JP2015120746A - 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化 - Google Patents

汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化 Download PDF

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Publication number
JP2015120746A
JP2015120746A JP2015054497A JP2015054497A JP2015120746A JP 2015120746 A JP2015120746 A JP 2015120746A JP 2015054497 A JP2015054497 A JP 2015054497A JP 2015054497 A JP2015054497 A JP 2015054497A JP 2015120746 A JP2015120746 A JP 2015120746A
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Japan
Prior art keywords
antibody
rabbit
framework
antibodies
amino acid
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English (en)
Japanese (ja)
Inventor
ボラス レオナルド
Borras Leonardo
ボラス レオナルド
ウレヒ デイビッド
Urech David
ウレヒ デイビッド
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Esbatech a Novartis Co LLC
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Esbatech a Novartis Co LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015054497A 2008-06-25 2015-03-18 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化 Withdrawn JP2015120746A (ja)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US61/075,692 2008-06-25
US61/075,697 2008-06-25
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
US61/155,041 2009-02-24
US61/155,105 2009-02-24
CH832/09 2009-06-02
CH8322009 2009-06-02

Related Parent Applications (1)

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JP2011515051A Division JP5856480B2 (ja) 2008-06-25 2009-06-25 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化

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JP2016088845A Division JP2016135815A (ja) 2008-06-25 2016-04-27 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化

Publications (1)

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JP2015120746A true JP2015120746A (ja) 2015-07-02

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Application Number Title Priority Date Filing Date
JP2015054497A Withdrawn JP2015120746A (ja) 2008-06-25 2015-03-18 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化
JP2016088845A Pending JP2016135815A (ja) 2008-06-25 2016-04-27 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化
JP2017148091A Active JP6568557B2 (ja) 2008-06-25 2017-07-31 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化
JP2019016882A Active JP6903083B2 (ja) 2008-06-25 2019-02-01 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化
JP2020080224A Withdrawn JP2020114260A (ja) 2008-06-25 2020-04-30 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化

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JP2016088845A Pending JP2016135815A (ja) 2008-06-25 2016-04-27 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化
JP2017148091A Active JP6568557B2 (ja) 2008-06-25 2017-07-31 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化
JP2019016882A Active JP6903083B2 (ja) 2008-06-25 2019-02-01 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化
JP2020080224A Withdrawn JP2020114260A (ja) 2008-06-25 2020-04-30 汎用性抗体フレームワークを用いたイエウサギ抗体のヒト化

Country Status (9)

