JP2015506961A - Ａｌｋ１アンタゴニストおよび腎細胞癌の治療におけるその使用 - Google Patents

Ａｌｋ１アンタゴニストおよび腎細胞癌の治療におけるその使用 Download PDF

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JP2015506961A
JP2015506961A JP2014555801A JP2014555801A JP2015506961A JP 2015506961 A JP2015506961 A JP 2015506961A JP 2014555801 A JP2014555801 A JP 2014555801A JP 2014555801 A JP2014555801 A JP 2014555801A JP 2015506961 A JP2015506961 A JP 2015506961A
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alk1
rcc
polypeptide
antibody
sequence
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JP2015506961A5 (https=
Inventor
ルパル エス． バット
ルパル エス． バット
ラヴィンドラ クマール
ラヴィンドラ クマール
ジェームス ダブリュ． ミエル
ジェームス ダブリュ． ミエル
ロバート ピアサル
ロバート ピアサル
マシュー シャーマン
マシュー シャーマン
ニコラス ソルバン
ニコラス ソルバン
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Beth lsrael Deaconess Medical Center
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Beth lsrael Deaconess Medical Center
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
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JP2014555801A 2012-02-02 2013-02-01 Ａｌｋ１アンタゴニストおよび腎細胞癌の治療におけるその使用 Pending JP2015506961A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261593864P 2012-02-02 2012-02-02
US61/593,864 2012-02-02
US201261597124P 2012-02-09 2012-02-09
US61/597,124 2012-02-09
PCT/US2013/024510 WO2013116781A1 (en) 2012-02-02 2013-02-01 Alk1 antagonists and their uses in treating renal cell carcinoma

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JP2015506961A true JP2015506961A (ja) 2015-03-05
JP2015506961A5 JP2015506961A5 (https=) 2016-03-17

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US (1) US20130202594A1 (https=)
EP (1) EP2809335A4 (https=)
JP (1) JP2015506961A (https=)
KR (1) KR20140123558A (https=)
CN (1) CN104321070A (https=)
AU (1) AU2013214779A1 (https=)
BR (1) BR112014019151A2 (https=)
CA (1) CA2863188A1 (https=)
MX (1) MX2014009277A (https=)
RU (1) RU2633638C2 (https=)
WO (1) WO2013116781A1 (https=)

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CN104321070A (zh) 2015-01-28
EP2809335A4 (en) 2015-10-28
WO2013116781A1 (en) 2013-08-08
BR112014019151A2 (pt) 2017-06-27
US20130202594A1 (en) 2013-08-08
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