JP2015198665A5 - - Google Patents
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- Publication number
- JP2015198665A5 JP2015198665A5 JP2015117465A JP2015117465A JP2015198665A5 JP 2015198665 A5 JP2015198665 A5 JP 2015198665A5 JP 2015117465 A JP2015117465 A JP 2015117465A JP 2015117465 A JP2015117465 A JP 2015117465A JP 2015198665 A5 JP2015198665 A5 JP 2015198665A5
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- cell
- seq
- nicotinamide
- nicotinamidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40225402P | 2002-08-09 | 2002-08-09 | |
| US60/402,254 | 2002-08-09 | ||
| US42861402P | 2002-11-22 | 2002-11-22 | |
| US60/428,614 | 2002-11-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010162637A Division JP2011015682A (ja) | 2002-08-09 | 2010-07-20 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015198665A JP2015198665A (ja) | 2015-11-12 |
| JP2015198665A5 true JP2015198665A5 (https=) | 2016-05-26 |
| JP6602561B2 JP6602561B2 (ja) | 2019-11-06 |
Family
ID=31720582
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004529297A Pending JP2005535342A (ja) | 2002-08-09 | 2003-08-08 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
| JP2010162637A Pending JP2011015682A (ja) | 2002-08-09 | 2010-07-20 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
| JP2015117465A Expired - Fee Related JP6602561B2 (ja) | 2002-08-09 | 2015-06-10 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004529297A Pending JP2005535342A (ja) | 2002-08-09 | 2003-08-08 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
| JP2010162637A Pending JP2011015682A (ja) | 2002-08-09 | 2010-07-20 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1551964A4 (https=) |
| JP (3) | JP2005535342A (https=) |
| AU (2) | AU2003264037B2 (https=) |
| CA (2) | CA2421269A1 (https=) |
| WO (1) | WO2004016726A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20060025337A1 (en) | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| CA2529510A1 (en) | 2003-07-01 | 2005-01-13 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| CA2553542A1 (en) * | 2003-10-31 | 2005-04-30 | Robarts Research Institute | Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of nad |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| EP1708689A2 (en) | 2003-12-29 | 2006-10-11 | The President and Fellows of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| JP2008501343A (ja) * | 2004-06-04 | 2008-01-24 | ワシントン・ユニバーシティ | 神経障害を治療するための方法および組成物 |
| PL1794306T3 (pl) | 2004-09-24 | 2010-05-31 | Bayer Cropscience Nv | Rośliny oporne na stres |
| EP1844157A4 (en) * | 2005-01-25 | 2009-11-25 | Univ Johns Hopkins | STRATEGIES FOR THE DESIGN OF SUBSTANCES TO BE TAKEN ON THE SIR2 FAMILY OF ENZYMES |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| EP1893759B1 (en) * | 2005-06-15 | 2009-08-12 | Bayer BioScience N.V. | Methods for increasing the resistance of plants to hypoxic conditions |
| US8158856B2 (en) * | 2006-03-21 | 2012-04-17 | Bayer Cropscience Nv | Stress resistant plants |
| PL2103212T3 (pl) | 2006-12-11 | 2015-03-31 | Okayama Barley Genome Tech Co Ltd | Regulator wzrostu roślin i jego zastosowanie |
| CN101686669B (zh) | 2007-11-13 | 2014-03-26 | 独立行政法人科学技术振兴机构 | 用于培育糖度提高的植物体的组合物及其用途 |
| JP5570731B2 (ja) * | 2008-02-28 | 2014-08-13 | 旭化成ファーマ株式会社 | ピロリン酸の測定方法 |
| EP2259782A4 (en) | 2008-03-03 | 2013-01-23 | Nad Life Pty Ltd | PHARMACEUTICAL FORMULATIONS OF RESVERATROL AND METHOD FOR THEIR USE IN THE TREATMENT OF CELL DISEASES |
| JP2011115098A (ja) * | 2009-12-04 | 2011-06-16 | Nippon Menaade Keshohin Kk | 加齢による皮膚明度の低下を予測する皮膚評価方法 |
| WO2013088956A1 (ja) | 2011-12-12 | 2013-06-20 | 岡山県 | 植物のアミノ酸含量を高めるための化合物およびその利用 |
| WO2014059034A2 (en) | 2012-10-09 | 2014-04-17 | President And Fellows Of Harvard College | Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
| WO2015069860A1 (en) * | 2013-11-06 | 2015-05-14 | President And Fellows Of Harvard College | Biological production of nad precursors and analogs |
| JP2017518306A (ja) | 2014-06-02 | 2017-07-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | 結晶性β−Ｄ−ニコチンアミドリボシドの製造および使用 |
| AU2015270090A1 (en) | 2014-06-06 | 2016-12-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| JP6623015B2 (ja) * | 2014-09-29 | 2019-12-18 | 国立研究開発法人理化学研究所 | 植物の耐塩性向上剤 |
