JP2015157851A5 - - Google Patents
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- Publication number
- JP2015157851A5 JP2015157851A5 JP2015094980A JP2015094980A JP2015157851A5 JP 2015157851 A5 JP2015157851 A5 JP 2015157851A5 JP 2015094980 A JP2015094980 A JP 2015094980A JP 2015094980 A JP2015094980 A JP 2015094980A JP 2015157851 A5 JP2015157851 A5 JP 2015157851A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- unit dosage
- diclofenac
- dissolution rate
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 61
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 52
- 229960001259 diclofenac Drugs 0.000 claims 52
- 238000004090 dissolution Methods 0.000 claims 28
- 239000002245 particle Substances 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 238000004519 manufacturing process Methods 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 13
- 239000011159 matrix material Substances 0.000 claims 12
- 239000002105 nanoparticle Substances 0.000 claims 8
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
- 229930195725 Mannitol Natural products 0.000 claims 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 4
- QFUFIDWMZKCFNQ-UHFFFAOYSA-M [Na+].OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCCCCCCCCCCOS([O-])(=O)=O Chemical compound [Na+].OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCCCCCCCCCCOS([O-])(=O)=O QFUFIDWMZKCFNQ-UHFFFAOYSA-M 0.000 claims 4
- 229960004977 anhydrous lactose Drugs 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 239000000594 mannitol Substances 0.000 claims 4
- 235000010355 mannitol Nutrition 0.000 claims 4
- 229960001855 mannitol Drugs 0.000 claims 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 4
- 238000003756 stirring Methods 0.000 claims 4
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 3
- 238000009837 dry grinding Methods 0.000 claims 3
- 229960001021 lactose monohydrate Drugs 0.000 claims 3
- 238000010298 pulverizing process Methods 0.000 claims 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 2
- 229960000590 celecoxib Drugs 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 2
- 239000007903 gelatin capsule Substances 0.000 claims 2
- 238000000227 grinding Methods 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 229960001375 lactose Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17229109P | 2009-04-24 | 2009-04-24 | |
| AU2009901748A AU2009901748A0 (en) | 2009-04-24 | A Novel Formulation of Diclofenac | |
| AU2009901748 | 2009-04-24 | ||
| US61/172,291 | 2009-04-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506289A Division JP6222924B2 (ja) | 2009-04-24 | 2010-04-23 | ジクロフェナクの新規製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015157851A JP2015157851A (ja) | 2015-09-03 |
| JP2015157851A5 true JP2015157851A5 (https=) | 2015-11-12 |
| JP6154846B2 JP6154846B2 (ja) | 2017-06-28 |
Family
ID=43010610
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506289A Expired - Fee Related JP6222924B2 (ja) | 2009-04-24 | 2010-04-23 | ジクロフェナクの新規製剤 |
| JP2015094980A Active JP6154846B2 (ja) | 2009-04-24 | 2015-05-07 | ジクロフェナクの新規製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506289A Expired - Fee Related JP6222924B2 (ja) | 2009-04-24 | 2010-04-23 | ジクロフェナクの新規製剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (12) | US8735450B2 (https=) |
| EP (2) | EP3290030A1 (https=) |
| JP (2) | JP6222924B2 (https=) |
| KR (5) | KR101580656B1 (https=) |
| CN (5) | CN106727477A (https=) |
| AP (2) | AP3774A (https=) |
| AU (1) | AU2010239080B2 (https=) |
| CA (1) | CA2759123C (https=) |
| CO (1) | CO6470810A2 (https=) |
| DK (1) | DK2421525T3 (https=) |
| EA (1) | EA201171285A1 (https=) |
| HK (2) | HK1202061A1 (https=) |
| IL (1) | IL215869B (https=) |
| MA (1) | MA33295B1 (https=) |
| MX (2) | MX337619B (https=) |
| MY (1) | MY168079A (https=) |
| NZ (3) | NZ595987A (https=) |
| PH (1) | PH12015500301A1 (https=) |
| SG (2) | SG175314A1 (https=) |
| TN (1) | TN2011000543A1 (https=) |
| UA (1) | UA106232C2 (https=) |
| WO (1) | WO2010121327A1 (https=) |
| ZA (1) | ZA201108650B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007264418B2 (en) | 2006-06-30 | 2012-05-03 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
| KR101580656B1 (ko) * | 2009-04-24 | 2015-12-30 | 아이슈티카 피티와이 리미티드 | 디클로페낙의 신규 제형 |
| SG10201607849TA (en) * | 2009-04-24 | 2016-11-29 | Iceutica Pty Ltd | Production of encapsulated nanoparticles at commercial scale |
