JP2015505841A5 - - Google Patents
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- Publication number
- JP2015505841A5 JP2015505841A5 JP2014546180A JP2014546180A JP2015505841A5 JP 2015505841 A5 JP2015505841 A5 JP 2015505841A5 JP 2014546180 A JP2014546180 A JP 2014546180A JP 2014546180 A JP2014546180 A JP 2014546180A JP 2015505841 A5 JP2015505841 A5 JP 2015505841A5
- Authority
- JP
- Japan
- Prior art keywords
- difluorophenyl
- difluoro
- pyridin
- ethynyl
- tetrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1CCN(*)CC1 Chemical compound CC1CCN(*)CC1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569279P | 2011-12-11 | 2011-12-11 | |
| US61/569,279 | 2011-12-11 | ||
| US201261701370P | 2012-09-14 | 2012-09-14 | |
| US61/701,370 | 2012-09-14 | ||
| PCT/US2012/068818 WO2013090210A1 (en) | 2011-12-11 | 2012-12-10 | Metalloenzyme inhibitor compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505841A JP2015505841A (ja) | 2015-02-26 |
| JP2015505841A5 true JP2015505841A5 (https=) | 2016-01-28 |
| JP6085613B2 JP6085613B2 (ja) | 2017-02-22 |
Family
ID=48613101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546180A Expired - Fee Related JP6085613B2 (ja) | 2011-12-11 | 2012-12-10 | 金属酵素阻害薬化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9309273B2 (https=) |
| EP (2) | EP3351541A1 (https=) |
| JP (1) | JP6085613B2 (https=) |
| KR (1) | KR102070345B1 (https=) |
| CN (2) | CN107011323A (https=) |
| AU (1) | AU2012352555B2 (https=) |
| BR (1) | BR112014013963B1 (https=) |
| CA (1) | CA2858681C (https=) |
| CY (1) | CY1120246T1 (https=) |
| DK (1) | DK2788343T3 (https=) |
| EA (1) | EA025437B1 (https=) |
| ES (1) | ES2671387T3 (https=) |
| HK (1) | HK1257823A1 (https=) |
| HR (1) | HRP20180809T1 (https=) |
| HU (1) | HUE037899T2 (https=) |
| IN (1) | IN2014MN01378A (https=) |
| LT (1) | LT2788343T (https=) |
| PL (1) | PL2788343T3 (https=) |
| PT (1) | PT2788343T (https=) |
| RS (1) | RS57248B1 (https=) |
| SI (1) | SI2788343T1 (https=) |
| TR (1) | TR201807418T4 (https=) |
| WO (1) | WO2013090210A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014MN00093A (https=) * | 2011-06-19 | 2015-06-19 | Viamet Pharmaceuticals Inc | |
| EA025266B1 (ru) * | 2011-06-23 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| EP3351541A1 (en) | 2011-12-11 | 2018-07-25 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| ES2774267T3 (es) * | 2012-01-20 | 2020-07-20 | Mycovia Pharmaceuticals Inc | Compuestos inhibidores de metaloenzimas |
| US9688671B2 (en) | 2013-06-12 | 2017-06-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| JP6633539B2 (ja) | 2014-03-19 | 2020-01-22 | ダウ アグロサイエンシィズ エルエルシー | ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換−ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程 |
| CA2942972A1 (en) | 2014-03-19 | 2015-09-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antifungal compound process |
| ES2800905T3 (es) * | 2014-03-19 | 2021-01-05 | Mycovia Pharmaceuticals Inc | Procedimiento para compuesto antifúngico |
| CA2942231A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942936A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| JP6572234B2 (ja) | 2014-03-19 | 2019-09-04 | ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド | 抗真菌化合物の調製方法 |
| AU2015231226B2 (en) * | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| BR112016021257B1 (pt) | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
| JP6359940B2 (ja) * | 2014-10-14 | 2018-07-18 | 国立大学法人 名古屋工業大学 | ジフルオロメチルアセチレン化合物類及びその製造方法 |
| WO2016126726A1 (en) | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors |
| SG11201708622UA (en) | 2015-02-02 | 2017-11-29 | Forma Therapeutics Inc | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| JP6847458B2 (ja) * | 2015-09-18 | 2021-03-24 | マイコヴィア ファーマシューティカルズ，インコーポレイテッド | 抗真菌化合物のプロセス |
| CN105348324B (zh) * | 2015-12-02 | 2017-06-30 | 河南农业大学 | 含有四唑杂环的有机磷化合物及其合成方法与应用 |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| SMT202100573T1 (it) | 2016-12-22 | 2021-11-12 | Calithera Biosciences Inc | Composizioni e metodi per l'inibizione dell'attivita' dell'arginasi |
| CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
