JP2015502547A5 - - Google Patents
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- Publication number
- JP2015502547A5 JP2015502547A5 JP2014547933A JP2014547933A JP2015502547A5 JP 2015502547 A5 JP2015502547 A5 JP 2015502547A5 JP 2014547933 A JP2014547933 A JP 2014547933A JP 2014547933 A JP2014547933 A JP 2014547933A JP 2015502547 A5 JP2015502547 A5 JP 2015502547A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- multispecific
- sample
- multispecific antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090001123 antibodies Proteins 0.000 claims 50
- 102000004965 antibodies Human genes 0.000 claims 50
- 239000000427 antigen Substances 0.000 claims 24
- 102000038129 antigens Human genes 0.000 claims 22
- 108091007172 antigens Proteins 0.000 claims 22
- 230000003302 anti-idiotype Effects 0.000 claims 11
- 239000000700 tracer Substances 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 4
- 108010055216 Anti-Idiotypic Antibodies Proteins 0.000 claims 2
- 101700071792 VA3 Proteins 0.000 claims 1
- 101700068531 VA5 Proteins 0.000 claims 1
- 101700009998 VA52 Proteins 0.000 claims 1
- 101700066103 VAL5 Proteins 0.000 claims 1
- 230000001809 detectable Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 101700023298 katG Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194350.2 | 2011-12-19 | ||
| EP11194350 | 2011-12-19 | ||
| PCT/EP2012/075991 WO2013092611A2 (en) | 2011-12-19 | 2012-12-18 | Method for the detection of free binding partner of a multispecific binder |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502547A JP2015502547A (ja) | 2015-01-22 |
| JP2015502547A5 true JP2015502547A5 (US20080131398A1-20080605-C00009.png) | 2016-02-04 |
| JP6203747B2 JP6203747B2 (ja) | 2017-09-27 |
Family
ID=47429825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547933A Active JP6203747B2 (ja) | 2011-12-19 | 2012-12-18 | 多特異性結合体の遊離結合パートナーの検出方法 |
Country Status (11)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| EP2810074B1 (en) | 2012-02-01 | 2017-08-23 | F. Hoffmann-La Roche AG | Method for the detection of a binding partner of a multispecific binder |
| JP6226976B2 (ja) | 2012-07-13 | 2017-11-08 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 多重特異性結合物を検出するための方法 |
| CN105683755B (zh) * | 2013-11-05 | 2019-08-13 | 豪夫迈·罗氏有限公司 | 陷阱分子和检测分子的用途及其相关试剂盒和组合物 |
| US10401368B2 (en) * | 2014-03-20 | 2019-09-03 | Pdl Biopharma, Inc. | Antibodies and methods for the detection of cell death |
| ES2761427T3 (es) | 2014-12-18 | 2020-05-19 | Hoffmann La Roche | Procedimientos para reducir interferencias |
| EP3655779A1 (en) * | 2017-07-20 | 2020-05-27 | CytomX Therapeutics, Inc. | Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof |
| CN109358192B (zh) * | 2018-02-08 | 2020-05-12 | 中国科学院上海药物研究所 | 一种去除抗药抗体检测样品中游离药物的装置和方法、该装置的制备方法及应用 |
| JP7370322B2 (ja) | 2018-06-04 | 2023-10-27 | 中外製薬株式会社 | 複合体を検出する方法 |
| CN117805397A (zh) * | 2024-02-29 | 2024-04-02 | 军科正源（北京）药物研究有限责任公司 | 检测游离vegf的方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56128722A (en) * | 1980-03-14 | 1981-10-08 | Terumo Corp | Removal of antiacetylcholinereceptor antibody and device therefor |
| US5219730A (en) | 1982-09-28 | 1993-06-15 | New York University | Idiotype-anti-idiotype immunoassay |
| US4828981A (en) | 1983-08-24 | 1989-05-09 | Synbiotics Corporation | Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents |
