JP2015506922A5 - - Google Patents
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- Publication number
- JP2015506922A5 JP2015506922A5 JP2014547635A JP2014547635A JP2015506922A5 JP 2015506922 A5 JP2015506922 A5 JP 2015506922A5 JP 2014547635 A JP2014547635 A JP 2014547635A JP 2014547635 A JP2014547635 A JP 2014547635A JP 2015506922 A5 JP2015506922 A5 JP 2015506922A5
- Authority
- JP
- Japan
- Prior art keywords
- ophthalmic
- acid
- branched
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 23
- 125000003342 alkenyl group Chemical group 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 238000009472 formulation Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- AKEXREJPEFSHCT-UHFFFAOYSA-N 10-hydroxydecanoyl (9Z,12Z)-octadeca-9,12-dienoate Chemical compound C(CCCCCCCC=C/CC=C/CCCCC)(=O)OC(CCCCCCCCCO)=O AKEXREJPEFSHCT-UHFFFAOYSA-N 0.000 claims 2
- UEGWWOVMHDARPA-UHFFFAOYSA-N 10-hydroxydecanoyl (Z)-octadec-9-enoate Chemical compound C(CCCCCCCC=C/CCCCCCCC)(=O)OC(CCCCCCCCCO)=O UEGWWOVMHDARPA-UHFFFAOYSA-N 0.000 claims 2
- KJTGDTBDBDFAFO-UHFFFAOYSA-N 16-hydroxyhexadecanoyl (9Z,12Z)-octadeca-9,12-dienoate Chemical compound C(CCCCCCCC=C/CC=C/CCCCC)(=O)OC(CCCCCCCCCCCCCCCO)=O KJTGDTBDBDFAFO-UHFFFAOYSA-N 0.000 claims 2
- KOITVLVSMOBKGI-KTKRTIGZSA-N 16-hydroxyhexadecanoyl (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCO KOITVLVSMOBKGI-KTKRTIGZSA-N 0.000 claims 2
- UUFGOXJUPRNHBR-UHFFFAOYSA-N C(CCCCCCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCCO)=O Chemical compound C(CCCCCCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCCO)=O UUFGOXJUPRNHBR-UHFFFAOYSA-N 0.000 claims 2
- CRWBYIMWBAJWTE-UHFFFAOYSA-N C(CCCCCCCCCCCCCCCCC)OC(CCCCCCCCCO)=O Chemical compound C(CCCCCCCCCCCCCCCCC)OC(CCCCCCCCCO)=O CRWBYIMWBAJWTE-UHFFFAOYSA-N 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- GDQHLDVYOKCEEY-UHFFFAOYSA-N [(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenyl] 10-hydroxydecanoate Chemical compound C(CCCC=C/CC=C/CC=C/CC=C/CCCCC)OC(=O)CCCCCCCCCO GDQHLDVYOKCEEY-UHFFFAOYSA-N 0.000 claims 2
- AYUXZRXXCQWNOK-UHFFFAOYSA-N [(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenyl] 16-hydroxyhexadecanoate Chemical compound C(CCCC=C/CC=C/CC=C/CC=C/CCCCC)OC(CCCCCCCCCCCCCCCO)=O AYUXZRXXCQWNOK-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FBWMYSQUTZRHAT-HZJYTTRNSA-N (9z,12z)-octadeca-9,12-dienoyl chloride Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(Cl)=O FBWMYSQUTZRHAT-HZJYTTRNSA-N 0.000 claims 1
- MLQBTMWHIOYKKC-KTKRTIGZSA-N (z)-octadec-9-enoyl chloride Chemical compound CCCCCCCC\C=C/CCCCCCCC(Cl)=O MLQBTMWHIOYKKC-KTKRTIGZSA-N 0.000 claims 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- 239000004902 Softening Agent Substances 0.000 claims 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- -1 carbomer 980 Polymers 0.000 claims 1
- 229940085237 carbomer-980 Drugs 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 229950008138 carmellose Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- WTBAHSZERDXKKZ-UHFFFAOYSA-N octadecanoyl chloride Chemical compound CCCCCCCCCCCCCCCCCC(Cl)=O WTBAHSZERDXKKZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 229960004063 propylene glycol Drugs 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011905421A AU2011905421A0 (en) | 2011-12-23 | Ophthalmic Formulation | |
| AU2011905421 | 2011-12-23 | ||
| PCT/AU2012/001595 WO2013091020A2 (en) | 2011-12-23 | 2012-12-21 | Ophthalmic formulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506922A JP2015506922A (ja) | 2015-03-05 |
| JP2015506922A5 true JP2015506922A5 (enExample) | 2016-02-18 |
| JP6087374B2 JP6087374B2 (ja) | 2017-03-01 |
Family
ID=48669621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547635A Active JP6087374B2 (ja) | 2011-12-23 | 2012-12-21 | 眼科用製剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US10385003B2 (enExample) |
| EP (3) | EP2794550B1 (enExample) |
| JP (1) | JP6087374B2 (enExample) |
| KR (3) | KR102291754B1 (enExample) |
| CN (1) | CN104271548B (enExample) |
| AU (1) | AU2012318266B2 (enExample) |
