.000 description 2
- SMGTYJPMKXNQFY-UHFFFAOYSA-N Octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 2
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003115 biocidal Effects 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229940079866 intestinal antibiotics Drugs 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- UCWYGNTYSWIDSW-QXMHVHEDSA-N (Z)-N-[3-(dimethylamino)propyl]octadec-9-enamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)NCCCN(C)C UCWYGNTYSWIDSW-QXMHVHEDSA-N 0.000 description 1
- NMMHHSLZJLPMEG-UHFFFAOYSA-N 2-(chloroamino)ethanesulfonic acid Chemical compound OS(=O)(=O)CCNCl NMMHHSLZJLPMEG-UHFFFAOYSA-N 0.000 description 1
- CSAVDNHVPJNKTC-UHFFFAOYSA-N 5-methyl-2-propan-2-ylcyclohexan-1-ol;5-methyl-2-propan-2-ylphenol;2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane Chemical compound CC(C)C1CCC(C)CC1O.CC(C)C1=CC=C(C)C=C1O.C1CC2CCC1(C)OC2(C)C CSAVDNHVPJNKTC-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241001214789 Basilea Species 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229940076522 Listerine Drugs 0.000 description 1
- 229940051866 Mouthwash Drugs 0.000 description 1
- IFYDWYVPVAMGRO-UHFFFAOYSA-N N-[3-(dimethylamino)propyl]tetradecanamide Chemical compound CCCCCCCCCCCCCC(=O)NCCCN(C)C IFYDWYVPVAMGRO-UHFFFAOYSA-N 0.000 description 1
- LOBOFOUJCFGHAP-UHFFFAOYSA-N N-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine;2-phenoxyethanol;dihydrochloride Chemical compound Cl.Cl.OCCOC1=CC=CC=C1.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 LOBOFOUJCFGHAP-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N Taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 description 1
- 229960004267 Taurolidine Drugs 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic Effects 0.000 description 1
- 230000000845 anti-microbial Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229920001688 coating polymer Polymers 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 230000000249 desinfective Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 229910052733 gallium Inorganic materials 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 230000002335 preservative Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 101700075094 sapD Proteins 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
Description
別の実施形態では、本発明は、平面状表面の下方に延びる角錐状先端部を有する複数の方形直方体基部のくぼみを有する成形型を準備することと、該くぼみ及び該平面状表面を充填するように該成形型に溶融加工可能なポリマーを適用することと、平面状表面と、該平面状表面の下方に延びる角錐状先端部を有する方形直方体基部の突起と、を有する、第１の成形接着構造体を形成することと、該成形接着構造体を該成形型から取り出すことと、を含む、接着構造体の製造プロセスを目的とする。
本発明の別の実施形態は、平面状表面の下方に延びる角錐状先端部を有する複数の方形直方体基部のくぼみを有する成形型を準備することと、該平面状表面に溶融加工可能なポリマーフィルムを適用することと、該ポリマーフィルム上に多孔性基部構造体を適用することと、該フィルムの一部を該くぼみに押し込み、同時に該多孔性基部構造体を該フィルムに積層するのに十分な圧力及び温度を該多孔性基部構造体及び該ポリマーフィルムに加えることと、該成形接着構造体を該成形型から取り出すことと、を含む、接着構造体の製造プロセスを目的とする。
