JP2015503625A5 - - Google Patents
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- JP2015503625A5 JP2015503625A5 JP2014552357A JP2014552357A JP2015503625A5 JP 2015503625 A5 JP2015503625 A5 JP 2015503625A5 JP 2014552357 A JP2014552357 A JP 2014552357A JP 2014552357 A JP2014552357 A JP 2014552357A JP 2015503625 A5 JP2015503625 A5 JP 2015503625A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- alkynyl
- alkenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *C(*)=CC(N(*)c1cccc(*c2c(c(*)c(*)[n]3*)c3nc(N(*)C(C=C)=CC=C(*)N3CCN(*)CC3)n2)c1)=O Chemical compound *C(*)=CC(N(*)c1cccc(*c2c(c(*)c(*)[n]3*)c3nc(N(*)C(C=C)=CC=C(*)N3CCN(*)CC3)n2)c1)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261586718P | 2012-01-13 | 2012-01-13 | |
| US61/586,718 | 2012-01-13 | ||
| PCT/US2013/021338 WO2013106792A1 (en) | 2012-01-13 | 2013-01-12 | Heterocyclic compounds and uses as anticancer agents. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015503625A JP2015503625A (ja) | 2015-02-02 |
| JP2015503625A5 true JP2015503625A5 (https=) | 2016-03-31 |
| JP6353788B2 JP6353788B2 (ja) | 2018-07-04 |
Family
ID=47604241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014552357A Expired - Fee Related JP6353788B2 (ja) | 2012-01-13 | 2013-01-12 | 抗がん剤としての複素環式化合物およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10799504B2 (https=) |
| EP (1) | EP2802568A1 (https=) |
| JP (1) | JP6353788B2 (https=) |
| CN (2) | CN110194748A (https=) |
| AU (1) | AU2013207712B2 (https=) |
| CA (1) | CA2861010A1 (https=) |
| HK (1) | HK1203927A1 (https=) |
| WO (1) | WO2013106792A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9586965B2 (en) | 2012-01-13 | 2017-03-07 | Acea Biosciences Inc. | Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases |
| WO2013106792A1 (en) | 2012-01-13 | 2013-07-18 | Acea Biosciences Inc. | Heterocyclic compounds and uses as anticancer agents. |
| US9464089B2 (en) * | 2012-01-13 | 2016-10-11 | Acea Biosciences Inc. | Heterocyclic compounds and uses thereof |
| US9034885B2 (en) | 2012-01-13 | 2015-05-19 | Acea Biosciences Inc. | EGFR modulators and uses thereof |
| KR102173433B1 (ko) * | 2013-07-11 | 2020-11-04 | 에이시아 바이오사이언시스 인코포레이티드. | 키나아제 억제제로써의 피리미딘 유도체 |
| BR112016005199B1 (pt) | 2013-08-23 | 2022-02-22 | Neupharma, Inc | Certos compostos químicos, composições, e métodos |
| CN104418858B (zh) * | 2013-08-30 | 2018-12-11 | 浙江医药股份有限公司新昌制药厂 | 2,6-二含氮取代的嘌呤衍生物及其制备方法和其药物组合物与应用 |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| NO2718543T3 (https=) * | 2014-02-04 | 2018-01-06 | ||
| NZ629796A (en) * | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| WO2016029002A2 (en) * | 2014-08-22 | 2016-02-25 | Clovis Oncology, Inc. | Growth factor receptor inhibitors |
| KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
| JP6854762B2 (ja) | 2014-12-23 | 2021-04-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤 |
| EP3270694A4 (en) * | 2015-02-17 | 2018-09-05 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| USRE50776E1 (en) | 2015-03-27 | 2026-02-03 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| JP6889494B2 (ja) * | 2015-10-09 | 2021-06-18 | エイシア セラピューティクス， インコーポレイテッド | ピロロピリミジンキナーゼ阻害剤の薬学的塩、物理的形態、および組成物、ならびにそれらを作製する方法 |
| WO2017190637A1 (zh) * | 2016-05-06 | 2017-11-09 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白酪氨酸激酶活性的稠合嘧啶类化合物 |
| WO2018035061A1 (en) | 2016-08-15 | 2018-02-22 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| AU2017408099A1 (en) | 2017-04-07 | 2019-11-07 | ACEA Therapeutics, Inc. | Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same |