| CN107970143B (zh) * | 2017-12-27 | 2020-11-20 | 广东省微生物研究所（广东省微生物分析检测中心） | 尖孢镰刀菌a654提取物在制备美白化妆品中的应用 |
| CN110885323A (zh) * | 2019-12-02 | 2020-03-17 | 中国人民解放军第二军医大学 | 一种三氮唑醇类衍生物、其制备方法及应用 |
| WO2024067784A1 (zh) * | 2022-09-30 | 2024-04-04 | 上海济煜医药科技有限公司 | 双环类化合物的无定形、结晶固体及其制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS228931B2 (cs) * | 1981-06-06 | 1984-05-14 | Pfizer | Způsob výroby 2-(2,4-difluorfenyl)-l,3-bis(lH-l,2,4-triazol-l-yl)propan- -2-oiu |
| EP0069442B1 (en) | 1981-06-06 | 1985-02-20 | Pfizer Limited | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| GB8304282D0 (en) * | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4616036A (en) * | 1985-09-12 | 1986-10-07 | Byron Hodgin | Formulation for the control of nematodes |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| EP0431519B1 (en) | 1989-12-04 | 1994-06-15 | G.D. Searle & Co. | System for transdermal albuterol administration |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| DE69228827T2 (de) | 1991-12-18 | 1999-10-21 | Minnesota Mining And Mfg. Co., Saint Paul | Mehrschichtige sperrstrukturen |
| EP0553769B1 (de) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Ballspielschläger, insbesondere Tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| JP2004359646A (ja) | 2003-06-09 | 2004-12-24 | Ss Pharmaceut Co Ltd | 抗真菌活性を有する新規アゾール誘導体 |
| US7241800B2 (en) | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
| UA108596C2 (xx) | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| AU2011242562B2 (en) * | 2010-04-24 | 2016-10-13 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| IN2014MN00093A (https=) * | 2011-06-19 | 2015-06-19 | Viamet Pharmaceuticals Inc | |
| EA025266B1 (ru) | 2011-06-23 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| EP3351541A1 (en) | 2011-12-11 | 2018-07-25 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| JO3754B1 (ar) | 2012-06-04 | 2021-01-31 | Pharmacyclics Llc | أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون |
| US9688671B2 (en) | 2013-06-12 | 2017-06-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| RS63566B1 (sr) | 2015-03-19 | 2022-10-31 | Mycovia Pharmaceuticals Inc | Antifungalna jedinjenja i procesi izrade |
-
2012
- 2012-12-10 EP EP18158614.0A patent/EP3351541A1/en not_active Withdrawn
- 2012-12-10 CN CN201710167134.6A patent/CN107011323A/zh active Pending
- 2012-12-10 LT LTEP12858190.7T patent/LT2788343T/lt unknown
- 2012-12-10 BR BR112014013963-6A patent/BR112014013963B1/pt not_active IP Right Cessation
- 2012-12-10 CN CN201280069217.7A patent/CN104203936B/zh not_active Expired - Fee Related
- 2012-12-10 DK DK12858190.7T patent/DK2788343T3/en active
- 2012-12-10 EA EA201491151A patent/EA025437B1/ru unknown
- 2012-12-10 PL PL12858190T patent/PL2788343T3/pl unknown
- 2012-12-10 ES ES12858190.7T patent/ES2671387T3/es active Active
- 2012-12-10 JP JP2014546180A patent/JP6085613B2/ja not_active Expired - Fee Related
- 2012-12-10 AU AU2012352555A patent/AU2012352555B2/en not_active Ceased
- 2012-12-10 TR TR2018/07418T patent/TR201807418T4/tr unknown
- 2012-12-10 KR KR1020147019230A patent/KR102070345B1/ko not_active Expired - Fee Related
- 2012-12-10 CA CA2858681A patent/CA2858681C/en active Active
- 2012-12-10 WO PCT/US2012/068818 patent/WO2013090210A1/en not_active Ceased
- 2012-12-10 EP EP12858190.7A patent/EP2788343B1/en active Active
- 2012-12-10 SI SI201231309T patent/SI2788343T1/sl unknown
- 2012-12-10 PT PT128581907T patent/PT2788343T/pt unknown
- 2012-12-10 RS RS20180620A patent/RS57248B1/sr unknown
- 2012-12-10 HU HUE12858190A patent/HUE037899T2/hu unknown
- 2012-12-10 IN IN1378MUN2014 patent/IN2014MN01378A/en unknown
- 2012-12-10 US US14/364,276 patent/US9309273B2/en not_active Expired - Fee Related
- 2012-12-10 HR HRP20180809TT patent/HRP20180809T1/hr unknown
-
2016
- 2016-04-01 US US15/088,786 patent/US9938255B2/en active Active
-
2018
- 2018-04-09 US US15/948,682 patent/US10370354B2/en active Active
- 2018-05-22 CY CY20181100534T patent/CY1120246T1/el unknown
-
2019
- 2019-01-04 HK HK19100175.6A patent/HK1257823A1/en unknown
- 2019-07-31 US US16/527,132 patent/US10919874B2/en not_active Expired - Fee Related
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