JP2015506174A5 - - Google Patents

Info

Publication number

JP2015506174A5

JP2015506174A5 JP2014551569A JP2014551569A JP2015506174A5 JP 2015506174 A5 JP2015506174 A5 JP 2015506174A5 JP 2014551569 A JP2014551569 A JP 2014551569A JP 2014551569 A JP2014551569 A JP 2014551569A JP 2015506174 A5 JP2015506174 A5 JP 2015506174A5

Authority

JP

Japan

Prior art keywords

nucleic acid

seq

acid molecule

molecule according

cgrp

Prior art date

2013-01-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108020004707 nucleic acids Proteins 0.000 claims 63
• 102000039446 nucleic acids Human genes 0.000 claims 63
• 239000002773 nucleotide Substances 0.000 claims 30
• 125000003729 nucleotide group Chemical group 0.000 claims 30
• 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims 18
• 239000000523 sample Substances 0.000 claims 15
• 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims 11
• 208000002193 Pain Diseases 0.000 claims 8
• 102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 claims 7
• 239000005557 antagonist Substances 0.000 claims 6
• 230000000694 effects Effects 0.000 claims 6
• 230000001404 mediated effect Effects 0.000 claims 6
• 239000002336 ribonucleotide Substances 0.000 claims 6
• 108091028664 Ribonucleotide Proteins 0.000 claims 5
• 239000005547 deoxyribonucleotide Substances 0.000 claims 5
• 238000001514 detection method Methods 0.000 claims 5
• 125000002652 ribonucleotide group Chemical group 0.000 claims 5
• 208000000094 Chronic Pain Diseases 0.000 claims 4
• 208000005298 acute pain Diseases 0.000 claims 4
• 230000000295 complement effect Effects 0.000 claims 4
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 239000002202 Polyethylene glycol Substances 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 229920001223 polyethylene glycol Polymers 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 206010019233 Headaches Diseases 0.000 claims 2
• 101001081479 Homo sapiens Islet amyloid polypeptide Proteins 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• 208000019695 Migraine disease Diseases 0.000 claims 2
• 230000036592 analgesia Effects 0.000 claims 2
• 230000033115 angiogenesis Effects 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 231100000869 headache Toxicity 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 206010027599 migraine Diseases 0.000 claims 2
• 229960005181 morphine Drugs 0.000 claims 2
• 201000001119 neuropathy Diseases 0.000 claims 2
• 230000007823 neuropathy Effects 0.000 claims 2
• 201000008482 osteoarthritis Diseases 0.000 claims 2
• 208000033808 peripheral neuropathy Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000004614 tumor growth Effects 0.000 claims 2
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
• 229920001612 Hydroxyethyl starch Polymers 0.000 claims 1
• 229930182558 Sterol Natural products 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000008030 elimination Effects 0.000 claims 1
• 238000003379 elimination reaction Methods 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 229940050526 hydroxyethylstarch Drugs 0.000 claims 1
• 230000014759 maintenance of location Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000012986 modification Methods 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• -1 polyoxypropylene Polymers 0.000 claims 1
• 229920001451 polypropylene glycol Polymers 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 150000003432 sterols Chemical class 0.000 claims 1
• 235000003702 sterols Nutrition 0.000 claims 1