| CN102438594A (zh) | 2009-04-24 | 2012-05-02 | 伊休蒂卡有限公司 | 吲哚美辛的新剂型 |
| JP5898613B2 (ja) * | 2009-04-24 | 2016-04-06 | イシューティカ ピーティーワイ リミテッド | 生物学的活性物質の溶解プロファイルを改善するための方法 |
| JP5909796B2 (ja) | 2012-03-02 | 2016-04-27 | 株式会社サンギ | 難溶性物質の水溶解性改善方法 |
| US20150250751A1 (en) * | 2012-10-16 | 2015-09-10 | Wockhardt Limited | Pharmaceutical compositions of diclofenac or salts thereof |
| US20140287039A1 (en) * | 2013-03-15 | 2014-09-25 | Iceutica Inc. | Abiraterone Acetate Formulation |
| US20150246060A1 (en) | 2013-03-15 | 2015-09-03 | Iceutica Inc. | Abiraterone Acetate Formulation and Methods of Use |
| US20150157646A1 (en) | 2013-09-27 | 2015-06-11 | Iceutica Inc. | Abiraterone Steroid Formulation |
| US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
| US20180153835A1 (en) * | 2015-06-05 | 2018-06-07 | Lupin Limited | Compositions of diclofenac acid |
| WO2017136617A1 (en) | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
| US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
| CN106267209A (zh) * | 2016-07-18 | 2017-01-04 | 苏州朗易生物医药研究有限公司 | 低剂量非甾体抗炎类药物组合物及其制备工艺 |
| EP4151306A1 (en) | 2016-11-10 | 2023-03-22 | Medisca Pharmaceutique Inc. | Pharmaceutical compounding methods and systems |
| CN106580886A (zh) * | 2016-12-05 | 2017-04-26 | 北京万全德众医药生物技术有限公司 | 一种双氯芬酸钾散剂及其制备方法 |
| US11311493B2 (en) * | 2017-04-07 | 2022-04-26 | Maa Laboratories, Inc. | Methods of improving the solubility and bioavailability of therapeutic agents |
| US12478612B2 (en) | 2017-06-30 | 2025-11-25 | Cindome Pharma, Inc. | Deuterated domperidone compositions, methods, and preparation |
| WO2019030773A1 (en) * | 2017-08-10 | 2019-02-14 | Sarudbhava Formulations Private Limited | DICLOFENAC COMPOSITIONS WITH LOW DOSE |
| KR20220007198A (ko) | 2020-07-10 | 2022-01-18 | 오훈 | 골프장의 홀컵 교체를 위한 홀 가공장치 및 그 홀의 시공방법 |
| CN114088624B (zh) * | 2021-11-09 | 2022-08-26 | 北京中检葆泰生物技术有限公司 | 用于谷物颗粒表面规则度检测设备 |
| CN115317464B (zh) * | 2022-09-01 | 2023-08-08 | 苏州弘森药业股份有限公司 | 一种双氯芬酸钾微胶囊及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2642486B2 (ja) | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| AU660852B2 (en) | 1992-11-25 | 1995-07-06 | Elan Pharma International Limited | Method of grinding pharmaceutical substances |
| US5478705A (en) | 1994-05-25 | 1995-12-26 | Eastman Kodak Company | Milling a compound useful in imaging elements using polymeric milling media |
| US5500331A (en) | 1994-05-25 | 1996-03-19 | Eastman Kodak Company | Comminution with small particle milling media |
| US5518738A (en) | 1995-02-09 | 1996-05-21 | Nanosystem L.L.C. | Nanoparticulate nsaid compositions |
| IE80467B1 (en) | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| IT1286778B1 (it) * | 1996-11-20 | 1998-07-17 | Alfa Wassermann Spa | Capsule contenenti diclofenac o suoi sali in soluzione |
| AU6853498A (en) * | 1997-04-22 | 1998-11-13 | Nippon Kayaku Kabushiki Kaisha | Flutamide preparations and method for manufacturing the same |
| US6375986B1 (en) | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
| JP4969761B2 (ja) | 2000-08-31 | 2012-07-04 | オバン・エナジー・リミテッド | 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法 |
| ES2292848T3 (es) | 2001-10-12 | 2008-03-16 | Elan Pharma International Limited | Composiciones que tienen una combinacion de caracteristicas de liberacion inmediata y liberacion controlada. |
| US7101576B2 (en) | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
| US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| GB0320522D0 (en) | 2003-09-02 | 2003-10-01 | Glaxo Group Ltd | Formulation |
| UA89513C2 (uk) | 2004-12-03 | 2010-02-10 | Элан Фарма Интернешнл Лтд. | Стабільна композиція з наночастинок ралоксифену гідрохлориду |
| CA2590675A1 (en) | 2004-12-15 | 2006-06-22 | Elan Pharma International Ltd. | Nanoparticulate tacrolimus formulations |
| EP1830824B1 (en) * | 2004-12-31 | 2016-01-13 | Iceutica Pty Ltd. | Nanoparticle composition and methods for synthesis thereof |
| WO2006099121A2 (en) | 2005-03-10 | 2006-09-21 | Elan Pharma International Limited | Formulations of a nanoparticulate finasteride, dutasteride and tamsulosin hydrochloride, and mixtures thereof |
| EP1877059B8 (en) | 2005-04-28 | 2010-05-19 | Wyeth a Corporation of the State of Delaware | Micronized tanaproget and compostions containing same |