Country Link
JP (5) JP2015120746A (ko)
KR (2) KR20210097819A (ko)
CL (1) CL2010001539A1 (ko)
ES (1) ES2771150T3 (ko)
HU (1) HUE047678T2 (ko)
PH (2) PH12013502219A1 (ko)
PT (2) PT2307458T (ko)
RU (2) RU2696202C1 (ko)
ZA (3) ZA201008592B (ko)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003074679A2 (en) * 2002-03-01 2003-09-12 Xencor Antibody optimization
WO2003097697A2 (en) * 2002-05-22 2003-11-27 Esbatech Ag Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
US20060216293A1 (en) * 2005-03-24 2006-09-28 Couto Fernando J R TNFalpha-neutralizing antibodies
WO2006131013A2 (en) * 2005-06-07 2006-12-14 Esbatech Ag STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα
WO2007001851A2 (en) * 2005-06-20 2007-01-04 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2007042775A2 (en) * 2005-10-07 2007-04-19 Photobiotics Limited Conjugates of photosensitisers and antibodies
JP2007528723A (ja) * 2003-08-22 2007-10-18 メディミューン，インコーポレーテッド 抗体のヒト化
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
WO2008118356A2 (en) * 2007-03-22 2008-10-02 Biogen Idec Ma Inc. Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2267620A1 (en) * 1996-07-16 1998-01-22 Andreas Pluckthun Immunoglobulin superfamily domains and fragments with increased solubility
CA2634294A1 (en) * 2000-08-03 2002-02-14 Therapeutic Human Polyclonals, Inc. Production of humanized antibodies in transgenic animals
WO2002086093A2 (en) * 2001-04-25 2002-10-31 Weigel Paul H Methods of using a hyaluronan receptor
WO2004016740A2 (en) * 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
WO2005016950A1 (en) * 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003074679A2 (en) * 2002-03-01 2003-09-12 Xencor Antibody optimization
WO2003097697A2 (en) * 2002-05-22 2003-11-27 Esbatech Ag Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
JP2007528723A (ja) * 2003-08-22 2007-10-18 メディミューン，インコーポレーテッド 抗体のヒト化
US20060216293A1 (en) * 2005-03-24 2006-09-28 Couto Fernando J R TNFalpha-neutralizing antibodies
WO2006131013A2 (en) * 2005-06-07 2006-12-14 Esbatech Ag STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα
WO2007001851A2 (en) * 2005-06-20 2007-01-04 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2007042775A2 (en) * 2005-10-07 2007-04-19 Photobiotics Limited Conjugates of photosensitisers and antibodies
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
