JP2015506174A - Cgrpに特異的に結合する核酸 - Google Patents

Cgrpに特異的に結合する核酸 Download PDF

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JP2015506174A
JP2015506174A JP2014551569A JP2014551569A JP2015506174A JP 2015506174 A JP2015506174 A JP 2015506174A JP 2014551569 A JP2014551569 A JP 2014551569A JP 2014551569 A JP2014551569 A JP 2014551569A JP 2015506174 A JP2015506174 A JP 2015506174A
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nucleic acid
acid molecule
cgrp
nucleotides
seq
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JP2015506174A5 (enExample
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シュルツヒェン,ジモーネ
プルシュケ,ヴェルナー
ヤロシュ,フロリアン
ヘーリッヒ,カイ
マーシュ,クリスティアン
クルースマン,スヴェン
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ノクソン・ファルマ・アクチエンゲゼルシャフト
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Priority claimed from PCT/EP2012/000089 external-priority patent/WO2012095303A1/en
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Publication of JP2015506174A publication Critical patent/JP2015506174A/ja
Publication of JP2015506174A5 publication Critical patent/JP2015506174A5/ja
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
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JP2014551569A 2012-01-10 2013-01-10 Cgrpに特異的に結合する核酸 Pending JP2015506174A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EPPCT/EP2012/000089 2012-01-10
PCT/EP2012/000089 WO2012095303A1 (en) 2011-01-10 2012-01-10 Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
EP12000105.2 2012-01-10
EP12000105 2012-01-10
PCT/EP2013/000055 WO2013104539A1 (en) 2012-01-10 2013-01-10 Nucleic acids specifically binding cgrp

Publications (2)

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JP2015506174A true JP2015506174A (ja) 2015-03-02
JP2015506174A5 JP2015506174A5 (enExample) 2016-03-03

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JP2014551569A Pending JP2015506174A (ja) 2012-01-10 2013-01-10 Cgrpに特異的に結合する核酸

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US (1) US9163243B2 (enExample)
EP (1) EP2802659A1 (enExample)
JP (1) JP2015506174A (enExample)
KR (1) KR20140111704A (enExample)
CN (1) CN104136612A (enExample)
AU (1) AU2013209130A1 (enExample)
BR (1) BR112014016939A2 (enExample)
CA (1) CA2860809A1 (enExample)
HK (1) HK1198370A1 (enExample)
IL (1) IL233515A0 (enExample)
MX (1) MX2014008456A (enExample)
RU (1) RU2014132706A (enExample)
SG (1) SG11201403769YA (enExample)
WO (1) WO2013104539A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016155994A (ja) * 2015-02-25 2016-09-01 学校法人 関西大学 ゲル素材及びその製造方法
CN108473560A (zh) * 2015-09-24 2018-08-31 泰瓦制药国际有限公司 预防、治疗和减轻(持续性)创伤后头痛
US11028161B2 (en) 2016-09-23 2021-06-08 Teva Pharmaceuticals International Gmbh Treating refractory migraine
US11555064B2 (en) 2014-03-21 2023-01-17 Teva Pharmaceuticals International Gmbh Treating headache comprising administering an antibody to calcitonin gene-related peptide

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2802660T3 (pl) 2012-01-10 2020-07-27 Aptarion Biotech Ag Nowe kwasy nukleinowe wiążące c5a
ES2607639B1 (es) 2015-09-30 2018-02-28 Urquima, S.A Sal de ácido maleico de un intermedio de silodosina
AU2019378732A1 (en) * 2018-11-12 2021-05-27 Aptarion Biotech Ag CXCL8 binding nucleic acids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060183700A1 (en) * 2002-05-06 2006-08-17 Noxxon Pharma Ag Cgrp binding nucleic acids