一実施形態において、活性薬剤は、ゲンタマイシン又はＺＥＶＴＥＲＡ（商標）（セフトビプロールメドカリル）ブランドの抗生物質（スイス国バーゼル（Basel）のバシリアファーマシューティカ社（Basilea Pharmaceutica Ltd.）から入手可能）のような薬剤を含めた抗生物質であってもよい。一実施形態では、接着構造体は、オクテニジン、オクテニジン二塩酸塩（Ｏｃｔｅｎｉｓｅｐｔ（登録商標）消毒薬（Ｓｃｈｕｌｋｅ ＆ Ｍａｙｒ（Ｎｏｒｄｅｒｓｔｅｄｔ，Ｇｅｒｍａｎｙ））の活性成分として入手可能）、ポリヘキサメチレンビグアニド（ＰＨＭＢ）（Ｂｒａｕｎ（Ｓｗｉｔｚｅｒｌａｎｄ）からＬａｖａｓｅｐｔ（登録商標）の活性成分として入手可能）、トリクロサン、銅（Ｃｕ）、銀（Ａｇ）、ナノ銀、金（Ａｕ）、セレン（Ｓｅ）、ガリウム（Ｇａ）、タウロリジン、Ｎ−クロロタウリン、Ｌｉｓｔｅｒｉｎｅ（登録商標）口腔洗浄薬などのアルコール系防腐薬、Ｎ−ラウリル−Ｌ−アルギニンエチルエステル（ＬＡＥ）、ミリスタミドプロピルジメチルアミン（ＭＡＰＤ、ＳＣＨＥＲＣＯＤＩＮＥ（商標）Ｍの活性成分として入手可能）、オレアミドプロピルジメチルアミン（ＯＡＰＤ、ＳＣＨＥＲＣＯＤＩＮＥ（商標）Ｏの活性成分として入手可能）、及び、ステアラミドプロピルジメチルアミン（ＳＡＰＤ、ＳＣＨＥＲＣＯＤＩＮＥ（商標）Ｓの活性成分として入手可能）など、（体液の存在下でも）種々の細菌及び酵母に対して使用される広域抗菌薬を含んでよい。一実施形態において、薬剤はオクテニジン二塩酸塩（以下、オクテニジンと呼ぶ）及び／又はＰＨＭＢであってもよい。活性薬剤は、薬剤の放出時間を調節するために、生体吸収性コーティングポリマーと共に適用されてもよい。
本発明の接着構造体は、平面状表面の下方に延びる角錐状先端部を有する複数の方形直方体基部のくぼみを有する成形型を準備することと、該成形型に溶融加工可能なポリマーを適用することと、該くぼみ及び該平面状表面を充填するために平面状表面と、該平面状表面の下方に延びる角錐状先端部を有する方形直方体基部の突起と、を有する、第１の成形接着構造体を形成することと、該成形接着構造体を該成形型から取り出すことと、によって形成できる。
（１１） 平面状表面の下方に延びる角錐状先端部を有する複数の方形直方体基部のくぼみを有する成形型を準備することと、
該成形型に溶融加工可能なポリマーフィルムを適用することと、
該ポリマーフィルムの一部を該くぼみに押し込むのに十分な圧力及び温度を、該フィルムに加え、平面状表面と、該平面状表面の下方に延びる角錐状先端部を有する方形直方体基部の突起と、を有する、第１の成形接着構造体を形成することと、
該成形接着構造体を該成形型から取り出すことと、を含む、接着構造体の製造プロセス。
（１２） 前記ポリマーを前記くぼみに流入させて充填すると同時に、多孔性基部構造体を前記第１の成形接着構造体に積層するように、前記温度及び圧力を加えることの前に、前記ポリマーフィルム上に前記多孔性基部構造体を適用すること、を更に含む、実施態様１１に記載のプロセス。
（１３） 前記第１の成形接着構造体を前記成形型から取り出すことの前に、多孔性基部構造体を前記くぼみの反対側の前記平面状表面に積層すること、を更に含む、実施態様１１に記載のプロセス。
（１４） 前記第１の成形接着構造体と実質的に同一の第２の成形接着構造体を作製することと、前記第１の接着構造体を該第２の接着構造体に積層することであって、積層することは、それぞれの成形型から積層された構造体を取り出すことの前に行われる、ことと、を更に含む、実施態様１１〜１３のいずれかに記載のプロセス。
（１５） 前記第１の成形接着構造体と異なる第２の成形接着構造体を作製することと、前記第１の接着構造体を該第２の接着構造体に積層することであって、積層することは、それぞれの成形型から積層された構造体を取り出すことの前に行われる、ことと、を更に含む、実施態様１１〜１３のいずれかに記載のプロセス。
該成形型に溶融加工可能なポリマーフィルムを適用することと、
該ポリマーフィルムの一部を該くぼみに押し込むのに十分な圧力及び温度を、該フィルムに加え、平面状表面と、該平面状表面の下方に延びる角錐状先端部を有する方形直方体基部の突起と、を有する、第１の成形接着構造体を形成することと、
該成形接着構造体を該成形型から取り出すことと、を含む、接着構造体の製造プロセス。
（１２） 前記ポリマーを前記くぼみに流入させて充填すると同時に、多孔性基部構造体を前記第１の成形接着構造体に積層するように、前記温度及び圧力を加えることの前に、前記ポリマーフィルム上に前記多孔性基部構造体を適用すること、を更に含む、実施態様１１に記載のプロセス。
（１３） 前記第１の成形接着構造体を前記成形型から取り出すことの前に、多孔性基部構造体を前記くぼみの反対側の前記平面状表面に積層すること、を更に含む、実施態様１１に記載のプロセス。
（１４） 前記第１の成形接着構造体と実質的に同一の第２の成形接着構造体を作製することと、前記第１の接着構造体を該第２の接着構造体に積層することであって、積層することは、それぞれの成形型から積層された構造体を取り出すことの前に行われる、ことと、を更に含む、実施態様１１〜１３のいずれかに記載のプロセス。
（１５） 前記第１の成形接着構造体と異なる第２の成形接着構造体を作製することと、前記第１の接着構造体を該第２の接着構造体に積層することであって、積層することは、それぞれの成形型から積層された構造体を取り出すことの前に行われる、ことと、を更に含む、実施態様１１〜１３のいずれかに記載のプロセス。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161581545P | 2011-12-29 | 2011-12-29 | |
| US61/581,545 | 2011-12-29 | ||
| PCT/US2012/072081 WO2013102085A1 (en) | 2011-12-29 | 2012-12-28 | Adhesive structure with tissue piercing protrusions on its surface |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508310A JP2015508310A (ja) | 2015-03-19 |