WO2008118356A2 (en) * 2007-03-22 2008-10-02 Biogen Idec Ma Inc. Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
JPN5011006345; ＳＡＩＪＯ　ＳＨＩＮＪＩ　ｅｔ　ａｌ: ＪＯＵＲＮＡＬ　ＯＦ　ＢＩＯＣＨＥＭＩＳＴＲＹ Ｖｏｌ．　１１８，　Ｎｏ．　１, 1995, ｐ．　２８-３２ *
JPN5011006346; ＷＯＥＲＮ　Ａ　ｅｔ　ａｌ: 'ＳＴＡＢＩＬＩＴＹ　ＥＮＧＩＮＥＥＲＩＮＧ　ＯＦ　ＡＮＴＩＢＯＤＹ　ＳＩＮＧＬＥ-ＣＨＡＩＮ　ＦＶ　ＦＲＡＧＭＥＮＴＳ' ＪＯＵＲＮＡＬ　ＯＦ　ＭＯＬＥＣＵＬＡＲ　ＢＩＯＬＯＧＹ Ｖｏｌ．　３０５，　Ｎｏ．　５, 20010202, ｐ．　９８９-１０１０ *
JPN5011006347; ＤＯＥＲＩＮＧ　Ｅ　ｅｔ　ａｌ: 'ＩＤＥＮＴＩＦＩＣＡＴＩＯＮ　ＡＮＤ　ＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮ　ＯＦ　Ａ　ＴＮＴ．ＡＬＰＨＡ．　ＡＮＴＡＧＯＮＩＳＴ　ＤＥＲＩＶＥＤ　ＦＲＯＭ　Ａ　ＭＯＮＯＣＬＯＮＡＬ　ＡＮＴＩＢＯＤＹ' ＭＯＬＥＣＵＬＡＲ　ＩＭＭＵＮＯＬＯＧＹ Ｖｏｌ．　３１，　Ｎｏ．　１４, 19941001, ｐ．　１０５９-１０６７, ＰＥＲＧＡＭＯＮ *
JPN5011006846; ＨＯＮＥＧＧＥＲ　Ａ　ｅｔ　ａｌ: ＪＯＵＲＮＡＬ　ＯＦ　ＭＯＬＥＣＵＬＡＲ　ＢＩＯＬＯＧＹ Ｖｏｌ．　３０９，　Ｎｏ．　３, 20010608, ｐ．　６５７-６７０ *
JPN5011006847; ＥＷＥＲＴ　Ｓ　ｅｔ　ａｌ: ＭＥＴＨＯＤＳ Ｖｏｌ．　３４，　Ｎｏ．　２, 20041001, ｐ．　１８４-１９９, ＡＣＡＤＥＭＩＣ　ＰＲＥＳＳ　ＩＮＣ． *
JPN5011006848; ＥＷＥＲＴ　Ｓ　ｅｔ　ａｌ: ＢＩＯＣＨＥＭＩＳＴＲＹ Ｖｏｌ．　４２，　Ｎｏ．　６, 20030218, ｐ．　１５１７-１５２８, ＡＭＥＲＩＣＡＮ　ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹ *
JPN5011006849; ＫＮＡＰＰＩＫ　Ａ　ｅｔ　ａｌ: ＪＯＵＲＮＡＬ　ＯＦ　ＭＯＬＥＣＵＬＡＲ　ＢＩＯＬＯＧＹ Ｖｏｌ．　２９６　Ｎｏ．　１, 20000211, ｐ．　５７-８６ *
JPN5011006850; ＰＯＰＫＯＶ　Ｍ　ｅｔ　ａｌ: ＪＯＵＲＮＡＬ　ＯＦ　ＭＯＬＥＣＵＬＡＲ　ＢＩＯＬＯＧＹ Ｖｏｌ．　３２５　Ｎｏ．　２, 20030110, ｐ．　３２５-３３５ *
JPN5011006851; ＪＵＮＧ　Ｓ　ｅｔ　ａｌ: ＰＲＯＴＥＩＮ　ＥＮＧＩＮＥＥＲＩＮＧ Ｖｏｌ．　１０，　Ｎｏ．　８, 19970101, ｐ．　９５９-９６６, ＯＸＦＯＲＤ　ＵＮＩＶＥＲＳＩＴＹ　ＰＲＥＳＳ *
JPN5011006852; ＲＯＣＨＡ　Ｒ　ｅｔ　ａｌ: ＰＡＴＨＯＬＯＧＹ　ＲＥＳＥＡＲＣＨ　ＡＮＤ　ＰＲＡＣＴＩＣＥ Ｖｏｌ．　２０４，　Ｎｏ．　９, 200809, ｐ．　６５５-６６２, ＧＵＳＴＡＶ　ＦＩＳＣＨＥＲ *
JPN5011006853; ＯＴＴＩＧＥＲ　ＭＩＣＨＡＥＬ　ｅｔ　ａｌ: ＩＮＶＥＳＴＩＧＡＴＩＶＥ　ＯＰＨＴＨＡＬＭＯＬＯＧＹ　＆　ＶＩＳＵＡＬ　ＳＣＩＥＮＣＥ Ｖｏｌ．　５０，　Ｎｏ．　２, 20090201, ｐ．　７７９-７８６ *
JPN5011006854; ＦＵＲＲＥＲ　ＥＳＴＨＥＲ　ｅｔ　ａｌ: ＩＮＶＥＳＴＩＧＡＴＩＶＥ　ＯＰＨＴＨＡＬＭＯＬＯＧＹ　＆　ＶＩＳＵＡＬ　ＳＣＩＥＮＣＥ Ｖｏｌ．　５０，　Ｎｏ．　２, 20090201, ｐ．　７７１-７７８ *
JPN5011006855; ＫＵＥＧＬＥＲ　ＭＡＲＫＵＳ　ｅｔ　ａｌ: ＰＲＯＴＥＩＮ　ＥＮＧＩＮＥＥＲＩＮＧ，　ＤＥＳＩＧＮ　＆　ＳＥＬＥＣＴＩＯＮ Ｖｏｌ．　２２，　Ｎｏ．　３, 200903, ｐ．　１３５-１４７ *

Also Published As

Publication number Publication date
RU2019119412A (ru) 2020-12-21
JP2016135815A (ja) 2016-07-28
RU2696202C1 (ru) 2019-07-31
ZA201008592B (en) 2014-02-26
JP6568557B2 (ja) 2019-08-28
JP2017190352A (ja) 2017-10-19
ZA201503267B (en) 2016-07-27
CL2010001539A1 (es) 2012-02-03
PH12013502219A1 (en) 2016-01-25
HUE047678T2 (hu) 2020-05-28
JP6903083B2 (ja) 2021-07-14
PT2752428T (pt) 2020-02-14
PT2307458T (pt) 2018-07-18
PH12018501715A1 (en) 2019-08-19
JP2019065050A (ja) 2019-04-25
ZA201308755B (en) 2015-08-26
KR20210097819A (ko) 2021-08-09
KR20190091578A (ko) 2019-08-06
ES2771150T3 (es) 2020-07-06
KR102284435B1 (ko) 2021-08-02
JP2020114260A (ja) 2020-07-30

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