KR101588259B1 - 독실아민 및 피리독신 및/또는 이들의 대사물질들 또는 염들의 제형물 - Google Patents

독실아민 및 피리독신 및/또는 이들의 대사물질들 또는 염들의 제형물 Download PDF

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KR101588259B1
KR101588259B1 KR1020147025058A KR20147025058A KR101588259B1 KR 101588259 B1 KR101588259 B1 KR 101588259B1 KR 1020147025058 A KR1020147025058 A KR 1020147025058A KR 20147025058 A KR20147025058 A KR 20147025058A KR 101588259 B1 KR101588259 B1 KR 101588259B1
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release
pyridoxine
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dosage form
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KR20140139496A (ko
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마농 브랑데릭
쟝-뤽 쌩-옹쥬
크리스뗄르 즈데옹
미셸르 갈로
에릭 제르베
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듀체스나이 아이엔씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020147025058A 2012-02-22 2013-02-18 독실아민 및 피리독신 및/또는 이들의 대사물질들 또는 염들의 제형물 Active KR101588259B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261601754P 2012-02-22 2012-02-22
US61/601,754 2012-02-22
PCT/CA2013/050125 WO2013123595A1 (en) 2012-02-22 2013-02-18 Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof

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Publication Number Publication Date
KR20140139496A KR20140139496A (ko) 2014-12-05
KR101588259B1 true KR101588259B1 (ko) 2016-01-25

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KR1020147025058A Active KR101588259B1 (ko) 2012-02-22 2013-02-18 독실아민 및 피리독신 및/또는 이들의 대사물질들 또는 염들의 제형물

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US (3) US9089489B2 (enExample)
EP (2) EP2787971A4 (enExample)
JP (2) JP5914701B2 (enExample)
KR (1) KR101588259B1 (enExample)
CN (1) CN104136004B (enExample)
AR (2) AR090126A1 (enExample)
AU (1) AU2013224598B2 (enExample)
BR (1) BR112014020186A8 (enExample)
CA (1) CA2848798C (enExample)
CL (1) CL2014001828A1 (enExample)
CY (1) CY1123122T1 (enExample)
DK (1) DK3326611T3 (enExample)
ES (1) ES2809713T3 (enExample)
HK (1) HK1197035A1 (enExample)
HU (1) HUE052301T2 (enExample)
IL (1) IL233644A (enExample)
LT (1) LT3326611T (enExample)
MX (1) MX355912B (enExample)
NZ (1) NZ627593A (enExample)
PL (1) PL3326611T3 (enExample)
PT (1) PT3326611T (enExample)
SG (1) SG11201403931YA (enExample)
TW (1) TWI638657B (enExample)
UY (1) UY34631A (enExample)
WO (1) WO2013123595A1 (enExample)

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JP6379194B2 (ja) 2013-07-22 2018-08-22 デュシネイ・インコーポレイテッド 悪心及び嘔吐の管理のための組成物
US9452181B2 (en) 2013-07-22 2016-09-27 Duchesnay Inc. Composition for the management of nausea and vomiting
CN103432126A (zh) * 2013-08-05 2013-12-11 北京阜康仁生物制药科技有限公司 一种治疗孕吐的药物组合物
PT3185856T (pt) * 2014-08-29 2018-10-09 Duchesnay Inc Formulação de libertação plurimodal de doxilamina e pirodoxina e/ou seus metabolitos ou sais
CA2995431A1 (en) 2015-08-17 2017-02-23 Aequus Pharmaceuticals Inc. Transdermal delivery of doxylamine succinate and pyridoxine hydrochloride
EP3697392B1 (en) 2017-10-17 2023-11-15 Synthon B.V. Tablets comprising tamsulosin and solifenacin
RS61368B1 (sr) * 2018-09-27 2021-02-26 Inibsa Ginecologia S A Postupak za pripremu višejediničnog oralnog doznog oblika sa modifikovanim oslobađanjem doksilamin sukcinata i piridoksin hidrohlorida
AR121619A1 (es) * 2020-03-25 2022-06-22 Inibsa Ginecologia S A Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparación
WO2022254277A1 (en) * 2021-05-31 2022-12-08 Maneesh Pharmaceuticals Ltd Extended release composition and its process for the preparation
AU2021225255B1 (en) * 2021-09-03 2022-06-16 Patel, Mihir MR Compositions, kits, and methods to provide synergistic and/or additive effects from comprised ingredients for the prevention, treatment and management of nausea and vomiting.
WO2024180559A1 (en) * 2023-03-01 2024-09-06 Akums Drugs & Pharmaceuticals Limited A stable tablet-in-tablet composition for nausea vomiting in pregnancy

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EP2787971A1 (en) 2014-10-15
CA2848798C (en) 2014-12-23
PL3326611T3 (pl) 2020-11-02
CY1123122T1 (el) 2021-10-29
AR122580A2 (es) 2022-09-21
HK1197035A1 (en) 2015-01-02
AU2013224598A1 (en) 2014-07-31
NZ627593A (en) 2015-12-24
TWI638657B (zh) 2018-10-21
MX355912B (es) 2018-05-04
AR090126A1 (es) 2014-10-22
LT3326611T (lt) 2020-08-25
JP5914701B2 (ja) 2016-05-11
EP3326611B1 (en) 2020-05-06
JP2015508082A (ja) 2015-03-16
AU2013224598B2 (en) 2015-09-17
IL233644A0 (en) 2014-08-31
HUE052301T2 (hu) 2021-04-28
EP2787971A4 (en) 2015-04-29
US20150366808A1 (en) 2015-12-24
CL2014001828A1 (es) 2014-11-14
SG11201403931YA (en) 2014-08-28
KR20140139496A (ko) 2014-12-05
DK3326611T3 (da) 2020-08-17
JP2016053092A (ja) 2016-04-14
BR112014020186A2 (enExample) 2017-06-20
US20160374946A1 (en) 2016-12-29
CN104136004B (zh) 2018-03-06
ES2809713T3 (es) 2021-03-05
UY34631A (es) 2013-09-30
US20140314680A1 (en) 2014-10-23
PT3326611T (pt) 2020-08-20
MX2014008594A (es) 2015-03-03
WO2013123595A1 (en) 2013-08-29
EP3326611A1 (en) 2018-05-30
US9089489B2 (en) 2015-07-28
TW201334780A (zh) 2013-09-01
CN104136004A (zh) 2014-11-05
US9375404B2 (en) 2016-06-28
CA2848798A1 (en) 2013-08-29
US9937132B2 (en) 2018-04-10
IL233644A (en) 2016-05-31
BR112014020186A8 (pt) 2017-07-11

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