|
US5420032A
(en)
|
1991-12-23 |
1995-05-30 |
Universitge Laval |
Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
|
|
US5792632A
(en)
|
1992-05-05 |
1998-08-11 |
Institut Pasteur |
Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
|
|
US6140466A
(en)
|
1994-01-18 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
|
DE69534629D1
(de)
|
1994-01-18 |
2005-12-29 |
Scripps Research Inst |
Derivate von zinkfingerproteinen und methoden
|
|
JP4285766B2
(ja)
|
1994-03-23 |
2009-06-24 |
オハイオ ユニバーシティ |
緻密にした核酸および細胞へのデリバリ
|
|
ATE524545T1
(de)
|
1994-08-20 |
2011-09-15 |
Gendaq Ltd |
Verbesserungen bei oder im zusammenhang mit bindeproteinen zur erkennung von dna
|
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
|
US5789538A
(en)
|
1995-02-03 |
1998-08-04 |
Massachusetts Institute Of Technology |
Zinc finger proteins with high affinity new DNA binding specificities
|
|
US5925523A
(en)
|
1996-08-23 |
1999-07-20 |
President & Fellows Of Harvard College |
Intraction trap assay, reagents and uses thereof
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
DE69942334D1
(de)
|
1998-03-02 |
2010-06-17 |
Massachusetts Inst Technology |
Poly-zinkfinger-proteine mit verbesserten linkern
|
|
DE69929600T2
(de)
|
1998-05-27 |
2006-09-07 |
Avigen Inc., Alameda |
Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
WO2001025255A2
(en)
|
1999-10-07 |
2001-04-12 |
Baylor College Of Medicine |
Novel zinc finger protein
|
|
CA2394850C
(en)
|
1999-12-06 |
2012-02-07 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
KR20020086508A
(ko)
|
2000-02-08 |
2002-11-18 |
상가모 바이오사이언스 인코포레이티드 |
약물 발견용 세포
|
|
US20020061512A1
(en)
|
2000-02-18 |
2002-05-23 |
Kim Jin-Soo |
Zinc finger domains and methods of identifying same
|
|
US20030044787A1
(en)
|
2000-05-16 |
2003-03-06 |
Joung J. Keith |
Methods and compositions for interaction trap assays
|
|
JP2002060786A
(ja)
|
2000-08-23 |
2002-02-26 |
Kao Corp |
硬質表面用殺菌防汚剤
|
|
AU9485101A
(en)
|
2000-09-28 |
2002-04-08 |
Sangamo Biosciences Inc |
Nuclear reprogramming using iwsi and related chromatin remodeling atpases
|
|
US20050235369A1
(en)
*
|
2001-03-28 |
2005-10-20 |
Yen Choo |
Gene regulation II
|
|
GB0108491D0
(en)
|
2001-04-04 |
2001-05-23 |
Gendaq Ltd |
Engineering zinc fingers
|
|
US7182944B2
(en)
|
2001-04-25 |
2007-02-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of increasing distribution of nucleic acids
|
|
US20040224385A1
(en)
|
2001-08-20 |
2004-11-11 |
Barbas Carlos F |
Zinc finger binding domains for cnn
|
|
AU2002359284A1
(en)
|
2001-12-17 |
2003-06-30 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor
|
|
US7074596B2
(en)
|
2002-03-25 |
2006-07-11 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthesis and use of anti-reverse mRNA cap analogues
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
US20060239966A1
(en)
|
2003-10-20 |
2006-10-26 |
Tornoee Jens |
In vivo gene therapy of parkinson's disease
|
|
PT1807009E
(pt)
|
2004-10-05 |
2015-02-25 |
Univ California |
Cânula escalonada
|
|
EP1877583A2
(en)
|
2005-05-05 |
2008-01-16 |
Arizona Board of Regents on behalf of the Unversity of Arizona |
Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences
|
|
AU2006283189B2
(en)
|
2005-08-23 |
2013-01-31 |
The Regents Of The University Of California |
Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
|
|
CA2891996A1
(en)
|
2005-10-18 |
2007-04-26 |
Duke University |
Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity
|
|
WO2007127803A2
(en)
|
2006-04-25 |
2007-11-08 |
The Regents Of The University Of California |
Administration of growth factors for the treatment of cns disorders
|
|
JP5266210B2
(ja)
|
2006-05-25 |
2013-08-21 |
サンガモ バイオサイエンシズ インコーポレイテッド |
改変開裂ハーフドメイン
|
|
US7837668B2
(en)
|
2006-10-10 |
2010-11-23 |
Ceregene, Inc. |
Needle assembly for use in delivering precise dosages of proteinaceous pharmaceutical compositions and methods for use of same
|
|
WO2008157688A2
(en)
|
2007-06-19 |
2008-12-24 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap
