JP2015508082A5 - - Google Patents
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- Publication number
- JP2015508082A5 JP2015508082A5 JP2014557951A JP2014557951A JP2015508082A5 JP 2015508082 A5 JP2015508082 A5 JP 2015508082A5 JP 2014557951 A JP2014557951 A JP 2014557951A JP 2014557951 A JP2014557951 A JP 2014557951A JP 2015508082 A5 JP2015508082 A5 JP 2015508082A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- oral dosage
- release oral
- release
- stage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006186 oral dosage form Substances 0.000 claims 37
- 239000002207 metabolite Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 16
- 239000000651 prodrug Substances 0.000 claims 16
- 229940002612 prodrug Drugs 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 15
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 14
- HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 claims 11
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 10
- 230000003111 delayed effect Effects 0.000 claims 9
- 206010047700 Vomiting Diseases 0.000 claims 8
- 239000002552 dosage form Substances 0.000 claims 8
- 229960005178 doxylamine Drugs 0.000 claims 8
- 208000024891 symptom Diseases 0.000 claims 8
- 235000008160 pyridoxine Nutrition 0.000 claims 7
- 239000011677 pyridoxine Substances 0.000 claims 7
- 229940011671 vitamin b6 Drugs 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 230000035935 pregnancy Effects 0.000 claims 4
- KBAUFVUYFNWQFM-UHFFFAOYSA-N Doxylamine succinate Chemical group OC(=O)CCC(O)=O.C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 KBAUFVUYFNWQFM-UHFFFAOYSA-N 0.000 claims 3
- 229960005008 doxylamine succinate Drugs 0.000 claims 3
- 235000020937 fasting conditions Nutrition 0.000 claims 3
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims 3
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims 3
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims 3
- 150000003227 pyridoxines Chemical class 0.000 claims 3
- AEDORKVKMIVLBW-BLDDREHASA-N 3-oxo-3-[[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methoxy]oxan-2-yl]methoxy]propanoic acid Chemical compound OCC1=C(O)C(C)=NC=C1CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(=O)CC(O)=O)O1 AEDORKVKMIVLBW-BLDDREHASA-N 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical group Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261601754P | 2012-02-22 | 2012-02-22 | |
| US61/601,754 | 2012-02-22 | ||
| PCT/CA2013/050125 WO2013123595A1 (en) | 2012-02-22 | 2013-02-18 | Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016004380A Division JP2016053092A (ja) | 2012-02-22 | 2016-01-13 | ドキシラミンおよびピリドキシン、ならびに／またはその代謝物もしくは塩の製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508082A JP2015508082A (ja) | 2015-03-16 |
| JP2015508082A5 true JP2015508082A5 (enExample) | 2015-04-23 |
| JP5914701B2 JP5914701B2 (ja) | 2016-05-11 |
Family
ID=49004884
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014557951A Active JP5914701B2 (ja) | 2012-02-22 | 2013-02-18 | ドキシラミンおよびピリドキシン、ならびに／またはその代謝物もしくは塩の製剤 |
| JP2016004380A Pending JP2016053092A (ja) | 2012-02-22 | 2016-01-13 | ドキシラミンおよびピリドキシン、ならびに／またはその代謝物もしくは塩の製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016004380A Pending JP2016053092A (ja) | 2012-02-22 | 2016-01-13 | ドキシラミンおよびピリドキシン、ならびに／またはその代謝物もしくは塩の製剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9089489B2 (enExample) |
| EP (2) | EP2787971A4 (enExample) |
| JP (2) | JP5914701B2 (enExample) |
| KR (1) | KR101588259B1 (enExample) |
| CN (1) | CN104136004B (enExample) |
| AR (2) | AR090126A1 (enExample) |
| AU (1) | AU2013224598B2 (enExample) |
| BR (1) | BR112014020186A8 (enExample) |
| CA (1) | CA2848798C (enExample) |
| CL (1) | CL2014001828A1 (enExample) |
| CY (1) | CY1123122T1 (enExample) |
| DK (1) | DK3326611T3 (enExample) |
| ES (1) | ES2809713T3 (enExample) |
| HK (1) | HK1197035A1 (enExample) |
| HU (1) | HUE052301T2 (enExample) |
| IL (1) | IL233644A (enExample) |
| LT (1) | LT3326611T (enExample) |
| MX (1) | MX355912B (enExample) |
| NZ (1) | NZ627593A (enExample) |
| PL (1) | PL3326611T3 (enExample) |
| PT (1) | PT3326611T (enExample) |