| EP0170302A1 (fr) | 1984-06-27 | 1986-02-05 | l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire | Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques |
| US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| WO1987002778A1 (en) | 1985-10-22 | 1987-05-07 | Cooper-Lipotech | Solid-phase liposome immunoassay system |
| IL92164A (en) | 1988-11-03 | 1996-01-19 | Igen Inc | Particle-based electrochemiluminescent test method |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| IL100866A (en) | 1991-02-06 | 1995-10-31 | Igen Inc | Luminescence test method and device based on magnetic tiny particles, containing many magnets |
| AU673190B2 (en) | 1992-07-13 | 1996-10-31 | Bionebraska, Inc. | Method for modification of recombinant polypeptides |
| GB9316369D0 (en) * | 1993-08-06 | 1993-09-22 | Surface Active Ltd | Diagnostic method |
| US6753189B1 (en) * | 1998-06-04 | 2004-06-22 | Mizuho Medy Co., Ltd. | Detection apparatus and method for the same |
| JPH11352129A (ja) * | 1998-06-04 | 1999-12-24 | Mizuho Medeii:Kk | 検出装置及び検出方法 |
| ES2256066T3 (es) * | 1999-11-16 | 2006-07-16 | Genentech, Inc. | Elisa para vegf. |
| EP1288308A1 (en) * | 2001-08-28 | 2003-03-05 | Roche Diagnostics GmbH | A method for the determination of multiple analytes |
| GB0320459D0 (en) | 2003-09-01 | 2003-10-01 | Selective Antibodies Ltd | Assay methods and materials |
| DE102004052729A1 (de) * | 2004-10-30 | 2006-05-04 | Roche Diagnostics Gmbh | Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten |
| WO2006096697A2 (en) | 2005-03-08 | 2006-09-14 | Tanox, Inc. | Methods for determining the bivalency of protein and antibody therapeutics |
| AR063125A1 (es) * | 2006-10-04 | 2008-12-30 | Genentech Inc | Ensayo elisa para la deteccion de vegf |
| EP1917854A1 (en) | 2006-11-06 | 2008-05-07 | F. Hoffmann-La Roche Ag | Method for producing anti idiotypic antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| JP5501439B2 (ja) | 2009-04-02 | 2014-05-21 | ロシュ グリクアート アクチェンゲゼルシャフト | 完全長抗体と単鎖Ｆａｂフラグメントとを含む多重特異的抗体 |
| BRPI1010297A2 (pt) | 2009-04-07 | 2017-06-06 | Roche Glycart Ag | anticorpos biespecíficos trivalentes. |
| CN102448985B (zh) | 2009-05-27 | 2015-08-05 | 霍夫曼-拉罗奇有限公司 | 三或四特异性抗体 |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| CN102207054B (zh) | 2010-03-31 | 2013-03-13 | 比亚迪股份有限公司 | 一种混合动力车的爆震控制系统及方法 |
| CN102207504A (zh) * | 2011-03-23 | 2011-10-05 | 北京华创远航科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
-
2012
- 2012-12-18 RU RU2014128510A patent/RU2633488C2/ru not_active IP Right Cessation
- 2012-12-18 CA CA2853917A patent/CA2853917A1/en not_active Abandoned
- 2012-12-18 JP JP2014547933A patent/JP6203747B2/ja active Active
- 2012-12-18 CN CN201280063032.5A patent/CN104040350B/zh active Active
- 2012-12-18 BR BR112014011535A patent/BR112014011535A2/pt not_active Application Discontinuation
- 2012-12-18 KR KR1020147016700A patent/KR20140099277A/ko not_active Application Discontinuation
- 2012-12-18 MX MX2014007095A patent/MX349003B/es active IP Right Grant
- 2012-12-18 WO PCT/EP2012/075991 patent/WO2013092611A2/en active Application Filing
- 2012-12-18 EP EP12806045.6A patent/EP2795335B1/en active Active
-
2014
- 2014-06-18 US US14/308,539 patent/US9671394B2/en active Active
-
2015
- 2015-03-09 HK HK15102356.7A patent/HK1201920A1/zh unknown
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