| JO3352B1 (ar) * | 2005-06-17 | 2019-03-13 | Apr Applied Pharma Res Sa | صيغ دايكلوفيناك وطرق استخدامه |
| DK1973527T3 (da) * | 2005-12-15 | 2010-02-01 | Acusphere Inc | Fremgangsmåder til fremstilling af partikelbaserede farmaceutiske formulationer til parenteral indgivelse |
| CA2631493A1 (en) * | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
| NZ705763A (en) | 2006-06-30 | 2016-10-28 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
| AU2007264418B2 (en) | 2006-06-30 | 2012-05-03 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
| KR101580656B1 (ko) | 2009-04-24 | 2015-12-30 | 아이슈티카 피티와이 리미티드 | 디클로페낙의 신규 제형 |
-
2010
- 2010-04-23 KR KR1020157018881A patent/KR101580656B1/ko not_active Expired - Fee Related
- 2010-04-23 NZ NZ595987A patent/NZ595987A/en unknown
- 2010-04-23 WO PCT/AU2010/000471 patent/WO2010121327A1/en not_active Ceased
- 2010-04-23 US US13/266,122 patent/US8735450B2/en active Active
- 2010-04-23 NZ NZ710383A patent/NZ710383A/en unknown
- 2010-04-23 KR KR1020167036214A patent/KR20170002683A/ko not_active Abandoned
- 2010-04-23 UA UAA201113804A patent/UA106232C2/uk unknown
- 2010-04-23 MX MX2011011222A patent/MX337619B/es active IP Right Grant
- 2010-04-23 MX MX2016003067A patent/MX347290B/es unknown
- 2010-04-23 KR KR1020147028068A patent/KR20140124873A/ko not_active Ceased
- 2010-04-23 AP AP2011005989A patent/AP3774A/en active
- 2010-04-23 CA CA2759123A patent/CA2759123C/en active Active
- 2010-04-23 MY MYPI2011005115A patent/MY168079A/en unknown
- 2010-04-23 CN CN201611035592.6A patent/CN106727477A/zh active Pending
- 2010-04-23 JP JP2012506289A patent/JP6222924B2/ja not_active Expired - Fee Related
- 2010-04-23 DK DK10766520.0T patent/DK2421525T3/en active
- 2010-04-23 CN CN201611088810.2A patent/CN106420667A/zh active Pending
- 2010-04-23 KR KR1020117027888A patent/KR20120029398A/ko not_active Ceased
- 2010-04-23 KR KR1020157002594A patent/KR20150018647A/ko not_active Ceased
- 2010-04-23 SG SG2011077450A patent/SG175314A1/en unknown
- 2010-04-23 CN CN2010800178856A patent/CN102438610A/zh active Pending
- 2010-04-23 SG SG10201401700XA patent/SG10201401700XA/en unknown
- 2010-04-23 AP AP2015008933A patent/AP2015008933A0/xx unknown
- 2010-04-23 CN CN201410295622.1A patent/CN104161743A/zh active Pending
- 2010-04-23 EP EP17174634.0A patent/EP3290030A1/en not_active Ceased
- 2010-04-23 MA MA34381A patent/MA33295B1/fr unknown
- 2010-04-23 CN CN201611080116.6A patent/CN106727424A/zh active Pending
- 2010-04-23 NZ NZ620887A patent/NZ620887A/en unknown
- 2010-04-23 EA EA201171285A patent/EA201171285A1/ru unknown
- 2010-04-23 EP EP10766520.0A patent/EP2421525B1/en active Active
- 2010-04-23 AU AU2010239080A patent/AU2010239080B2/en active Active
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2011
- 2011-10-23 IL IL215869A patent/IL215869B/en active IP Right Grant
- 2011-10-24 TN TNP2011000543A patent/TN2011000543A1/en unknown
- 2011-11-23 CO CO11160596A patent/CO6470810A2/es not_active Application Discontinuation
- 2011-11-24 ZA ZA2011/08650A patent/ZA201108650B/en unknown
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2013
- 2013-01-25 US US13/750,869 patent/US8679544B2/en active Active
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2014
- 2014-01-29 US US14/167,652 patent/US8999387B2/en active Active
- 2014-05-14 US US14/277,287 patent/US9017721B2/en active Active
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2015
- 2015-02-11 PH PH12015500301A patent/PH12015500301A1/en unknown
- 2015-02-12 US US14/621,269 patent/US9180096B2/en active Active
- 2015-02-13 US US14/621,863 patent/US9173854B2/en active Active
- 2015-02-13 US US14/621,919 patent/US9180095B2/en active Active
- 2015-02-13 US US14/622,050 patent/US9186328B2/en active Active
- 2015-03-13 HK HK15102596.7A patent/HK1202061A1/xx unknown
- 2015-05-07 JP JP2015094980A patent/JP6154846B2/ja active Active
- 2015-11-09 US US14/936,494 patent/US20160058707A1/en not_active Abandoned
- 2015-11-16 US US14/942,513 patent/US20160067199A1/en not_active Abandoned
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2016
- 2016-12-21 US US15/387,295 patent/US20170100356A1/en not_active Abandoned
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2017
- 2017-05-18 HK HK17105039.3A patent/HK1231383A1/zh unknown
-
2018
- 2018-06-14 US US16/009,146 patent/US20180296514A1/en not_active Abandoned
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