| SG (1) | SG11201403931YA (enExample) |
| TW (1) | TWI638657B (enExample) |
| UY (1) | UY34631A (enExample) |
| WO (1) | WO2013123595A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014020186A8 (pt) | 2012-02-22 | 2017-07-11 | Duchesnay Inc | Formulação de doxilamina e piridoxina e/ou seus metabólitos ou sais |
| US9452181B2 (en) | 2013-07-22 | 2016-09-27 | Duchesnay Inc. | Composition for the management of nausea and vomiting |
| EP3024466B1 (en) | 2013-07-22 | 2018-04-04 | Duchesnay Inc. | Composition for the management of nausea and vomiting |
| CN103432126A (zh) * | 2013-08-05 | 2013-12-11 | 北京阜康仁生物制药科技有限公司 | 一种治疗孕吐的药物组合物 |
| JP6272561B2 (ja) * | 2014-08-29 | 2018-01-31 | デュシネイ・インコーポレイテッド | ドキシラミン並びにピリドキシン及び／またはそれらの代謝産物もしくは塩の多峰性放出製剤 |
| CA2995431A1 (en) | 2015-08-17 | 2017-02-23 | Aequus Pharmaceuticals Inc. | Transdermal delivery of doxylamine succinate and pyridoxine hydrochloride |
| WO2019076966A1 (en) | 2017-10-17 | 2019-04-25 | Synthon B.V. | TABLETS COMPRISING TAMSULOSIN AND SOLIFENACIN |
| RS61368B1 (sr) * | 2018-09-27 | 2021-02-26 | Inibsa Ginecologia S A | Postupak za pripremu višejediničnog oralnog doznog oblika sa modifikovanim oslobađanjem doksilamin sukcinata i piridoksin hidrohlorida |
| AR121619A1 (es) * | 2020-03-25 | 2022-06-22 | Inibsa Ginecologia S A | Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparación |
| WO2022254277A1 (en) * | 2021-05-31 | 2022-12-08 | Maneesh Pharmaceuticals Ltd | Extended release composition and its process for the preparation |
| AU2021225255B1 (en) * | 2021-09-03 | 2022-06-16 | Patel, Mihir MR | Compositions, kits, and methods to provide synergistic and/or additive effects from comprised ingredients for the prevention, treatment and management of nausea and vomiting. |
| EP4565232A1 (en) * | 2023-03-01 | 2025-06-11 | Akums Drugs And Pharmaceuticals Limited | A stable tablet-in-tablet composition for nausea vomiting in pregnancy |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8518301D0 (en) | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
| GB8524001D0 (en) | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
| US4842867A (en) | 1986-05-09 | 1989-06-27 | Alza Corporation | Pulsed drug delivery of doxylamine |
| IT1201136B (it) | 1987-01-13 | 1989-01-27 | Resa Farma | Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive |
| US5110597A (en) | 1987-06-25 | 1992-05-05 | Alza Corporation | Multi-unit delivery system |
| US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| US5387421A (en) | 1991-01-31 | 1995-02-07 | Tsrl, Inc. | Multi stage drug delivery system |
| NZ286242A (en) | 1991-03-26 | 1997-11-24 | Csl Ltd | Use of veterinary implant as a single dose vaccination system: rupturable polymer film coating around core of active agent and water soluble excipient |
| US5260068A (en) | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
| US5260069A (en) | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| DE19716732C2 (de) | 1997-03-07 | 1999-03-25 | Max Delbrueck Centrum | Spezifische Magnetosomen, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| US7744916B2 (en) | 1997-06-11 | 2010-06-29 | Umd, Inc. | Coated vaginal device for delivery of anti-migraine and anti-nausea drugs |
| FR2772615B1 (fr) | 1997-12-23 | 2002-06-14 | Lipha | Comprime multicouche pour la liberation instantanee puis prolongee de substances actives |
| US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
| EP1165054A4 (en) | 1999-04-06 | 2005-02-09 | Pharmaquest Ltd | PHARMACEUTICAL DOSAGE FORM FOR INTERMITTENT DELIVERY OF METHYLPHENIDATE |
| US6197329B1 (en) * | 1999-05-03 | 2001-03-06 | Drugtech Corporation | Anti-nausea compositions and methods |
| US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
| WO2001037721A2 (en) | 1999-11-22 | 2001-05-31 | The Research Foundation Of State University Of New York | Magnetic nanoparticles for selective therapy |
| US6627223B2 (en) | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
| US6500457B1 (en) | 2000-08-14 | 2002-12-31 | Peirce Management, Llc | Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent |
| US6924273B2 (en) | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
