JP2015506482A5 - - Google Patents

Info

Publication number

JP2015506482A5

JP2015506482A5 JP2014555777A JP2014555777A JP2015506482A5 JP 2015506482 A5 JP2015506482 A5 JP 2015506482A5 JP 2014555777 A JP2014555777 A JP 2014555777A JP 2014555777 A JP2014555777 A JP 2014555777A JP 2015506482 A5 JP2015506482 A5 JP 2015506482A5

Authority

JP

Japan

Prior art keywords

blood

inhibitor

plasma

instrument

anticoagulant

Prior art date

2013-02-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 210000004369 blood Anatomy 0.000 claims 20
• 239000008280 blood Substances 0.000 claims 20
• 239000003112 inhibitor Substances 0.000 claims 13
• 239000003146 anticoagulant agent Substances 0.000 claims 12
• 229940127219 anticoagulant drug Drugs 0.000 claims 12
• 229940127218 antiplatelet drug Drugs 0.000 claims 12
• 239000002904 solvent Substances 0.000 claims 8
• 238000000034 method Methods 0.000 claims 6
• 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 5
• 150000003180 prostaglandins Chemical class 0.000 claims 5
• 229940122204 Cyclooxygenase inhibitor Drugs 0.000 claims 4
• 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 4
• 102000012479 Serine Proteases Human genes 0.000 claims 4
• 108010022999 Serine Proteases Proteins 0.000 claims 4
• 229960001123 epoprostenol Drugs 0.000 claims 4
• KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims 4
• 238000002955 isolation Methods 0.000 claims 4
• 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 4
• 239000002599 prostaglandin synthase inhibitor Substances 0.000 claims 4
• 229920000858 Cyclodextrin Polymers 0.000 claims 3
• 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 claims 3
• 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 claims 3
• 102000018389 Exopeptidases Human genes 0.000 claims 3
• 108010091443 Exopeptidases Proteins 0.000 claims 3
• 239000002202 Polyethylene glycol Substances 0.000 claims 3
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 3
• 229960002240 iloprost Drugs 0.000 claims 3
• HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 3
• 229920001223 polyethylene glycol Polymers 0.000 claims 3
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 3
• 239000003001 serine protease inhibitor Substances 0.000 claims 3
• 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
• 102000035195 Peptidases Human genes 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
• 229940098773 bovine serum albumin Drugs 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• -1 cyprosten Chemical compound 0.000 claims 2
• 229960002768 dipyridamole Drugs 0.000 claims 2
• IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims 2
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 2
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
• XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 2
• 230000000087 stabilizing effect Effects 0.000 claims 2
• ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 2
• GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 1
• LGIPMFCHTFFLFR-PRYZLTTQSA-N 13,14-dehydro-15-cyclohexyl Carbaprostacyclin Chemical compound C([C@@H]1[C@H]2CC(/C[C@H]2C[C@H]1O)=C/CCCC(O)=O)#CC1(O)CCCCC1 LGIPMFCHTFFLFR-PRYZLTTQSA-N 0.000 claims 1
• IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 claims 1
• RJADQDXZYFCVHV-JQMWNLLFSA-N 5-[(2s,4r,5r,6ar)-5-hydroxy-4-[(e,3s)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[b]furan-2-yl]pentanoic acid Chemical compound O1[C@@H](CCCCC(O)=O)CC2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@H]21 RJADQDXZYFCVHV-JQMWNLLFSA-N 0.000 claims 1
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
• XZFRIPGNUQRGPI-WBQKLGIQSA-N Carbaprostacyclin Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WBQKLGIQSA-N 0.000 claims 1
• 102000005927 Cysteine Proteases Human genes 0.000 claims 1
• 108010005843 Cysteine Proteases Proteins 0.000 claims 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
• 229940122601 Esterase inhibitor Drugs 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
• ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims 1
• 101710090406 Meprin A subunit alpha Proteins 0.000 claims 1
• CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 1
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 229940122055 Serine protease inhibitor Drugs 0.000 claims 1
• 101710102218 Serine protease inhibitor Proteins 0.000 claims 1
• 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
• 229960005305 adenosine Drugs 0.000 claims 1
• 229960000711 alprostadil Drugs 0.000 claims 1
• 229960002890 beraprost Drugs 0.000 claims 1
• CTPOHARTNNSRSR-APJZLKAGSA-N beraprost Chemical compound O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC(O)=O CTPOHARTNNSRSR-APJZLKAGSA-N 0.000 claims 1
• 239000000090 biomarker Substances 0.000 claims 1
• 238000004820 blood count Methods 0.000 claims 1
• 229940001468 citrate Drugs 0.000 claims 1
• 239000000701 coagulant Substances 0.000 claims 1
• 239000013078 crystal Substances 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 235000018417 cysteine Nutrition 0.000 claims 1
• 229960001259 diclofenac Drugs 0.000 claims 1
• DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 1
• XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
• 229960002986 dinoprostone Drugs 0.000 claims 1
• QLBHNVFOQLIYTH-UHFFFAOYSA-L dipotassium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical group [K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O QLBHNVFOQLIYTH-UHFFFAOYSA-L 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000002329 esterase inhibitor Substances 0.000 claims 1
• 239000011521 glass Substances 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
• 229960001680 ibuprofen Drugs 0.000 claims 1
• 229960000905 indomethacin Drugs 0.000 claims 1
• OJZYRQPMEIEQFC-UAWLTFRCSA-N limaprost Chemical compound CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(O)=O OJZYRQPMEIEQFC-UAWLTFRCSA-N 0.000 claims 1
• 229950009365 limaprost Drugs 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 229960001929 meloxicam Drugs 0.000 claims 1
• PZRHRDRVRGEVNW-UHFFFAOYSA-N milrinone Chemical compound N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C PZRHRDRVRGEVNW-UHFFFAOYSA-N 0.000 claims 1
• 229960003574 milrinone Drugs 0.000 claims 1
• 229960002009 naproxen Drugs 0.000 claims 1
• CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
• 229960002702 piroxicam Drugs 0.000 claims 1
• QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims 1
• 239000004033 plastic Substances 0.000 claims 1
• 229920003023 plastic Polymers 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 1
• 235000019833 protease Nutrition 0.000 claims 1
• 235000019419 proteases Nutrition 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 229910052708 sodium Inorganic materials 0.000 claims 1
• 239000011734 sodium Substances 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1
• 229960003676 tenidap Drugs 0.000 claims 1
• LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 claims 1
• 229960002871 tenoxicam Drugs 0.000 claims 1
• WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 claims 1
• 229960000278 theophylline Drugs 0.000 claims 1
• 230000009974 thixotropic effect Effects 0.000 claims 1
• 229950005371 zaprinast Drugs 0.000 claims 1
• REZGGXNDEMKIQB-UHFFFAOYSA-N zaprinast Chemical compound CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1 REZGGXNDEMKIQB-UHFFFAOYSA-N 0.000 claims 1