| WO2019046163A1 (en) * | 2017-08-28 | 2019-03-07 | Zhihong Chen | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND ASSOCIATED THERAPEUTIC METHODS |
| EP3810132A4 (en) | 2018-06-25 | 2022-06-22 | Dana-Farber Cancer Institute, Inc. | TAIRE FAMILY KINASE INHIBITORS AND RELATED USES |
| CN112752750B (zh) * | 2018-08-09 | 2025-11-28 | 艾森医药公司 | N-(嘧啶基苯基)-丙烯酰胺化合物的固体形式及其用途 |
| EP3613738A1 (en) * | 2018-08-23 | 2020-02-26 | Lead Discovery Center GmbH | 4-substituted pyrrolo[2,3-b]pyridine as erbb modulators useful for treating cancer |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| US12281126B2 (en) | 2018-12-28 | 2025-04-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 and uses thereof |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2024092047A1 (en) * | 2022-10-26 | 2024-05-02 | Sorrento Therapeutics, Inc. | Administration of pyrrolopyrimidine-based kinase inhibitors for treatment of psoriasis |
| WO2025155780A1 (en) * | 2024-01-17 | 2025-07-24 | Ohio State Innovation Foundation | Ttk kinase inhibitors and methods of use |
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| CA2442742A1 (en) | 2001-02-21 | 2002-08-29 | Mitsubishi Pharma Corporation | Quinazoline derivatives |
| US6881737B2 (en) | 2001-04-11 | 2005-04-19 | Amgen Inc. | Substituted triazinyl acrylamide derivatives and methods of use |
| WO2003026664A1 (en) | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
| CA2493101C (en) | 2002-07-20 | 2012-05-08 | Acea Biosciences, Inc. | Impedance based apparatuses and methods for analyzing cells and particles |
| US7468255B2 (en) | 2002-12-20 | 2008-12-23 | Acea Biosciences | Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology |
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| WO2013106792A1 (en) | 2012-01-13 | 2013-07-18 | Acea Biosciences Inc. | Heterocyclic compounds and uses as anticancer agents. |
| US9464089B2 (en) * | 2012-01-13 | 2016-10-11 | Acea Biosciences Inc. | Heterocyclic compounds and uses thereof |
| US9586965B2 (en) | 2012-01-13 | 2017-03-07 | Acea Biosciences Inc. | Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases |
| US9034885B2 (en) | 2012-01-13 | 2015-05-19 | Acea Biosciences Inc. | EGFR modulators and uses thereof |
| EP3170825B1 (en) | 2012-08-06 | 2019-04-10 | ACEA Biosciences Inc. | Novel pyrrolopyrimidine compounds as inhibitors of protein kinases |
| KR102173433B1 (ko) | 2013-07-11 | 2020-11-04 | 에이시아 바이오사이언시스 인코포레이티드. | 키나아제 억제제로써의 피리미딘 유도체 |
| CN104306348B (zh) | 2014-09-30 | 2017-05-31 | 地奥集团成都药业股份有限公司 | 一种辛伐他汀片及其制备方法 |
| JP6889494B2 (ja) | 2015-10-09 | 2021-06-18 | エイシア セラピューティクス， インコーポレイテッド | ピロロピリミジンキナーゼ阻害剤の薬学的塩、物理的形態、および組成物、ならびにそれらを作製する方法 |
| AU2017408099A1 (en) | 2017-04-07 | 2019-11-07 | ACEA Therapeutics, Inc. | Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same |
-
2013
- 2013-01-12 WO PCT/US2013/021338 patent/WO2013106792A1/en not_active Ceased
- 2013-01-12 HK HK15104284.0A patent/HK1203927A1/xx unknown
- 2013-01-12 CA CA2861010A patent/CA2861010A1/en not_active Abandoned
- 2013-01-12 US US13/740,182 patent/US10799504B2/en active Active
- 2013-01-12 CN CN201910414017.4A patent/CN110194748A/zh active Pending
- 2013-01-12 AU AU2013207712A patent/AU2013207712B2/en not_active Ceased
- 2013-01-12 CN CN201380013279.0A patent/CN104203924B/zh not_active Expired - Fee Related
- 2013-01-12 EP EP13701326.4A patent/EP2802568A1/en not_active Withdrawn
- 2013-01-12 JP JP2014552357A patent/JP6353788B2/ja not_active Expired - Fee Related
-
2017
- 2017-02-17 US US15/435,722 patent/US10596174B2/en active Active
-
2020
- 2020-08-24 US US17/001,147 patent/US11612602B2/en active Active
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