JP2015117181A - 敗血症治療剤 - Google Patents

敗血症治療剤 Download PDF

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Publication number
JP2015117181A
JP2015117181A JP2012035965A JP2012035965A JP2015117181A JP 2015117181 A JP2015117181 A JP 2015117181A JP 2012035965 A JP2012035965 A JP 2012035965A JP 2012035965 A JP2012035965 A JP 2012035965A JP 2015117181 A JP2015117181 A JP 2015117181A
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JP
Japan
Prior art keywords
sepsis
therapeutic agent
seq
monoclonal antibody
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012035965A
Other languages
English (en)
Japanese (ja)
Inventor
藤 秀 次 佐
Hidetsugu Sato
藤 秀 次 佐
藤 武 後
Takeshi Goto
藤 武 後
森 直 哉 大
Naoya Omori
森 直 哉 大
貴 真 江
Takamasa Ko
貴 真 江
田 弥 生 島
Yayoi Shimada
田 弥 生 島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Josai University
Original Assignee
Josai University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Josai University filed Critical Josai University
Priority to JP2012035965A priority Critical patent/JP2015117181A/ja
Priority to TW102106211A priority patent/TWI605059B/zh
Priority to PCT/JP2013/054551 priority patent/WO2013125687A1/ja
Priority to KR1020147024978A priority patent/KR102159412B1/ko
Priority to US14/380,292 priority patent/US20150079090A1/en
Priority to CN201380020995.1A priority patent/CN104379165B/zh
Priority to EP13751092.1A priority patent/EP2815763B1/en
Priority to IN7875DEN2014 priority patent/IN2014DN07875A/en
Publication of JP2015117181A publication Critical patent/JP2015117181A/ja
Priority to US15/292,450 priority patent/US20170096478A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012035965A 2012-02-22 2012-02-22 敗血症治療剤 Pending JP2015117181A (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2012035965A JP2015117181A (ja) 2012-02-22 2012-02-22 敗血症治療剤
TW102106211A TWI605059B (zh) 2012-02-22 2013-02-22 Inflammatory disease treatment agent
PCT/JP2013/054551 WO2013125687A1 (ja) 2012-02-22 2013-02-22 炎症疾患治療剤
KR1020147024978A KR102159412B1 (ko) 2012-02-22 2013-02-22 염증 질환 치료제
US14/380,292 US20150079090A1 (en) 2012-02-22 2013-02-22 Therapeutic agent for inflammatory disease
CN201380020995.1A CN104379165B (zh) 2012-02-22 2013-02-22 炎症疾病治疗剂
EP13751092.1A EP2815763B1 (en) 2012-02-22 2013-02-22 Therapeutic agent for inflammatory disease
IN7875DEN2014 IN2014DN07875A (OSRAM) 2012-02-22 2013-02-22
US15/292,450 US20170096478A1 (en) 2012-02-22 2016-10-13 Therapeutic agent for inflammatory disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012035965A JP2015117181A (ja) 2012-02-22 2012-02-22 敗血症治療剤

Publications (1)

Publication Number Publication Date
JP2015117181A true JP2015117181A (ja) 2015-06-25

Family

ID=49005863

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012035965A Pending JP2015117181A (ja) 2012-02-22 2012-02-22 敗血症治療剤

Country Status (8)

Country Link
US (2) US20150079090A1 (OSRAM)
EP (1) EP2815763B1 (OSRAM)
JP (1) JP2015117181A (OSRAM)
KR (1) KR102159412B1 (OSRAM)
CN (1) CN104379165B (OSRAM)
IN (1) IN2014DN07875A (OSRAM)
TW (1) TWI605059B (OSRAM)
WO (1) WO2013125687A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103534271B (zh) 2010-08-20 2016-06-22 学校法人城西大学 有免疫抑制活性的单克隆抗体或其抗原结合片段
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US11041017B2 (en) * 2016-03-29 2021-06-22 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
WO2018056150A1 (ja) * 2016-09-23 2018-03-29 ティーエフケイ株式会社 化合物又はその塩、抗炎症剤、肺がんに対する抗がん剤、化合物又はその塩の製造方法、炎症性疾患の治療方法及び肺がんの治療方法
CN119912525B (zh) * 2025-04-02 2025-07-29 天津不二蛋白有限公司 含抗炎症肽序列的大豆蛋白水解物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101056979B (zh) * 2004-09-03 2013-06-05 阿梅特拉斯法玛有限公司 抗组蛋白h1单克隆抗体及用于产生其的杂交瘤
EP2196212A4 (en) * 2007-10-04 2012-01-25 Josai University Corp PREPARATION AND METHOD FOR THE ADMINISTRATION OF A VACCINE AND IONTOPHORESE DEVICE WITH THE PREPARATION
JP2011503012A (ja) * 2007-11-06 2011-01-27 オクラホマ・メディカル・リサーチ・ファウンデーション 予後に関するバイオマーカーおよび治療の分子標的としての細胞外ヒストン
CN103534271B (zh) * 2010-08-20 2016-06-22 学校法人城西大学 有免疫抑制活性的单克隆抗体或其抗原结合片段

Also Published As

Publication number Publication date
US20170096478A1 (en) 2017-04-06
CN104379165B (zh) 2018-08-03
US20150079090A1 (en) 2015-03-19
CN104379165A (zh) 2015-02-25
TWI605059B (zh) 2017-11-11
EP2815763A4 (en) 2015-07-22
KR20140138699A (ko) 2014-12-04
TW201350502A (zh) 2013-12-16
KR102159412B1 (ko) 2020-09-23
EP2815763B1 (en) 2018-06-13
EP2815763A1 (en) 2014-12-24
WO2013125687A1 (ja) 2013-08-29
IN2014DN07875A (OSRAM) 2015-04-24

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