| BR (1) | BR112014015430B1 (enExample) |
| CA (1) | CA2859997C (enExample) |
| CO (1) | CO7101242A2 (enExample) |
| DK (1) | DK2794550T3 (enExample) |
| ES (1) | ES2716806T3 (enExample) |
| HU (1) | HUE042760T2 (enExample) |
| MX (1) | MX364693B (enExample) |
| PL (1) | PL2794550T3 (enExample) |
| PT (1) | PT2794550T (enExample) |
| RU (1) | RU2625301C2 (enExample) |
| SI (1) | SI2794550T1 (enExample) |
| TR (1) | TR201902752T4 (enExample) |
| WO (1) | WO2013091020A2 (enExample) |
| ZA (1) | ZA201404642B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014015430B1 (pt) | 2011-12-23 | 2022-03-03 | Western Sydney University | Compostos, formulações oftálmicas e seus usos |
| WO2019005222A1 (en) * | 2017-06-29 | 2019-01-03 | Advaite LLC. | TREATMENT AND DIAGNOSIS OF OCULAR SURFACE DISORDERS |
| NO345574B1 (en) * | 2018-06-19 | 2021-04-26 | Epax Norway As | Composition for treatment of dry eye disease and meibomianitis |
| EP4329730A2 (en) * | 2021-04-30 | 2024-03-06 | Helsingin Yliopisto | A specific combination of lipids and methods and uses related thereto |
| CN115607534A (zh) * | 2021-07-16 | 2023-01-17 | 云南拜奥泰克生物技术有限责任公司 | 一种mlct替代睑酯油及其制备方法 |
| FI20225982A1 (en) * | 2022-11-02 | 2024-05-03 | Univ Helsinki | New formulations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2855047B1 (fr) * | 2003-05-19 | 2007-11-30 | Oreal | Composition comprenant une base sphingoide, un activateur de la voie des 4-et/ou des 6-hydroxylases et un acide gras, utilisation pour renforcer la fonction barriere de la peau |
| US8455016B2 (en) * | 2004-03-12 | 2013-06-04 | Melbj Holdings, Llc | Treatment for meibomian gland dysfunction or obstruction |
| US8569367B2 (en) * | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| US20080312194A1 (en) * | 2007-02-28 | 2008-12-18 | Ousler Iii George W | Methods and compositions for normalizing meibomian gland secretions |
| IT1393419B1 (it) | 2009-03-19 | 2012-04-20 | Medivis S R L | Composizioni oftalmiche a base di acidi grassi polinsaturi omega-3 e omega-6. |
| BR112014015430B1 (pt) * | 2011-12-23 | 2022-03-03 | Western Sydney University | Compostos, formulações oftálmicas e seus usos |
-
2012
- 2012-12-21 BR BR112014015430-9A patent/BR112014015430B1/pt active IP Right Grant
- 2012-12-21 KR KR1020207004568A patent/KR102291754B1/ko active Active
- 2012-12-21 CA CA2859997A patent/CA2859997C/en active Active
- 2012-12-21 WO PCT/AU2012/001595 patent/WO2013091020A2/en not_active Ceased
- 2012-12-21 AU AU2012318266A patent/AU2012318266B2/en active Active
- 2012-12-21 ES ES12860686T patent/ES2716806T3/es active Active
- 2012-12-21 MX MX2014007629A patent/MX364693B/es active IP Right Grant
- 2012-12-21 KR KR1020217025498A patent/KR20210104916A/ko not_active Ceased
- 2012-12-21 EP EP12860686.0A patent/EP2794550B1/en active Active
- 2012-12-21 EP EP24203699.4A patent/EP4494707A3/en active Pending
- 2012-12-21 DK DK12860686.0T patent/DK2794550T3/en active
- 2012-12-21 PL PL12860686T patent/PL2794550T3/pl unknown
- 2012-12-21 KR KR1020147020528A patent/KR102080951B1/ko active Active
- 2012-12-21 TR TR2019/02752T patent/TR201902752T4/tr unknown
- 2012-12-21 PT PT12860686T patent/PT2794550T/pt unknown
- 2012-12-21 EP EP18187476.9A patent/EP3459929A1/en not_active Withdrawn
- 2012-12-21 CN CN201280069966.XA patent/CN104271548B/zh active Active
- 2012-12-21 HU HUE12860686A patent/HUE042760T2/hu unknown
- 2012-12-21 US US14/367,836 patent/US10385003B2/en active Active
- 2012-12-21 SI SI201231543T patent/SI2794550T1/sl unknown
- 2012-12-21 JP JP2014547635A patent/JP6087374B2/ja active Active
- 2012-12-21 RU RU2014129437A patent/RU2625301C2/ru active
-
2014
- 2014-06-24 ZA ZA2014/04642A patent/ZA201404642B/en unknown
- 2014-07-22 CO CO14158909A patent/CO7101242A2/es unknown
-
2019
- 2019-07-18 US US16/515,387 patent/US20200190015A1/en not_active Abandoned
-
2021
- 2021-05-12 US US17/318,581 patent/US20210403410A1/en not_active Abandoned
-
2024
- 2024-03-18 US US18/608,522 patent/US20240368069A1/en not_active Abandoned
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