| CA2350195C (en) * | 2000-12-20 | 2003-06-10 | Duchesnay Inc. | Rapid onset formulation of pyridoxine hydrochloride and doxylamine succinate |
| EP1372602B1 (en) | 2001-01-09 | 2007-04-18 | Microchips, Inc. | Flexible microchip devices for ophthalmic and other applications |
| US6997863B2 (en) | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US7704542B2 (en) | 2001-09-12 | 2010-04-27 | Xanodyne Pharmaceuticals, Inc. | Vitamin/mineral compositions with DHA |
| CA2392486A1 (en) | 2002-07-05 | 2002-12-08 | Duchesnay Inc. | Pharmaceutical dosage form bearing pregnancy-friendly indicia |
| KR100725973B1 (ko) | 2002-08-16 | 2007-06-11 | 마이크로칩스 인코포레이티드 | 전열적 제거를 이용한 제어 방출 장치 및 방법 |
| GB0229725D0 (en) | 2002-12-19 | 2003-01-29 | Univ Wales Medicine | Haplotype partitioning and growth hormone SNPs |
| ATE424928T1 (de) | 2004-09-01 | 2009-03-15 | Microchips Inc | Behältervorrichtungen mit mehreren verschlüssen zur gesteuerten abgabe oder exponierung des behälterinhalts |
| GB0502475D0 (en) * | 2005-02-07 | 2005-03-16 | Sb Pharmco Inc | Novel compositions |
| US20070141147A1 (en) * | 2005-12-21 | 2007-06-21 | Auriga Laboratories, Inc. | Sequential release pharmaceutical formulations |
| US9034843B2 (en) | 2007-09-14 | 2015-05-19 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
| KR101190708B1 (ko) * | 2010-03-12 | 2012-10-12 | 주식회사 대웅제약 | 모사프리드 또는 이의 염을 포함하는 서방형 약학 조성물 |
| WO2011124953A2 (en) * | 2010-04-07 | 2011-10-13 | Lupin Limited | Controlled release pharmaceutical compositions of tapentadol |
| JP2013533241A (ja) * | 2010-06-22 | 2013-08-22 | ティダブリューアイ・ファーマシューティカルズ・インコーポレイテッド | 食物効果が減少した制御放出組成物 |
| BR112014020186A8 (pt) | 2012-02-22 | 2017-07-11 | Duchesnay Inc | Formulação de doxilamina e piridoxina e/ou seus metabólitos ou sais |
| WO2013123569A1 (en) | 2012-02-22 | 2013-08-29 | Duchesnay Inc. | Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
| US9452181B2 (en) | 2013-07-22 | 2016-09-27 | Duchesnay Inc. | Composition for the management of nausea and vomiting |
-
2013
- 2013-02-18 BR BR112014020186A patent/BR112014020186A8/pt not_active Application Discontinuation
- 2013-02-18 EP EP13751706.6A patent/EP2787971A4/en not_active Withdrawn
- 2013-02-18 LT LTEP17195445.6T patent/LT3326611T/lt unknown
- 2013-02-18 SG SG11201403931YA patent/SG11201403931YA/en unknown
- 2013-02-18 KR KR1020147025058A patent/KR101588259B1/ko active Active
- 2013-02-18 CN CN201380009335.3A patent/CN104136004B/zh active Active
- 2013-02-18 MX MX2014008594A patent/MX355912B/es active IP Right Grant
- 2013-02-18 HK HK14110576.5A patent/HK1197035A1/xx unknown
- 2013-02-18 CA CA2848798A patent/CA2848798C/en active Active
- 2013-02-18 EP EP17195445.6A patent/EP3326611B1/en active Active
- 2013-02-18 PL PL17195445T patent/PL3326611T3/pl unknown
- 2013-02-18 PT PT171954456T patent/PT3326611T/pt unknown
- 2013-02-18 WO PCT/CA2013/050125 patent/WO2013123595A1/en not_active Ceased
- 2013-02-18 JP JP2014557951A patent/JP5914701B2/ja active Active
- 2013-02-18 HU HUE17195445A patent/HUE052301T2/hu unknown
- 2013-02-18 NZ NZ627593A patent/NZ627593A/en unknown
- 2013-02-18 AU AU2013224598A patent/AU2013224598B2/en active Active
- 2013-02-18 ES ES17195445T patent/ES2809713T3/es active Active
- 2013-02-18 DK DK17195445.6T patent/DK3326611T3/da active
- 2013-02-21 TW TW102106004A patent/TWI638657B/zh active
- 2013-02-21 UY UY0001034631A patent/UY34631A/es active IP Right Grant
- 2013-02-22 AR ARP130100543A patent/AR090126A1/es not_active Application Discontinuation
-
2014
- 2014-03-27 US US14/228,228 patent/US9089489B2/en active Active
- 2014-07-10 CL CL2014001828A patent/CL2014001828A1/es unknown
- 2014-07-14 IL IL233644A patent/IL233644A/en active IP Right Grant
-
2015
- 2015-06-22 US US14/746,635 patent/US9375404B2/en active Active
-
2016
- 2016-01-13 JP JP2016004380A patent/JP2016053092A/ja active Pending
- 2016-05-24 US US15/163,621 patent/US9937132B2/en active Active
-
2020
- 2020-07-17 CY CY20201100652T patent/CY1123122T1/el unknown
-
2021
- 2021-06-09 AR ARP210101574A patent/AR122580A2/es not_active Application Discontinuation
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