|
|
CA2700231C
(en)
|
2007-09-27 |
2018-09-18 |
Sangamo Biosciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
|
AU2009212247A1
(en)
|
2008-02-08 |
2009-08-13 |
Sangamo Therapeutics, Inc. |
Treatment of chronic pain with zinc finger proteins
|
|
KR101802393B1
(ko)
|
2008-06-10 |
2017-11-28 |
상가모 테라퓨틱스, 인코포레이티드 |
Ｂａｘ- 및 ｂａｋ-결함 세포주들의 제조 방법 및 조성물
|
|
SG191561A1
(en)
|
2008-08-22 |
2013-07-31 |
Sangamo Biosciences Inc |
Methods and compositions for targeted single-stranded cleavage and targeted integration
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
JP5866283B2
(ja)
|
2009-07-28 |
2016-02-17 |
サンガモ バイオサイエンシーズ， インコーポレイテッド |
トリヌクレオチド反復疾患を治療するための方法および組成物
|
|
BR112012002291A2
(pt)
|
2009-07-31 |
2016-11-29 |
Ethris Gmbh |
"polirribonucleotídeo com uma sequência que codifica uma proteína ou fragmento de proteína, implante, e, processo para a seleção de sequências de nucleotídeos"
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
EP3594333B1
(en)
|
2010-02-08 |
2023-11-01 |
Sangamo Therapeutics, Inc. |
Engineered cleavage half-domains
|
|
PT2566972T
(pt)
|
2010-05-03 |
2020-03-02 |
Sangamo Biosciences Inc |
Composições para a ligação de módulos de dedo de zinco
|
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス， インコーポレイテッド |
新規のｄｎａ結合タンパク質及びその使用
|
|
AU2012340213B2
(en)
|
2011-11-16 |
2017-12-07 |
Sangamo Therapeutics, Inc. |
Modified DNA-binding proteins and uses thereof
|
|
CN108285491B
(zh)
|
2012-02-29 |
2021-08-10 |
桑格摩生物科学股份有限公司 |
治疗亨廷顿氏病的方法和组合物
|
|
AU2014223344A1
(en)
|
2013-02-27 |
2015-10-01 |
Massachusetts Institute Of Technology |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
US9585971B2
(en)
|
2013-09-13 |
2017-03-07 |
California Institute Of Technology |
Recombinant AAV capsid protein
|
|
WO2015070212A1
(en)
|
2013-11-11 |
2015-05-14 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
MX2016007325A
(es)
|
2013-12-12 |
2017-07-19 |
Broad Inst Inc |
Composiciones y metodos de uso de sistemas crispr-cas en desordenes debidos a repeticion de nucleotidos.
|
|
CN106459894B
(zh)
|
2014-03-18 |
2020-02-18 |
桑格摩生物科学股份有限公司 |
用于调控锌指蛋白表达的方法和组合物
|
|
WO2015153760A2
(en)
|
2014-04-01 |
2015-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a nervous system disorder
|
|
RU2691102C2
(ru)
|
2014-05-08 |
2019-06-11 |
Сангамо Байосайенсиз, Инк. |
Способы и композиции для лечения болезни хантингтона
|
|
EP3152319A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
GB201418965D0
(https=)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
WO2017040813A2
(en)
|
2015-09-02 |
2017-03-09 |
University Of Massachusetts |
Detection of gene loci with crispr arrayed repeats and/or polychromatic single guide ribonucleic acids
|
|
JP2019500899A
(ja)
|
2015-11-23 |
2019-01-17 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
|
|
BR112018012894A2
(en)
|
2015-12-23 |
2018-12-04 |
Crispr Therapeutics Ag |
Materials and Methods for Treatment of Amyotrophic Lateral Sclerosis and / or Frontotemporal Lobular Degeneration
|
|
WO2018002762A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis (als) and other related disorders
|
|
MA46018A
(fr)
|
2016-08-19 |
2019-06-26 |
Bluebird Bio Inc |
Activateurs d'édition du génome
|
|
SG10201913948PA
(en)
|
2016-08-24 |
2020-03-30 |
Sangamo Therapeutics Inc |
Engineered target specific nucleases
|
|
WO2018039471A2
(en)
|
2016-08-25 |
2018-03-01 |
Trustees Of Boston University |
Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins
|
|
CN110214184B
(zh)
|
2016-12-01 |
2024-07-02 |
桑格摩生物治疗股份有限公司 |
τ蛋白调节剂以及用于其递送的方法和组合物
|
|
WO2018208972A1
(en)
|
2017-05-09 |
2018-11-15 |
University Of Massachusetts |
Methods of treating amyotrophic lateral sclerosis (als)
|
|
CA3079727A1
(en)
|
2017-10-24 |
2019-05-02 |
Sangamo Therapeutics, Inc. |
Methods and compositions for the treatment of rare diseases
|
|
MX2021012836A
(es)
*
|
2019-04-23 |
2021-12-10 |
Sangamo Therapeutics Inc |
Moduladores de la expresion del gen del marco de lectura abierto 72 del cromosoma 9 y usos de los mismos.
|