PH12013502219A1 - Humanization of rabbit antibodies using a universal antibody framework - Google Patents

Humanization of rabbit antibodies using a universal antibody framework

Info

Publication number
PH12013502219A1
PH12013502219A1 PH12013502219A PH12013502219A PH12013502219A1 PH 12013502219 A1 PH12013502219 A1 PH 12013502219A1 PH 12013502219 A PH12013502219 A PH 12013502219A PH 12013502219 A PH12013502219 A PH 12013502219A PH 12013502219 A1 PH12013502219 A1 PH 12013502219A1
Authority
PH
Philippines
Prior art keywords
universal antibody
humanization
rabbit antibodies
antibody framework
antibodies
Prior art date
Application number
PH12013502219A
Other languages
English (en)
Inventor
Borras Leonardo
Urech David
Original Assignee
Esbatech Alcon Biomed Res Unit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CH2009/000222 external-priority patent/WO2009155726A2/en
Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit
Publication of PH12013502219A1 publication Critical patent/PH12013502219A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PH12013502219A 2008-06-25 2013-10-25 Humanization of rabbit antibodies using a universal antibody framework PH12013502219A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
CH8322009 2009-06-02
PCT/CH2009/000222 WO2009155726A2 (en) 2008-06-25 2009-06-25 Humanization of rabbit antibodies using a universal antibody framework

Publications (1)

Publication Number Publication Date
PH12013502219A1 true PH12013502219A1 (en) 2016-01-25

Family

ID=53532693

Family Applications (2)

Application Number Title Priority Date Filing Date
PH12013502219A PH12013502219A1 (en) 2008-06-25 2013-10-25 Humanization of rabbit antibodies using a universal antibody framework
PH12018501715A PH12018501715A1 (en) 2008-06-25 2018-08-13 Humanization of rabbit antibodies using a universal antibody framework

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH12018501715A PH12018501715A1 (en) 2008-06-25 2018-08-13 Humanization of rabbit antibodies using a universal antibody framework

Country Status (9)

Country Link
JP (5) JP2015120746A (ko)
KR (2) KR20210097819A (ko)
CL (1) CL2010001539A1 (ko)
ES (1) ES2771150T3 (ko)
HU (1) HUE047678T2 (ko)
PH (2) PH12013502219A1 (ko)
PT (2) PT2307458T (ko)
RU (2) RU2696202C1 (ko)
ZA (3) ZA201008592B (ko)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2267620A1 (en) * 1996-07-16 1998-01-22 Andreas Pluckthun Immunoglobulin superfamily domains and fragments with increased solubility
CA2634294A1 (en) * 2000-08-03 2002-02-14 Therapeutic Human Polyclonals, Inc. Production of humanized antibodies in transgenic animals
WO2002086093A2 (en) * 2001-04-25 2002-10-31 Weigel Paul H Methods of using a hyaluronan receptor
WO2003074679A2 (en) * 2002-03-01 2003-09-12 Xencor Antibody optimization
CN102093477B (zh) * 2002-05-22 2014-02-26 艾斯巴技术-诺华有限责任公司 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法
WO2004016740A2 (en) * 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
WO2005016950A1 (en) * 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
EP1660534A2 (en) * 2003-08-22 2006-05-31 MedImmune, Inc. Humanization of antibodies
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
BRPI0611765B1 (pt) * 2005-06-07 2022-09-27 Esbatech Ag Anticorpo ou fragmento de anticorpo estável e solúvel que se liga especificamente ao tnf-alfa seus usos e composição diagnóstica ou terapêutica
KR101103108B1 (ko) * 2005-06-20 2012-01-04 제넨테크, 인크. 종양의 진단 및 치료를 위한 조성물 및 방법
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
MX2009010120A (es) * 2007-03-22 2009-10-19 Ucb Pharma Sa Proteinas de union, incluyendo anticuerpos, derivados de anticuerpo y fragmentos de anticuerpo, que se unen especificamente cd154 y sus usos.

Also Published As

Publication number Publication date
RU2019119412A (ru) 2020-12-21
JP2016135815A (ja) 2016-07-28
RU2696202C1 (ru) 2019-07-31
ZA201008592B (en) 2014-02-26
JP6568557B2 (ja) 2019-08-28
JP2017190352A (ja) 2017-10-19
ZA201503267B (en) 2016-07-27
CL2010001539A1 (es) 2012-02-03
HUE047678T2 (hu) 2020-05-28
JP6903083B2 (ja) 2021-07-14
PT2752428T (pt) 2020-02-14
PT2307458T (pt) 2018-07-18
PH12018501715A1 (en) 2019-08-19
JP2019065050A (ja) 2019-04-25
ZA201308755B (en) 2015-08-26
KR20210097819A (ko) 2021-08-09
JP2015120746A (ja) 2015-07-02
KR20190091578A (ko) 2019-08-06
ES2771150T3 (es) 2020-07-06
KR102284435B1 (ko) 2021-08-02
JP2020114260A (ja) 2020-07-30

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