JP2018504391A5 - - Google Patents
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- Publication number
- JP2018504391A5 JP2018504391A5 JP2017533825A JP2017533825A JP2018504391A5 JP 2018504391 A5 JP2018504391 A5 JP 2018504391A5 JP 2017533825 A JP2017533825 A JP 2017533825A JP 2017533825 A JP2017533825 A JP 2017533825A JP 2018504391 A5 JP2018504391 A5 JP 2018504391A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- och
- foregoing
- solvate
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000012453 solvate Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims 1
- 229940127450 Opioid Agonists Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 102000048260 kappa Opioid Receptors Human genes 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 108020001588 κ-opioid receptors Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3872/DEL/2014 | 2014-12-23 | ||
| IN3872DE2014 | 2014-12-23 | ||
| PCT/US2015/066725 WO2016106133A1 (en) | 2014-12-23 | 2015-12-18 | N-methyl-n-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the kappa opioid receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504391A JP2018504391A (ja) | 2018-02-15 |
| JP2018504391A5 true JP2018504391A5 (enExample) | 2019-01-24 |
| JP6665189B2 JP6665189B2 (ja) | 2020-03-13 |
Family
ID=55236907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533825A Expired - Fee Related JP6665189B2 (ja) | 2014-12-23 | 2015-12-18 | κオピオイド受容体に対するＮ−メチル−Ｎ−（１−フェニル−２−（１−ピロリジニル）エチル）−２−アミノフェニルアセトアミド誘導体作動薬 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10322107B2 (enExample) |
| EP (1) | EP3237388B1 (enExample) |
| JP (1) | JP6665189B2 (enExample) |
| WO (1) | WO2016106133A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9815824B2 (en) * | 2013-06-28 | 2017-11-14 | Nektar Therapeutics | Kappa opioid agonists and uses thereof |
| WO2016106133A1 (en) | 2014-12-23 | 2016-06-30 | Nektar Therapeutics | N-methyl-n-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the kappa opioid receptor |
| US20230095235A1 (en) * | 2020-03-11 | 2023-03-30 | Purdue Pharma L.P. | Compositions and methods for naloxone delivery |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
| US5232978A (en) | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
| US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| DK1694363T3 (en) | 2003-12-16 | 2014-03-24 | Nektar Therapeutics | Monodisperse PEGylated Naloxole Compositions |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| WO2014146111A2 (en) * | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Analgesic compounds and methods of use |
| US9815824B2 (en) * | 2013-06-28 | 2017-11-14 | Nektar Therapeutics | Kappa opioid agonists and uses thereof |
| WO2016106133A1 (en) | 2014-12-23 | 2016-06-30 | Nektar Therapeutics | N-methyl-n-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the kappa opioid receptor |
-
2015
- 2015-12-18 WO PCT/US2015/066725 patent/WO2016106133A1/en not_active Ceased
- 2015-12-18 JP JP2017533825A patent/JP6665189B2/ja not_active Expired - Fee Related
- 2015-12-18 US US15/539,061 patent/US10322107B2/en active Active
- 2015-12-18 EP EP15828717.7A patent/EP3237388B1/en not_active Not-in-force
-
2019
- 2019-05-14 US US16/412,096 patent/US11241415B2/en active Active