JP2015501291A5 - - Google Patents
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- JP2015501291A5 JP2015501291A5 JP2014532118A JP2014532118A JP2015501291A5 JP 2015501291 A5 JP2015501291 A5 JP 2015501291A5 JP 2014532118 A JP2014532118 A JP 2014532118A JP 2014532118 A JP2014532118 A JP 2014532118A JP 2015501291 A5 JP2015501291 A5 JP 2015501291A5
- Authority
- JP
- Japan
- Prior art keywords
- region
- antibody
- fusion protein
- protein according
- regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161539416P | 2011-09-26 | 2011-09-26 | |
| US61/539,416 | 2011-09-26 | ||
| PCT/US2012/057393 WO2013049254A1 (en) | 2011-09-26 | 2012-09-26 | Hybrid constant regions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501291A JP2015501291A (ja) | 2015-01-15 |
| JP2015501291A5 true JP2015501291A5 (cg-RX-API-DMAC7.html) | 2015-11-19 |
| JP6205363B2 JP6205363B2 (ja) | 2017-09-27 |
Family
ID=47996377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014532118A Active JP6205363B2 (ja) | 2011-09-26 | 2012-09-26 | ハイブリッド定常領域 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8952134B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2760891B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6205363B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103974977A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2849765C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013049254A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9382319B2 (en) | 2011-09-26 | 2016-07-05 | Jn Biosciences Llc | Hybrid constant regions |
| WO2013049254A1 (en) | 2011-09-26 | 2013-04-04 | Jn Biosciences Llc | Hybrid constant regions |
| CN104583239B (zh) | 2012-05-10 | 2018-09-18 | 生物蛋白有限公司 | 多特异单克隆抗体 |
| EP2880057A4 (en) * | 2012-08-02 | 2016-03-23 | Jn Biosciences Llc | MULTIMERIZED FUSION ANTIBODIES OR PROTEINS THROUGH THE MUTATION OF A CYSTEINE AND A PIECE OF TAIL |
| US20150038682A1 (en) * | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
| EP3041862B1 (en) * | 2013-09-05 | 2020-05-06 | IGM Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| CN106132994A (zh) * | 2014-03-05 | 2016-11-16 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
| UY36021A (es) * | 2014-03-05 | 2015-09-30 | Ucb Biopharma Sprl | Proteìnas fc multimèricas |
| WO2015167948A1 (en) | 2014-04-30 | 2015-11-05 | Albert Einstein College Of Medicine Of Yeshiva University | Tmigd2 and its derivatives as blockers or binders of cancer-expressed hhla2 for immunotherapies |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| IL308212A (en) * | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| CA2980751A1 (en) * | 2015-03-25 | 2016-09-29 | Stephen F. Carroll | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| CA2981183A1 (en) | 2015-04-07 | 2016-10-13 | Greg Lazar | Antigen binding complex having agonistic activity and methods of use |
| HK1245675A1 (zh) | 2015-04-17 | 2018-08-31 | Igm Biosciences, Inc. | 多价人免疫缺陷病毒抗原结合分子及其用途 |
| GB201515745D0 (en) * | 2015-09-04 | 2015-10-21 | Ucb Biopharma Sprl | Proteins |
| RU2018130525A (ru) * | 2016-01-27 | 2020-02-27 | Цсл Беринг Ленгнау Аг | РЕКОМБИНАНТНЫЕ Fc-МУЛЬТИМЕРЫ IgG |
| CA3030659A1 (en) * | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
| WO2018187702A2 (en) * | 2017-04-07 | 2018-10-11 | Igm Biosciences A/S | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function |
| IL270366B1 (en) | 2017-05-08 | 2025-09-01 | Adimab Llc | Anti-cd3-binding domains and antibodies comprising them, and methods for their generation and use |