| WO2020097116A1 (en) * | 2018-11-05 | 2020-05-14 | Rejuvenation Therapeutics | Compositions and methods for culturing yeast cells |
| US20220324899A1 (en) * | 2019-08-14 | 2022-10-13 | Metro International Biotech, Llc | Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide |
| CN111394268B (zh) * | 2019-12-20 | 2021-06-18 | 合肥康诺生物制药有限公司 | 基因工程菌及其构建方法、应用，生产nad+的方法 |
| CN112451673A (zh) * | 2020-12-10 | 2021-03-09 | 汤臣倍健股份有限公司 | 线粒体功能干预材料在制备改善线粒体功能的保健品或药品中的应用及其筛选方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| WO1987000201A1 (en) | 1985-07-05 | 1987-01-15 | Whitehead Institute For Biomedical Research | Epithelial cells expressing foreign genetic material |
| EP0378576B1 (en) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
| WO1989005345A1 (en) | 1987-12-11 | 1989-06-15 | Whitehead Institute For Biomedical Research | Genetic modification of endothelial cells |
| JP2917998B2 (ja) | 1988-02-05 | 1999-07-12 | ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ | 修飾された肝細胞およびその用途 |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| JP3249516B2 (ja) | 1990-10-31 | 2002-01-21 | ソマティクス セラピー コーポレイション | 遺伝子治療のためのレトロウイルスのベクター |
| EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
| ATE245703T1 (de) | 1992-09-22 | 2003-08-15 | Biofocus Discovery Ltd | Rekombinante viren, die an ihrer äusseren oberfläche ein nichtvirales polypeptid präsentieren |
| EP0746625B1 (en) | 1992-11-09 | 2004-03-31 | THE UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Targetable vector particles |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| BR9405507A (pt) | 1993-07-13 | 1999-05-25 | Rhone Poulenc Rorer Sa | Adenovirus recombinante defeituoso linhagem celular e composição farmaceutica |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5698443A (en) | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
| JP3816518B2 (ja) | 1994-06-10 | 2006-08-30 | ジェンベク、インコーポレイティッド | 相補的なアデノウイルスベクター系と細胞系 |
| WO1996013597A2 (en) | 1994-10-28 | 1996-05-09 | The Trustees Of The University Of Pennsylvania | Improved adenovirus and methods of use thereof |
| US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
| US5872005A (en) | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
| NZ300387A (en) | 1994-12-12 | 2001-07-27 | Genetic Therapy Inc | Adenoviral vector modified to reduce host immune and inflammatory responses and its use in gene therapy treatment |
| DK0811073T3 (da) | 1995-02-24 | 2007-05-21 | Univ Pennsylvania | Avendelse af immunmodulatorer til fremstilling af medikamenter til inhibering af immunresponser mod co-administrerede rekombinanter |
| US5688676A (en) | 1995-06-07 | 1997-11-18 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| AU722196B2 (en) | 1995-08-30 | 2000-07-27 | Genzyme Corporation | Chromatographic purification of adenovirus and AAV |
| GB9816781D0 (en) | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
| AU2001294173A1 (en) * | 2000-10-03 | 2002-04-15 | Takara Bio Inc. | Method of screening physiologically active substance |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| PL1794306T3 (pl) * | 2004-09-24 | 2010-05-31 | Bayer Cropscience Nv | Rośliny oporne na stres |
| US9515947B1 (en) | 2013-03-15 | 2016-12-06 | EMC IP Holding Company LLC | Method and system for providing a virtual network-aware storage array |
| KR20160071054A (ko) | 2014-12-11 | 2016-06-21 | 에스케이하이닉스 주식회사 | 반도체 메모리 장치 및 그의 동작 방법 |
| US9609948B2 (en) | 2015-04-28 | 2017-04-04 | Qianglong Furniture Co., Ltd. | Rotating armrest apparatus |
-
2003
- 2003-03-07 CA CA002421269A patent/CA2421269A1/en not_active Abandoned
- 2003-08-08 CA CA002495185A patent/CA2495185A1/en not_active Abandoned
- 2003-08-08 EP EP03788377A patent/EP1551964A4/en not_active Withdrawn
- 2003-08-08 AU AU2003264037A patent/AU2003264037B2/en not_active Ceased
- 2003-08-08 WO PCT/US2003/025016 patent/WO2004016726A2/en not_active Ceased
- 2003-08-08 JP JP2004529297A patent/JP2005535342A/ja active Pending
- 2003-08-08 EP EP11179088A patent/EP2431480A3/en not_active Withdrawn
-
2010
- 2010-07-20 JP JP2010162637A patent/JP2011015682A/ja active Pending
- 2010-09-10 AU AU2010219395A patent/AU2010219395B2/en not_active Ceased
-
2015
- 2015-06-10 JP JP2015117465A patent/JP6602561B2/ja not_active Expired - Fee Related
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