JP2015506989A - ベンダムスチン製剤 - Google Patents

ベンダムスチン製剤 Download PDF

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Publication number
JP2015506989A
JP2015506989A JP2014556835A JP2014556835A JP2015506989A JP 2015506989 A JP2015506989 A JP 2015506989A JP 2014556835 A JP2014556835 A JP 2014556835A JP 2014556835 A JP2014556835 A JP 2014556835A JP 2015506989 A JP2015506989 A JP 2015506989A
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Japan
Prior art keywords
bendamustine
containing composition
long
term storage
polyethylene glycol
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Pending
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JP2014556835A
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English (en)
Japanese (ja)
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JP2015506989A5 (enExample
Inventor
アール． パレプ，ナゲッシュ
アール． パレプ，ナゲッシュ
クリストファー バクストン，フィリップ
クリストファー バクストン，フィリップ
サンダラム，シュリカンス
Original Assignee
イーグル・ファーマシューティカルズ・インコーポレーテッド
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Publication of JP2015506989A publication Critical patent/JP2015506989A/ja
Publication of JP2015506989A5 publication Critical patent/JP2015506989A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014556835A 2012-02-14 2013-02-14 ベンダムスチン製剤 Pending JP2015506989A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261598729P 2012-02-14 2012-02-14
US61/598,729 2012-02-14
PCT/US2013/026187 WO2013123227A1 (en) 2012-02-14 2013-02-14 Formulations of bendamustine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018010326A Division JP2018109005A (ja) 2012-02-14 2018-01-25 ベンダムスチン製剤

Publications (2)

Publication Number Publication Date
JP2015506989A true JP2015506989A (ja) 2015-03-05
JP2015506989A5 JP2015506989A5 (enExample) 2016-03-17

Family

ID=48946112

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014556835A Pending JP2015506989A (ja) 2012-02-14 2013-02-14 ベンダムスチン製剤
JP2018010326A Pending JP2018109005A (ja) 2012-02-14 2018-01-25 ベンダムスチン製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018010326A Pending JP2018109005A (ja) 2012-02-14 2018-01-25 ベンダムスチン製剤

Country Status (6)

Country Link
US (1) US20130210879A1 (enExample)
EP (1) EP2814487A4 (enExample)
JP (2) JP2015506989A (enExample)
CN (2) CN109157535A (enExample)
CA (1) CA2864118A1 (enExample)
WO (1) WO2013123227A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020090481A (ja) * 2018-11-27 2020-06-11 日本化薬株式会社 ベンダムスチンを含有する溶液製剤
JP2020516665A (ja) * 2017-04-13 2020-06-11 オンコノバ セラピューティクス インコーポレイテッド （ｅ）−２，６−ジアルコキシスチリル４−置換ベンジルスルホンを投与するための安定性及びバイオアベイラビリティを向上させた製剤
JP2020109066A (ja) * 2019-01-07 2020-07-16 コーアイセイ株式会社 ベンダムスチンの液体製剤

