JP2015500295A5 - - Google Patents
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- Publication number
- JP2015500295A5 JP2015500295A5 JP2014546161A JP2014546161A JP2015500295A5 JP 2015500295 A5 JP2015500295 A5 JP 2015500295A5 JP 2014546161 A JP2014546161 A JP 2014546161A JP 2014546161 A JP2014546161 A JP 2014546161A JP 2015500295 A5 JP2015500295 A5 JP 2015500295A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- infection
- alkyl
- mtb
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- OWQPOVKKUWUEKE-UHFFFAOYSA-N 1,2,3-benzotriazine Chemical group N1=NN=CC2=CC=CC=C21 OWQPOVKKUWUEKE-UHFFFAOYSA-N 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 125000003386 piperidinyl group Chemical group 0.000 claims description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 9
- 238000000034 method Methods 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 2
- GDAXJBDYNVDMDF-UHFFFAOYSA-N 1,2,4-benzotriazine Chemical compound N1=NC=NC2=CC=CC=C21 GDAXJBDYNVDMDF-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567829P | 2011-12-07 | 2011-12-07 | |
| US61/567,829 | 2011-12-07 | ||
| PCT/US2012/068636 WO2013086467A1 (en) | 2011-12-07 | 2012-12-07 | Benzotriazine oxides as drugs targeting mycobacterium tuberculosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500295A JP2015500295A (ja) | 2015-01-05 |
| JP2015500295A5 true JP2015500295A5 (enExample) | 2016-05-26 |
Family
ID=48574967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546161A Pending JP2015500295A (ja) | 2011-12-07 | 2012-12-07 | ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9663478B2 (enExample) |
| EP (1) | EP2800744A4 (enExample) |
| JP (1) | JP2015500295A (enExample) |
| CN (1) | CN104105692B (enExample) |
| WO (1) | WO2013086467A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015500295A (ja) * | 2011-12-07 | 2015-01-05 | エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ | ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類 |
| CN110862357B (zh) * | 2018-08-28 | 2021-06-08 | 浙江工业大学 | 一种苯并三嗪类化合物及其合成方法与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794742A (fr) * | 1972-02-01 | 1973-07-30 | Bayer Ag | Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition |
| US3980779A (en) * | 1972-02-01 | 1976-09-14 | Bayer Aktiengesellschaft | 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same |
| US4001410A (en) * | 1972-02-01 | 1977-01-04 | Bayer Aktiengesellschaft | 3-amino-1,2,4-benzotriazine-1,4-di-n-oxide compositions and method of using same |
| DE2255825C3 (de) * | 1972-11-15 | 1978-03-30 | Bayer Ag, 5090 Leverkusen | Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4) |
| US3991189A (en) * | 1972-11-15 | 1976-11-09 | Bayer Aktiengesellschaft | Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives |
| IL44058A (en) * | 1973-02-02 | 1978-10-31 | Ciba Geigy Ag | 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them |
| US5175287A (en) * | 1986-09-25 | 1992-12-29 | S R I International | Process for preparing 1,2,4-benzotriazine oxides |
| WO1988002366A1 (en) * | 1986-09-25 | 1988-04-07 | Sri International | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
| EP0478545B1 (en) * | 1989-09-18 | 1999-08-11 | Sri International | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
| DE4244009A1 (de) * | 1992-12-24 | 1994-06-30 | Boehringer Mannheim Gmbh | Verwendung von Benzotriazinen als PLA¶2¶-Inhibitoren, neue Benzotriazine, Verfahren zu ihrer Herstellung und Arzneimittel |
| US5484612A (en) * | 1993-09-22 | 1996-01-16 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin |
| US5672702A (en) * | 1995-12-04 | 1997-09-30 | Sanofi | Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide |
| JP2005509033A (ja) * | 2001-11-13 | 2005-04-07 | サノフィ−シンテラボ | ３−アミノ−１，２，４−ベンゾトリアジンジオキドを調製する方法 |
| NZ521436A (en) * | 2002-09-17 | 2005-07-29 | Auckland Uniservices Ltd | DNA- targeted benzotriazine 1,4-dioxides and their use in cancer therapy |
| GB0501999D0 (en) * | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| CA2603088C (en) * | 2005-03-31 | 2015-05-26 | Auckland Uniservices Limited | Tricyclic 1,2,4-triazine oxides and compositions therefrom for therapeutic use in cancer treatments |
| JP2015500295A (ja) * | 2011-12-07 | 2015-01-05 | エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ | ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類 |
-
2012
- 2012-12-07 JP JP2014546161A patent/JP2015500295A/ja active Pending
- 2012-12-07 EP EP12856224.6A patent/EP2800744A4/en not_active Withdrawn
- 2012-12-07 CN CN201280069153.0A patent/CN104105692B/zh not_active Expired - Fee Related
- 2012-12-07 WO PCT/US2012/068636 patent/WO2013086467A1/en not_active Ceased
- 2012-12-23 US US13/726,135 patent/US9663478B2/en not_active Expired - Fee Related
-
2017
- 2017-04-11 US US15/484,136 patent/US20170217908A1/en not_active Abandoned
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