JP2015506926A5 - - Google Patents
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- JP2015506926A5 JP2015506926A5 JP2014548277A JP2014548277A JP2015506926A5 JP 2015506926 A5 JP2015506926 A5 JP 2015506926A5 JP 2014548277 A JP2014548277 A JP 2014548277A JP 2014548277 A JP2014548277 A JP 2014548277A JP 2015506926 A5 JP2015506926 A5 JP 2015506926A5
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- Japan
- Prior art keywords
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579609P | 2011-12-22 | 2011-12-22 | |
| US61/579,609 | 2011-12-22 | ||
| US201261644831P | 2012-05-09 | 2012-05-09 | |
| US61/644,831 | 2012-05-09 | ||
| PCT/IB2012/057227 WO2013093720A2 (en) | 2011-12-22 | 2012-12-12 | Anti-diabetic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506926A JP2015506926A (ja) | 2015-03-05 |
| JP2015506926A5 true JP2015506926A5 (https=) | 2016-02-04 |
| JP6165168B2 JP6165168B2 (ja) | 2017-07-19 |
Family
ID=47561699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548277A Expired - Fee Related JP6165168B2 (ja) | 2011-12-22 | 2012-12-12 | 抗糖尿病化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9163227B2 (https=) |
| EP (1) | EP2793928B1 (https=) |
| JP (1) | JP6165168B2 (https=) |
| KR (1) | KR101640697B1 (https=) |
| CN (1) | CN104066438B (https=) |
| AU (1) | AU2012356219B2 (https=) |
| BR (1) | BR112014014898A2 (https=) |
| CA (1) | CA2859969A1 (https=) |
| DK (1) | DK2793928T3 (https=) |
| ES (1) | ES2623786T3 (https=) |
| IL (1) | IL233206A (https=) |
| MX (1) | MX2014007626A (https=) |
| SG (1) | SG11201402640SA (https=) |
| TW (1) | TWI560202B (https=) |
| WO (1) | WO2013093720A2 (https=) |
| ZA (1) | ZA201403755B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524919A (zh) | 2012-05-17 | 2018-09-14 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| HK1211232A1 (en) | 2012-12-21 | 2016-05-20 | Sanofi | Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| JP7297408B2 (ja) * | 2015-02-06 | 2023-06-26 | セル アイディーエックス， インコーポレイテッド | 抗原をカップリングさせた免疫試薬 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) * | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| KR102403089B1 (ko) * | 2017-07-05 | 2022-06-02 | 바이오셀즈(베이징) 바이오테크 코., 엘티디. | 폴리펩타이드의 약학적으로 허용 가능한 염 및 이의 용도 |
| CN111491951B (zh) | 2017-12-22 | 2024-05-24 | 豪夫迈·罗氏有限公司 | 通过疏水相互作用色谱法耗尽轻链错配的抗体变体 |
| CA3104686A1 (en) * | 2018-07-03 | 2020-01-09 | Bristol-Myers Squibb Company | Fgf-21 formulations |
| CN115322794B (zh) | 2020-01-11 | 2025-09-19 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| CN111333714A (zh) * | 2020-03-05 | 2020-06-26 | 成都奥达生物科技有限公司 | 一种长效glp-1化合物 |
| AR124395A1 (es) * | 2020-12-17 | 2023-03-22 | Intarcia Therapeutics Inc | Agonistas del receptor del polipéptido tipo glucagón 1 (glp-1) de acción prolongada y métodos de uso de los mismos |
| CN112986575B (zh) * | 2020-12-29 | 2023-03-17 | 上海药明康德新药开发有限公司 | 一种串联式验证dna编码苗头化合物修饰抗体的方法 |
| TW202423476A (zh) * | 2021-03-23 | 2024-06-16 | 美商美國禮來大藥廠 | 含腸促胰島素(incretin)類似物之組合物及其用途 |
| CN117222423A (zh) * | 2021-04-30 | 2023-12-12 | 信达生物制药(苏州)有限公司 | 一种oxm3储存剂、oxm3制剂及制备方法 |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN121358769A (zh) * | 2023-05-17 | 2026-01-16 | 昂科医药 | Ph敏感性抗ctla-4抗体及其用途 |
| CN116804630B (zh) * | 2023-08-03 | 2024-03-05 | 中拓生物有限公司 | 一种血清同型半胱氨酸测定试剂盒 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5733757A (en) | 1995-12-15 | 1998-03-31 | The Scripps Research Institute | Aldolase catalytic antibody |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| US6326176B1 (en) | 1997-12-18 | 2001-12-04 | The Scripps Research Institute | Aldol condensations by catalytic antibodies |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| JP2003516121A (ja) | 1999-09-27 | 2003-05-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 不可逆的に結合するエンジニアリング抗体 |