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3158991B1 (en) 2010-01-28 2021-03-17 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
ES2718902T3 (es) 2012-03-20 2019-07-05 Eagle Pharmaceuticals Inc Composición líquida destinada a ser utilizada en un método de tratamiento de condiciones en respuesta a la bendamustina en pacientes que requieren volúmenes reducidos para administración
HUE064884T2 (hu) * 2012-03-20 2024-04-28 Eagle Pharmaceuticals Inc Bendamusztin kiszerelések
US20230241218A1 (en) * 2012-07-10 2023-08-03 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
CN109953954A (zh) 2013-08-27 2019-07-02 V·沃道里斯 苯达莫司汀医药组合物
US9603930B2 (en) 2014-12-04 2017-03-28 Navinta, Llc Liquid bendamustine formulation
JP2016141734A (ja) * 2015-02-02 2016-08-08 三菱瓦斯化学株式会社 ポリアセタール樹脂組成物及び成形体
CN105726472B (zh) * 2016-03-25 2019-12-13 南京康玻斯医药科技有限公司 苯达莫司汀药剂组合物及应用
US11826466B2 (en) 2016-08-31 2023-11-28 Navinta, Llc Bendamustine solution formulations
US10905677B2 (en) 2016-08-31 2021-02-02 Navinta, Llc Bendamustine solution formulations
US11730815B2 (en) 2018-11-26 2023-08-22 Good Health, Llc Stable liquid pharmaceutical compositions comprising bendamustine
CN110123747A (zh) * 2019-04-26 2019-08-16 嘉兴市爵拓科技有限公司 苯达莫司汀的制剂
CN111166722B (zh) * 2019-12-07 2022-03-25 四川汇宇制药股份有限公司 一种注射用盐酸苯达莫司汀冻干前药液及其制备方法
CN111557904A (zh) * 2020-04-09 2020-08-21 比卡生物科技（广州）有限公司 苯达莫司汀组合物及其用途
US11707450B1 (en) 2022-03-03 2023-07-25 Slayback Pharma Llc Stable pharmaceutical compositions of bendamustine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026771A1 (ja) * 2005-08-31 2007-03-08 Ono Pharmaceutical Co., Ltd. 点滴用注射剤
WO2011094565A1 (en) * 2010-01-28 2011-08-04 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
WO2011151087A1 (en) * 2010-06-02 2011-12-08 Astellas Deutschland Gmbh Oral dosage forms of bendamustine
JP2012503666A (ja) * 2008-09-25 2012-02-09 セファロン、インク． ベンダムスチン液体製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
EP2052723A4 (en) * 2006-08-14 2010-07-28 Eisai R&D Man Co Ltd STABLE LYOPHILIZED PREPARATION
JP5721949B2 (ja) * 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
DE102007003184A1 (de) * 2007-01-22 2008-07-24 Orlowski, Michael, Dr. Verfahren zur Beladung von strukturierten Oberflächen
JP2012525387A (ja) * 2009-04-28 2012-10-22 セファロン、インク． ベンダムスチンの経口製剤
US9655898B2 (en) * 2010-07-28 2017-05-23 Eagle Pharmaceuticals, Inc. Pharmaceutical compositions containing pemetrexed having extended storage stability

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026771A1 (ja) * 2005-08-31 2007-03-08 Ono Pharmaceutical Co., Ltd. 点滴用注射剤
JP2012503666A (ja) * 2008-09-25 2012-02-09 セファロン、インク． ベンダムスチン液体製剤
WO2011094565A1 (en) * 2010-01-28 2011-08-04 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
WO2011151087A1 (en) * 2010-06-02 2011-12-08 Astellas Deutschland Gmbh Oral dosage forms of bendamustine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PHARMAZIE, vol. 49, JPN6016048674, 1994, pages 775 - 777, ISSN: 0003759681 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020516665A (ja) * 2017-04-13 2020-06-11 オンコノバ セラピューティクス インコーポレイテッド （ｅ）−２，６−ジアルコキシスチリル４−置換ベンジルスルホンを投与するための安定性及びバイオアベイラビリティを向上させた製剤
JP7202313B2 (ja) 2017-04-13 2023-01-11 オンコノバ セラピューティクス インコーポレイテッド （ｅ）－２，６－ジアルコキシスチリル４－置換ベンジルスルホンを投与するための安定性及びバイオアベイラビリティを向上させた製剤
JP2020090481A (ja) * 2018-11-27 2020-06-11 日本化薬株式会社 ベンダムスチンを含有する溶液製剤
JP2020109066A (ja) * 2019-01-07 2020-07-16 コーアイセイ株式会社 ベンダムスチンの液体製剤
JP7235288B2 (ja) 2019-01-07 2023-03-08 コーアイセイ株式会社 ベンダムスチンの液体製剤

Also Published As

Publication number Publication date
CN109157535A (zh) 2019-01-08
US20130210879A1 (en) 2013-08-15
CN104203235B (zh) 2018-11-23
EP2814487A4 (en) 2015-07-15
EP2814487A1 (en) 2014-12-24
JP2018109005A (ja) 2018-07-12
CA2864118A1 (en) 2013-08-22
WO2013123227A1 (en) 2013-08-22
CN104203235A (zh) 2014-12-10

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