| JP2015508310A5 true JP2015508310A5 (ja) | 2017-02-16 |
| JP6153945B2 JP6153945B2 (ja) | 2017-06-28 |
Family
ID=48695476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550513A Expired - Fee Related JP6153945B2 (ja) | 2011-12-29 | 2012-12-28 | 表面上に組織貫入突起を有する接着構造体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10278701B2 (ja) |
| EP (1) | EP2797607B1 (ja) |
| JP (1) | JP6153945B2 (ja) |
| CN (1) | CN104220079B (ja) |
| BR (1) | BR112014016029B1 (ja) |
| RU (1) | RU2635453C2 (ja) |
| WO (1) | WO2013102085A1 (ja) |
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| US9492952B2 (en) | 2010-08-30 | 2016-11-15 | Endo-Surgery, Inc. | Super-hydrophilic structures |
| US20120143228A1 (en) | 2010-08-30 | 2012-06-07 | Agency For Science Technology And Research | Adhesive structure with stiff protrusions on adhesive surface |
| BR112014016029B1 (pt) | 2011-12-29 | 2020-05-19 | Agency Science Tech & Res | estrutura adesiva e processo para produzir uma estrutura adesiva |
| US8926881B2 (en) | 2012-04-06 | 2015-01-06 | DePuy Synthes Products, LLC | Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them |
| US8969648B2 (en) | 2012-04-06 | 2015-03-03 | Ethicon, Inc. | Blood clotting substrate and medical device |
| DE102013004574A1 (de) * | 2013-03-11 | 2014-09-11 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat |
| DE102013014295A1 (de) * | 2013-08-22 | 2015-02-26 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat |
| RU2699811C1 (ru) * | 2014-03-07 | 2019-09-11 | Айконлаб Инк. | Многоцелевой имплантат с заданной структурой поверхности для реконструкции мягких тканей |
| JP6308851B2 (ja) * | 2014-04-11 | 2018-04-11 | 三井化学株式会社 | 樹脂シート及びその製造方法 |
| US10856992B2 (en) * | 2016-04-27 | 2020-12-08 | AOD Holdings, LLC | Implant device(s) including tapered protrusions and method(s) for inserting the same into bone |
| WO2019006013A1 (en) * | 2017-06-28 | 2019-01-03 | The Regents Of The University Of California | MEDICAL IMPLANTS HAVING ENHANCED ROUGHNESS |
| CA3095118A1 (en) | 2018-03-26 | 2019-10-03 | DePuy Synthes Products, Inc. | Three-dimensional porous structures for bone ingrowth and methods for producing |
| RU2020135532A (ru) | 2018-03-30 | 2022-05-04 | Депуи Синтез Продактс, Инк. | Текстуры поверхности трехмерных пористых структур для врастания кости и способы их изготовления |
| RU2020135533A (ru) | 2018-03-30 | 2022-05-05 | Депуи Синтез Продактс, Инк. | Комбинированные фиксирующие элементы трехмерных пористых структур для врастания кости и способы их изготовления |
| CA3155565A1 (en) | 2019-09-25 | 2021-04-01 | Depuy Ireland Unlimited Company | Three-dimensional porous structures for bone ingrowth and methods for producing |
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