| US6294374B1 (en) | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
| WO2001036640A2 (en) | 1999-11-18 | 2001-05-25 | Chiron Corporation | Human fgf-21 gene and gene expression products |
| WO2003011213A2 (en) | 2001-07-30 | 2003-02-13 | Eli Lilly And Company | Method for treating diabetes and obesity |
| JP2005519891A (ja) | 2002-01-15 | 2005-07-07 | イーライ・リリー・アンド・カンパニー | 危篤状態の患者における罹病率および死亡率を低下させる方法 |
| CN1890371A (zh) | 2003-12-10 | 2007-01-03 | 伊莱利利公司 | 成纤维细胞生长因子的21突变蛋白 |
| WO2005072769A1 (en) | 2004-01-26 | 2005-08-11 | Eli Lilly And Company | Use of fgf-21 and thiazolidinedione for treating type 2 diabetes |
| CA2557782A1 (en) | 2004-03-17 | 2005-10-06 | Eli Lilly And Company | Glycol linked fgf-21 compounds |
| SI1751184T1 (sl) | 2004-05-13 | 2010-01-29 | Lilly Co Eli | Fgf-21 fuzijski proteini |
| WO2006028714A1 (en) | 2004-09-02 | 2006-03-16 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| EA011390B1 (ru) | 2004-09-02 | 2009-02-27 | Эли Лилли Энд Компани | Мутантные белки (мутеины) фактора роста фибробластов 21 |
| US20080176790A1 (en) | 2004-10-29 | 2008-07-24 | Defrees Shawn | Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) |
| US7655627B2 (en) | 2004-12-14 | 2010-02-02 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| WO2006078463A2 (en) | 2005-01-21 | 2006-07-27 | Eli Lilly And Company | Method for treating cardiovascular disease |
| WO2006094269A2 (en) * | 2005-03-03 | 2006-09-08 | Covx Technologies Ireland Limited | Anti-angiogenic compounds |
| CN101287485A (zh) * | 2005-03-03 | 2008-10-15 | 爱尔兰考夫克斯科技有限公司 | 抗血管生成化合物 |
| US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| CA2682147C (en) * | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| CA2693504A1 (en) | 2007-08-03 | 2009-02-12 | Eli Lilly And Company | Treatment for obesity |
| CN101993485B (zh) * | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
| US20120148586A1 (en) * | 2009-08-27 | 2012-06-14 | Joyce Ching Tsu Chou | Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders |
-
2012
- 2012-12-12 JP JP2014548277A patent/JP6165168B2/ja not_active Expired - Fee Related
- 2012-12-12 AU AU2012356219A patent/AU2012356219B2/en not_active Ceased
- 2012-12-12 TW TW101147080A patent/TWI560202B/zh not_active IP Right Cessation
- 2012-12-12 WO PCT/IB2012/057227 patent/WO2013093720A2/en not_active Ceased
- 2012-12-12 EP EP12816137.9A patent/EP2793928B1/en not_active Not-in-force
- 2012-12-12 CN CN201280063933.4A patent/CN104066438B/zh not_active Expired - Fee Related
- 2012-12-12 US US13/712,873 patent/US9163227B2/en not_active Expired - Fee Related
- 2012-12-12 DK DK12816137.9T patent/DK2793928T3/en active
- 2012-12-12 KR KR1020147020397A patent/KR101640697B1/ko not_active Expired - Fee Related
- 2012-12-12 ES ES12816137.9T patent/ES2623786T3/es active Active
- 2012-12-12 MX MX2014007626A patent/MX2014007626A/es unknown
- 2012-12-12 BR BR112014014898-8A patent/BR112014014898A2/pt not_active IP Right Cessation
- 2012-12-12 SG SG11201402640SA patent/SG11201402640SA/en unknown
- 2012-12-12 CA CA2859969A patent/CA2859969A1/en not_active Abandoned
-
2014
- 2014-05-22 ZA ZA2014/03755A patent/ZA201403755B/en unknown
- 2014-06-17 IL IL233206A patent/IL233206A/en not_active IP Right Cessation
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