| EP3759229A4 (en) * | 2018-02-26 | 2021-12-29 | IGM Biosciences Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| AU2019287720B2 (en) | 2018-06-14 | 2025-08-28 | Regeneron Pharmaceuticals, Inc. | CD79A chimeric antigen receptors |
| CA3103414A1 (en) | 2018-06-14 | 2019-12-19 | Bioatla, Inc. | Multi-specific antibody constructs |
| SG11202103720XA (en) * | 2018-10-23 | 2021-05-28 | Igm Biosciences Inc | MULTIVALENT IgM- AND IgA-Fc-BASED BINDING MOLECULES |
| CA3115547A1 (en) * | 2018-11-14 | 2020-05-22 | Jn Biosciences Llc | Multimeric hybrid fc proteins for replacement of ivig |
| AU2020291922A1 (en) * | 2019-06-14 | 2022-02-10 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for treating cancer |
| EP4130047A4 (en) * | 2020-02-27 | 2024-07-31 | Huahui Health Ltd. | SOLUBLE ACE2 AND FUSION PROTEIN AND THEIR USES |
| KR102450007B1 (ko) * | 2020-10-16 | 2022-10-04 | 주식회사 아이엠바이오로직스 | IgM 영역을 이용한 융합단백질 플랫폼 |
| EP4342908A4 (en) * | 2021-06-17 | 2024-10-23 | Fapon Biotech Inc. | CHIMERIC IMMUNGLOBULIN |
| EP4370541A1 (en) | 2021-07-14 | 2024-05-22 | 2seventy bio, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
| WO2023196996A2 (en) | 2022-04-08 | 2023-10-12 | 2Seventy Bio, Inc. | Multipartite receptor and signaling complexes |
| WO2024196707A2 (en) * | 2023-03-17 | 2024-09-26 | The Board Of Trustees Of The University Of Illinois | Chimeric antibody molecules based on tetrameric teleost immunoglobulin m |
| AU2024329875A1 (en) * | 2024-01-02 | 2025-07-17 | Gempharmatech Co., Ltd | Animal model generating humanized antibody and construction method thereof |
| KR20250173023A (ko) * | 2024-05-30 | 2025-12-10 | 주식회사 아이엠바이오로직스 | J 사슬에 연결되는 링커 및 이를 포함하는 j 사슬 복합체 |
| CN119638846B (zh) * | 2025-01-09 | 2025-11-04 | 康复大学青岛中心医院 | uMtCK抗体或其抗原结合片段 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8719963D0 (en) * | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
| DE10001372A1 (de) * | 2000-01-14 | 2001-08-02 | Deutsches Krebsforsch | Anti-CD3-Einzelketten-Antikörper mit humanem Cmu3- und Cmu4- Domänen |
| AU2001257445B2 (en) * | 2000-04-28 | 2006-11-02 | Planet Biotechnology, Inc. | Immunoadhesin for the prevention of rhinovirus infection |
| CN1911965B (zh) * | 2001-01-17 | 2013-05-29 | 新兴产品开发西雅图有限公司 | 结合域-免疫球蛋白融合蛋白 |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| HUP0303428A2 (hu) * | 2001-03-07 | 2004-01-28 | Merck Patent Gmbh. | Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez |
| WO2005047602A1 (en) * | 2003-11-13 | 2005-05-26 | Dsm Ip Assets B.V. | Use of a vulcanised thermoplastic elastomer or styrene-ethylene-butadiene-styrene polymer as infill material in artificial turf systems |
| CN101778867A (zh) * | 2007-06-08 | 2010-07-14 | 地中海大学 | 用于治疗胰腺肿瘤的组合物和方法 |
| WO2013049254A1 (en) | 2011-09-26 | 2013-04-04 | Jn Biosciences Llc | Hybrid constant regions |
-
2012
- 2012-09-26 WO PCT/US2012/057393 patent/WO2013049254A1/en not_active Ceased
- 2012-09-26 JP JP2014532118A patent/JP6205363B2/ja active Active
- 2012-09-26 CA CA2849765A patent/CA2849765C/en active Active
- 2012-09-26 EP EP12836751.3A patent/EP2760891B1/en active Active
- 2012-09-26 US US13/627,929 patent/US8952134B2/en active Active
- 2012-09-26 CN CN201280047037.9A patent/CN103974977A/zh active Pending
-
2014
- 2014-11-17 US US14/543,845 patent/US20150073130A1/en not_active Abandoned
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