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5840867A (en) 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US6682886B1 (en) 1994-04-28 2004-01-27 Gilead Sciences, Inc. Bivalent binding molecules of 7 transmembrane G protein-coupled receptors
ATE265466T1 (de) 1994-08-16 2004-05-15 Human Genome Sciences Inc Calcitoninrezeptor
WO1996038579A1 (en) 1995-06-02 1996-12-05 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to growth factors
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
RU2180311C1 (ru) 2001-07-05 2002-03-10 Мешалкин Георгий Алексеевич Защитная пробка
EP1306382A1 (de) 2001-10-26 2003-05-02 Noxxon Pharma AG Modifizierte L-Nukleinsäure
ATE469164T1 (de) 2001-10-26 2010-06-15 Noxxon Pharma Ag Modifizierte l-nukleinsäure
ATE441706T1 (de) 2002-02-20 2009-09-15 Gen Hospital Corp Konjugate mit biologisch abbaubarem polymer und verwendung dafür
RU2394041C2 (ru) 2003-04-13 2010-07-10 Энзон Фармасьютикалз, Инк. Полимерные олигонуклеотидные пролекарства
GB0314472D0 (en) 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
EP1713509A2 (de) 2004-02-09 2006-10-25 Noxxon Pharma AG Verfahren zur herstellung von konjugaten aus polysacchariden und polynukleotiden
CA2940803A1 (en) 2004-03-23 2005-10-27 Ascendis Pharma Gmbh Prodrug linker
WO2006052790A2 (en) 2004-11-05 2006-05-18 The Children's Hospital Of Philadelphia Biodegradable linkers for molecular therapies
CN101217967B (zh) * 2005-05-04 2014-09-10 诺松制药股份公司 镜像异构体的新用途
AU2007296054B2 (en) 2006-09-15 2013-03-28 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
US20100062436A1 (en) 2006-10-31 2010-03-11 Noxxon Pharma Ag Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule
EP2561079A1 (en) 2010-04-21 2013-02-27 Noxxon Pharma AG Lipid binding nucleic acids
CA2824073A1 (en) * 2011-01-10 2012-07-19 Noxxon Pharma Ag Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060183700A1 (en) * 2002-05-06 2006-08-17 Noxxon Pharma Ag Cgrp binding nucleic acids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, no. 6, JPN6016038922, 1997, pages 1087 - 1096 *
NUCLEIC ACIDS RESEARCH, vol. VOl.31, No.21 e130, JPN6016038921, 2003, pages 1 - 7 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11555064B2 (en) 2014-03-21 2023-01-17 Teva Pharmaceuticals International Gmbh Treating headache comprising administering an antibody to calcitonin gene-related peptide
JP2016155994A (ja) * 2015-02-25 2016-09-01 学校法人 関西大学 ゲル素材及びその製造方法
CN108473560A (zh) * 2015-09-24 2018-08-31 泰瓦制药国际有限公司 预防、治疗和减轻(持续性)创伤后头痛
JP2018532728A (ja) * 2015-09-24 2018-11-08 テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー (持続性)外傷後頭痛の予防、治療および低減
JP2020002172A (ja) * 2015-09-24 2020-01-09 テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー (持続性)外傷後頭痛の予防、治療および低減
US11028161B2 (en) 2016-09-23 2021-06-08 Teva Pharmaceuticals International Gmbh Treating refractory migraine
US11028160B2 (en) 2016-09-23 2021-06-08 Teva Pharmaceuticals International Gmbh Treating refractory migraine
US12139528B2 (en) 2016-09-23 2024-11-12 Teva Pharmaceuticals International Gmbh Treating refractory migraine

Also Published As

Publication number Publication date
IL233515A0 (en) 2014-08-31
RU2014132706A (ru) 2016-02-27
BR112014016939A2 (pt) 2019-09-24
HK1198370A1 (en) 2015-04-10
KR20140111704A (ko) 2014-09-19
US9163243B2 (en) 2015-10-20
US20150031755A1 (en) 2015-01-29
SG11201403769YA (en) 2014-07-30
EP2802659A1 (en) 2014-11-19
MX2014008456A (es) 2014-11-25
CA2860809A1 (en) 2013-07-18
WO2013104539A1 (en) 2013-07-18
CN104136612A (zh) 2014-11-05
AU2013209130A1 (en) 2014-07-10

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