JP2015501642A5 - - Google Patents
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- Publication number
- JP2015501642A5 JP2015501642A5 JP2014545423A JP2014545423A JP2015501642A5 JP 2015501642 A5 JP2015501642 A5 JP 2015501642A5 JP 2014545423 A JP2014545423 A JP 2014545423A JP 2014545423 A JP2014545423 A JP 2014545423A JP 2015501642 A5 JP2015501642 A5 JP 2015501642A5
- Authority
- JP
- Japan
- Prior art keywords
- genomic dna
- promoter
- expression cassette
- dna sequence
- gapdh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 60
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 60
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 44
- 239000002773 nucleotide Substances 0.000 claims 38
- 125000003729 nucleotide group Chemical group 0.000 claims 38
- 238000011144 upstream manufacturing Methods 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 16
- 102000040430 polynucleotide Human genes 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 16
- 239000013604 expression vector Substances 0.000 claims 15
- 241000124008 Mammalia Species 0.000 claims 13
- 239000012634 fragment Substances 0.000 claims 8
- 239000003623 enhancer Substances 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 6
- 108020004999 messenger RNA Proteins 0.000 claims 6
- 230000008488 polyadenylation Effects 0.000 claims 6
- 238000013518 transcription Methods 0.000 claims 6
- 230000035897 transcription Effects 0.000 claims 6
- 101100006921 Homo sapiens NCAPD2 gene Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000002068 genetic effect Effects 0.000 claims 3
- 230000010076 replication Effects 0.000 claims 3
- 108091029430 CpG site Proteins 0.000 claims 2
- 108091034057 RNA (poly(A)) Proteins 0.000 claims 2
- 108091081024 Start codon Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101001066129 Homo sapiens Glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 102000047486 human GAPDH Human genes 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567675P | 2011-12-07 | 2011-12-07 | |
| US61/567,675 | 2011-12-07 | ||
| PCT/IB2012/056977 WO2013084157A1 (en) | 2011-12-07 | 2012-12-05 | Expression cassette |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017092184A Division JP2017200476A (ja) | 2011-12-07 | 2017-05-08 | 発現カセット |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015501642A JP2015501642A (ja) | 2015-01-19 |
| JP2015501642A5 true JP2015501642A5 (https=) | 2016-01-28 |
Family
ID=47561694
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545423A Pending JP2015501642A (ja) | 2011-12-07 | 2012-12-05 | 発現カセット |
| JP2017092184A Pending JP2017200476A (ja) | 2011-12-07 | 2017-05-08 | 発現カセット |
| JP2019124927A Active JP7096790B2 (ja) | 2011-12-07 | 2019-07-04 | 発現カセット |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017092184A Pending JP2017200476A (ja) | 2011-12-07 | 2017-05-08 | 発現カセット |
| JP2019124927A Active JP7096790B2 (ja) | 2011-12-07 | 2019-07-04 | 発現カセット |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20130344604A1 (https=) |
| EP (1) | EP2788483B1 (https=) |
| JP (3) | JP2015501642A (https=) |
| KR (1) | KR102135745B1 (https=) |
| CN (1) | CN104093834A (https=) |
| AU (2) | AU2012348558A1 (https=) |
| BR (1) | BR112014013597A2 (https=) |
| CA (1) | CA2856479A1 (https=) |
| EA (1) | EA037273B1 (https=) |
| ES (1) | ES2679291T3 (https=) |
| HK (1) | HK1202578A1 (https=) |
| IL (1) | IL232845A0 (https=) |
| MX (1) | MX362393B (https=) |
| SG (1) | SG11201402477VA (https=) |
| WO (1) | WO2013084157A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX377591B (es) * | 2014-10-15 | 2025-03-10 | Amgen Inc | Elementos promotores y reguladores para mejorar la expresión de genes heterólogos en células hospederas. |
| WO2016074016A1 (en) * | 2014-11-10 | 2016-05-19 | Murdoch Childrens Research Institute | Vectors and methods for targeted integration in loci comprising constitutively expressed genes |
| CN106868044A (zh) * | 2017-02-15 | 2017-06-20 | 扬州大学 | 一种转基因动物毛色报告基因表达盒、表达载体及应用 |
| WO2019183248A1 (en) | 2018-03-21 | 2019-09-26 | Nature Technology Corporation | Viral and non-viral nanoplasmid vectors with improved production |
| CN114540352A (zh) * | 2022-02-16 | 2022-05-27 | 艾瑞生命科学技术(常州)有限公司 | 一种多核苷酸、载体元件及表达载体和宿主细胞及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0173552B1 (en) * | 1984-08-24 | 1991-10-09 | The Upjohn Company | Recombinant dna compounds and the expression of polypeptides such as tpa |
| KR20000006334A (ko) * | 1998-06-26 | 2000-01-25 | 이선경 | 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터 |
| KR20030027947A (ko) * | 2000-08-10 | 2003-04-07 | 오노 야꾸힝 고교 가부시키가이샤 | 세포사를 유도하는 글리세릴알데히드-3-인산 탈수소효소프로모터 |
| WO2007068265A1 (en) * | 2005-12-12 | 2007-06-21 | Research Corporation Technologies, Inc. | Hybrid 3’ untranslated regions suitable for efficient protein expression in mammalian cells |
-
2012
- 2012-12-05 EP EP12816132.0A patent/EP2788483B1/en active Active
- 2012-12-05 CA CA2856479A patent/CA2856479A1/en not_active Abandoned
- 2012-12-05 SG SG11201402477VA patent/SG11201402477VA/en unknown
- 2012-12-05 HK HK15102932.0A patent/HK1202578A1/xx unknown
- 2012-12-05 US US14/003,410 patent/US20130344604A1/en not_active Abandoned
- 2012-12-05 MX MX2014006869A patent/MX362393B/es active IP Right Grant
- 2012-12-05 ES ES12816132.0T patent/ES2679291T3/es active Active
- 2012-12-05 EA EA201491034A patent/EA037273B1/ru unknown
- 2012-12-05 JP JP2014545423A patent/JP2015501642A/ja active Pending
- 2012-12-05 BR BR112014013597-5A patent/BR112014013597A2/pt not_active Application Discontinuation
- 2012-12-05 AU AU2012348558A patent/AU2012348558A1/en not_active Abandoned
- 2012-12-05 WO PCT/IB2012/056977 patent/WO2013084157A1/en not_active Ceased
- 2012-12-05 CN CN201280069001.0A patent/CN104093834A/zh active Pending
- 2012-12-05 KR KR1020147018672A patent/KR102135745B1/ko active Active
-
2014
- 2014-05-28 IL IL232845A patent/IL232845A0/en unknown
-
2017
- 2017-05-08 JP JP2017092184A patent/JP2017200476A/ja active Pending
- 2017-07-18 US US15/653,243 patent/US20180163225A1/en not_active Abandoned
-
2018
- 2018-06-18 AU AU2018204332A patent/AU2018204332B2/en active Active
-
2019
- 2019-04-29 US US16/397,006 patent/US20200087679A1/en not_active Abandoned
- 2019-07-04 JP JP2019124927A patent/JP7096790B2/ja active Active
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